References of "SEGHAYE, Marie-Christine"
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See detailExercise-triggered chest pain as an isolated symptom of myocarditis in children
Tshimanga, Prisca; Daron, Benoît; FARHAT, Nesrine ULg et al

in Clinics and Practice (2016), 6:843

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See detailGenetics 2 Multiple fractures, genetics to the rescue!
HENNUY, Nadège ULg; NYAMUGABO MUNYERE NKANA, Kindja ULg; FLORKIN, Benoît ULg et al

in Belgian Journal of Paediatrics (2016, March), 18(1), 63

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See detailVaricella paediatric hospitalisations in Belgium: a 1-year national survey.
Blumental, Sophie; Sabbe, Martine; Lepage, Philippe et al

in Archives of disease in childhood (2016), 101(1), 16-22

BACKGROUND: Varicella universal vaccination (UV) has been implemented in many countries for several years. Nevertheless, varicella UV remains debated in Europe and few data are available on the real ... [more ▼]

BACKGROUND: Varicella universal vaccination (UV) has been implemented in many countries for several years. Nevertheless, varicella UV remains debated in Europe and few data are available on the real burden of infection. We assessed the burden of varicella in Belgium through analysis of hospitalised cases during a 1-year period. METHODS: Data on children admitted to hospital with varicella were collected through a national network from November 2011 to October 2012. Inclusion criteria were either acute varicella or related complications up to 3 weeks after the rash. RESULTS: Participation of 101 hospitals was obtained, covering 97.7% of the total paediatric beds in Belgium. 552 children were included with a median age of 2.1 years. Incidence of paediatric varicella hospitalisations reached 29.5/10(5) person-years, with the highest impact among those 0-4 years old (global incidence and odds of hospitalisation: 79/10(5) person-years and 1.6/100 varicella cases, respectively). Only 14% (79/552) of the cohort had an underlying chronic condition. 65% (357/552) of children had >/=1 complication justifying their admission, 49% were bacterial superinfections and 10% neurological disorders. Only a quarter of children (141/552) received acyclovir. Incidence of complicated hospitalised cases was 19/10(5) person-years. Paediatric intensive care unit admission and surgery were required in 4% and 3% of hospitalised cases, respectively. Mortality among Belgian paediatric population was 0.5/10(6) and fatality ratio 0.2% among our cohort. CONCLUSIONS: Varicella demonstrated a substantial burden of disease in Belgian children, especially among the youngest. Our thorough nationwide study, run in a country without varicella UV, offers data to support varicella UV in Belgium. [less ▲]

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See detailRole of inflammatory- and growth factors in the pathophysiology of gestational diabetes-related complications in neonates
Guffins, Amandine; FARHAT, Nesrine ULg; GKIOUGKI, Evangelia ULg et al

in Belgian Journal of Paediatrics (2016), 18(1), 82

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See detailQuand une anomalie encerclante des arcs aortiques se cache derrière des symptômes respiratoires et digestifs de l'enfant
SOLOWIANIUK, Marie ULg; SOULATGES, C.; FARHAT, Nesrine ULg et al

in Revue Médicale de Liège (2016), 71(11), 502-508

Aortic arch anomalies are relatively frequent and account for 15 to 20 % of all congenital cardiovascular malformations. They can be discovered in case of symptoms of airway- or esophageal compression ... [more ▼]

Aortic arch anomalies are relatively frequent and account for 15 to 20 % of all congenital cardiovascular malformations. They can be discovered in case of symptoms of airway- or esophageal compression such as dysphagia, chronic cough, stridor, wheezing and recurrent respiratory infections. We report the cases of two children with encircling aortic arch anomaly. The 3-year-old boy had complained of chronic respiratory symptoms such as laryngitis and asthma since the age of 4 months. The 20-month-old boy presented with intermittent stridor, dysphagia and frequent vomiting. In both patients, the cervico-thoracic CT-scan showed a right aortic arch with retro-esophageal left subclavian artery and Kommerell’s diverticulum. Surgery was curative. The understanding of normal and abnormal embryologic development of the aortic arch, and the knowledge of the different types of vascular compression and their clinical signs are mandatory for the early diagnosis and adequate treatment of such malformations. [less ▲]

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See detailPrenatal diagnosis of a terminal chromosome 1 (q42-q44) deletion : original case report and review of the literature
VAN LINTHOUT, Christine ULg; EMONARD, Violaine ULg; GATOT, Jean-Stéphane ULg et al

in Facts, Views and Vision in Obgyn (2016), 8(2), 101-103

Terminal chromosome 1q deletion is rarely reported but causes typical malformations that have been well described in childhood. Clinical features include facial dysmorphy, growth and/or psychomotor ... [more ▼]

Terminal chromosome 1q deletion is rarely reported but causes typical malformations that have been well described in childhood. Clinical features include facial dysmorphy, growth and/or psychomotor retardation, brain agenesis or hypoplasia of the corpus callosum, epilepsy and occasional urogenital or cardiac malformations. The diagnosis of this condition is usually made at birth. The rare cases of antenatal diagnosis were based on microcephaly and growth retardation. In the present case, the foetus presented with an hypoplasia of the corpus callosum, a dysmorphic profile and a single umbilical artery. The foetal echocardiography suggested a noncompaction of the left ventricular myocardium. No microcephaly or growth retardation were noted. We compare our antenatal findings to those described in the literature with the aim to better define the antenatal phenotype of the terminal chromosome 1 deletion syndrome. [less ▲]

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See detailLe syndrome de Marfan chez l'enfant et l'adolescent : cas clinique
Magotteaux, S.; BULK, Saskia ULg; FARHAT, Nesrine ULg et al

in Revue Médicale de Liège (2016), 71(7-8), 342-348

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See detailLa simulation haute-fidélité: un nouvel outil de formation et de recherche en pédiatrie
Bragard, Isabelle ULg; FARHAT, Nesrine ULg; Seghaye, Marie-Christine ULg et al

in Revue Médicale de Liège (2016), 71(10), 455-460

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See detailEvaluation of the effectiveness of simulation of cardiac arrhythmias in children
Bragard, Isabelle ULg; Seghaye, Marie-Christine ULg; Baugnon, Thomas et al

Poster (2015, May)

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See detailGene expression of cytokines, growth factors and apoptosis regulators in a neonatal model of pulmonary stenosis.
Liersch, Peter N.; Schwarz, Andreas; Sachweh, Joerg et al

in Future cardiology (2015), 11(3), 297-307

ABSTRACT Background: Right ventricular remodeling due to pulmonary stenosis increases morbidity in children. Its pathophysiology needs to be clarified. METHODS: Six newborn lambs underwent pulmonary ... [more ▼]

ABSTRACT Background: Right ventricular remodeling due to pulmonary stenosis increases morbidity in children. Its pathophysiology needs to be clarified. METHODS: Six newborn lambs underwent pulmonary arterial banding, seven sham operation. mRNA encoding for cytokines, growth factors and regulators of apoptosis was sequentially measured in myocardium and blood before and up to 12 weeks postoperatively. RESULTS: Experimental animals showed hypertrophy and fibrosis of the right ventricular myocardium, myocardial over-expression of CT-1-mRNA and higher blood concentrations of mRNA encoding for VEGF, TGF-beta, Bak and BcL-xL than controls, respectively. CONCLUSION: Neonatal pulmonary stenosis leads to myocardial hypertrophy that is associated with CT-1 gene expression and with activation of growth- and apoptosis pathways in blood cells. [less ▲]

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See detailParaspinal arterio-venous fistula in children: two more cases of an exceptional malformation
FARHAT, Nesrine ULg; DESPRECHINS, Brigitte ULg; OTTO, Bernard ULg et al

in Clinics and Practice (2015), 5(2), 707-709

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See detailDeficiency of Interleukin-1 Receptor-associated Kinase 4 Presenting as Fatal Pseudomonas aeruginosa Bacteremia in Two Siblings.
STERGIOPOULOU, Theodouli ULg; Walsh, Thomas J.; SEGHAYE, Marie-Christine ULg et al

in The Pediatric infectious disease journal (2015), 34(3), 299-300

Interleukin-1 receptor-associated kinase 4 (IRAK-4) deficiency is a primary immunodeficiency of innate immunity. This is the case of a previous healthy toddler and his sibling, who both died of fulminant ... [more ▼]

Interleukin-1 receptor-associated kinase 4 (IRAK-4) deficiency is a primary immunodeficiency of innate immunity. This is the case of a previous healthy toddler and his sibling, who both died of fulminant sepsis due to Pseudomonas aeruginosa. Subsequent genetic analysis demonstrated IRAK-4 deficiency with compound heterozygous splice mutations. Fulminant fatal Pseudomonas aeruginosa sepsis may be the first manifestation of IRAK-4 deficiency. [less ▲]

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See detailComment je traite ... une mucoviscidose
BENDAVID, G.; VANDERHELST, E.; LOUIS, Renaud ULg et al

in Revue Médicale de Liège (2015), 70(3), 108-114

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See detailEvaluation de l’efficacité de la simulation haute fidélité dans la prise en charge des troubles du rythme cardiaque chez l’enfant: étude pilote
SCHUMACHER, Katharina ULg; Seghaye, Marie-Christine ULg; Baugnon, Thomas et al

in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2015, March), 17(1),

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