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See detailThe C2-hydrocarbon link in cometary comae
Weiler, M.; Bockelée-Morvan, D.; Hutsemekers, Damien ULg et al

in EPSC Abstract 2012 (2012)

Comet 8P/Tuttle was the target of an ESO multiwavelength observing campaign in 2008. Observations of the spatial distribution of C2 and C3 were obtained, as well as simultaneous direct detections of the ... [more ▼]

Comet 8P/Tuttle was the target of an ESO multiwavelength observing campaign in 2008. Observations of the spatial distribution of C2 and C3 were obtained, as well as simultaneous direct detections of the C2 parent species C2H2 and C2H6. We combine these observations to investigate the origin of cometary C2. The observed C2 column densities are inconsistent with a production of C2 from C2H2, C2H6, and C3. Based on a photochemical model, we quantitatively discuss the influence of further potential C2 parent species. The assumption of C4H2 as an additional C2 parent species in comet 8P/Tuttle provides the best explanation for the observed C2 column densities. [less ▲]

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See detailHigh-dispersion infrared spectroscopic observations of comet 8P/Tuttle with VLT/CRIRES
Kobayashi, H.; Bockelée-Morvan, D.; Kawakita, H. et al

in Astronomy and Astrophysics (2010), 509

We report on the composition of the Halley-family comet (HFC) 8P/Tuttle investigated with high-dispersion near-infrared spectroscopic observations. The observations were carried out at the ESO VLT (Very ... [more ▼]

We report on the composition of the Halley-family comet (HFC) 8P/Tuttle investigated with high-dispersion near-infrared spectroscopic observations. The observations were carried out at the ESO VLT (Very Large Telescope) with the CRIRES instrument as part of a multi-wavelength observation campaign of 8P/Tuttle performed in late January and early February 2008. Radar observations suggested that 8P/Tuttle is a contact binary, and it was proposed that these components might be heterogeneous in chemistry. We determined mixing ratios of organic volatiles with respect to H[SUB]2[/SUB]O and found that mixing ratios were consistent with previous near infrared spectroscopic observations obtained in late December 2007 and in late January 2008. It has been suggested that because 8P/Tuttle is a contact binary, it might be chemically heterogeneous. However, we find no evidence for chemical heterogeneity within the nucleus of 8P/Tuttle. We also compared the mixing ratios of organic molecules in 8P/Tuttle with those of both other HFCs and long period comets (LPCs) and found that HCN, C[SUB]2[/SUB]H[SUB]2[/SUB], and C[SUB]2[/SUB]H[SUB]6[/SUB] are depleted whereas CH[SUB]4[/SUB] and CH[SUB]3[/SUB]OH have normal abundances. This may indicate that 8P/Tuttle was formed in a different region of the early solar nebula than other HFCs and LPCs. We estimated the conversion efficiency from C[SUB]2[/SUB]H[SUB]2[/SUB] to C[SUB]2[/SUB]H[SUB]6[/SUB] by hydrogen addition reactions on cold grains by employing the C[SUB]2[/SUB]H[SUB]6[/SUB]/(C[SUB]2[/SUB]H[SUB]6[/SUB]+C[SUB]2[/SUB]H[SUB]2[/SUB]) ratio. The C[SUB]2[/SUB]H[SUB]6[/SUB]/(C[SUB]2[/SUB]H[SUB]6[/SUB]+C[SUB]2[/SUB]H[SUB]2[/SUB]) ratio in 8P/Tuttle is consistent with the ratios found in other HFCs and LPCs within the error bars. We also discuss the source of C[SUB]2[/SUB] and CN based on our observations and conclude that the abundances of C[SUB]2[/SUB]H[SUB]2[/SUB] and C[SUB]2[/SUB]H[SUB]6[/SUB] are insufficient to explain the C[SUB]2[/SUB] abundances in comet 8P/Tuttle and that the abundance of HCN is insufficient to explain the CN abundances in the comet, so at least one additional parent is needed for each species, as pointed out in previous study. Based on observations collected at the European Southern Observatory, Paranal, Chile (ESO Prog. 080.C-0615 and 280.C-5053).We regret to note the death of Dr. J. -M. Zucconi in 2009 May. [less ▲]

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See detailThe CN isotopic ratios in comets
Manfroid, Jean ULg; Jehin, Emmanuel ULg; Hutsemekers, Damien ULg et al

in Astronomy and Astrophysics (2009), 503

Our aim is to determine the isotopic ratios [SUP]12[/SUP]C/[SUP]13[/SUP]C and [SUP]14[/SUP]N/[SUP]15[/SUP]N in a variety of comets and link these measurements to the formation and evolution of the solar ... [more ▼]

Our aim is to determine the isotopic ratios [SUP]12[/SUP]C/[SUP]13[/SUP]C and [SUP]14[/SUP]N/[SUP]15[/SUP]N in a variety of comets and link these measurements to the formation and evolution of the solar system. The [SUP]12[/SUP]C/[SUP]13[/SUP]C and [SUP]14[/SUP]N/[SUP]15[/SUP]N isotopic ratios are measured for the CN radical by means of high-resolution optical spectra of the R branch of the B-X (0, 0) violet band. 23 comets from different dynamical classes have been observed, sometimes at various heliocentric and nucleocentric distances, in order to estimate possible variations of the isotopic ratios in parent molecules. The [SUP]12[/SUP]C/[SUP]13[/SUP]C and [SUP]14[/SUP]N/[SUP]15[/SUP]N isotopic ratios in CN are remarkably constant (average values of, respectively, 91.0 ± 3.6 and 147.8 ± 5.7) within our measurement errors, for all comets whatever their origin or heliocentric distance. While the carbon isotopic ratio does agree with the terrestrial value (89), the nitrogen ratio is a factor of two lower than the terrestrial value (272), indicating a fractionation in the early solar system, or in the protosolar nebula, common to all the comets of our sample. This points towards a common origin of the comets independently of their birthplaces, and a relationship between HCN and CN. Appendices and Table [see full textsee full textsee full text] are only available in electronic form at http://www.aanda.org Based on observations made with ESO Telescopes at the La Silla Paranal Observatory under programmes ID 268.C-5570, 270.C-5043, 073.C-0525, 274.C-5015 and 075.C-0355(A). [less ▲]

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See detailA Multi-Wavelength Simultaneous Study of the Composition of the Halley Family Comet 8P/Tuttle
Jehin, Emmanuel ULg; Bockelée-Morvan, Dominique; Dello Russo, N. et al

in Earth, Moon, and Planets (2009), 105

We report on simultaneous optical and infrared observations of the Halley Family comet 8P/Tuttle performed with the ESO Very Large Telescope. Such multi-wavelength and coordinated observations are a good ... [more ▼]

We report on simultaneous optical and infrared observations of the Halley Family comet 8P/Tuttle performed with the ESO Very Large Telescope. Such multi-wavelength and coordinated observations are a good example of what can be done to support space missions. From high resolution optical spectroscopy of the CN (0,0) 388 nm and NH[SUB]2[/SUB] (0,9,0) 610 nm bands using UVES at UT2 we determined [SUP]12[/SUP]C/[SUP]13[/SUP]C = 90 ± 10 and [SUP]14[/SUP]N/[SUP]15[/SUP]N = 150 ± 20 in CN and we derived a nuclear spin temperature of NH[SUB]3[/SUB] of 29 ± 1 K. These values are similar to those found in Oort-Cloud and Jupiter Family comets. From low resolution long slit spectroscopy with FORS1 at UT2 we determined the CN, C[SUB]3[/SUB] and C[SUB]2[/SUB] production rates and the parent and daughter scale lengths up to 5.2 10[SUP]5[/SUP] km tailward. From high resolution IR spectroscopy with CRIRES at UT1 we measured simultaneously the production rates and mixing ratios of H[SUB]2[/SUB]O, HCN, C[SUB]2[/SUB]H[SUB]2[/SUB], CH[SUB]4[/SUB], C[SUB]2[/SUB]H[SUB]6[/SUB], and CH[SUB]3[/SUB]OH. [less ▲]

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See detailIsotopic abundance in the CN coma of comets: Ten years of measurements
Schulz, R.; Jehin, Emmanuel ULg; Manfroid, Jean ULg et al

in Planetary and Space Science (2008), 56

Over the past 10 years the isotopic ratios of carbon ([SUP]12[/SUP]C/[SUP]13[/SUP]C) and nitrogen ([SUP]14[/SUP]N/[SUP]15[/SUP]N) have been determined for a dozen comets, bright enough to allow obtaining ... [more ▼]

Over the past 10 years the isotopic ratios of carbon ([SUP]12[/SUP]C/[SUP]13[/SUP]C) and nitrogen ([SUP]14[/SUP]N/[SUP]15[/SUP]N) have been determined for a dozen comets, bright enough to allow obtaining the required measurements from the ground. The ratios were derived from high-resolution spectra of the CN coma measured in the B[SUP]2[/SUP]â [SUP]+[/SUP]â X[SUP]2[/SUP]â [SUP]+[/SUP] (0, 0) emission band around 387 nm. The observed comets belong to different dynamical classes, including dynamically new as well as long- and short-period comets from the Halley- and Jupiter-family. In some cases the comets could be observed at various heliocentric distances. All values determined for the carbon and nitrogen isotopic ratios were consistent within the error margin irrespective of the type of comet or the heliocentric distance at which it was observed. Our investigations resulted in average ratios of [SUP]12[/SUP]C/[SUP]13[/SUP]C=91±21 and nitrogen [SUP]14[/SUP]N/[SUP]15[/SUP]N=141±29. Whilst the value for the carbon isotopic ratio is in good agreement with the solar and terrestrial value of 89, the nitrogen isotopic ratio is very different from the telluric value of 272. [less ▲]

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See detailHigh-dispersion Spectroscopic Observations Of 8P/Tuttle With VLT/CRIRES
Kobayashi, Hitomi; Bockelee-Morvan, D.; Dello Russo, N. et al

in Bulletin of the American Astronomical Society (2008, September 01), 40

We present near-infrared observations of organic molecules in comet 8P/Tuttle. Comet 8P/Tuttle is a Halley-type comet and its last perihelion was in early January 2008. Our observations were carried out ... [more ▼]

We present near-infrared observations of organic molecules in comet 8P/Tuttle. Comet 8P/Tuttle is a Halley-type comet and its last perihelion was in early January 2008. Our observations were carried out on January 28 and February 4 using CRIRES (CRyogenic high-resolution InfraRed Echelle Spectrograph) at the Very Large Telescope (VLT). We used a 0.2" slit which provided a spectral resolving power of 80,000. We detected H[SUB]2[/SUB]O, OH, HCN, C[SUB]2[/SUB]H[SUB]2[/SUB] on Jan 28, and H[SUB]2[/SUB]O, OH, CH[SUB]4[/SUB], C[SUB]2[/SUB]H[SUB]6[/SUB], and CH[SUB]3[/SUB]OH on Feb 4. We find that 8P/Tuttle is depleted in HCN, C[SUB]2[/SUB]H[SUB]2[/SUB] and C[SUB]2[/SUB]H[SUB]6[/SUB] relative to H[SUB]2[/SUB]O compared with most other Oort cloud comets studied to date. Perhaps these depletions suggest that 8P/Tuttle formed in a different region from most Oort cloud comets, but it is also possible that the depletions are caused by repeated passages through the inner solar system. [less ▲]

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See detailLarge Excess of Heavy Nitrogen in Both Hydrogen Cyanide and Cyanogen from Comet 17P/Holmes
Bockelée-Morvan, D.; Biver, N.; Jehin, Emmanuel ULg et al

in Astrophysical Journal (2008), 679(Letters), 49-52

From millimeter and optical observations of the Jupiter-family comet 17P/Holmes performed soon after its huge outburst of 2007 October 24, we derive [SUP]14[/SUP]N/[SUP]15[/SUP]N = 139 +/- 26 in HCN and ... [more ▼]

From millimeter and optical observations of the Jupiter-family comet 17P/Holmes performed soon after its huge outburst of 2007 October 24, we derive [SUP]14[/SUP]N/[SUP]15[/SUP]N = 139 +/- 26 in HCN and [SUP]14[/SUP]N/[SUP]15[/SUP]N = 165 +/- 40 in CN, establishing that HCN has the same nonterrestrial isotopic composition as CN. The same conclusion is obtained for the long-period comet C/1995 O1 (Hale-Bopp) after a reanalysis of previously published measurements. These results are compatible with HCN being the prime parent of CN in cometary atmospheres. The [SUP]15[/SUP]N excess relative to the Earth's atmospheric value indicates that N-bearing volatiles in the solar nebula underwent important N isotopic fractionation at some stage of solar system formation. HCN molecules never isotopically equilibrated with the main nitrogen reservoir in the solar nebula before being incorporated in Oort Cloud and Kuiper Belt comets. The [SUP]12[/SUP]C/[SUP]13[/SUP]C ratios in HCN and CN are measured to be consistent with the terrestrial value. [less ▲]

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See detailOptical Spectroscopy of the B and C Fragments of Comet 73P/Schwassmann-Wachmann 3 at the ESO VLT
Jehin, Emmanuel ULg; Manfroid, Jean ULg; Kawakita, H. et al

in LPI contribution 1405 (2008)

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See detailA Multi-Wavelength Simultaneous Study of the Composition of the Halley-Family Comet 8P/Tuttle at the VLT
Bockelée-Morvan, Dominique; Dello Russo, N.; Jehin, Emmanuel ULg et al

in LPI contribution 1405 (2008)

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See detailCarbon and Nitrogen Isotopic Ratios in Comets
Jehin, Emmanuel ULg; Manfroid, Jean ULg; Hutsemekers, Damien ULg et al

in LPI contribution 1405 (2008)

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See detailA cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy
Hilfiker-Kleiner, D.; Kaminski, K.; Podewski, E. et al

in Cell (2007), 128(3), 589-600

Postpartum cardiomyopathy (PPCM) is a disease of unknown etiology and exposes women to high risk of mortality after delivery. Here, we show that female mice with a cardiomyocyte-specific deletion of stat3 ... [more ▼]

Postpartum cardiomyopathy (PPCM) is a disease of unknown etiology and exposes women to high risk of mortality after delivery. Here, we show that female mice with a cardiomyocyte-specific deletion of stat3 develop PPCM. In these mice, cardiac cathepsin D (CD) expression and activity is enhanced and associated with the generation of a cleaved antiangiogenic and proapoptotic 16 kDa form of the nursing hormone prolactin. Treatment with bromocriptine, an inhibitior of prolactin secretion, prevents the development of PPCM, whereas forced myocardial generation of 16 kDa prolactin impairs the cardiac capillary network and function, thereby recapitulating the cardiac phenotype of PPCM. Myocardial STAT3 protein levels are reduced and serum levels of activated CD and 16 kDa prolactin are elevated in PPCM patients. Thus, a biologically active derivative of the pregnancy hormone prolactin mediates PPCM, implying that inhibition of prolactin release may represent a novel therapeutic strategy for PPCM. [less ▲]

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See detailDeep Impact: High-Resolution Optical Spectroscopy with the ESO VLT and the Keck I Telescope
Jehin, Emmanuel ULg; Manfroid, Jean ULg; Hutsemekers, Damien ULg et al

in Astrophysical Journal (2006), 641(Letters), 145-148

We report on observations of comet 9P/Tempel 1 carried out before, during, and after the NASA Deep Impact event (UT July 4), with the optical spectrometers UVES and HIRES mounted on the telescopes Kueyen ... [more ▼]

We report on observations of comet 9P/Tempel 1 carried out before, during, and after the NASA Deep Impact event (UT July 4), with the optical spectrometers UVES and HIRES mounted on the telescopes Kueyen of the ESO VLT (Chile) and Keck I on Mauna Kea (Hawaii), respectively. A total observing time of about 60 hr, distributed over 15 nights around the impact date, allowed us (1) to find a periodic variation of 1.709 +/- 0.009 days in the CN and NH flux, explained by the presence of two major active regions; (2) to derive a lifetime >~5 × 10[SUP]4[/SUP] s (at 1.5 AU) for the parent of the CN radical from a simple modeling of the CN light curve after the impact; (3) to follow the gas and dust spatial profiles' evolution during the 4 hr following the impact and derive the projected velocities (400 and 150 m s[SUP]-1[/SUP], respectively); and (4) to show that the material released by the impact has the same carbon and nitrogen isotopic composition as the surface material ([SUP]12[/SUP]C/[SUP] 13[/SUP]C = 95 +/- 15 and [SUP]14[/SUP]N/[SUP]15[/SUP]N = 145 +/- 20). [less ▲]

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See detailDeep Impact: Observations from a Worldwide Earth-Based Campaign
Meech, K. J.; Ageorges, N.; A'Hearn, M. F. et al

in Science (2005), 310

On 4 July 2005, many observatories around the world and in space observed the collision of Deep Impact with comet 9P/Tempel 1 or its aftermath. This was an unprecedented coordinated observational campaign ... [more ▼]

On 4 July 2005, many observatories around the world and in space observed the collision of Deep Impact with comet 9P/Tempel 1 or its aftermath. This was an unprecedented coordinated observational campaign. These data show that (i) there was new material after impact that was compositionally different from that seen before impact; (ii) the ratio of dust mass to gas mass in the ejecta was much larger than before impact; (iii) the new activity did not last more than a few days, and by 9 July the comet's behavior was indistinguishable from its pre-impact behavior; and (iv) there were interesting transient phenomena that may be correlated with cratering physics. [less ▲]

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See detailIsotopic abundances of carbon and nitrogen in Jupiter-family and Oort Cloud comets
Hutsemekers, Damien ULg; Manfroid, Jean ULg; Jehin, Emmanuel ULg et al

in Astronomy and Astrophysics (2005), 440(Letters), 21-24

The [SUP]12[/SUP]C[SUP]14[/SUP]N/[SUP]12[/SUP]C[SUP]15[/SUP]N and [SUP]12[/SUP]C[SUP]14[/SUP]N/[SUP]13[/SUP]C[SUP]14[/SUP]N isotopic ratios are determined for the first time in a Jupiter-family comet, 88P ... [more ▼]

The [SUP]12[/SUP]C[SUP]14[/SUP]N/[SUP]12[/SUP]C[SUP]15[/SUP]N and [SUP]12[/SUP]C[SUP]14[/SUP]N/[SUP]13[/SUP]C[SUP]14[/SUP]N isotopic ratios are determined for the first time in a Jupiter-family comet, 88P/1981 Q1 Howell, and in the chemically peculiar Oort Cloud comet C/1999 S4 (LINEAR). By comparing these measurements to previous ones derived for six other Oort Cloud comets (including one of Halley-type), we find that both the carbon and nitrogen isotopic ratios are constant within the uncertainties. The mean values are [SUP]12[/SUP]C/[SUP]13[/SUP]C ~= 90 and [SUP]14[/SUP]N/[SUP]15[/SUP]N ~=145 for the eight comets. These results strengthen the view that CN radicals originate from refractory organics formed in the protosolar molecular cloud and subsequently incorporated in comets. [less ▲]

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See detailIsotopic abundance of nitrogen and carbon in distant comets
Manfroid, Jean ULg; Jehin, Emmanuel ULg; Hutsemekers, Damien ULg et al

in Astronomy and Astrophysics (2005), 432(Letters), 5-8

The [SUP]12[/SUP]C[SUP]14[/SUP]N/[SUP]12[/SUP]C[SUP]15[/SUP]N and [SUP]12[/SUP]C[SUP]14[/SUP]N/[SUP]13[/SUP]C[SUP]14[/SUP]N isotopic ratios have been determined in comets C/1995 O1 (Hale-Bopp), C/2001 Q4 ... [more ▼]

The [SUP]12[/SUP]C[SUP]14[/SUP]N/[SUP]12[/SUP]C[SUP]15[/SUP]N and [SUP]12[/SUP]C[SUP]14[/SUP]N/[SUP]13[/SUP]C[SUP]14[/SUP]N isotopic ratios have been determined in comets C/1995 O1 (Hale-Bopp), C/2001 Q4 (NEAT) and C/2003 K4 (LINEAR) at heliocentric distances of, respectively, 2.7, 3.7 and 2.6 AU. These ratios have also been measured at rË 1 AU. No significant differences were found between all determinations, nor with the value obtained for other comets. If confirmed, the discrepancy between the nitrogen isotopic ratios from optical and millimeter measurements on CN and HCN would rule out HCN as a major parent of the cometary CN radicals. Based on observations collected at the European Southern Observatory, Paranal, Chile (ESO Programmes 270.C-5043, 073.C-0525 and 274.C-5015). [less ▲]

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See detailRecent advances in the understanding of the role of nitric oxide in cardiovascular homeostasis.
Schulz, R.; Rassaf, T.; MASSION, Paul ULg et al

in Pharmacology & Therapeutics (2005), 108(3), 225-56

Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) generation. To date, 3 distinct NOS isoforms have been identified: neuronal NOS (NOS1), inducible NOS (NOS2), and endothelial ... [more ▼]

Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) generation. To date, 3 distinct NOS isoforms have been identified: neuronal NOS (NOS1), inducible NOS (NOS2), and endothelial NOS (NOS3). Biochemically, NOS consists of a flavin-containing reductase domain, a heme-containing oxygenase domain, and regulatory sites. NOS catalyse an overall 5-electron oxidation of one Nomega-atom of the guanidino group of L-arginine to form NO and L-citrulline. NO exerts a plethora of biological effects in the cardiovascular system. The basal formation of NO in mitochondria by a mitochondrial NOS seems to be one of the main regulators of cellular respiration, mitochondrial transmembrane potential, and transmembrane proton gradient. This review focuses on recent advances in the understanding of the role of enzyme and enzyme-independent NO formation, regulation of NO bioactivity, new aspects of NO on cardiac function and morphology, and the clinical impact and perspectives of these recent advances in our knowledge on NO-related pathways. [less ▲]

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See detailThe deep impact campaign at ESO: the gas component
Rauer, H.; Jehin, Emmanuel ULg; Manfroid, Jean ULg et al

Poster (2005)

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See detailComet C/2001 Q4 (NEAT) at its closest approach to the Earth
Tozzi, G. P.; Boehnhardt, H.; Del Bo, M. et al

in American Astronomical Society, DPS meeting #36 (2004, November 01)

Comet C/2001 Q4 (NEAT) was observed at ESO (La Silla) for three consecutive nights at the beginning of May, 2004 at its closest approach to Earth. The observations consisted of quasi-simultaneous multi ... [more ▼]

Comet C/2001 Q4 (NEAT) was observed at ESO (La Silla) for three consecutive nights at the beginning of May, 2004 at its closest approach to Earth. The observations consisted of quasi-simultaneous multi-wavelength exposures in the visible, near-IR and thermal-IR in order to study different properties of the solid component that are responsible for the scattering and emission of radiation in different spectral ranges. The comet was observed with the 3.6m telescope, equipped with TIMMI2 for the thermal-IR region, the NTT, equipped with EMMI and SOFI for the visible and near-IR regions. Narrow band images and long slit spectra were recorded for each spectral region. In the near-IR range, polarimetric observations were also performed during the last night. The aim of the observations was the characterization of the solid component at small scalelength to search for possible short lifetime organic components, as those found in the comet C/2000 WM1 (Tozzi et al., 2004, A&A, 424, 235), dust fragmentation etc.. Here we report preliminary results of the analysis of these observations. [less ▲]

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