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See detailIsolated chlamydia trachomatis infection and cervical intraepithelial neoplasia in adolescence
To, Hong ULg

in The 2012 Conference of Asia Oceania Research Organisation on Genital Infection and Neoplasia, Hongkong 13-15 July 2012 (2012, July 15)

Many authors suggest an association between CT infection and dysplasia or neoplastic cervical atypia, but evidence of an isolated Chlamydia trachomatis (CT) infection increasing the risk of developing ... [more ▼]

Many authors suggest an association between CT infection and dysplasia or neoplastic cervical atypia, but evidence of an isolated Chlamydia trachomatis (CT) infection increasing the risk of developing cervical intraepithelial neoplasia (CIN) remains unproven. We present a case of isolated CT infection in an adolescent 17 year old girl who was referred to our hospital with high grade cervical squamous intraepithelial lesion (HSIL) on her Pap smear. CT was detected in both the rapid test of the endocervix specimen and PCR testing of urine, but human papilloma virus (HPV) infection (Qualitative HPV PCR test) was not present. CIN3 was confirmed on biopsy of the thick acetowhite and mosaic zone at colposcopy. Isolated CT infection is a potential factor in the development of CIN in adolescence. [less ▲]

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See detailRisk factor of fetal chromosomal aberrations in the south of Vietnam
To, Hong ULg

in European Federation of Societies for Ultrasound in Medicine and Biology (2012, April 22)

Objectives: The aim of this study is to find the risk factors of fetal chromosomal aberrations in order to classify a high risk pregnancy in our prenatal care unit. Material and methods: A prospective ... [more ▼]

Objectives: The aim of this study is to find the risk factors of fetal chromosomal aberrations in order to classify a high risk pregnancy in our prenatal care unit. Material and methods: A prospective study was carried out during one year in our clinic. 523 cases of amniocentesis was followed up and evaluated the relation with abnormal result (fetal aneuploidies) and the risk factors such as advanced maternal age (≥ 35 years old), parity, habitation, positive triple test (≥ 1/250), fetal malformation history and abnormal signs in the first and second trimester scanning. Results: The incidence of fetal aneuploidy was 3.4% (18/523 [95%CI: 2.1-5.4%]) and the trisomy 21 showed the most common in these chromosomal aberrations (67%). The younger women (< 35 years old), nulliparous, positive triple test and abnormal ultrasonographic findings (included increased nuchal translucency [≥ 2.4mm], absent nasal bone in the first trimester scanning and/or echogenic nodule in ventricular) was identified as the risk factors of fetal aneuploidies (OR was 2.3 [95%CI: 0.8-6.7], 4.0 [95%CI: 1.4-13.2], 3.3 [95%CI: 0.3-33.5] and 9.4 [95%CI: 1.1-79.2], respectively). The abnormal ultrasonographic findings found a relation significantly with abnormal chromosomes (p=0.04). Conclusion: Abnormal ultrasonographic findings in the first and second trimester were the important markers for predicting fetal aneuploidy, especially trisomy 21. [less ▲]

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See detailFeasibility of scanning fetal anatomy in the first trimester of gestation
To, Hong ULg

in European Federation of Societies for Ultrasound in Medicine and Biology (2012, April 22)

Objectives: This study aims to evaluate the feasibility of performing an anatomy scanned for fetal abnormalities at the time of nuchal translucency (NT) measurement in Vietnamese population Material and ... [more ▼]

Objectives: This study aims to evaluate the feasibility of performing an anatomy scanned for fetal abnormalities at the time of nuchal translucency (NT) measurement in Vietnamese population Material and methods: In a prospective study, 2500 singleton pregnancies measured fetal NT and scanned structural anatomy in the first trimester; then checked fetal morphology systematically at 18-24 weeks and followed up to their delivery. According to ultrasonographic abnormalities and amniocentesis, we evaluated the detection rate of ultrasound for aneuploidy in the first and second trimester of gestation. Results: The sensitivity and specificity of ultrasound for aneuploidy was 17.2% and 99.7%, respectively. All 13 cases of fetal ultrasonographic anomalies related significantly with an increased NT (≥ 2.4mm) (p < 0.001). 30.8% of these abnormalities that included cystic hygroma, omphalocele and holoprosencephaly were detected at 11-13.6 weeks’ gestation. In the second trimester scanning, 69.2% of major structural anomalies found and the detection rate of central nervous system malformation, abnormal heart, abdominal wall defect, face anomaly and skeletal deformities were 85.7%, 100%, 66.7%, 50% and 75%, alternatively. Conclusion: Scanning of fetal anatomy at the time of NT measuring is useful to detect fetal abnormalities, especially aneuploidy in Vietnamese pregnancies. [less ▲]

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See detailFetal nuchal translucency thickness in different cut-off points for aneuploidy screening in the south of Vietnam
To, Hong ULg; Schaaps, Jean-Pierre ULg; Foidart, Jean-Michel ULg

in Journal of Obstetrics and Gynaecology Research (2011), 37(10), 1327-1334

Aims: The purpose of this study was to define the most suitable cut-off point for fetal nuchal translucency thickness in a screening program for aneuploidy and trisomy 21 in the south of Vietnam. <br ... [more ▼]

Aims: The purpose of this study was to define the most suitable cut-off point for fetal nuchal translucency thickness in a screening program for aneuploidy and trisomy 21 in the south of Vietnam. <br />Material & Methods: Two thousand and five hundred cases of singleton pregnancies were followed prospectively from the first trimester to the delivery. The rate of aneuploidy was calculated by seeking a relationship to increased fetal nuchal translucency thickness then calculating the sensitivity and specificity of different cut-off points in thickness measurement to find the most suitable point for screening. <br />Results: The prevalence of fetal abnormality was 1.5% (95% CI 1.1–2.1), and 1.2% (95% CI 0.8–1.7) of aneuploidy cases found and the commonest was trisomy 21. A cut-off point at 2.4 mm showed the highest level of sensitivity and specificity for the detection of aneuploidy (65.5 and 95.7%) and trisomy 21 (75.0 and 95.1%), with a false-positive rate of 4.3 and 4.9%, respectively. <br />Conclusion: Using a cut-off point of nuchal translucency at 2.4 mm has potential for aneuploidy and trisomy 21 screening in the south of Vietnam. [less ▲]

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See detailEndometrial thickness in different cut-off points for predicting abnormal endometrium in Vietnamese women with postmenopausal bleeding
To, Hong ULg

in Ultrasound in Medicine & Biology (2011, August 26), 37(8S), 118

Purpose: The aim of this study is to find the suitable cutoff point of endometrial thickness (ET) for predicting abnormal endometrium in Vietnamese women with postmenopausal bleeding (PMB). Material ... [more ▼]

Purpose: The aim of this study is to find the suitable cutoff point of endometrial thickness (ET) for predicting abnormal endometrium in Vietnamese women with postmenopausal bleeding (PMB). Material & Methods: A prospective study was carried out during 2 years. 308 women, who did not use any hormone therapy, were suffered from PMB. All of them were measured ET by transvaginal sonography before an endometrial biopsy. Dilation and curettage (D&C) was indicated in women with ET ≥ 3 mm to diagnose an abnormal endometrium (hyperplasia atypia or cancer). We compared the sensitivity and false-negative rate at each 1-mm interval cutoff point of ET for detecting these histopathologies. Results: 292 women gave their consent to perform an endometrial biopsy (D&C). Their mean age was 59.4 ± 9.3 years. The median time of amenorrhea was 5 years (range 2-13 years); 12.67% (95%CI 9.10-17.04) of cases were diagnosed an abnormal ET in which the mean of endometrial thickness found was 4.0±1.7 mm (95% CI 3.8-11.8). In comparison to seven cutoff points, the ET at 4 mm showed the highest detection rate of abnormal endometrium in women with PMB (95% of sensitivity for 4% false-negative rate) Conclusion: The ET at 4 mm is the most suitable cutoff point for predicting an abnormal endometrium in Vietnamese women with PMB. [less ▲]

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See detailStillbirth following severe symmetric fetal growth restriction due to reactivation of Epstein–Barr virus infection in pregnancy
To, Hong ULg

in Journal of Obstetrics and Gynaecology Research (2011)

Epstein–Barr virus (EBV) infection in pregnancy and consequent fetal outcomes are rarely reported. The majority of cases described strongly support the possibility of transmission of this virus in utero ... [more ▼]

Epstein–Barr virus (EBV) infection in pregnancy and consequent fetal outcomes are rarely reported. The majority of cases described strongly support the possibility of transmission of this virus in utero and during delivery, resulting in stillbirth and/or congenital defects. We present a case of EBV reactivation in pregnancy that caused a severe symmetrical fetal growth restriction (FGR) and ultimately spontaneous fetal death. A 36-year-old woman, whose infection status was undetermined, was diagnosed with severe FGR at 24 weeks’ gestation. The fetal karyotype was normal. EBV DNA was detected in the amniotic fluid and maternal immunoglobulin G antibodies were positive. At 30 weeks’ gestation, the fetus died spontaneously. Placental examination found evidence of deciduitis and villitis. Reactivation of EBV infection appears to be related to FGR and warrants further research to determine the optimal management strategy in pregnancy. [less ▲]

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See detailAnalysis of fetal death in relation with increased fetal nuchal translucency thickness in the south of Vietnam
To, Hong ULg; SCHAAPS, Jean-Pierre ULg; FOIDART, Jean-Michel ULg

in Nobuyuki, Taniguichi (Ed.) Asian Federation of Societies for Ultrasound in Medicine and Biology: AFSUMB, New Delhi 18-21 november 2010 (2010, November 18)

Objectives: The aim of this study was to investigate the fetal deaths relation with an increased fetal nuchal translucency (NT) thickness in the South of Vietnam. Methods: A total of 2500 singleton ... [more ▼]

Objectives: The aim of this study was to investigate the fetal deaths relation with an increased fetal nuchal translucency (NT) thickness in the South of Vietnam. Methods: A total of 2500 singleton pregnancies were measured fetal NT thickness and performed free beta subunit of human Chorionic Gonadotropin (free β-hCG) and pregnancy associated plasma protein-A (PAPP-A) routinely in the first trimester, then scanned systematically for fetal structure by ultrasonography at the second trimester of gestation, next followed to their delivery and examined neonatal status. For suspicion of fetal abnormality, amniocentesis was indicated to confirm a fetal karyotype. Fetal abnormal chromosome was counselled a termination of pregnancy (TOP). 5 groups of fetal NT thickness was divided: group of normal fetal NT thickness (< 2.4mm), group of mild increased of fetal NT thickness (2.4-3.4mm), group of moderate increased fetal NT (3.5-4.4mm), group of severe fetal NT (4.5-5.4mm) and group of very severe fetal NT (≥ 5.5mm). We evaluated the fetal deaths (included spontaneous abortion, fetal death intra-uterine, and terminated pregnancy due to aneuploidy and/or structural abnormality), then look for a relation between an increased fetal NT thickness and those fetal adverse outcomes. Results: Fetal NT thickness cut-off point at 2.4mm or more was defined as an increased fetal NT thickness with 65.5% of sensitivity for fetal abnormal detection. 5.3% (133/2500) was the prevalence of increased fetal NT thickness. 2.8% (71/2500) of cases had been indicated an amniocentesis. A total incidence of fetal death was found 1.5% (37/2500). In group of fetal NT thickness < 2.4mm, the rate of abnormal karyotype was 0.4% (10/2367), none case of fetal deaths obtained. In the fetal NT group of 2.4-3.4mm, total of fetal death found 26.4% (32/121) that included 12.4% (15/121) of abnormal karyotype, 8.3% (10/121) of abnormal ultrasound scanning, 5.8% (7/121) of fetal demised, and 0.8% (1 case) of neonatal defect due to G6PD deficiency. In the group of 3.5-4.4mm, 33.3% (3/9) of fetuses were died (22.2% was due to aneuploidy and 11.1% was due to miscarriage spontaneously). In the group of 4.5-5.4mm, 1 case (50%) of trisomy 18 was detected and in the group of ≥ 5.5mm, 1 case (100%) of trisomy 21 had been diagnosed. When fetal NT thickness increased, the possibility of fetal demised was higher significantly: likelihood ratio (LR) augmented from 15.2 in the fetal NT group at 2.4-3.4mm to 169.5 in fetal NT group at ≥ 5.5mm (p < 0.01, Pearson chi2). Conclusion: An increased fetal NT thickness was useful finding for prediction of fetal deaths (included fetal abortion, demised or terminated) in the prenatal diagnosis and care program in the South of Vietnam. [less ▲]

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See detailAnalysis of fetal death in relation with increased fetal nuchal translucency thickness in the south of Vietnam
To, Hong ULg; Schaaps, Jean-Pierre ULg; Foidart, Jean-Michel ULg

in Asian Federation of Societies for Ultrasound in Medicine and Biology (2010, November 18)

Objectives: The aim of this study was to investigate the fetal deaths relation with an increased fetal nuchal translucency (NT) thickness in the South of Vietnam. Methods: A total of 2500 singleton ... [more ▼]

Objectives: The aim of this study was to investigate the fetal deaths relation with an increased fetal nuchal translucency (NT) thickness in the South of Vietnam. Methods: A total of 2500 singleton pregnancies were measured fetal NT thickness and performed free beta subunit of human Chorionic Gonadotropin (free β-hCG) and pregnancy associated plasma protein-A (PAPP-A) routinely in the first trimester, then scanned systematically for fetal structure by ultrasonography at the second trimester of gestation, next followed to their delivery and examined neonatal status. For suspicion of fetal abnormality, amniocentesis was indicated to confirm a fetal karyotype. Fetal abnormal chromosome was counselled a termination of pregnancy (TOP). 5 groups of fetal NT thickness was divided: group of normal fetal NT thickness (< 2.4mm), group of mild increased of fetal NT thickness (2.4-3.4mm), group of moderate increased fetal NT (3.5-4.4mm), group of severe fetal NT (4.5-5.4mm) and group of very severe fetal NT (≥ 5.5mm). We evaluated the fetal deaths (included spontaneous abortion, fetal death intra-uterine, and terminated pregnancy due to aneuploidy and/or structural abnormality), then look for a relation between an increased fetal NT thickness and those fetal adverse outcomes. Results: Fetal NT thickness cut-off point at 2.4mm or more was defined as an increased fetal NT thickness with 65.5% of sensitivity for fetal abnormal detection. 5.3% (133/2500) was the prevalence of increased fetal NT thickness. 2.8% (71/2500) of cases had been indicated an amniocentesis. A total incidence of fetal death was found 1.5% (37/2500). In group of fetal NT thickness < 2.4mm, the rate of abnormal karyotype was 0.4% (10/2367), none case of fetal deaths obtained. In the fetal NT group of 2.4-3.4mm, total of fetal death found 26.4% (32/121) that included 12.4% (15/121) of abnormal karyotype, 8.3% (10/121) of abnormal ultrasound scanning, 5.8% (7/121) of fetal demised, and 0.8% (1 case) of neonatal defect due to G6PD deficiency. In the group of 3.5-4.4mm, 33.3% (3/9) of fetuses were died (22.2% was due to aneuploidy and 11.1% was due to miscarriage spontaneously). In the group of 4.5-5.4mm, 1 case (50%) of trisomy 18 was detected and in the group of ≥ 5.5mm, 1 case (100%) of trisomy 21 had been diagnosed. When fetal NT thickness increased, the possibility of fetal demised was higher significantly: likelihood ratio (LR) augmented from 15.2 in the fetal NT group at 2.4-3.4mm to 169.5 in fetal NT group at ≥ 5.5mm (p < 0.01, Pearson chi2). Conclusion: An increased fetal NT thickness was useful finding for prediction of fetal deaths (included fetal abortion, demised or terminated) in the prenatal diagnosis and care program in the South of Vietnam. [less ▲]

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