References of "SCHOLTES, Félix"
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See detailOsteopontin predicts radiotherapy response of glioblastoma patients : new role in DNA damage repair
Henry, Aurélie ULg; Nokin, Marie-Julie; Leroi, Natacha ULg et al

Conference (2016, March 22)

- Introduction: Glioblastoma (GBM) is the most aggressive and common solid human brain tumor. Because of GBM heterogeneity, location and aggressiveness, none of the available treatment is curative. These ... [more ▼]

- Introduction: Glioblastoma (GBM) is the most aggressive and common solid human brain tumor. Because of GBM heterogeneity, location and aggressiveness, none of the available treatment is curative. These treatments include maximal surgical resection, radiotherapy and concomitant or adjuvant chemotherapy with Temozolomide. However, the prognosis of adult patients with GBM remains poor and the survival outcome after treatment does not exceed 15 months. GBM-composing cells have developed many strategies to counteract these current therapies. Among the wide hallmarks acquired to survive, high osteopontin (OPN) expression correlates with lower overall and disease-free/relapse-free survival in all tumors combined, as well in brain cancer. Our recent study (Lamour V and Henry A, IJC 2015) has demonstrated the role of OPN in the tumorigenicity of glioblastoma cells and its importance in the maintenance of the stem characters. In the continuation of this work, our recent studies focused on the potential role of OPN in the resistance of GBM cells to radiotherapy and its potential implication in the initiation of Double Strand Breaks (DSBs) repair mechanisms. - Aims: In the context of this study, different GBM cell lines (U251-MG, U87-MG and U87 Viii) were used to assess the role of OPN in the initiation of the DSBs repair mechanism after an exposure to gamma-irradiation. - Methods and results: We performed the transient transfection of different GBM cell lines (U251-MG, U87-MG and U87-MG overexpressing EGFR VIII) with siRNAs specifically directed against OPN. After irradiation, all these OPN-depleted cells consistently showed a lower induction of γ–H2AX compared to control (irrelevant siRNA) as evidenced by western blot and immunofluorescence techniques. Thereafter, clonogenic assays allowed to prove that the survival of OPN-depleted cells was affected after an exposure to irradiation. To assess the importance of OPN expression in the response to radiotherapy, an heterotopic xenograft model was used. In brief, IPTG-inducible U87 shOPN clones were injected subcutaneously in NOD-SCID mice and were allowed to form a tumor. When average tumor volume reached a predetermined size range, mice were treated (or not) with IPTG by intraperitoneal injection during five days. At the end of the treatment, tumors were selectively exposed to gamma-irradiation by using a small animal irradiator X-RAD 225Cx (Precision X-Ray Inc., North Branford, CT). One week later, mice were sacrificed and tumors were measured. In this pilot study, we observed that mice in which the tumor was depleted in OPN displayed a slight regression in the tumor growth compared to mice that received radiotherapy alone (no IPTG), where the tumor volume remained constant. - Conclusions: Taken together, these preliminary data meet the fact that OPN is important in the response of GBM to radiotherapy. The in vitro results converge to the fact that OPN might be implicated in the initiation of the DSBs repair following irradiation. Currently, we would like to investigate this hypothesis in vivo but also to check the effect of OPN depletion combined to radiotherapy on the survival of mice in an orthotopic xenograft model. [less ▲]

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See detailClinical and molecular classification of glioblastoma patients
Lambert, Jérémy ULg; Kaoma, Tony; Van Dyck, Eric et al

Poster (2016, March 19)

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See detailClinical and molecular classification of glioblastoma patients
Lambert, Jérémy ULg; Gorlia, Thierry; Van Dyck, Eric et al

Scientific conference (2015, December 03)

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See detailAge and WHO Performance Score are major clinical prognostic factors in glioblastoma
Lambert, Jérémy ULg; Scholtes, Félix ULg; MARTIN, Didier ULg

Conference (2015, March 21)

In glioblastoma patients with similar prognostic factors—like age, performance status and extent of surgical resection—clinical evolution is still variable. In addition, the benefit of resection of ... [more ▼]

In glioblastoma patients with similar prognostic factors—like age, performance status and extent of surgical resection—clinical evolution is still variable. In addition, the benefit of resection of recurrent tumours is uncertain. In this study, prognostic subgroups are established on a clinical basis and the benefit of surgery for recurrence is compared between them. Recursive partitioning analysis on EORTC sample 26981 (n=239) identified clinical factors influencing Progression-Free Survival (PFS), in order to create prognostic subgroups, whose PFS and survival after recurrence were compared using Kaplan-Meier curves and log-rank tests. Results were validated on a sample from Liège University Hospital (n=92). WHO Performance Status (WHO-PS) and age at first intervention (“age”) defined 4 subgroups. PFS was shorter in WHO-PS 2–3 than WHO PS 0–1 patients. In both groups, age was the second classifying factor (cut-off: 47.5y for WHO-PS 0–1, 60.5y for WHO-PS 2–3). The 4 subgroups had significantly different median PFS (77.5, 144, 234.5 and 346.5 days) and median overall survival (126, 330, 476 and 675 days). Survival after recurrence was correlated with PFS, and recurrence resection was associated with longer survival, regardless of the prognostic subgroup. Clinical prognostic glioblastoma subgroups with distinct PFS exist and can be defined by WHO-PS and age. This classification can be used as a clinical basis to identify molecular patterns associated with prognosis. In addition, in all subgroups, this retrospective analysis suggests a benefit of surgical resection when feasible. [less ▲]

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See detailIdentification de sous-groupes de glioblastome sur base de critères cliniques
Lambert, Jérémy ULg; Scholtes, Félix ULg; MARTIN, Didier ULg

Poster (2014, December)

Glioblastoma has terrible outcomes, but the disease evolution varies a lot between patients. We used a sample of 239 patients (EORTC 26981) and a validation sample of 93 patients (CHU Liège) to class ... [more ▼]

Glioblastoma has terrible outcomes, but the disease evolution varies a lot between patients. We used a sample of 239 patients (EORTC 26981) and a validation sample of 93 patients (CHU Liège) to class patients in groups with the same risk of recurrence. 4 distinct subgroups were created using recursive partitioning analysis. In the future, genetic profile will be compared between these groups to find markers of aggressiveness. Moreover, survival after recurrence is closely related to subgroups, and a surgical resection of the recurrence shows positive effect in each subgroup. [less ▲]

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See detailFacteurs de mauvais pronostic d’une lomboradiculalgie opérée par (micro) discectomie
Demoulin, Christophe ULg; Bavi, F.; DEFAWEUX, Michel ULg et al

in Revue du Rhumatisme (2014, December), 81S

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See detailGlioma metastatis : a case series and review
REUTER, Gilles ULg; LOMBARD, Arnaud ULg; SCHOLTES, Félix ULg et al

Poster (2014, March 29)

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See detailNotre cerveau reptilien
Scholtes, Félix ULg; Martin, Didier ULg

Scientific conference (2014, March 12)

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See detailLe traitement multidisciplinaire du glioblastome
BARTHELEMY, Nicole ULg; GENNIGENS, Christine ULg; Scholtes, Félix ULg et al

in Revue Médicale de Liège (2014), 69

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See detailIntraoperative MRI versus standard neuron- avigation for the neurosurgical treatment of glioblastoma: a randomized controlled trial.
Kubben, PL; Scholtes, Félix ULg; Schijns, OEMG et al

in Surgical Neurology (2014), 5

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See detailHead Trauma and Distal Anterior Cerebral Artery Aneurysm: Potential Role of an Adhesion to the Falx
Scholtes, Félix ULg; HENROTEAUX, Adrienne ULg; OTTO, Bernard ULg et al

in Journal of Neurological Surgery. Part A, Central European Neurosurgery (2014), [Epub ahead of print]

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See detailGlioblastoma metastases:case report and literature review
REUTER, Gilles ULg; Lombard, Arnaud ULg; SCHOLTES, Félix ULg et al

Poster (2013, March 30)

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See detailMalformations vasculaires du système nerveux central : que faire quand on en trouve ?
SCHOLTES, Félix ULg; MARTIN, Didier ULg

Scientific conference (2013, January 16)

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See detailLa hernie discale lombaire paralysante : une urgence chirurgicale ? Réflexion à propos d'une série de 24 patients et des données de la littérature.
DUBUISSON, Annie ULg; Borlon, S.; SCHOLTES, Félix ULg et al

in Neuro-Chirurgie (2013), 59(2), 64-8

BACKGROUND AND PURPOSE: Paralysing lumbar disc herniation (LDH): what and when to do? Few studies have analyzed the optimal timing of surgery in case of paralysing LDH. METHODS: Twenty-four charts were ... [more ▼]

BACKGROUND AND PURPOSE: Paralysing lumbar disc herniation (LDH): what and when to do? Few studies have analyzed the optimal timing of surgery in case of paralysing LDH. METHODS: Twenty-four charts were retrospectively reviewed of patients suffering of LDH with severe motor deficit. RESULTS: There were 16 men and eight women. Mean age was 45.1 years. Seventeen patients suffered of lumbar pain, 15 of radicular pain and all of a severe motor deficit, implying mostly the ankle flexion (17 patients). LDH was most frequently located at L4/L5 or L5/S1 level. Surgery was proposed to all patients at the end of the consultation. Nine patients were operated within 48 hours. The mean interval between onset of motor deficit and operation was 20 days. The statistical analysis did not reveal any significant difference among different prognostic factors between the 17 patients with good motor recovery and the seven patients with poor motor recovery. In particular the operative delay did not appear to influence the degree of motor recovery. Literature review on paralysing LDH provides five published series since 1996, including 28 to 116 patients. Two series, including the single prospective one, conclude that the degree of recovery of motor function is inversely related to the degree and duration of motor deficit. CONCLUSIONS: Our retrospective series of 24 operated paralysing LDH did not reveal any prognostic factor for motor recovery. There is no evidence based medicine data in the literature about the optimal timing of decompressive surgery. A relative consensus exists among spine surgeons for paralysing LDH: since operative indication is obvious, surgery should be done as soon as possible. [less ▲]

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See detailSolitary fibrous tumour of the vagus nerve
SCHOLTES, Félix ULg; SCHOLSEM, Martin; Martin, Didier ULg

Conference (2012, March 10)

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See detailThird ventricle colloid cysts
REUTER, Gilles ULg; SCHOLTES, Félix ULg; LENELLE, Jacques ULg et al

Conference (2012, March 10)

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See detailPost-traumatic thoracic outlet syndrome
DUBUISSON, Annie ULg; lamotte, Catherine; FOIDART, Marguerite ULg et al

in Acta Neurochirurgica (2012)

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See detailMultifocal choroid plexus papilloma: a case report.
Scholsem, Martin; Scholtes, Félix ULg; Robe, Pierre ULg et al

in Clinical neuropathology (2012), 31(6), 430-4

BACKGROUND: Multiple choroid plexus papillomas (CPPs) are rare. Usually, they correspond to villous hypertrophy or metastasis occurring during cerebrospinal dissemination. Multiple CPPs have rarely been ... [more ▼]

BACKGROUND: Multiple choroid plexus papillomas (CPPs) are rare. Usually, they correspond to villous hypertrophy or metastasis occurring during cerebrospinal dissemination. Multiple CPPs have rarely been reported as synchronous tumors. CASE REPORT: Three synchronous CPPs were resected in a 59-year-old female 6 years after their first imaging description. Pathology showed mucus-producing CPP in all 3, 1 of the 3 presenting some signs of atypia. No p53 or hSNF5/INI1 mutation, or signs of polyoma viruses infection were found. CONCLUSION: Although no clear cause for the multifocality was found, the simultaneous presence of the three tumors and their benign histology suggest that they were synchronous and not metastatic. The issue of differentiating synchronous CPPs from metastatic CPP is discussed. [less ▲]

Detailed reference viewed: 41 (5 ULg)