References of "Salmon, Eric"
     in
Bookmark and Share    
Peer Reviewed
See detailSelf in Dementia
Antoine, Nicolas ULg; Genon, Sarah ULg; Bastin, Christine ULg et al

in Mishara; Corlett, P.; Fletcher, P. (Eds.) et al Phenomenological Neuropsychiatry, How Patient Experience Bridges Clinic with Clinical Neuroscience (in press)

Detailed reference viewed: 102 (18 ULg)
Peer Reviewed
See detailRecollection versus familiarité dans le vieillissement normal et pathologique : Impact du format du test
Simon, Jessica ULg; Gilsoul, Jessica ULg; SALMON, Eric ULg et al

Poster (2017, May 19)

If familiarity is better preserved than recollection in aging and in the early stage of Alzheimer's disease (Koen & Yonelinas, 2014), the experimental conditions promoting its use should be beneficial to ... [more ▼]

If familiarity is better preserved than recollection in aging and in the early stage of Alzheimer's disease (Koen & Yonelinas, 2014), the experimental conditions promoting its use should be beneficial to these populations. One condition influencing the relative contribution of recollection and familiarity during recognition is the format of the test. The aim of this study was to investigate the impact of test format on recollection and familiarity in normal aging and in MCI in two tasks where the level of performance is equalized. Seventy young participants, 70 younger-old (55-69 years old), 69 older-old (70-85 years old), and 13 MCIs were presented with forced-choice and yes/no visual recognition memory tasks with the Remember/Know/ Guess paradigm. Young participants had better recognition memory performance than younger-old, who performed better than older-old and MCIs. Recollection and familiarity declined progressively in healthy aging. In MCI, recollection was more affected than familiarity, but patients demonstrated a more liberal use of familiarity. Finally, test format did not influence strongly the results. Young people used recollection more often in the forced-choice task compared to the yes/no task. [less ▲]

Detailed reference viewed: 20 (2 ULg)
Peer Reviewed
See detailExploration des processus de recollection et de familiarité chez des patients présentant une plainte mnésique : une étude longitudinale
Simon, Jessica ULg; Collette, Fabienne ULg; SALMON, Eric ULg et al

Poster (2017, May 19)

Recollection refers to recall of details about past events, and familiarity is a feeling of oldness. In this study, we tested how recollection and familiarity are affected in patients with memory ... [more ▼]

Recollection refers to recall of details about past events, and familiarity is a feeling of oldness. In this study, we tested how recollection and familiarity are affected in patients with memory complaints compared to normal aging. We recruited 23 healthy older participants, 9 patients with subjective memory impairment (SCI) and 23 patients with mild cognitive impairment (MCI). Participants performed one 2-alternative forced-choice and one Yes-No recognition memory task including pictures and words, followed by a short neuropsychological evaluation. Fifteen healthy participants and 23 patients (9 SCI and 14 MCI) took part in a neuropsychological follow-up after a mean delay of 21 months. At inclusion, MCI patients had poorer performance in recognition than the other groups, which did not differ. MCI patients had worse performance regarding familiarity and recollection indexes compared to healthy controls and SCI, who exhibit similar performance. There was no interaction between groups and format or material. During the follow-up evaluation, five MCI returned to a normal level of efficiency and were considered as SCI. Based on the French adaptation of the free and cued selective reminding test (RLRI-16), we calculated cognitive decline curves in our patients. We observed that recollection and familiarity indexes were explained by the decline curves calculated on the number of freely recalled items. So, recollection and familiarity were used less efficiently in MCI than SCI although both groups complained about their memory. [less ▲]

Detailed reference viewed: 15 (2 ULg)
Peer Reviewed
See detailRecollection versus familiarity in normal aging and in mild cognitive impairment: Impact of test format
Simon, Jessica ULg; Gilsoul, Jessica ULg; SALMON, Eric ULg et al

Poster (2017, March 24)

If familiarity is better preserved than recollection in aging and in the early stage of Alzheimer's disease (Koen & Yonelinas, 2014), the experimental conditions promoting its use should be beneficial to ... [more ▼]

If familiarity is better preserved than recollection in aging and in the early stage of Alzheimer's disease (Koen & Yonelinas, 2014), the experimental conditions promoting its use should be beneficial to these populations. One condition influencing the relative contribution of recollection and familiarity during recognition is the format of the test. The aim of this study was to investigate the impact of test format on recollection and familiarity in normal aging and in MCI in two tasks where the level of performance is equalized. Seventy young participants, 70 younger-old (55-69 years old), 69 older-old (70-85 years old), and 13 MCIs were presented with forced-choice and yes/no visual recognition memory tasks with the Remember/Know/ Guess paradigm. Young participants had better recognition memory performance than younger-old, who performed better than older-old and MCIs. Recollection and familiarity declined progressively in healthy aging. In MCI, recollection was more affected than familiarity, but patients demonstrated a more liberal use of familiarity. Finally, test format did not influence strongly the results. Young people used recollection more often in the forced-choice task compared to the yes/no task. [less ▲]

Detailed reference viewed: 19 (2 ULg)
Full Text
Peer Reviewed
See detailAnosognosia for behavioral disorder is related to confidence for false self-related memories in Alzheimer’s disease
Mélon, Marlène; Collette, Fabienne ULg; Salmon, Eric ULg et al

Poster (2017, March 24)

Impaired self-awareness (i.e. anosognosia) and altered metacognitive monitoring in memory tasks have both been evidenced in AD. Furthermore, cognitive studies showed disrupted interaction between self and ... [more ▼]

Impaired self-awareness (i.e. anosognosia) and altered metacognitive monitoring in memory tasks have both been evidenced in AD. Furthermore, cognitive studies showed disrupted interaction between self and memory cognitive systems in AD, reducing cognitive advantages of self-related memories (i.e. decreasing self reference effect, SRE) in these patients. However, how anosognosia relates to impaired metacognitive monitoring in AD, particularly for self-related memories, is still an open question. To investigate this question, an ecological memory task based on face-name associations was administrated to 20 healthy older controls (HC) and 20 mild AD patients. The influence of self-reference at encoding was assessed on subsequent name recall and recollective experience, as well as on predictive (feeling-of-knowing, FOK) and postretrieval (judgments-of-confidence, JOC) metacognitive judgments on name recognition in all participants. Furthermore relationships between metacognitive outcomes and awareness of daily cognitive and behavioral impairment was examined in AD. Altered SRE was evidenced in name recall and recollective experience in AD. Patients also showed impaired FOK and JOC, as well as lower awareness of their daily functioning impairment (anosognosia). Nevertheless, differential effect of self on metacognitive judgment in AD and HC was only observed on JOC for false memories. Importantly, anosognosia for behavioral disorders was related to post-retrieval confidence for false recognition of self-related items in AD patients. Thus, anosognosia concerning behavioral disorder and altered post-retrieval monitoring of self-related memories appear to be related in AD. We hypothesized that impaired monitoring of personal false memories may lead AD patients to rely on distorted recent reality when providing judgment about their everyday behavioral functioning. [less ▲]

Detailed reference viewed: 32 (1 ULg)
Full Text
Peer Reviewed
See detailRelating pessimistic memory predictions to Alzheimer’s disease brain structure
Genon, Sarah ULg; Simon, Jessica ULg; Bahri, Mohamed Ali ULg et al

Poster (2017, March 23)

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory ... [more ▼]

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory retrieval and investigated the neural correlates of pessimistic predictions for successfully retrieved memories in AD patients. AD patients and healthy older participants provided predictive judgements on their recognition performance before retrieval of famous (semantic) and recently learned (episodic) names. Correlations between grey matter volume (GMV) in T1 images and behavioural scores were examined with multivariate (PLS) and univariate (GLM) analyses in AD patients. AD patients showed a significant proportion of successful name recognition preceded by pessimistic prediction (Prediction_low_hits) in episodic memory. PLS revealed that behavioural pattern in AD patients was related with a mainly right lateralized pattern of GMV decrease including medial temporal lobe and posterior cingulate cortex, but also right ventrolateral prefrontal cortex (VLPFC). GLM further confirmed that pessimistic prediction negatively correlated with GMV in VLPFC. Thus, impaired monitoring processes (possibly influenced by inaccurate beliefs) allowing inferences about one’s own memory performance are primarily related to decrease GMV in VLPFC in AD patients. [less ▲]

Detailed reference viewed: 31 (1 ULg)
Peer Reviewed
See detailRecognition memory is associated with hippocampal volume in aging population: new evidence from brain imaging study
Narbutas, Justinas ULg; Blanpain, Manon ULg; Van Egroo, Maxime ULg et al

Poster (2017, March 23)

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory ... [more ▼]

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory declines with aging and this has been associated with hippocampal dysfunction. The main objective of our study was to explore how performance on a recognition memory task designed to assess pattern separation is associated with hippocampal volume in aging population. Methods. Fourteen healthy late middle-aged participants (52-69 years-old) were evaluated on a Mnemonic Similarity Task (MST). In this task, participants study pictures and then have to discriminate between targets, similar lures, and unrelated foil objects. Recognition memory (RM) is assessed as the difference between hits and false alarms to unrelated foils, while pattern separation Bias metric (BPS) is the difference between the rate of ‘‘Similar’’ responses given to the lure items minus ‘‘Similar’’ responses given to the foils. Hippocampal volume was calculated using ASHS software, which uses T1-weighted and T2-weighted MRI to obtain optimal segmentation of hippocampal subfields. Results. Correlation analysis of preliminary data revealed that RM was significantly positively associated with the volume of the left subiculum and left perirhinal area 35, while there were no significant correlations in the right hemisphere. BPS was positively correlated with the volume of right CA2 region, but negatively associated with the volume of right CA3 region, what is more contradictory according to the current literature. No significant link was found between BPS and the volume of hippocampal subfields in the left hemisphere. Conclusion. In a middle-aged population, better visual recognition memory is associated with larger volume of the left subiculum and perirhinal area 35, two regions supporting representation of objects [less ▲]

Detailed reference viewed: 62 (13 ULg)
Full Text
Peer Reviewed
See detailThe frequency and influence of dementia risk factors in prodromal Alzheimer’s disease
Bos, Isabelle; Vos, Stephanie J.; Frölich, Lutz et al

in Neurobiology of Aging (2017), 56

We investigated whether dementia risk factors were associated with prodromal Alzheimer’s disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer’s Association ... [more ▼]

We investigated whether dementia risk factors were associated with prodromal Alzheimer’s disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer’s Association criteria, and with cognitive decline. 1394 subjects from with Mild Cognitive Impairment (MCI) from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of ten risk factors between the subgroups and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared to those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with MCI. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e. preclinical) of AD. [less ▲]

Detailed reference viewed: 18 (1 ULg)
Full Text
Peer Reviewed
See detailThe impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: an EADC study
Bosco, P.; Redolfi, A.; Bocchetta, M. et al

in Alzheimer's & Dementia : The Journal of the Alzheimer's Association (2017)

Detailed reference viewed: 35 (3 ULg)
Full Text
Peer Reviewed
See detailAnosognosie et monitoring des souvenirs associés au « soi » dans la Maladie d’Alzheimer
Genon, Sarah ULg; Mélon, Marlène; Collette, Fabienne ULg et al

Conference (2017)

Chez les patients atteints de maladie d’Alzheimer (MA), on observe dès les stades débutants d’une part un phénomène d’anosognosie, qui peut être considéré comme une altération de la conscience de soi, et ... [more ▼]

Chez les patients atteints de maladie d’Alzheimer (MA), on observe dès les stades débutants d’une part un phénomène d’anosognosie, qui peut être considéré comme une altération de la conscience de soi, et d’autre part un dysfonctionnement des processus de monitoring mnésique [1]. En outre, l’interaction entre le soi et la mémoire (conférant un bénéfice mnésique pour les informations associées à soi), apparaît significativement altérée dans la MA. Dans la présente étude, nous avons examiné les relations entre l’anosognosie et le monitoring lors de la récupération en mémoire d’informations expérimentalement associées à soi. Nous avons évalué les processus de monitoring lors de la récupération en mémoire à l’aide d’une tâche expérimentale de 32 paires visage-prénom, ainsi que l’anosognosie à l’aide du questionnaire d’anosognosie dans la démence (AQD, [2]) chez 20 patients MA et 20 personnes âgées contrôles (AC). Durant la phase d’encodage, les paires visage-prénom ont été présentées aux participants soit comme des personnes faisant partie de leur famille (soi) soit comme des personnes faisant partie de la famille de l’expérimentateur (autrui). Ensuite, nous avons évalué les jugements de « sentiment de savoir » (FOK), les performances de rappel et de reconnaissance, ainsi que les jugements de confiance (JOC) des participants pour le nom de chaque personne lorsque son visage était présenté. Nos résultats ont confirmé l’altération de la conscience de soi (c’est-à-dire l’anosognosie mesurée par l’AQD), l’altération du bénéfice mnésique pour les informations associées à soi, ainsi que l’altération des processus de monitoring lors de la récupération en mémoire (FOK et JOC) chez les patients MA. Néanmoins, une modification de l’interaction entre le soi et les processus de monitoring chez ces patients a été observée uniquement au niveau des sentiments de confiance pour des souvenirs erronés. Nous avons également observé que l’anosognosie des troubles comportementaux était significativement corrélée à la proportion de sentiments de confiance pour des reconnaissances erronées sur les items associés à soi. En conclusion, notre étude suggère que l’altération de la conscience des troubles comportementaux chez les patients MA pourrait être liée à un déficit de monitoring des souvenirs liés à soi. C’est-à-dire que la conscience altérée du dysfonctionnement au quotidien pourrait s’appuyer sur des souvenirs personnels déformés. [less ▲]

Detailed reference viewed: 36 (0 ULg)
Full Text
Peer Reviewed
See detailThe neural bases of proactive and reactive control processes in normal aging
Manard, Marine ULg; François, Sarah ULg; Phillips, Christophe ULg et al

in Behavioural Brain Research (2017), 320

Introduction. Research on cognitive control suggests an age-related decline in proactive control abilities (anticipatory control), whereas reactive control (following conflict detection) seems to remain ... [more ▼]

Introduction. Research on cognitive control suggests an age-related decline in proactive control abilities (anticipatory control), whereas reactive control (following conflict detection) seems to remain intact. As proactive and reactive control abilities are associated with specific brain networks, this study investigated age-related effects on the neural substrates associated with each kind of control. Methods. In an event-related fMRI study, a modified version of the Stroop task was administered to groups of 20 young and 20 older healthy adults. Based on the theory of dual mechanisms of control, the Stroop task has been built to induce proactive or reactive control depending on task context. Results. Behavioral results (p < .05) indicated faster processing of interfering items in the mostly incongruent (MI) than the mostly congruent (MC) context in both young and older participants. fMRI results showed that reactive control is associated with increased activity in left frontal areas for older participants. For proactive control, decreased activity in the bilateral anterior cingulate cortex was associated with more activity in the right middle frontal gyrus in the older than the younger group. Conclusion. These observations support the hypothesis that aging affects the neural networks associated with reactive and proactive cognitive control differentially. These age-related changes are very similar to those observed in young adults with low dopamine availability, suggesting that a general mechanism (prefrontal dopamine availability) may modulate brain networks associated with various kinds of cognitive control. [less ▲]

Detailed reference viewed: 33 (7 ULg)
Full Text
Peer Reviewed
See detailFluctuations of Attentional Networks and Default Mode Network during the Resting State Reflect Variations in Cognitive States: Evidence from a Novel Resting-state
Van Calster, Laurens ULg; D'Argembeau, Arnaud ULg; SALMON, Eric ULg et al

in Journal of Cognitive Neuroscience (2017)

Neuroimaging studies have revealed the recruitment of a range of neural networks during the resting state, which might reflect a variety of cognitive experiences and processes occurring in an individual's ... [more ▼]

Neuroimaging studies have revealed the recruitment of a range of neural networks during the resting state, which might reflect a variety of cognitive experiences and processes occurring in an individual's mind. In this study, we focused on the default mode network (DMN) and attentional networks and investigated their association with distinct mental states when participants are not performing an explicit task. To investigate the range of possible cognitive experiences more directly, this study proposes a novel method of resting-state fMRI experience sampling, informed by a phenomenological investigation of the fluctuation of mental states during the resting state. We hypothesized that DMN activity would increase as a function of internal mentation and that the activity of dorsal and ventral networks would indicate states of top–down versus bottom–up attention at rest. Results showed that dorsal attention network activity fluctuated as a function of subjective reports of attentional control, providing evidence that activity of this network reflects the perceived recruitment of controlled attentional processes during spontaneous cognition. Activity of the DMN increased when participants reported to be in a subjective state of internal mentation, but not when they reported to be in a state of perception. This study provides direct evidence for a link between fluctuations of resting-state neural activity and fluctuations in specific cognitive processes. [less ▲]

Detailed reference viewed: 40 (7 ULg)
Full Text
Peer Reviewed
See detailRelating pessimistic memory predictions to Alzheimer’s disease brain structure
Genon, Sarah ULg; Simon, Jessica ULg; Bahri, Mohamed Ali ULg et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2016), 85

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory ... [more ▼]

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory retrieval and investigated the neural correlates of pessimistic predictions for successfully retrieved memories in AD patients. AD patients and healthy older participants provided predictive judgements on their recognition performance before retrieval of famous (semantic) and recently learned (episodic) names. Correlations between grey matter volume (GMV) in T1 images and behavioural scores were examined with multivariate (PLS) and univariate (GLM) analyses in AD patients. AD patients showed a significant proportion of successful name recognition preceded by pessimistic prediction (Prediction_low_hits) in episodic memory. PLS revealed that behavioural pattern in AD patients was related with a mainly right lateralized pattern of GMV decrease including medial temporal lobe and posterior cingulate cortex, but also right ventrolateral prefrontal cortex (VLPFC). GLM further confirmed that pessimistic prediction negatively correlated with GMV in VLPFC. Thus, impaired monitoring processes (possibly influenced by inaccurate beliefs) allowing inferences about one’s own memory performance are primarily related to decrease GMV in VLPFC in AD patients. [less ▲]

Detailed reference viewed: 84 (13 ULg)
Full Text
See detailEVALUATING THE SPECIFICITY OF [18F]UCB-H FOR THE ISOFORM SV2A, COMPARED WITH ISOFORMS SV2B AND SV2C
Serrano Navacerrada, Maria Elisa ULg; Aerts, Joël ULg; Bahri, Mohamed Ali ULg et al

Poster (2016, November 18)

Background: SV2A is the most studied isoform of the Synaptic Vesicle 2 proteins, which are involved in the synaptic vesicle trafficking, being important in normal and pathological process, like the ... [more ▼]

Background: SV2A is the most studied isoform of the Synaptic Vesicle 2 proteins, which are involved in the synaptic vesicle trafficking, being important in normal and pathological process, like the epilepsy (1, 2). [18F]UCB-H was developed like a tool to study the role of this isoform with neuroimaging techniques (3, 4). The objective of this study was to evaluate its specificity to this isoform comparing with the others, through a competition assay in rats with ex-vivo autoradiography and mPET imaging. Methods: Forty male Sprague-Dawley were used in ex-vivo autoradiography experiments (N=20) and in microPET imaging (N=20). Animals were pre-treated 30 minutes before the injection of [18F]UCB-H with a dose IP either of vehicle, Keppra (SV2A ligand), UCB068 (SV2B ligand) or UCB054 (SV2C ligand). Ex-vivo autoradiography was carried out 5 minutes after radiotracer injection while mPET images were acquiring with a dynamic scanner of 1 hour. Data were expressed in Standard Uptake Value and then, the area under the curve was calculated for the total process. Results: In ex-vivo autoradiography, ANOVA of two-ways showed statistical significant differences in brain uptake of [18F]UCB-H among the groups pretreated with Keppra or the ligand for SV2B and the control group. Regarding mPET data, statistical significant differences were found between the group injected with keppra and the rest of groups. Conclusion: Even if a considerable affinity between the ligands UCB068 and UCB054, and the receptor for the isoform SV2A exists, it is only detected during the first 5 minutes (ex-vivo technique), being certainly due to a nonspecific binding. This binding is not strong enough to show a direct competition with the radiotracer during a mPET acquisition. These results allow us to conclude that [18F]UCB-H is a suitable radiotracer for the imaging of the isoform SV2A in vivo, allowing us the clinical study about the molecular base of a disease with a high population impact, like the epilepsy. [less ▲]

Detailed reference viewed: 26 (3 ULg)
Full Text
Peer Reviewed
See detailIncreasing the salience of fluency cues does not reduce the recognition memory impairment in Alzheimer’s disease!
Simon, Jessica ULg; Bastin, Christine ULg; SALMON, Eric ULg et al

in Journal of Neuropsychology (2016)

In Alzheimer’s disease (AD), it is now well established that recollection is impaired from the beginning of the disease, whereas findings are less clear concerning familiarity. One of the most important ... [more ▼]

In Alzheimer’s disease (AD), it is now well established that recollection is impaired from the beginning of the disease, whereas findings are less clear concerning familiarity. One of the most important mechanisms underlying familiarity is the sense of familiarity driven by processing fluency. In this study, we attempted to attenuate recognition memory deficits in AD by maximizing the salience of fluency cues in two conditions of a recognition memory task. In one condition, targets and foils have been created from the same pool of letters (Overlap condition). In a second condition, targets and foils have been derived from two separate pools of letters (No-Overlap condition), promoting the use of letter-driven visual and phonetic fluency. Targets and foils were low-frequency words. The memory tasks were performed by 15 patients with AD and 16 healthy controls. Both groups improved their memory performance in the No-Overlap condition compared to the Overlap condition. Patients with AD were able to use fluency cues during recognition memory as older adults did, but this did not allow to compensate for dysfunction of recognition memory processes. [less ▲]

Detailed reference viewed: 33 (9 ULg)
Peer Reviewed
See detailThe influence of COMT on the neural substrates of short-term memory in normal aging
Manard, Marine ULg; Salmon, Eric ULg; Collette, Fabienne ULg

Conference (2016, September 02)

Working memory dopaminergic modulation is generally expressed in healthy aging by an advantage for carriers of the Met allele at behavioral and brain activity levels. However, most tasks used did not ... [more ▼]

Working memory dopaminergic modulation is generally expressed in healthy aging by an advantage for carriers of the Met allele at behavioral and brain activity levels. However, most tasks used did not allow to easily disentangle the contribution of maintenance and manipulation processes. We explored the effect of COMT genotype on the maintenance process using a Sternberg memory task varying the amount of information presented, in young and older homozygous carriers for the Val and Met alleles of the COMT gene. Although no clear behavioral difference was observed between groups, patterns of cerebral activity indicate difficulties for Met older individuals to maintain stable representations. These results will be discussed in terms of dopaminergic contribution to stability/flexibility of cognitive processes during aging. [less ▲]

Detailed reference viewed: 65 (1 ULg)
Full Text
Peer Reviewed
See detailEffects of aging on task- and stimulus-related cerebral attention networks
Kurth, Sophie ULg; Majerus, Steve ULg; Bastin, Christine ULg et al

in Neurobiology of Aging (2016), 44

Interactions between a dorsal attention (DAN) and a ventral attention cerebral network (VAN) have been reported in young participants during attention or short term memory (STM) tasks. Since it remains an ... [more ▼]

Interactions between a dorsal attention (DAN) and a ventral attention cerebral network (VAN) have been reported in young participants during attention or short term memory (STM) tasks. Since it remains an under-investigated question, age effects on DAN and VAN activity and their functional balance were explored during performance of a STM task. Older and young groups showed similar behavioral patterns of results. At the cerebral level, DAN activation increased as a function of increasing STM load in both groups, suggesting preserved activity in DAN during healthy aging. Age-related over-recruitment in regions of the DAN in the higher task load raised the question of compensation attempt versus less efficient use of neural resources in older adults. Lesser decrease of VAN activation with increasing load and decreased stimulus-driven activation in the VAN, especially in the higher load, in older participants suggested age-related reduced response in the VAN. However, functional connectivity measures showed that VAN was still functionally connected to the DAN in older participants. [less ▲]

Detailed reference viewed: 59 (31 ULg)
Peer Reviewed
See detailThe influence of COMT on the neural substrates of short-term memory in normal aging
Collette, Fabienne ULg; Manard, Marine ULg; Salmon, Eric ULg

Conference (2016, July 21)

Working memory dopaminergic modulation is generally expressed in healthy aging by an advantage for carriers of the Met allele at behavioral and brain activity levels. However, most tasks used did not ... [more ▼]

Working memory dopaminergic modulation is generally expressed in healthy aging by an advantage for carriers of the Met allele at behavioral and brain activity levels. However, most tasks used did not allow to easily disentangle the contribution of maintenance and manipulation processes. We explored the effect of COMT genotype on the maintenance process using a Sternberg memory task varying the amount of information presented, in young and older homozygous carriers for the Val and Met alleles of the COMT gene. Although no clear behavioral difference was observed between groups, patterns of cerebral activity indicate difficulties for Met older individuals to maintain stable representations. These results will be discussed in terms of dopaminergic contribution to stability/flexibility of cognitive processes during aging. [less ▲]

Detailed reference viewed: 68 (2 ULg)