References of "Song, X. Y"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailMucosal gene signatures to predict response to infliximab in patients with ulcerative colitis
Arijs, I.; Li, K.; Toedter, G. et al

in Gut (2009), 58(12), 1612-9

BACKGROUND AND AIMS: Infliximab is an effective treatment for ulcerative colitis with over 60% of patients responding to treatment and up to 30% reaching remission. The mechanism of resistance to anti ... [more ▼]

BACKGROUND AND AIMS: Infliximab is an effective treatment for ulcerative colitis with over 60% of patients responding to treatment and up to 30% reaching remission. The mechanism of resistance to anti-tumour necrosis factor alpha (anti-TNFalpha) is unknown. This study used colonic mucosal gene expression to provide a predictive response signature for infliximab treatment in ulcerative colitis. METHODS: Two cohorts of patients who received their first treatment with infliximab for refractory ulcerative colitis were studied. Response to infliximab was defined as endoscopic and histological healing. Total RNA from pre-treatment colonic mucosal biopsies was analysed with Affymetrix Human Genome U133 Plus 2.0 Arrays. Quantitative RT-PCR was used to confirm microarray data. RESULTS: For predicting response to infliximab treatment, pre-treatment colonic mucosal expression profiles were compared for responders and non-responders. Comparative analysis identified 179 differentially expressed probe sets in cohort A and 361 in cohort B with an overlap of 74 probe sets, representing 53 known genes, between both analyses. Comparative analysis of both cohorts combined, yielded 212 differentially expressed probe sets. The top five differentially expressed genes in a combined analysis of both cohorts were osteoprotegerin, stanniocalcin-1, prostaglandin-endoperoxide synthase 2, interleukin 13 receptor alpha 2 and interleukin 11. All proteins encoded by these genes are involved in the adaptive immune response. These markers separated responders from non-responders with 95% sensitivity and 85% specificity. CONCLUSION: Gene array studies of ulcerative colitis mucosal biopsies identified predictive panels of genes for (non-)response to infliximab. Further study of the pathways involved should allow a better understanding of the mechanisms of resistance to infliximab therapy in ulcerative colitis. ClinicalTrials.gov number, NCT00639821. [less ▲]

Detailed reference viewed: 10 (6 ULg)
Full Text
Peer Reviewed
See detailEIT and LASCO Observations of the Initiation of a Coronal Mass Ejection
Dere, K. P.; Brueckner, G. E.; Howard, R. A. et al

in Solar Physics (1997), 175

We present the first observations of the initiation of a coronal mass ejection (CME) seen on the disk of the Sun. Observations with the EIT experiment on SOHO show that the CME began in a small volume and ... [more ▼]

We present the first observations of the initiation of a coronal mass ejection (CME) seen on the disk of the Sun. Observations with the EIT experiment on SOHO show that the CME began in a small volume and was initially associated with slow motions of prominence material and a small brightening at one end of the prominence. Shortly afterward, the prominence was accelerated to about 100 km s[SUP]-1[/SUP] and was preceded by a bright loop-like structure, which surrounded an emission void, that traveled out into the corona at a velocity of 200 400 km s[SUP]-1[/SUP]. These three components, the prominence, the dark void, and the bright loops are typical of CMEs when seen at distance in the corona and here are shown to be present at the earliest stages of the CME. The event was later observed to traverse the LASCO coronagraphs fields of view from 1.1 to 30 Ro. Of particular interest is the fact that this large-scale event, spanning as much as 70 deg in latitude, originated in a volume with dimensions of roughly 35" (2.5 x 10[SUP]4[/SUP] km). Further, a disturbance that propagated across the disk and a chain of activity near the limb may also be associated with this event as well as a considerable degree of activity near the west limb. [less ▲]

Detailed reference viewed: 40 (11 ULg)
Full Text
Peer Reviewed
See detailEIT Observations of the Extreme Ultraviolet Sun
Moses, D.; Clette, Frédéric; Delaboudinière, J.-P. et al

in Solar Physics (1997), 175

The Extreme Ultraviolet Imaging Telescope (EIT) on board the SOHO spacecraft has been operational since 2 January 1996. EIT observes the Sun over a 45 x 45 arc min field of view in four emission line ... [more ▼]

The Extreme Ultraviolet Imaging Telescope (EIT) on board the SOHO spacecraft has been operational since 2 January 1996. EIT observes the Sun over a 45 x 45 arc min field of view in four emission line groups: Feix, x, Fexii, Fexv, and Heii. A post-launch determination of the instrument flatfield, the instrument scattering function, and the instrument aging were necessary for the reduction and analysis of the data. The observed structures and their evolution in each of the four EUV bandpasses are characteristic of the peak emission temperature of the line(s) chosen for that bandpass. Reports on the initial results of a variety of analysis projects demonstrate the range of investigations now underway: EIT provides new observations of the corona in the temperature range of 1 to 2 MK. Temperature studies of the large-scale coronal features extend previous coronagraph work with low-noise temperature maps. Temperatures of radial, extended, plume-like structures in both the polar coronal hole and in a low latitude decaying active region were found to be cooler than the surrounding material. Active region loops were investigated in detail and found to be isothermal for the low loops but hottest at the loop tops for the large loops. [less ▲]

Detailed reference viewed: 25 (6 ULg)
Full Text
Peer Reviewed
See detailFirst Results from EIT
Clette, Frédéric; Delaboudiniere, J.-P.; Artzner, G. E. et al

in 1st Advances in Solar Physics Euroconference. Advances in Physics of Sunspots (1997)

The Extreme-UV Imaging telescope has already produced more than 15000 wide-field images of the corona and transition region, on the disk and up to 1.5R_o above the limb, with a pixel size of 2.6\arcsec ... [more ▼]

The Extreme-UV Imaging telescope has already produced more than 15000 wide-field images of the corona and transition region, on the disk and up to 1.5R_o above the limb, with a pixel size of 2.6\arcsec. By using four different emission lines, it provides the global temperature distribution in the quiet corona, in the range 0.5 to 3*E(6) K. Its excellent sensitivity and wide dynamic range allow unprecedented views of low emission features, even inside coronal holes. Those so-called ``quiet'' regions actually display a wide range of dynamical phenomena, in particular at small spatial scales and at time scales going down to only a few seconds, as revealed by all EIT time sequences of full- or partial-field images. The initial results presented here demonstrate the importance of this wide-field imaging experiment for a good coordination between SOHO and ground-based solar telescopes, as well as for science planning. [less ▲]

Detailed reference viewed: 19 (4 ULg)
Full Text
Peer Reviewed
See detailEIT: Extreme-Ultraviolet Imaging Telescope for the SOHO Mission
Delaboudinière, J.-P.; Artzner, G. E.; Brunaud, J. et al

in Solar Physics (1995), 162

The Extreme-ultraviolet Imaging Telescope (EIT) will provide wide-field images of the corona and transition region on the solar disc and up to 1.5 Ro above the solar limb. Its normal incidence multilayer ... [more ▼]

The Extreme-ultraviolet Imaging Telescope (EIT) will provide wide-field images of the corona and transition region on the solar disc and up to 1.5 Ro above the solar limb. Its normal incidence multilayer-coated optics will select spectral emission lines from Fe IX (171 Å), Fe XII (195 Å), Fe XV (284 Å), and He II (304 Å) to provide sensitive temperature diagnostics in the range from 6 × 10[SUP]4[/SUP] K to 3 × 10[SUP]6[/SUP] K. The telescope has a 45 x 45 arcmin field of view and 2.6 arcsec pixels which will provide approximately 5-arcsec spatial resolution. The EIT will probe the coronal plasma on a global scale, as well as the underlying cooler and turbulent atmosphere, providing the basis for comparative analyses with observations from both the ground and other SOHO instruments. This paper presents details of the EIT instrumentation, its performance and operating modes. [less ▲]

Detailed reference viewed: 53 (6 ULg)