References of "Sanchez, Christelle"
     in
Bookmark and Share    
Full Text
See detailWP1 - A summary
Sanchez, Christelle ULiege

Conference (2017, September 20)

Detailed reference viewed: 13 (1 ULiège)
Full Text
Peer Reviewed
See detailChondrocyte secretome: a source of novel insights and exploratory biomarkers of osteoarthritis
Sanchez, Christelle ULiege; Bay-Jensen, Anne-Christine; Pap, Thomas et al

in Osteoarthritis and Cartilage (2017), 25

Detailed reference viewed: 45 (8 ULiège)
Full Text
Peer Reviewed
See detailStudy of the evolution of the osteoarthritis pathology and the mechanical properties of cartilage in a spontaneous osteoarthritis model in the Dunkin-Hartley guinea pigs.
Legrand, Catherine ULiege; Centonze, Prescilia ULiege; Comblain, Fanny ULiege et al

Poster (2017, April 27)

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan content, the integrity of the tidemark, the cellularity, and osteophytes ... [more ▼]

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan content, the integrity of the tidemark, the cellularity, and osteophytes. In parallel to these histological analyzes, we studied the mechanical properties of cartilage at different stages of disease progression in the Dunkin-Hartley guinea pigs. We also correlated the severity of histological lesions with the mechanical properties of cartilage. [less ▲]

Detailed reference viewed: 45 (4 ULiège)
Full Text
Peer Reviewed
See detailStudy of the evolution of the osteoarthritis pathology and the mechanical properties of cartilage in a spontaneous osteoarthritis model in the Dunkin-Hartley guinea pigs.
Legrand, Catherine ULiege; Centonze, Prescilia ULiege; Comblain, Fanny ULiege et al

in Osteoarthritis and Cartilage (2017, April), 25

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan con- tent, the integrity of the tidemark, the cellularity, and osteophytes ... [more ▼]

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan con- tent, the integrity of the tidemark, the cellularity, and osteophytes. In parallel to these histological analyzes, we studied the mechanical properties of cartilage at different stages of disease progression in the Dunkin-Hartley guinea pigs. We also correlated the severity of histo- logical lesions with the mechanical properties of cartilage. [less ▲]

Detailed reference viewed: 22 (3 ULiège)
Full Text
Peer Reviewed
See detailEffect of moderate increasing exercice on the mechanical balance of the knee joint in young rats
Rahnamay Moshtagh, Parisa; Korthagen, N; Plomp, S et al

Conference (2017)

Detailed reference viewed: 11 (2 ULiège)
Full Text
Peer Reviewed
See detailReview of soluble biomarkers of osteoarthritis: lessons from animal model
Legrand, Catherine ULiege; Lambert, Cécile ULiege; Comblain, Fanny ULiege et al

in Cartilage (2017)

Osteoarthritis (OA) is one of the leading causes of disability within the adult population. Currently, its diagnosis is mainly based on clinical examination and standard radiography. To date, there is no ... [more ▼]

Osteoarthritis (OA) is one of the leading causes of disability within the adult population. Currently, its diagnosis is mainly based on clinical examination and standard radiography. To date, there is no way to detect the disease at a molecular level, before the appearance of structural changes and symptoms. So an attractive alternative for monitoring OA is the measurement of biochemical markers in blood, urine, or synovial fluid, which could reflect metabolic changes in joint tissue and therefore disease onset and progression. Animal models are relevant to investigate the early stage of OA and metabolic changes occurring in joint tissues. The goal of this narrative review is to summarize the scientific data available in the literature on soluble biomarkers in animal models of OA. [less ▲]

Detailed reference viewed: 24 (3 ULiège)
Full Text
Peer Reviewed
See detailStudy of the evolution of the osteoarthritis pathology and the mechanical properties of cartilage in a spontaneous osteoarthritis model in the Dunkin-Hartley guinea pigs.
Legrand, Catherine ULiege; Centonze, Prescilia ULiege; Comblain, Fanny ULiege et al

Poster (2016, November 16)

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan content, the integrity of the tidemark, the cellularity, and osteophytes ... [more ▼]

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan content, the integrity of the tidemark, the cellularity, and osteophytes. In parallel to these histological analyzes, we studied the mechanical properties of cartilage at different stages of disease progression in the Dunkin-Hartley guinea pigs. We also correlated the severity of histological lesions with the mechanical properties of cartilage. [less ▲]

Detailed reference viewed: 35 (4 ULiège)
Full Text
Peer Reviewed
See detailOsteoarthritis biomarkers derived from cartilage extracellular matrix: Current status and future perspectives.
Henrotin, Yves ULiege; Sanchez, Christelle ULiege; Bay-Jensen, A. C. et al

in Annals of physical and rehabilitation medicine (2016), 59(3), 145-148

Specific soluble biomarkers can be powerful tools for the diagnosis, prognosis and personalized management of osteoarthritis (OA). Biomarkers are potential indicators of the effect of a drug on cartilage ... [more ▼]

Specific soluble biomarkers can be powerful tools for the diagnosis, prognosis and personalized management of osteoarthritis (OA). Biomarkers are potential indicators of the effect of a drug on cartilage metabolism and provide crucial information about the mechanisms of drug action. In this review, we address key questions concerning the use of biomarkers in OA management: Why do we need soluble biomarkers? What are the most widely investigated biomarkers derived from cartilage extracellular matrix? What are the most common pitfalls in interpreting soluble biomarker measurements? What are the perspectives and future research directions in this field? We review current evidence to propose that cartilage-derived soluble biomarkers are complementary "drug development tools" that can be applied during drug development from preclinical research to clinical evaluation. In the future, such biomarkers could be surrogate markers of clinical and/or imaging outcomes. Successful standardization and implementation of automated biomarker assays will facilitate their use in companion diagnostics in the context of personalized medicine for enhanced management of OA. [less ▲]

Detailed reference viewed: 36 (5 ULiège)
Full Text
Peer Reviewed
See detailFibulin-3 fragments are prognostic biomarkers of osteoarthritis incidence in overweight and obese women
Runhaar, Jos; Sanchez, Christelle ULiege; Taralla, Sébastien et al

in Osteoarthritis Cartilage (2016), 24(4), 672-678

OBJECTIVE: To determine the association between three fibulin-3 peptides and the incidence of radiographic and clinical knee osteoarthritis (OA). DESIGN: Women between 50 and 60 years, with a BMI >/=27 kg ... [more ▼]

OBJECTIVE: To determine the association between three fibulin-3 peptides and the incidence of radiographic and clinical knee osteoarthritis (OA). DESIGN: Women between 50 and 60 years, with a BMI >/=27 kg/m2, free of knee OA, were recruited. Using binary logistic regression, the association between baseline concentration of serum fibulin (Fib)3-1, Fib3-2 and Fib3-3 and incidence of clinical and radiographic knee OA after 30 months of follow-up was evaluated. RESULTS: Baseline and follow-up measurements were available for 241 women with a mean age of 55.9 +/- 3.2 years and mean BMI of 31.7 +/- 3.6 kg/m2. None of the concentrations of the three Fib3 epitopes were associated with the incidence of medial or lateral joint space narrowing (JSN) >/=1.0 mm or the incidence of Kellgren & Lawrence (K&L) grade >/=2 after 30 months. All three Fib3 epitopes were associated with the incidence of the clinical and radiographic ACR-criteria and Fib3-1 and Fib3-3 also with chronic pain at follow-up. When adjusted for the other Fib3 peptide concentrations, only Fib3-1 was significantly associated to the incidence of the American College of Rheumatology (ACR)-criteria (OR 3.2 [1.2-8.7]) and chronic pain at follow-up (OR 3.0 [1.2-7.7]). CONCLUSIONS: Baseline fibulin-3 concentrations are associated with the incidence of clinical knee OA among middle-aged overweight and obese women. Therewith, they meet the criteria of a prognostic biomarker according to the BIPED biomarker classification for OA. Further validation of the fibulin-3 epitopes seems warranted in order to better distinguish subgroups of individuals at increased risk for knee OA development. [less ▲]

Detailed reference viewed: 32 (5 ULiège)
Full Text
Peer Reviewed
See detailReview of soluble biomarkers of osteoarthritis: lessons from animal model
Legrand, Catherine ULiege; Lambert, Cécile ULiege; Comblain, Fanny ULiege et al

in Osteoarthritis and Cartilage (2016, April), 24(suppl 1), 88

Detailed reference viewed: 44 (12 ULiège)
Full Text
Peer Reviewed
See detailOsteoarthritic sclerotic subchondral osteoblasts secreted elevated concentration of fibulin-3 fragments in vitro
Sanchez, Christelle ULiege; Lambert, Cécile ULiege; Comblain, Fanny ULiege et al

in Osteoarthritis and Cartilage (2016, April), 24(suppl 1), 83

Detailed reference viewed: 42 (9 ULiège)
Full Text
Peer Reviewed
See detailIdentification of a Spectrum of Therapeutic Targets of a New Treatment for Osteoarthritis Composed by Curcuminoids Extract, Hydrolyzed Collagen and Green Tea Extract
Comblain, Fanny ULiege; Dubuc, Jean-Emile; Lambert, Cécile ULiege et al

in Osteoarthritis and Cartilage (2016, April), 24(Supp 1), 353

Detailed reference viewed: 38 (10 ULiège)
Full Text
Peer Reviewed
See detailRestriction of spontaneous and prednisolone-induced leptin production to dedifferentiated state in human hip OA chondrocytes: role of Smad1 and b-catenin activation
CHARLIER, Edith ULiege; MALAISE, Olivier ULiege; Zeddou, Mustapha et al

in Osteoarthritis and Cartilage (2016)

Objective: The aetiology of OA is not fully understood although several adipokines such as leptin are known mediators of disease progression. Since leptin levels were increased in synovial fluid compared ... [more ▼]

Objective: The aetiology of OA is not fully understood although several adipokines such as leptin are known mediators of disease progression. Since leptin levels were increased in synovial fluid compared to serum in OA patients, it was suggested that joint cells themselves could produce leptin. However, exact mechanisms underlying leptin production by chondrocytes are poorly understood. Nevertheless, prednisolone, although displaying powerful anti-inflammatory properties has been recently reported to be potent stimulator of leptin and its receptor in OA synovial fibroblasts. Therefore, we investigated, in vitro, spontaneous and prednisolone-induced leptin production in OA chondrocytes, focusing on transforming growth factor-b (TGFb) and Wnt/b-catenin pathways. Design: We used an in vitro dedifferentiation model, comparing human freshly isolated hip OA chondrocytes cultivated in monolayer during 1 day (type II, COL2A1 þ; type X, COL10A1 þ and type I collagen, COL1A1 ") or 14 days (COL2A1 "; COL10A1 " and COL1A1þ). Results: Leptin expression was not detected in day1 OA chondrocytes whereas day14 OA chondrocytes produced leptin, significantly increased with prednisolone. Activin receptor-like kinase 1 (ALK1)/ALK5 ratio was shifted during dedifferentiation, from high ALK5 and phospho (p)-Smad2 expression at day1 to high ALK1, endoglin and p-Smad1/5 expression at day14. Moreover, inactive glycogen synthase kinase 3 (GSK3) and active b-catenin were only found in dedifferentiated OA chondrocytes. Smad1 and b-catenin but not endoglin stable lentiviral silencing led to a significant decrease in leptin production by dedifferentiated OA chondrocytes. Conclusions: Only dedifferentiated OA chondrocytes produced leptin. Prednisolone markedly enhanced leptin production, which involved Smad1 and b-catenin activation [less ▲]

Detailed reference viewed: 25 (12 ULiège)