References of "Sartor, Francis"
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See detailFactors influencing the PCDD/F levels in plasma of Belgian blood donors
Debacker, Neomi; Van Wouwe, Nathalie; Sasse, André et al

in Organohalogen Compounds (2005)

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See detailDIOXIN BODY BURDEN AMONG BLOOD DONORS BEFORE AND AFTER THE BELGIAN DIOXIN/PCB INCIDENT
Debacker, Noemi; Sasse, André; Van Wouwe, Nathalie et al

in Organohalogen Compounds (2004)

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See detailApplication of the CALUX bioassay for epidemiological study: analyses of Belgian human plasma
Van Wouwe, Nathalie; Debacker, Noemi; Sasse, André et al

in Organohalogen Compounds (2004)

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See detailAnalysis of PCDD/Fs in human blood plasma using CALUX bioassay and GC-HRMS: a comparison
Van Wouwe, Nathalie; Eppe, Gauthier ULg; Xhrouet, Céline ULg et al

in Organohalogen Compounds (2003)

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See detailDeterminants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium
Thijs, Lutgarde; Staessen, Jan; Amery, Antoon et al

in Environmental Health Perspectives (1992), 98

This report investigated the distribution of serum zinc and the factors determining serum zinc concentration in a large random population sample. The 197 participants (959 men and 1018 women), 20-80 years ... [more ▼]

This report investigated the distribution of serum zinc and the factors determining serum zinc concentration in a large random population sample. The 197 participants (959 men and 1018 women), 20-80 years old, constituted a stratified random sample of the population of four Belgian districts, representing two areas with low and two with high environmental exposure to cadmium. For each exposure level, a rural and an urban area were selected. The serum concentration of zinc, frequently used as an index for zinc status in human subjects, was higher in men (13.1 µmole/L, range 6.5-23.0 µmole/L) than in women (12.6 µmoleL, range 6.3-23.2 µmole/L). In men, 20% of the variance of serum zinc was explained by age (linear and squared term, R=0.29), diurnal variation (r=0.29), and total cholesterol (r=0.16). After adjustment for these covariates, a negative relationship was observed between serum zinc and both blood (r= -0.10) and urinary cadmium (r= -0.14). In women, 11% of the variace could be explained by age (linear and squared term, R = 0.15), diurnal variation in serum zinc (r=0.27), creatinine clearance (r= -0.11), log y-glutamyltranspeptidase (r= 0.08), cholesterol (r= 0.07), contraceptive pill intake (r= -0.07), and log serum ferritin (r=0.06). Before and after adjustment for significant covariates, serum zinc was, on average, lowest in the two districts where the body burden of cadmium, as assessed by urinary cadmium excretion, was highest. These results were not altered when subjects exposed to heavy metals at work were excluded from analysis. [less ▲]

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See detailEffects of exposure to cadmium on calcium metabolism : a population study
Staessen, Jan; Amery, Antoon; Bernard, Alfred et al

in British Journal of Industrial Medicine (1991), 48

The objective was to investigate the hypothesis that environmental exposure to cadmium may affect calcium metabolism in the population at large. The 1987 participants (965 men and 1022 women), from 20 to ... [more ▼]

The objective was to investigate the hypothesis that environmental exposure to cadmium may affect calcium metabolism in the population at large. The 1987 participants (965 men and 1022 women), from 20 to 80 years old, constituted a random sample of the population of four Belgian districts. The urinary excretion of cadmium, a mesure of lifetime exposure, averaged 9.3 nmo/24h in men (range 0.4-324 nmol/24h) and 7.1 nmol/24h (range 0.1-71 nmol/24h) in women. Serum alkaline phosphatase activity and the urinary excretion of calcium correlated significantly and positively with urinary cadmium excretion in both men and women, and serum total calcium concentration negatively with urinary cadmium excretion in men only. The regression coefficients obtained after adjustment for significant covariates indicated that when urinary cadmium excretion increased twofold, serum alkaline phosphatase activity and urinary calcim excretion rose by 3-4% and 0.25 mmol/24h respectively, whereas in men serum total calcium concentration fell by 6 µmol/l. After adjustment for significant covariates the relation between serum total calcium concentration and urinary cadmium excretion was not significant in women. The findings suggest that even at environmental exposure levels calcium metabolism is gadually affected, as cadmium accumulates in the body. The morbidity associated with this phenomenon in industrialised countries remains presently unknown and requires further investigation. [less ▲]

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See detailHealth effects of environmental exposure to cadmium: objectives, design and organization of the Cadmibel
Lauwerys, Robert; Amery, Antoon; Bernard, Alfred et al

in Environmental Health Perspectives (1990), 87

Cadmium is a cumulative environmental pollutant. For the general population mainly exposed by the oral route and through tobacco smoke inhalation, the kidney is the critical organ. Belgium is the ... [more ▼]

Cadmium is a cumulative environmental pollutant. For the general population mainly exposed by the oral route and through tobacco smoke inhalation, the kidney is the critical organ. Belgium is the principal producer of cadmium in Europe, and certain areas of the country are polluted by cadmium mainly because of past emissions from nonferrous industries. Preliminary studies carried out in one polluted area have suggested that environmental pollution might lead to an increased uptake of cadmium by the human body and possibly to health effects. Thus, a large-scale morbidity study has been initiated to assess the validity of this hypothesis. The present paper describes the protocol of this study. Its main objectives are to determine to what extent environmental exposure to cadmium resulting from industrial emissions may lead to accumulation of the metal in the human organism; to establish whether or not environmental exposure may induce renal changes and/or influence blood pressure; and to assess the acceptable internal dose of cadmium for the genral population. The study design takes advantage of the fact that biological indicators of exposure, body burden, and early nephrotoxic effects of cadmium ar available, which increase the likelihood of detecting a cause-effect relationship. [less ▲]

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See detailPsychometrical performance of young belgian boys with unusual lead absorption : A pilot study
Thirion, Paul ULg; Sartor, Francis; Deltour, Jean-Jacques et al

in Rondia, Désiré (Ed.) Belgian research on metals cycling : Proceedings of a symposium held in Brussels, 11-12 october 1985 (1986)

Two groups of boys, 4-5 years old, living respectively in a high and low lead intake risk areas (Verviers and Liege) have been compared for two intelligence scales, for the developmental test of the ... [more ▼]

Two groups of boys, 4-5 years old, living respectively in a high and low lead intake risk areas (Verviers and Liege) have been compared for two intelligence scales, for the developmental test of the visual perception, for two French vocabulary tests and for the hair lead content. Possible psychological or sociological bias have been controlled by the matching of boys for familial variables and by exclusion of children with a non acceptable medical and psychological previous history. The results show a higher geometric mean for the hair lead concentration in the Verviers children. The mean scores of the Wechsler full scale IQ and the vocabulary tests do not differ significantly in the investigated groups. The performance subtests of the intelligence scales however give different results at the usual 5% level. The small size of the samples examined in this pilot study precludes any conclusion about the causality or the strength of the association. [less ▲]

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