References of "Tassoudji, Nazli"
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See detailLa gestion des médicaments photosensibilisants
DEZFOULIAN, Bita ULg; LEBAS, Eglantine ULg; DE SCHAETZEN VAN BRIENEN, Virginie ULg et al

in Skin Inc (2012), 15(3), 16-21

L'arrivée de l'été nous confronte à nouveau aux réactions médicamenteuses photo-induites. Deux types de réactions photosensibles sont rencontrés : la photoallergie médicamenteuse, plutôt rare, et la ... [more ▼]

L'arrivée de l'été nous confronte à nouveau aux réactions médicamenteuses photo-induites. Deux types de réactions photosensibles sont rencontrés : la photoallergie médicamenteuse, plutôt rare, et la phototoxicité médicamenteuse, beaucoup plus fréquente. Ces réactions peuvent se produire aussi bien avec des médicaments topiques que systémiques. La liste des médicaments classiquement en cause est actuellement enrichie de nouveaux médicaments tels que le voriconazole, l'ipilimumab et le vémurafénib. Cette revue présente les pricipaux mécanismes en cause, une mise à jour de la liste des médicaments photosensibilisants et la gestion prophylactique et thérapeutique des patients. [less ▲]

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See detailPHOTODYNAMIC THERAPY FOR MULTI-RESISTANT CUTANEOUS LANGERHANS CELL HISTIOCYTOSIS
FAILLA, Valérie ULg; WAUTERS, Odile ULg; CAUCANAS, MARIE et al

in Rare Tumors (2010), 2:e34

Langerhans cell histiocytosis is a rare group of proliferative disorders. Beside cutaneous involvement, other internal organs ca be affected. The treatment of cutaneous lesions is difficult and relies on ... [more ▼]

Langerhans cell histiocytosis is a rare group of proliferative disorders. Beside cutaneous involvement, other internal organs ca be affected. The treatment of cutaneous lesions is difficult and relies on topical corticosteroids, carmustine, nitrogen mustard, and photochemotherapy. Systemic steroids and vinblastine are used for recalcitrant skin lesions. Howerver, some cases fail to respond. An 18-month old boy presented a CD1a+, S100a+ Langerhans cell histocytosis with cutaneous and severe scalp involvement. Topical corticosteroids and nitrogen mustard failed to improve the skin lesions. Systemic corticosteroids and vinblastine improved the truncal involvement but had no effect on the scalp lesions. Methylaminolevulinate (MAL) based photodynamic therapy (PDT) resulted in a significant regression of the scalp lesions. Control histology revealed an almost complete clearance of the tumor infiltrate. Clinical follow-up after six months showed no recurrence. Although spontaneous regression of cutaneous Langerhans cell histiocytosis is observed, the rapid effect of photodynamic therapy for refractory skin lesions. Larger series are needed to determine whether photodynamic therapy deserves a place in the treatment of multiresistant cutaneous Langerhans cell histiocytosis. [less ▲]

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See detailCongenital infantile digital fibromatosis: a case report and review of the literature
Failla, Valérie ULg; Wauters, Odile ULg; Tassoudji, Nazli ULg et al

in Rare Tumors (2009), 1

Infantile digital fibromatosis (IDF) is a rare benign fibroproliferative tumor of early childhood. IDF preferentially affects the fingers and the toes. Malignant transformation or metastases habe never ... [more ▼]

Infantile digital fibromatosis (IDF) is a rare benign fibroproliferative tumor of early childhood. IDF preferentially affects the fingers and the toes. Malignant transformation or metastases habe never been reported. Surgical treatment has been advocated previously but local recurrences were frequently observed. Recent literature supports clinical surveilllance without any medical or surgical intervention as spontaneous regression usually occurs after two to three years. A six-month-old Caucasian girl with IDF on the left fourth digit is presented here. The tumor progressively increased in size after birth. Topical imiquimod cream and diflucortolone valerate cream, both displaying antifibrotic properties, had no effect on tumor growth. Currently, the lesion size remains stable without any treatment. Early recognition of IDF is important in order to avoid unnecessary surgical intervention that may prove to be potentially aggravating, unless serious functional or cosmetic concerns intervene. Parents should be rassured concerning the benign nature of IDF and be informed that spontaneous involution of IDF might be expected. [less ▲]

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See detailCorynebacterium-associated skin infections.
Blaise, Géraldine; Nikkels, Arjen ULg; Hermanns-Le, Trinh ULg et al

in International Journal of Dermatology (2008), 47(9), 884-90

BACKGROUND: Corynebacterium spp. are diphtheroid bacteria responsible for pitted keratolysis, a common plantar infection confined to the thick stratum corneum. AIM: To study a series of demographic ... [more ▼]

BACKGROUND: Corynebacterium spp. are diphtheroid bacteria responsible for pitted keratolysis, a common plantar infection confined to the thick stratum corneum. AIM: To study a series of demographic features of patients suffering from pitted keratolysis, and to present a review of the Corynebacterium-associated infections, including pitted keratolysis, erythrasma, and trichobacteriosis. MATERIALS AND METHODS: A 2-year, two-center, prospective survey assessed the demographics of pitted keratolysis, including age, gender, site of infection, symptoms, patients' complaints, the use of protective and/or occlusive shoes, seasonality of diagnosis, drug intake, associated skin signs (including dyshidrosis, erythrasma, and trichobacteriosis), recurrences, and previous diagnoses and treatments. RESULTS: The mean age of the 53 patients with pitted keratolysis was 24.9 years (range, 10-57 years). The male to female ratio was 7.8:1. The soles of both feet were commonly involved (92.4%). Pressure-bearing areas were the usual sites of infection, ranging from restricted involvement of the toes (12/53, 22.6%) to spreading to the entire plantar surface (15/53, 28.3%). A total of 36 (68%) of the 53 patients complained of hyperhidrosis. An unpleasant smell and pain were noted by 35 (66%) and 25 (47%) of the 53 patients, respectively. Occlusive and protective shoes were worn in 51 (96.2%) and 31 (58.4%) of the 53 cases, respectively. CONCLUSION: Pitted keratolysis commonly affects young male patients wearing protective shoes for professional reasons, inducing a moist and warm environment. Hyperhidrosis, an unpleasant smell, and pain are the main clinical complaints. [less ▲]

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See detailExceptional simultaneous herpesvirus infections. Pityriasis rosea and recurrent varicella in an immunocompetent child
Nikkels, Arjen ULg; Tassoudji, Nazli ULg; Thirion, Laurence et al

in Journal of Pediatric Infectious Diseases (2006)

Dual cutaneous herpesvirus (alpha-alpha, alpha-beta infections are exceptional. We report the first case of a simultaneous alpha- and delta-herpesvirus infection corresponding to recurrent varicella and ... [more ▼]

Dual cutaneous herpesvirus (alpha-alpha, alpha-beta infections are exceptional. We report the first case of a simultaneous alpha- and delta-herpesvirus infection corresponding to recurrent varicella and human delta herpesviruses 6 and 7-associated pityriasis rosea in an 8-year-old immunocompetent boy. This condition likely represents a stroke of misfortune, although a special link between two herpesvirus infections cannot be formally excluded. [less ▲]

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See detailOral antifungal-exacerbated inflammatory flare-up reactions of dermatomycosis: Case reports and review of the literature
Nikkels, Arjen ULg; Tassoudji, Nazli ULg; Pierard, Gérald ULg

in American Journal of Clinical Dermatology (2006), 7(5), 327-331

Inflammatory flare-up reactions of some dermatomycoses, particularly those caused by zoophilic fungi, are typical and potentially severe adverse effects following the intake of some oral antifungals ... [more ▼]

Inflammatory flare-up reactions of some dermatomycoses, particularly those caused by zoophilic fungi, are typical and potentially severe adverse effects following the intake of some oral antifungals. However, this condition has not previously been reported with the most frequently used antifungals in dermatology, namely fluconazole, itraconazole, and terbinafine. In this report, we describe five patients, observed over a 10-year period, who presented with inflammatory exacerbations following oral antifungal therapy for dermatomycoses. We also review the literature on inflammatory reactions exacerbated by oral antifungal agents. Details of the patients' age, sex, occupation, and atopic background; the site of the lesion, its clinical and histologic features, and any systemic signs; the identity of the fungal pathogen; the antifungal agent taken by the patient; the time between drug intake and occurrence of the flare-up; the approach to management; and the outcome were documented for each patient. A PubMed literature search was also conducted, focusing on inflammatory exacerbations induced by griseofulvin, ketoconazole, itraconazole, fluconazole, and terbinafine. The patients were four farmers and one veterinarian (all male). All primary lesions were inflammatory dermatophytoses, including one kerion. Inflammatory exacerbation of the skin lesions started 12-24 hours after the intake of oral antifungals. Mild systemic changes, including slight fever and malaise, occurred in two cases. Itraconazole 400 mg/day was implicated as the causative agent in four cases and terbinafine 250 mg/day in one case. Mycologic cultures grew Trichophyton verrucosum in four cases. Antifungal treatment was discontinued in all patients. Oral and topical corticosteroids were administered to the two patients with systemic changes; the other three patients were treated with topical corticosteroids only. Two days after the onset of corticosteroids, lower doses of itraconazole (100 mg/day) and terbinafine (125 mg/day) were reintroduced. All lesions healed after 4-5 weeks. The PubMed search did not identify any articles that described inflammatory exacerbations of dermatomycoses induced by oral antifungals. Inflammatory flare-up of der-matomycoses is a rare but potentially severe cutaneous complication of oral antifungal use. Occupational contact with animals, inflammatory dermatomycoses, and zoophilic fungi represent common features in these patients. Although evidence-based data are not available, clinical experience shows that, in addition to antifungal therapy, topical and/or systemic corticosteroids are helpful to reduce the inflammatory reactions. The cases described in this article represent the first published report of oral antifungal-exacerbated inflammatory flare-up reactions of dermatomycosis in patients taking itraconazole or terbinafine. [less ▲]

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See detailCutaneous adverse reactions following anti-infective vaccinations.
Nikkels, Arjen ULg; Tassoudji, Nazli ULg; Pierard, Gérald ULg

in American Journal of Clinical Dermatology (2005), 6(2), 79-87

Although widely administered, anti-infective vaccinations are rarely responsible for cutaneous adverse effects. In this context, hepatitis B and bacillus Calmette-Guerin vaccines are the most frequently ... [more ▼]

Although widely administered, anti-infective vaccinations are rarely responsible for cutaneous adverse effects. In this context, hepatitis B and bacillus Calmette-Guerin vaccines are the most frequently incriminated products. Cutaneous adverse effects are less frequently encountered following administration of vaccines against varicella, diphtheria/tetanus/pertussis (primary and booster doses), measles, poliomyelitis, rubella, pneumococcus, tick-borne encephalitis, smallpox, Meningococcus and influenza. The adverse effects can occur at the site of or at a distance from the injection. The patho-mechanisms of local adverse cutaneous reactions include predominantly nonspecific lymphoid or granulomatous reactions. Allergic reactions to the vaccine strain, adjuvants, conservatives or other components are less frequently involved in local vaccine adverse effects. Systemic reactions are mainly mediated by immediate type or immune complex-related allergic reactions to toxoid-, ovalbumin-, gelatin- or pneumococcal-containing vaccines. Systemic reactions are sometimes related to a specific vaccine strain. Other cutaneous reactions may also occur through unknown patho-mechanisms. No vaccine type or strain is specifically associated with a particular type of cutaneous adverse effect. This article presents seven case reports of cutaneous adverse effects following anti-infective vaccination then reviews the relevant literature on this subject. [less ▲]

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See detailPhotodynamic therapy and imiquimod immunotherapy for basal cell carcinomas
Nikkels, Arjen ULg; Pierard-Franchimont, Claudine ULg; Tassoudji, Nazli ULg et al

in Acta Clinica Belgica (2005), 60(5, Sep-Oct), 227-234

Photodynamic therapy (PDT) and topical imiquimod immunotherapy (TII) are two recently introduced treatment modalities for certain types of basal cell carcinomas (BCC). We present a review of the relevant ... [more ▼]

Photodynamic therapy (PDT) and topical imiquimod immunotherapy (TII) are two recently introduced treatment modalities for certain types of basal cell carcinomas (BCC). We present a review of the relevant literature and report our own findings regarding the efficacy and tolerance of PDT and TII in the treatment of BCCs. According to published studies, the cure rates range from 75-95% for PDT and 42-100% for TII, depending on treatment modalities and BCC type. In our observations, 13 patients with nodular or superficial BCCs were treated by PDT using two courses of 3-hour topical application of methyl aminolevulinate, followed by 8 minutes illumination (lambda = 634 rim, e = 37J/cm(2)). Biopsies were taken before and one month after PDT. Side effects including pain and crusting were assessed. Eight patients with superficial BCC were treated by TII using 3 monthly courses each consisting of 3 weekly applications for 3 weeks followed by one week out of treatment. Biopsies were taken before and after 3 months of TII. Adverse reactions including erythema, oozing, ulceration, and crusting were recorded. Clinico-histological cure was obtained in 12/13 PDT cases as assessed after I month, and in 6/8 TII cases after 3 months. Minimal pain during illumination and crust formation were observed in 7/13 and 3/13 PDT cases, respectively. Variable erythema, oozing, ulceration, and crusting were observed in all TII-treated lesions. It is concluded that PDT represents an active and well tolerated alternative treatment for both nodular and superficial BCCs. TII also shows activity, although the tolerance may be poor and cure needs a longer time to be obtained. The final cosmetic appearance was fine following both PDT and TII procedures. Both PDT and TII may leave intact neoplastic aggregates inside the skin. They cannot be clinically perceived, leading to unexpected recurrences. It is stressed that the currently available efficacy information about PDT and TII deals with short term follow-up periods. A 5-year follow-up must be awaited before drawing firm conclusions. [less ▲]

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See detailSkin cancer screening campaign in the German speaking Community of Belgium.
Nikkels, Arjen ULg; Tassoudji, Nazli ULg; Jerusalem-Noury, E. et al

in Acta Clinica Belgica (2004), 59(4), 194-8

The incidence of primary malignant melanoma (MM) and skin carcinomas, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), is progressively raising. As long as their diagnosis and ... [more ▼]

The incidence of primary malignant melanoma (MM) and skin carcinomas, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), is progressively raising. As long as their diagnosis and therapeutic managements are initiated early, their prognosis remains favorable. This underlines the importance of early recognition of skin cancers. Furthermore, it has been demonstrated that skin cancer screening programs are efficacious in increasing the population awareness of the early signs of skin cancer and of the dangers of UV - exposure. A skin cancer screening campaign was organised by dermatologists of the German-speaking Community of Belgium in cooperation with the Department of Family, Health, and Social Affairs of the Regional Ministry of the German-speaking Community of Belgium. In order to increase the screening selectivity, two risk populations were targeted; patients presenting 30 or more moles, and patients over 50 years of age presenting recent skin changes of the head and neck area. A media campaign using radio, television and daily press was started to increase the population awareness of the dangers of UV exposure and of the early signs of skin cancer. During 2 screening days, three-hour sessions were organised in 2 health centers located in Eupen and St Vith. A total of 148 patients were examined. A total of 124/148 patients met the selection criteria predefined during the media announcement. The simultaneous presence of 4 dermatologists during the screening sessions allowed a second opinion for warning lesions. Four BBCs as well as 23 patients pesenting dysplastic nevi were clinically diagnosed. During the 2 months following the screening campaign 5 MMs were identified by the same dermatologists in their routine practice. In conclusion, this skin cancer screening campaign led to the diagnosis of 4 carcinomas. The campaign furthermore increased the patient awareness, permitting the diagnosis of 5 MMs during the 2 following months. This figure represents about 30% of all MMs diagnosed yearly in this region of Belgium. [less ▲]

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See detailRevisiting childhood herpes zoster.
Nikkels, Arjen ULg; Tassoudji, Nazli ULg; Pierard, Gérald ULg

in Pediatric Dermatology (2004), 21(1), 18-23

Herpes zoster is rare in otherwise healthy children, but it is more common in association with immunosuppression. Maternal varicella infection during pregnancy and varicella occurring in the newborn ... [more ▼]

Herpes zoster is rare in otherwise healthy children, but it is more common in association with immunosuppression. Maternal varicella infection during pregnancy and varicella occurring in the newborn represent risk factors for childhood herpes zoster. However, some controversies persist about risk factors, diagnosis, and the natural history of childhood disease. In a 2-year prospective study, 18 children with herpes zoster were clinically diagnosed in outpatient consultations in a hospital dermatology unit. Data about age, dermatome involvement, underlying disease, and history of previous varicella were recorded. Tzanck smears, biopsy specimens, and sera were obtained from 18, 4, and 10 children, respectively. The varicella zoster virus major envelope glycoprotein gE was detected in 16 of 18 smears and all four biopsies. Herpes simplex virus I was demonstrated in one of the smears. The established risk factors for childhood herpes zoster were only found in one child. Evidence for previous full-blown varicella and varicella with few lesions was recorded in 7 and 4 of the 17 immunocompetent children, respectively. No history of varicella was recalled in 6 of 17 cases, although a serologic clue of past varicella infection (IgM negative, IgG positive) was disclosed. Recurrent herpes zoster was diagnosed in one immunocompromised child. Zoster-associated pain was localized and the disease severity remained mild in all children. Established risk factors for childhood herpes zoster were only rarely found in our series of patients. In contrast, unrecognized varicella and varicella with few lesions were frequently recorded and may represent additional risk factors for shingles in childhood. Zosteriform herpes simplex virus infections should be differentiated from childhood herpes zoster, emphasizing the importance of precise viral identification. [less ▲]

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See detailImage du mois. Une tumeur préauriculaire.
Tassoudji, Nazli ULg; Nikkels, Arjen ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2002), 57(2), 65-66

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See detailRelativite de la prise en charge des cancers cutanes. Plaidoyer pour la synergie entre le medecin generaliste et le dermatologue-oncologue
Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg; Cornil, F. et al

in Revue Médicale de Liège (2000), 55(4), 247-252

The clinical diagnosis and treatment of cutaneous cancers represent a frequent situation in cancerology. About one third of all human cancers take their origin from the skin. The general practitioner and ... [more ▼]

The clinical diagnosis and treatment of cutaneous cancers represent a frequent situation in cancerology. About one third of all human cancers take their origin from the skin. The general practitioner and the dermatologist-oncologist play the key role in that field of health care. [less ▲]

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See detailBreaking the Relentless Course of Hallopeau's Acrodermatitis by Dapsone
Nikkels, Arjen ULg; Tassoudji, Nazli ULg; Pierard, Gérald ULg

in European Journal of Dermatology (1999), 9(2), 126-128

We report the case of a 74-year-old man who suffered for four years from recurrent generalized pustular eruptions associated with acrodermatitis continua of Hallopeau (ACH). Initial therapy using topical ... [more ▼]

We report the case of a 74-year-old man who suffered for four years from recurrent generalized pustular eruptions associated with acrodermatitis continua of Hallopeau (ACH). Initial therapy using topical corticosteroids, tars and PUVA failed to improve the acral lesions. The disease was also unresponsive to systemic therapy using corticosteroids, methotrexate, etretinate, acitretine and cyclosporin A. Serious side-effects were experienced with these drugs. A marked improvement of the generalized pustules was observed under treatment combining etretinate and methotrexate, without having any effect on the acropustulosis. During hospitalization, a topical tar therapy cleared the pustular rash. Again no effect was observed on the acral lesions. Disulone (DDS) therapy, initiated at a dose of 200 mg/day, completely cleared ACH after 4 weeks. The disease relapsed when the dose was reduced to 100 mg/day. Increasing the DDS to 150 mg/day was rapidly followed by a new clearance of the acral lesions. After a 3-month treatment, the patient has remained lesion free and no DDS-related side-effects have occurred. In conclusion, sulfones may be considered as an alternative therapeutic option in drug-resistant ACH. [less ▲]

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See detailLes mélanomes cutanés, un spectre de cancers émergents chez la femme en région wallonne
Pierard-Franchimont, Claudine ULg; Arrese Estrada, Jorge ULg; Cornil, F. et al

in Revue Médicale de Liège (1999), 54(5), 495-499

The Mosan Study Group of Pigmented Neoplasms was founded about 15 years ago. It has collected more than 20.000 cutaneous malignancies including melanoms and basal and squamous cell carcinomas. The ... [more ▼]

The Mosan Study Group of Pigmented Neoplasms was founded about 15 years ago. It has collected more than 20.000 cutaneous malignancies including melanoms and basal and squamous cell carcinomas. The incidence of these cancers in on the rise in Wallonia. In particular, malignant melanoms represent a spectrum of emerging cancers characterized by a proteiform biological outcome. They mostly affect young women. The major risk factor appears to be iterative and unwise ultraviolet exposures. The prevention of malenomas is basically founded on such a dogma and accordingly relies on sunscreens. However, controversies about their beneficial effects are rife and fueled by axiomas and contradictory sophisms. At the exception of surgery, the therapeutic options for the diverse types of melanomas do not yet fulfill the scope of evidence-based medicine. [less ▲]

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See detailLe zona chez l'enfant
Nikkels, Arjen ULg; Tassoudji, Nazli ULg; Pierard, Gérald ULg

in Skin (1999), 2(1), 7-8

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See detailL1-protein in incipient lymphocyte-depleted graft-versus-host disease. Expression in keratinocytes and coexpression with Factor XIIIa in dermal cells
Pierard, Gérald ULg; Tassoudji, Nazli ULg; Arrese Estrada, Jorge ULg et al

in Turkish Journal of Dermatology = Dermatopatoloji Dergisi (1998), 7

With the introduction of effective immunosuppressive regimens some cutaneous rashes following bone marrow transplant may appear histologically unremarkable. We report three cases of cyclosporin-abated ... [more ▼]

With the introduction of effective immunosuppressive regimens some cutaneous rashes following bone marrow transplant may appear histologically unremarkable. We report three cases of cyclosporin-abated cutaneous graft-versus-host reaction (GVHR) where the most straightful histologic clue was the epidermal L1-protein (calprotectin) expression revealed by a positive immunolabelling using the Mac 387 antibody. The epidermis looked otherwise normal and inflammatory cells were scant in the dermis. The expression of calprotectin by keratinocytes occurred early in cutaneous GVHR. In addition, CD45RO-positive T memory lymphocytes were exceedingly rare in the dermis while a few Mac 387-positive monocytes coexpressed Factor XIIIa immunoreactivity. Hyperplasia of the Factor XIIIa-positive dendrocytic population was obvious. Calprotectin and Factor XIIIa immunolagellings should be regarded as a diagnostic adjunct in lymphocyte-depleted cutaneous GVHR. Calprotectin positivity of the epidermis is indicative although not specific for such condition. However, its combination with a low lymphocytes/monocytes ratio in the dermis which is enriched in plup dendrocytes is almost diagnostic. [less ▲]

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See detailNaevocyte Triggering by Recombinant Human Growth Hormone
Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg; Nikkels, Arjen ULg et al

in Journal of Pathology (The) (1996), 180(1), 74-79

The influence of growth hormone and insulin-like growth factor I on human melanocytes is being increasingly recognized. Clinical evidence has shown that when recombinant human growth hormone (hGH) is ... [more ▼]

The influence of growth hormone and insulin-like growth factor I on human melanocytes is being increasingly recognized. Clinical evidence has shown that when recombinant human growth hormone (hGH) is administered to children of short stature, the growth of melanocytic naevi is boosted. This study was conducted on 56 hGH-triggered naevi and nine similar lesions excised before or after hGH therapy for hypopituitarism and Turner's syndrome. A series of 40 naevi excised from age-matched healthy children served as controls. Atypicality of naevocytes was investigated using image analysis, AgNOR counts, immunohistochemistry (HMB-45, NKI-C3, Ki-67, anti-bcl-2-oncoprotein), and DNA flow cytometry. The data associate hGH treatment with anisokaryosis and increased AgNOR and Ki-67 counts in naevocytes. The same cells also show abnormal patterns of HMB-45 immunolabelling. These indications of naevocyte activation were not suggestive of malignant transformation. hGH-triggered melanocytomas should be added to the list of atypical melanocytic naevi. The long-term evolution of these lesions remains unknown and the potential risk of malignant transformation awaits careful evaluation. [less ▲]

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See detailImprovement in the inflammatory aspect of androgenetic alopecia. A pilot study with an antimicrobial lotion
Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg; Tassoudji, Nazli ULg et al

in Journal of Dermatological Treatment (1996), 7

Androgenetic alopecia (AGA) is a common yet poorly understood condition. In particular, the significance of inflammatory cells close to the infrainfundibulum of transitional hairs remains obscure. This ... [more ▼]

Androgenetic alopecia (AGA) is a common yet poorly understood condition. In particular, the significance of inflammatory cells close to the infrainfundibulum of transitional hairs remains obscure. This study was conducted in 20 men who used a lotion containing the antimicrobials, piroctone olamine and triclosan, regularly for 18 months. At entry, mild pruritus and abnormal hair loss were reported by the volunteers. During treatments, pruritus resolved rapidly. Comparison of clinical photographs and trichograms taken at 3-month intervals suggested signs of hair regrowth with moderate increase in density of transitional hairs. Biopsies taken at 6-month intervals were processed for immunohistochemistry. There was a decrease in the density of activated T cells in the region of the follicular infrainfundibulum and isthmus over time. UgG deposits found within the epithelial sheaths at entry to the study were absent in the subsequent biopsies. The volume of the sebaceous glands, as assessed by computerized morphometry, was not modified by the treatment. It was concluded that inflammation associated with AGA transitional hairs may be driven by the presence of microorganisms harboured in the infrainfundibulum. They may modulate the severity of AGA and may potentially be controllable. This offers a new possibility of prevention and partial reversal of hair loss in AGA. [less ▲]

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See detailNeuropeptides cutanés
Tassoudji, Nazli ULg; Nikkels, Arjen ULg; Pierard, Gérald ULg

in Les Nouvelles Dermatologiques (1994), 13

The neuropeptides act as mediators in the transmission of nervous influx and as messengers between the nervous system and other cell populations. The skin contains numerous neuropeptides which are ... [more ▼]

The neuropeptides act as mediators in the transmission of nervous influx and as messengers between the nervous system and other cell populations. The skin contains numerous neuropeptides which are involved in the regulation of inflammation, immunomodulation, and thermoregulation. Cutaneous trophicity, pigmentation, and to a lesser extent sebaccous secretions are also influenced by neuropeptides. This review describes the functions of the most important neuropeptides encountered at the level of the skin. [less ▲]

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See detailDiagnostic des infections cutanées par les herpes virus de types simplex et varicelle-zona
Nikkels, Arjen ULg; Hermanns-Le, Trinh ULg; Tassoudji, Nazli ULg et al

in Revue Médicale de Liège (1993), 48(7), 401-405

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