Smart block copolymers for biomedical applications

Poster (2011, September 03)

Stimuli-responsive polymers are polymers that respond with rapid changes to external stimuli such as pH, temperature, light or ionic strength. Responses to the stimuli may manifest themselves as changes ... [more ▼]

Stimuli-responsive polymers are polymers that respond with rapid changes to external stimuli such as pH, temperature, light or ionic strength. Responses to the stimuli may manifest themselves as changes in solubility, shape or surface characteristics. They can also lead to the fomation of micelles or a sol-gel transition. These materials are very intersesting for different biomedical applications such as drug delivery systems, tissue engineering or sensors. In this work, we focused on two separate systems: on the one hand, micelles and, on the other hand, iron oxide nanoparticles. These nanoparticles are generally synthesized in a one-step process by alkaline coprecipitation of iron (II) and iron (III) precursors in aqueous solutions (Massart process). However, iron oxide nanoparticle suspensions produced by Massart process are not stable enough in physiological conditions to be used as is. A stabiliser coating is needed to avoid aggregation and consequent precipitation of the colloids in body fluids. For this coating, the polymer blocks chosen are: the poly(ethylene oxide) (PEO), the poly(acrylic acid) (PAA) and the poly(N-isopropyl acrylamide) (PNIPAM). The high flexibility and hydrophilicity of PEO chains make it an outstanding candidate for confering stealthiness to micelles and nanoparticles in order to avoid their rapid removal from the body by the opsonization process. The PAA is the pH-responsive block and the anchoring block. The PNIPAM is the thermoresponsive block with a thermal transition close to 37°C (99°F). Triblock copolymer was synthesized by a Reversible Addition Fragmentation Transfer Polymerization (RAFT) process combining poly(acrylic acid) PAA, poly(N-isopropylacrylamide) and poly(ethylene oxide) or poly[acrylate methoxy poly(ethylene oxide)]. This triblock copolymer was used alone to form micelles and with iron oxide to make magnetic stabilized nanoparticles. The behaviour of micelles and coated nanoparticles was investigated in different conditions by a combination of dynamic light scattering (DLS), transmission electron microscopy (TEM) and zeta potential measurements. Moreover, PAA-b-PNIPAM-b-PAMPEO nanofibers were obtained using electrospinning technique. These nanofibers present interesting prospects in the field of biomaterials and biomedical applications as they mimic the extracellular matrix of the skin. [less ▲]

Stimuli-responsive triblock copolymer for biomedical applications

Conference (2011, April 29)

Magnetic hybrid based on iron oxide nanoparticles and thermoresponsive block copolymer for biomedical applications

Poster (2010, March 18)

Design of thermoresponsive magnetic nanoparticles for hyperthermia

Poster (2009, June 14)

Synthesis and pH-dependent micellization of diblock copolymer mixtures

in Journal of Colloid & Interface Science (2009), 329(2), 235-243

This work focused on the preparation and the aqueous solution properties of hybrid polymeric micelles consisting of a hydrophobic poly(ε-caprolactone) (PCL) core and a mixed shell of hydrophilic poly ... [more ▼]

This work focused on the preparation and the aqueous solution properties of hybrid polymeric micelles consisting of a hydrophobic poly(ε-caprolactone) (PCL) core and a mixed shell of hydrophilic poly(ethylene oxide) (PEO) and pH-sensitive poly(2-vinylpyridine) (P2VP). The hybrid micelles were successfully prepared by the rapid addition of acidic water to a binary solution of PCL34-b-PEO114 and PCL32-b-P2VP52 diblock copolymers in N,N-dimethylformamide. These micelles were pH-responsive as result of the pH-dependent ionization of the P2VP block. The impact of pH on the self-assembly of the binary mixture of diblocks—thus on the composition, shape, size and surface properties of the micelles—was studied by a variety of experimental techniques, i.e., dynamic and static light scattering, transmission electron microscopy, Zeta potential, fluorescence spectroscopy and complement hemolytic 50 test. [less ▲]

Synthesis of new polymeric ligands for the stabilisation of nanoparticles

Poster (2007, August 31)