   Les effets cutanés indésirables des antagonistes du TNF alphaFAILLA, Valérie  ; SABATIELLO, Murielle ; LEBAS, Eglantine et alin Revue Médicale de Liège (2012) The TNF alpha antagonists, including adalimumab, etanercept and infliximab, represent a class of anti-inflammatory and immunosuppressive drugs. Although cutaneous adverse effects are uncomon, they are ... [more ▼] The TNF alpha antagonists, including adalimumab, etanercept and infliximab, represent a class of anti-inflammatory and immunosuppressive drugs. Although cutaneous adverse effects are uncomon, they are varied. There is no particular risk profile to develop cutaneous adverse effects. The principal acute side effects are injection site reactions and pruritus. The major long term cutaneous side effects are infectious and inflammatory conditions. Neoplastic skin diseases are exceptional. the association with other immunosuppressive agents can increase the risk of developing cutaneous adverse effects. Some adverse effects, such as lupus erythematosus, require immediate withdrawal of the biological treatment, while in other cases temporary withdrawal is sufficient. The majority of the other cutaneous adverse effects can be dealt without interrupting biologic treatment. Preclinical and clinical investigations revealed that the new biologics, aiming IL12/23, IL23 and IL17, present a similar profile of cutaneous adverse effects, although inflammatory skin reactions may be less often encountered compared to TNF alpha antagonists. [less ▲] Detailed reference viewed: 76 (16 ULg) Childhood Herpes Zoster-Triggered Guttate PsoriasisFAILLA, Valérie ; NIKKELS, Nazli ; SABATIELLO, Murielle et alin Open Dermatology Journal (The) (2012) Psoriasis is commonly triggered or exacerbated by various stress factors, certain drugs, or streptococcal throat infections. Viral infections such as HIV, CMV, chikungunya, or herpes simplex virus are ... [more ▼] Psoriasis is commonly triggered or exacerbated by various stress factors, certain drugs, or streptococcal throat infections. Viral infections such as HIV, CMV, chikungunya, or herpes simplex virus are very uncommon triggers for psoriasis. Cases of varicella-triggered psoriasis are exceptional. A 7-year-old boy with a previous history of guttate psoriasis presented with generalized acute guttate psoriasis shortly after an extensive herpes zoster infection affecting the first and second left lumbar dermatomes. INF-alpha and granulocyte monocyte colony stimulating factor influence peripheral monocytes to transform into INF-dendritic cells (DC's), similar to those involved in psoriasis. These INF-DC's express toll-like receptors 7 and 8, which are responsive to viral single stranded RNA. Hence, viral infections and interferon (INF)-alpha may play a role in triggering psoriasis. [less ▲] Detailed reference viewed: 26 (1 ULg)Pemetrexed-induced pityriasis lichenoides-like dermatitis.SABATIELLO, Murielle ; ; et alin Journal of the European Academy of Dermatology & Venereology (2012), 26(1), 127-9 Detailed reference viewed: 13 (2 ULg)L'iatrogénie cytostatique simulatrice. Apparence d'un pityriasis lichénoïde aigu induit par le pemetrexed.SABATIELLO, Murielle ; ; et alin Dermatologie Actualité (2011), 125 Detailed reference viewed: 16 (0 ULg)Le botryomycome.Wauters, Odile ; Sabatiello, Murielle ; Nikkels, Nazli et alin Annales de Dermatologie et de Vénéréologie (2010), 137(3), 238-42237243 Detailed reference viewed: 91 (18 ULg)Virale orale infectiesLebas, Eglantine ; Wauters, Odile ; Sabatiello, Murielle et alin Nederlands tijdschrift voor dermatologie en venereologie (2009), 19(9), 500-503 Detailed reference viewed: 46 (4 ULg)Effets indésirables cutanés des antagonistes du TNFaNikkels, Arjen ; ; Sabatiello, Murielle in Skin (2009), 12(6), 165-170 Detailed reference viewed: 19 (5 ULg) |
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