References of "Schaaps, Jean-Pierre"
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See detailIndividual decisions in placenta increta and percreta: a case series.
CHANTRAINE, Frédéric ULg; NISOLLE, Michelle ULg; PETIT, Philippe ULg et al

in Journal of Perinatal Medicine (2012), 40(3), 265-70

Abstract Objective: Placenta increta or percreta is an uncommon pathology, sometimes associated with high maternal morbidity. Its prevalence increases proportionally to the number of cesarean sections ... [more ▼]

Abstract Objective: Placenta increta or percreta is an uncommon pathology, sometimes associated with high maternal morbidity. Its prevalence increases proportionally to the number of cesarean sections. This study analyzed the changes of our management strategy to devise treatment guidelines for this uncommon disorder. Materials and methodology: Between 2005 and 2011, 10 cases of placenta increta or percreta were managed at our university hospital maternity department. Results: Among the 10 cases, seven were diagnosed prenatally. Two patients were diagnosed early, at 14 and 17 weeks of gestational age, and their pregnancies were terminated. Five had hysterectomies during the intrapartum period, and despite attempted conservative treatment for the two others, hysterectomy proved necessary 2 months postpartum because of intrauterine infections. Seven of the 10 women had hysterectomies. Conclusion: Prenatal diagnosis of placenta increta or percreta is essential to plan the delivery in a competent tertiary care center. The decision to perform a cesarean hysterectomy or leave the placenta in situ for spontaneous delivery is based on the extent of infiltration, the patient's hemodynamic status, and her desire to remain fertile. The high-risk of infection and severe hemorrhage must not be overlooked should conservative treatment be chosen. This situation requires prolonged close monitoring. [less ▲]

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See detailFetal nuchal translucency thickness in different cut-off points for aneuploidy screening in the south of Vietnam
To, Hong ULg; Schaaps, Jean-Pierre ULg; Foidart, Jean-Michel ULg

in Journal of Obstetrics and Gynaecology Research (2011), 37(10), 1327-1334

Aims: The purpose of this study was to define the most suitable cut-off point for fetal nuchal translucency thickness in a screening program for aneuploidy and trisomy 21 in the south of Vietnam. <br ... [more ▼]

Aims: The purpose of this study was to define the most suitable cut-off point for fetal nuchal translucency thickness in a screening program for aneuploidy and trisomy 21 in the south of Vietnam. <br />Material & Methods: Two thousand and five hundred cases of singleton pregnancies were followed prospectively from the first trimester to the delivery. The rate of aneuploidy was calculated by seeking a relationship to increased fetal nuchal translucency thickness then calculating the sensitivity and specificity of different cut-off points in thickness measurement to find the most suitable point for screening. <br />Results: The prevalence of fetal abnormality was 1.5% (95% CI 1.1–2.1), and 1.2% (95% CI 0.8–1.7) of aneuploidy cases found and the commonest was trisomy 21. A cut-off point at 2.4 mm showed the highest level of sensitivity and specificity for the detection of aneuploidy (65.5 and 95.7%) and trisomy 21 (75.0 and 95.1%), with a false-positive rate of 4.3 and 4.9%, respectively. <br />Conclusion: Using a cut-off point of nuchal translucency at 2.4 mm has potential for aneuploidy and trisomy 21 screening in the south of Vietnam. [less ▲]

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See detailLe cas clinique du mois: Issue défavorable d'une grossesse triple
CAPELLE, Xavier ULg; BAVI DIDO, Jean-Vincent ULg; Schaaps, Jean-Pierre ULg et al

in Revue Médicale de Liège (2011), 66(9), 466-9

Body stalk anomaly is rarely described in triplet gestation after medically assisted procreation. The relationship between congenital anomaly, multiple pregnancy, and medically assisted procreation is ... [more ▼]

Body stalk anomaly is rarely described in triplet gestation after medically assisted procreation. The relationship between congenital anomaly, multiple pregnancy, and medically assisted procreation is briefly discussed. [less ▲]

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See detailLe cas clinique du mois. Hydrocephalie liee a i'X: a spropos d'un cas en medecine foetale.
Syrios, K.; Delbecoue, K.; GAILLEZ, Stephanie ULg et al

in Revue Médicale de Liège (2011), 66(3), 126-9

X-linked hydrocephaly (Li Syndrome) is a rare cause of hydrocephaly. It is, however, the most common genetic form of congenital hydrocephaly and consists of the association of hydrocephaly, mental ... [more ▼]

X-linked hydrocephaly (Li Syndrome) is a rare cause of hydrocephaly. It is, however, the most common genetic form of congenital hydrocephaly and consists of the association of hydrocephaly, mental retardation, leg spasticity and adducted thumbs. The phenotype is variable. A mutation of the LICAM gene is known to be the aetiology of the syndrome. We present an antenatal case managed in our department. [less ▲]

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See detailVascularization of the placenta and the sub-placental myometrium: feasibility and reproducibility of a three-dimensional power Doppler ultrasound quantification technique. A pilot study.
Morel, O.; Grange, G.; Fresson, J. et al

in Journal of Maternal-Fetal & Neonatal Medicine (2011), 24(2), 284-290

Objective. To assess the feasibility of placental and myometrial vascularization quantification using 3D power Doppler ultrasonography. Methods. 3D standardized acquisition was performed in the mid part ... [more ▼]

Objective. To assess the feasibility of placental and myometrial vascularization quantification using 3D power Doppler ultrasonography. Methods. 3D standardized acquisition was performed in the mid part of the utero-placental unit, once, in 38 patients undergoing normal pregnancies between 15 and 39 weeks. Vascularization parameters (VI, FI, and VFI) of placentae and myometrium were measured. Intra and inter-observer, as well as inter-acquisition reproducibility were evaluated. Results. Intra-class Correlation Coefficient of vascularization measurements were at least 0.94 for intra-observer, 0.92 for inter-observer, and 0.56 for inter-acquisition reproducibility. There was no significant difference for placental measurements for VI, FI and VFI between the second trimester and the third trimester pregnancies. Concerning the myometrium, we observed no significant difference between second and third trimester for FI. However, VI (28.090 vs. 19.374) and VFI (17.691 vs. 11.336) was significantly lower in the third trimester (p < 0.01). Conclusion. 3D quantification of placental and myometrial vascular parameters is feasible with a high intra and inter-observer reproducibility. Evaluating a potential myometrial vascular impairment appears to be as relevant as studying the placenta alone and might be of great clinical interest. We believe that this technique should therefore be evaluated in clinical observational studies. [less ▲]

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See detailAnalysis of fetal death in relation with increased fetal nuchal translucency thickness in the south of Vietnam
To, Hong ULg; SCHAAPS, Jean-Pierre ULg; FOIDART, Jean-Michel ULg

in Nobuyuki, Taniguichi (Ed.) Asian Federation of Societies for Ultrasound in Medicine and Biology: AFSUMB, New Delhi 18-21 november 2010 (2010, November 18)

Objectives: The aim of this study was to investigate the fetal deaths relation with an increased fetal nuchal translucency (NT) thickness in the South of Vietnam. Methods: A total of 2500 singleton ... [more ▼]

Objectives: The aim of this study was to investigate the fetal deaths relation with an increased fetal nuchal translucency (NT) thickness in the South of Vietnam. Methods: A total of 2500 singleton pregnancies were measured fetal NT thickness and performed free beta subunit of human Chorionic Gonadotropin (free β-hCG) and pregnancy associated plasma protein-A (PAPP-A) routinely in the first trimester, then scanned systematically for fetal structure by ultrasonography at the second trimester of gestation, next followed to their delivery and examined neonatal status. For suspicion of fetal abnormality, amniocentesis was indicated to confirm a fetal karyotype. Fetal abnormal chromosome was counselled a termination of pregnancy (TOP). 5 groups of fetal NT thickness was divided: group of normal fetal NT thickness (< 2.4mm), group of mild increased of fetal NT thickness (2.4-3.4mm), group of moderate increased fetal NT (3.5-4.4mm), group of severe fetal NT (4.5-5.4mm) and group of very severe fetal NT (≥ 5.5mm). We evaluated the fetal deaths (included spontaneous abortion, fetal death intra-uterine, and terminated pregnancy due to aneuploidy and/or structural abnormality), then look for a relation between an increased fetal NT thickness and those fetal adverse outcomes. Results: Fetal NT thickness cut-off point at 2.4mm or more was defined as an increased fetal NT thickness with 65.5% of sensitivity for fetal abnormal detection. 5.3% (133/2500) was the prevalence of increased fetal NT thickness. 2.8% (71/2500) of cases had been indicated an amniocentesis. A total incidence of fetal death was found 1.5% (37/2500). In group of fetal NT thickness < 2.4mm, the rate of abnormal karyotype was 0.4% (10/2367), none case of fetal deaths obtained. In the fetal NT group of 2.4-3.4mm, total of fetal death found 26.4% (32/121) that included 12.4% (15/121) of abnormal karyotype, 8.3% (10/121) of abnormal ultrasound scanning, 5.8% (7/121) of fetal demised, and 0.8% (1 case) of neonatal defect due to G6PD deficiency. In the group of 3.5-4.4mm, 33.3% (3/9) of fetuses were died (22.2% was due to aneuploidy and 11.1% was due to miscarriage spontaneously). In the group of 4.5-5.4mm, 1 case (50%) of trisomy 18 was detected and in the group of ≥ 5.5mm, 1 case (100%) of trisomy 21 had been diagnosed. When fetal NT thickness increased, the possibility of fetal demised was higher significantly: likelihood ratio (LR) augmented from 15.2 in the fetal NT group at 2.4-3.4mm to 169.5 in fetal NT group at ≥ 5.5mm (p < 0.01, Pearson chi2). Conclusion: An increased fetal NT thickness was useful finding for prediction of fetal deaths (included fetal abortion, demised or terminated) in the prenatal diagnosis and care program in the South of Vietnam. [less ▲]

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See detailAnalysis of fetal death in relation with increased fetal nuchal translucency thickness in the south of Vietnam
To, Hong ULg; Schaaps, Jean-Pierre ULg; Foidart, Jean-Michel ULg

in Asian Federation of Societies for Ultrasound in Medicine and Biology (2010, November 18)

Objectives: The aim of this study was to investigate the fetal deaths relation with an increased fetal nuchal translucency (NT) thickness in the South of Vietnam. Methods: A total of 2500 singleton ... [more ▼]

Objectives: The aim of this study was to investigate the fetal deaths relation with an increased fetal nuchal translucency (NT) thickness in the South of Vietnam. Methods: A total of 2500 singleton pregnancies were measured fetal NT thickness and performed free beta subunit of human Chorionic Gonadotropin (free β-hCG) and pregnancy associated plasma protein-A (PAPP-A) routinely in the first trimester, then scanned systematically for fetal structure by ultrasonography at the second trimester of gestation, next followed to their delivery and examined neonatal status. For suspicion of fetal abnormality, amniocentesis was indicated to confirm a fetal karyotype. Fetal abnormal chromosome was counselled a termination of pregnancy (TOP). 5 groups of fetal NT thickness was divided: group of normal fetal NT thickness (< 2.4mm), group of mild increased of fetal NT thickness (2.4-3.4mm), group of moderate increased fetal NT (3.5-4.4mm), group of severe fetal NT (4.5-5.4mm) and group of very severe fetal NT (≥ 5.5mm). We evaluated the fetal deaths (included spontaneous abortion, fetal death intra-uterine, and terminated pregnancy due to aneuploidy and/or structural abnormality), then look for a relation between an increased fetal NT thickness and those fetal adverse outcomes. Results: Fetal NT thickness cut-off point at 2.4mm or more was defined as an increased fetal NT thickness with 65.5% of sensitivity for fetal abnormal detection. 5.3% (133/2500) was the prevalence of increased fetal NT thickness. 2.8% (71/2500) of cases had been indicated an amniocentesis. A total incidence of fetal death was found 1.5% (37/2500). In group of fetal NT thickness < 2.4mm, the rate of abnormal karyotype was 0.4% (10/2367), none case of fetal deaths obtained. In the fetal NT group of 2.4-3.4mm, total of fetal death found 26.4% (32/121) that included 12.4% (15/121) of abnormal karyotype, 8.3% (10/121) of abnormal ultrasound scanning, 5.8% (7/121) of fetal demised, and 0.8% (1 case) of neonatal defect due to G6PD deficiency. In the group of 3.5-4.4mm, 33.3% (3/9) of fetuses were died (22.2% was due to aneuploidy and 11.1% was due to miscarriage spontaneously). In the group of 4.5-5.4mm, 1 case (50%) of trisomy 18 was detected and in the group of ≥ 5.5mm, 1 case (100%) of trisomy 21 had been diagnosed. When fetal NT thickness increased, the possibility of fetal demised was higher significantly: likelihood ratio (LR) augmented from 15.2 in the fetal NT group at 2.4-3.4mm to 169.5 in fetal NT group at ≥ 5.5mm (p < 0.01, Pearson chi2). Conclusion: An increased fetal NT thickness was useful finding for prediction of fetal deaths (included fetal abortion, demised or terminated) in the prenatal diagnosis and care program in the South of Vietnam. [less ▲]

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See detailUltrasound assessment of the intima and media layers on the carotid arteries in peri- and postmenopausal women
Chantraine, Frédéric ULg; Tutschek, B.; Coudoux, Elodie ULg et al

in European Journal of Ultrasound (2010), 31(S 01), 906

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See detailPrenatal diagnosis of benign extreme hyperlordosis.
Chantraine, Frédéric ULg; Tutschek, Boris; Senterre, Thibault ULg et al

in Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine (2009), 28(8), 1097

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See detailHistopathological diagnosis of a type vii mucopolysaccharidosis after pregnancy termination.
Delbecque, Katty ULg; Gaillez, Stephanie ULg; Schaaps, Jean-Pierre ULg

in Fetal & Pediatric Pathology (2009), 28(1), 1-8

Type VII mucopolysaccharidosis is a very rare recessive lysosomal storage disease. We diagnosed a type VII MPS in a case of severe fetal hydrops after pregnancy termination at 23 weeks of gestation. The ... [more ▼]

Type VII mucopolysaccharidosis is a very rare recessive lysosomal storage disease. We diagnosed a type VII MPS in a case of severe fetal hydrops after pregnancy termination at 23 weeks of gestation. The diagnosis was suspected on histopathological examination by the presence of foam cells in many viscera and foamy placental Hofbauer cells. Enzyme assay on cultured amniotic cells showed a markedly deficient beta-glucuronidase activity, thus confirming the diagnosis. This report shows the importance of a precise necropsy diagnosis in nonimmune hydrops because of putative implications for genetic counseling and prenatal diagnosis in subsequent pregnancies. [less ▲]

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See detailRh D foeto-maternal alloimmunization prophylaxis with anti-D immunoglobulins reviewed in the era of foetal RHD genotyping.
Minon, J. M.; Gerard, Christiane ULg; Schaaps, Jean-Pierre ULg et al

in Acta Clinica Belgica (2009), 64(3), 195-202

In Belgium, prevention of anti-D immunization is currently based on systematic postnatal prophylaxis associated with targeted antenatal injection in high-risk situations of foeto-maternal haemorrhage.The ... [more ▼]

In Belgium, prevention of anti-D immunization is currently based on systematic postnatal prophylaxis associated with targeted antenatal injection in high-risk situations of foeto-maternal haemorrhage.The failures of prevention are mainly due to the non-respect of established guidelines for RhlG prophylaxis, and to spontaneous undetected foetal-maternal haemorrhages without any obvious cause during the third trimester of pregnancy. In order to reduce the rate of residual post-pregnancy anti-D immunization, several countries decided to associate the classical prophylaxis to a routine antenatal anti-D prophylaxis (RAADP) during the 28th or 29th week of gestation. Since a few years, the foetal RHD genotyping in maternal plasma enables us to limit the antenatal prophylaxis only to those D- women carrying a D+ foetus. This paper deals with: the advantages of an antenatal prevention in the light of non-invasive foetal RHD genotyping, the rules rendering prevention protocols efficient whatever the algorithm applied, and the recommended immuno-haematology follow-up of women who received RhlG. [less ▲]

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See detailLes défauts d'implantation placentaire et leurs conséquences sur la fonction endothéliale maternelle
Foidart, Jean-Michel ULg; Noël, Agnès ULg; Chantraine, Frédéric ULg et al

in Bulletin Académique National de Médecine (2009), 193(5), 1059-66

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See detailA rare case of placental choriangioma associated with neonatal diffuse hemangomatosis.
Capelle, Xavier ULg; Syrios, Petros ULg; Chantraine, Frédéric ULg et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2009), 38(3), 246-249

Placental chorioangioma is a benign vascular tumor. Lesions larger than 4cm may cause fetal and maternal complications. Its association with disseminated neonatal hemangiomatosis is rarely described. We ... [more ▼]

Placental chorioangioma is a benign vascular tumor. Lesions larger than 4cm may cause fetal and maternal complications. Its association with disseminated neonatal hemangiomatosis is rarely described. We report a case of a large chorioangioma associated with an hydrops foetalis and disseminated neonatal hemangiomatosis. The relationship between placental chorioangioma and hemangioma is briefly discussed. [less ▲]

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See detailDysregulation of anti-angiogenic agents (sFlt-1, PLGF, and sEndoglin) in preeclampsia--a step forward but not the definitive answer
Foidart, Jean-Michel ULg; Schaaps, Jean-Pierre ULg; Chantraine, Frédéric ULg et al

in Journal of Reproductive Immunology (2009), 82(2), 106-11

Preeclampsia (PE) is a pregnancy-specific syndrome characterized by hypertension, proteinuria and edema, which resolves on placental delivery. It is thought to be the consequence of impaired placentation ... [more ▼]

Preeclampsia (PE) is a pregnancy-specific syndrome characterized by hypertension, proteinuria and edema, which resolves on placental delivery. It is thought to be the consequence of impaired placentation due to inadequate trophoblastic invasion of the maternal spiral arteries. In PE the maternal plasma concentration of free vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) is decreased whereas the concentration of soluble fms-like tyrosine kinase-1 (sFlt-1) and of soluble endoglin (sEng) is increased. These soluble receptors may bind VEGF, PLGF and TGFβ1 and TGFβ3 in the maternal circulation, causing endothelial dysfunction in many maternal tissues. Hence there is a view that the pathogenesis is more or less clarified. According to the vascular theory, poor placentation leads to poor uteroplacental perfusion and hypoxia, which stimulates sFlt-1 and sEng production causing the maternal syndrome. This assumption has been recently challenged. The role of hypoxia as the main stimulus for release of sFlt-1 has been questioned and the role of inflammatory mechanisms has been emphasized. According to this inflammatory theory, poor placentation may predispose more to placental oxidative stress than hypoxia and endothelial dysfunction may be part of a broader disorder of systemic inflammation. Finally, the recent demonstration of activating auto-antibodies to the angiotensin 1 receptor that experimentally play a major pathogenic role in PE further suggests a pleiotropism of aetiologies for this condition. The purpose of this review is to critically evaluate the recent hypotheses and their possible insights on early diagnosis, prevention and treatment. [less ▲]

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See detailHow I explore the benefit of 3D/4D ultrasound in obstetrics
Chantraine, Frédéric ULg; Schaaps, Jean-Pierre ULg; Foidart, Jean-Michel ULg

in Revue Médicale de Liège (2008), 63(3), 153-7

During recent years, 3D has become an important tool in ultrasound. In obstetrics, the classic 2D examination with Doppler is now often completed by 3D. In this article the strengths and weaknesses of ... [more ▼]

During recent years, 3D has become an important tool in ultrasound. In obstetrics, the classic 2D examination with Doppler is now often completed by 3D. In this article the strengths and weaknesses of this technique are discussed. [less ▲]

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See detailRoutine Fetal Rhd Genotyping with Maternal Plasma: A Four-Year Experience in Belgium
Minon, J. M.; Gerard, Christiane ULg; Senterre, J. M. et al

in Transfusion (2008), 48(2), 373-81

BACKGROUND: The objective was to evaluate the diagnostic value of RHD fetal genotyping from the plasma of D- mothers as soon as 10 weeks' gestation in a routine clinical practice in Belgium. STUDY DESIGN ... [more ▼]

BACKGROUND: The objective was to evaluate the diagnostic value of RHD fetal genotyping from the plasma of D- mothers as soon as 10 weeks' gestation in a routine clinical practice in Belgium. STUDY DESIGN AND METHODS: A prospective study was conducted between November 2002 and December 2006. DNA extraction was performed in an automated closed tube system. Fetal RHD/SRY genotypes were detected in the plasma of 563 pregnant mothers by real-time polymerase chain reaction (PCR) targeting multiple exons 4, 5, and 10 of the RHD gene and targeting an SRY gene sequence. These were compared to the D phenotypes determined in the 581 babies they delivered. RESULTS: By combining amplification of three exons, the concordance rate of fetal RHD genotypes in maternal plasma and newborn D phenotypes at delivery was 100 percent (99.8% including one unusual false-positive). The presence of nonfunctional RHD genes and the absence of a universal fetal marker, irrespective of fetal sex, did not influence the accuracy of fetal RhD status prediction. The RHD genotyping from 18 twin pregnancies was also assessed. Five weak D women were excluded from the RHD fetal genotyping prediction. Three discrepant results (0.5%) between predicted fetal genotype and cord blood phenotype were not confirmed by the baby phenotypes from venipuncture blood. CONCLUSION: Prenatal prediction of fetal RHD by targeting multiple exons from the maternal plasma with real-time PCR is highly sensitive and accurate. Over 4 years, this experience has highly modified our management of D- pregnant women. [less ▲]

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See detailNew methods of prenatal screening for trisomy 21
Capelle, Xavier ULg; Schaaps, Jean-Pierre ULg; Foidart, Jean-Michel ULg

in Revue Médicale de Liège (2008), 63(2), 82-6

Down syndrome is the most commonly recognized genetic cause of mental retardation. The risk of trisomy 21 is directly related to maternal age which can be viewed as the first screening test in the 1970's ... [more ▼]

Down syndrome is the most commonly recognized genetic cause of mental retardation. The risk of trisomy 21 is directly related to maternal age which can be viewed as the first screening test in the 1970's. New strategies for Down syndrom, have emerged with higher sensitivity and lower false-positive rate. These strategies are based on sonographic and maternal serum markers. The most specific but complex strategy is based on the integrated test, i.e., the integration of the quadruple test performed in the second trimester to the first trimester combined screening: for a 85% detection rate, the false positive rate is estimated to 0.9%. This strategy deprives the patient of an early diagnosis. Alternatives strategies do exist which can perform similar detection rate but with increasing false positive rate. To date Down syndrom, screening has not been coordinated by a national body; it would be usefull to ensure the sonographist formation, perform quality audit and decrease variations in practice. [less ▲]

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See detailPredictive value of antenatal ultrasound for the neonatal diagnostic of renal and ureteral anomaly
Loumaye, F.; De Gottal, E.; Schaaps, Jean-Pierre ULg et al

in Revue Médicale de Liège (2008), 63(12), 737-41

Pyelectasis is a dilatation of the renal pelvis. It must be differentiated from hydronephrosis which is a dilation of the renal pelvis and of the renal calyces. In this retrospective study, we focused on ... [more ▼]

Pyelectasis is a dilatation of the renal pelvis. It must be differentiated from hydronephrosis which is a dilation of the renal pelvis and of the renal calyces. In this retrospective study, we focused on the treatment and follow up of 31 newborns in whom a pyelectasis had been diagnosed in utero. At the end of the study, 20 babies showed no sign of an urologic disorder whereas 11 babies did. Our study suggests that it is crucial to search for an urologic disorder in the neonatal period when a fetal pyelectasis has been diagnosed. [less ▲]

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See detailGestion antenatale et issue postnatale des foetus atteints de laparoschisis
Capelle, Xavier ULg; Schaaps, Jean-Pierre ULg; Foidart, Jean-Michel ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2007), 36(5), 486-95

OBJECTIVES: To assess the relevance and the quality of gastroschisis's care in a mid level referral centre. METHOD: A retrospective analysis was performed for infants diagnosed or born with gastroschisis ... [more ▼]

OBJECTIVES: To assess the relevance and the quality of gastroschisis's care in a mid level referral centre. METHOD: A retrospective analysis was performed for infants diagnosed or born with gastroschisis between 1992 and 2003 at the Citadelle hospital, Department of Obstetrics and Gynaecology, University of Liege. RESULTS: Twenty-four cases of gastroschisis were identified. For 22 of them (92%) antenatal sonographic diagnosis was performed at a mean gestational age of 23 weeks. Antenatal diagnosis did not allow to identify additional malformation or chromosomal anomaly. Postnatal diagnosis allows to identify 3 infants with minor cardiac anomalies without functional consequence and one X fragile syndrome. One pregnancy was electively terminated at 24 weeks and one late intrauterine death was reported at 35 weeks. Bowel atresia, stenosis or ischemia were present at birth for 8 cases (33%). Out of 24 cases 22 were live born. 10 infants out of 22 (45%) underwent uncomplicated primary surgical repair. Three infants out of 22 (14%) underwent delayed closure without complications. Nine infants out 22 (41%) underwent multiple surgery (2 to 6). In this group all had postnatal complications, some with multisystem complications, including 3 deaths, 6 with infectious complications, 5 with gastrointestinal complications and 2 with genitourinary or haematological complications. Hospital stay range from 19 to 378 days (median, 51 days). Length of stay and time to full enteral feeding were longer if oligohydramnios or sonographic signs of intestinal damage were found. Among infants born before 35 weeks, only those with intestinal damage at birth had length of stay or time to full enteral feeding longer. Out of 22 live born infants 19 survived (86%) after one year. Survival rate without handicap due to gastroschisis is 84%. CONCLUSION: Sonographic examination is a valid method for prenatal diagnosis and surveillance. Our survival rate agrees with recent data in the literature. It has to be noticed that hospital stay is lengthy and complications are frequent. The most important prognostic factor is the condition of the bowel at birth and there is no antenatal means to predict severe damage. [less ▲]

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See detailLe genotypage RHD foetal sur sang maternel dans le suivi prenatal des patientes Rh D negatif
Dricot, J. F.; Minon, J. M.; Schaaps, Jean-Pierre ULg et al

in Revue Médicale de Liège (2006), 61(12), 820-6

Since the beginning of RHD genotyping in maternal plasma, no Rh D positive baby was diagnosed RHD negative in our institution. Genotyping from circulating DNA in maternal plasma is as efficient as ... [more ▼]

Since the beginning of RHD genotyping in maternal plasma, no Rh D positive baby was diagnosed RHD negative in our institution. Genotyping from circulating DNA in maternal plasma is as efficient as genotyping on amniocyts but without the associated risks. We propose a prophylactic injection based on fetal genotyping RHD in maternal blood with 300 microg anti-D immunoglobulin at 28 weeks of amenhorrea in all of Rh D negative pregnant women whitch fetuses positive RHD. [less ▲]

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