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See detailZinc complexes with 1,2,4-triazole functionalized amino acid derivatives: Synthesis, structure and b-lactamase assay
Naik, Anil; Beck, Joséphine; Dîrtu, Marinela et al

in Inorganica Chimica Acta (2011), 368

Coordinating abilities of 4R-1,2,4-triazole derivatives (R = glycine ethyl ester (L1), glycine (L2), diethylamino malonate (L3), methionine (L4) and diethyl aminomethylphosphonate (L5)) towards ZnII ions ... [more ▼]

Coordinating abilities of 4R-1,2,4-triazole derivatives (R = glycine ethyl ester (L1), glycine (L2), diethylamino malonate (L3), methionine (L4) and diethyl aminomethylphosphonate (L5)) towards ZnII ions have been studied in solution, in solid state and versus three zinc-b-lactamases. The crystal structure of [Zn3(L4)6(H2O)6] (6) is described; it is the first crystal structure involving a 1,2,4-triazole functionalized methionine. It forms a trinuclear complex with central zinc octahedrally coordinated by only L4, whereas terminal zinc ions coordination sphere is completed by three water molecules. L4 exhibits a dual functionality of a bridging bidentate ligand as well as an anion. A dense hydrogen bonding network connects these trinuclear entity into a 3D supramolecular network. The ZnII ions in 6 are held at equidistance (3.848 Å) which coincidently matches with the corresponding Zn Zn distance in the binuclear zinc enzyme from Bacillus cereus (3.848 and 4.365 Å). Among L1–L5 screened for b-lactamase assay, L4 shows modest inhibition for BcII enzyme. [less ▲]

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See detail(Di)-aminoguanidine Functionalization through Transamination: An Avenue to an Auspicious Class of Supramolecular Synthons
Naik, Anil D; Tinant, Bernard; Léonard, Alexandre ULg et al

in Crystal Growth & Design (2011), 11

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See detailNovel chiral 1-phosphono-1,3-butadiene for asymmetric hetero Diels-Alder cycloadditions with nitroso and azodicarboxylate dienophiles
Monbaliu, Jean-Christophe ULg; Tinant, Bernard; Peeters, Daniel et al

in Tetrahedron Letters (2010), 51

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See detailLarge ring 1,3-bridged 2-azetidinones: experimental and theoretical studies
Urbach, Allan; Dive, Georges ULg; Tinant, Bernard et al

in European Journal of Medicinal Chemistry (2009), 44

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See detailReactivity of (R)-4-phenyloxazolidin-2-thione chiral auxiliary: from deprotection to heterocyclic interconversion
Monbaliu, Jean-Christophe ULg; Tinant, Bernard; Marchand-Brynaert, Jacqueline

in Heterocycles (2008), 75

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See detailNMR and X-ray diffraction analysis of 3-thioamido-5- phosphono-1-cyclohexene derivatives: Conformational and stereochemical assignments
Monbaliu, Jean-Christophe ULg; Tinant, Bernard; Marchand-Brynaert, Jacqueline

in Journal of Molecular Structure (2008)

[4 + 2] Cycloaddition; ; Vinyl phosphonate dienophiles; ; Cyclohexene conformations; NMR analysis; X-ray diffraction

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See detailThe search for tolerant Lewis acid catalysts. Part2: enantiopure cycloalkyldialkylsilyl triflimide catalysts
Tang Zilong; Mathieu, Benoît; Tinant, Bernard et al

in Tetrahedron (2007), 63(35), 8449-8462

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See detailDiterpenes from the leaves of Croton Zambesicus
Block, Sébastien; Baccelli, Chiara; Tinant, Bernard et al

in Phytochemistry (2004), 65

Two new trachylobane- and one isopimarane-type diterpenoids: ent-18-hydroxy-trachyloban-3-one; ent-trachyloban-3-one; isopimara-7,15-dien-3b-ol, were isolated from the leaves of Croton zambesicus ... [more ▼]

Two new trachylobane- and one isopimarane-type diterpenoids: ent-18-hydroxy-trachyloban-3-one; ent-trachyloban-3-one; isopimara-7,15-dien-3b-ol, were isolated from the leaves of Croton zambesicus, together with trans-phytol, b-sitosterol, a-amyrin and stigmasterol. The structures were determined by extensive NMR techniques and X-ray analysis. The cytotoxicity of these compounds has been evaluated on cancer and non-cancer cell-lines. [less ▲]

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