References of "SCHOENEN, Jean"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailSphenopalatine ganglion stimulation in neurovascular headaches
SCHOENEN, Jean ULg

in Progress in Neurological Surgery (2015), 29

Abstract The interest for the sphenopalatine ganglion (SPG) in neurovascular headaches dates back to 1908 when Sluder presented his work on the role of the sphenopalatine ganglion in «nasal headaches» ... [more ▼]

Abstract The interest for the sphenopalatine ganglion (SPG) in neurovascular headaches dates back to 1908 when Sluder presented his work on the role of the sphenopalatine ganglion in «nasal headaches» that are now part of the trigeminal autonomic cephalalgias and cluster headache (ICHD-III beta). Since then various interventions with blocking or lesional properties have targeted the SPG (transnasal injection of lidocaine and other agents, alcohol or steroid injections, radiofrequency lesions or even ganglionectomy); sucess rates varied, but benefit was usually transient. Here we briefly review some anatomo-physiological characteristics of the SPG and hypotheses about its pathophysiological role in neurovascular headaches before describing recent therapeutic results obtained with electrical stimulation of the SPG. Based on results of a prospective randomized controlled study, SPG stimulation appears to be an effective treatment option for patients with chronic cluster headaches; efficacy data indicate that acute electrical stimulation of the SPG provided significant attack pain relief and in many cases pain freedom compared to sham stimulation. Moreover, in some patients SPG stimulation was associated with a significant and clinically meaningful reduction in cluster headache attack frequency; this preventive effect of SPG stimulation warrants further investigation. For migraine attacks, the outcome of the proof-of-concept study using a temporary electrode implanted in the pterygopalatine fossa was less encouraging – but an ongoing multi-center trial evaluates the efficacy of long-term SPG stimulation against sham stimulation for acute and preventive treatment in patients with frequent migraine. [less ▲]

Detailed reference viewed: 54 (2 ULg)
Peer Reviewed
See detailCerebral FDG uptake changes with supraorbital transcutaneous electrical stimulation for episodic migraine prevention
D'Ostilio, Kevin ULg; Thibaut, Aurore ULg; Laureys, Steven ULg et al

Conference (2015, May)

Background: A recent multicentre RCT has shown that supraorbital transcutaneous stimulation (STS) targeting branches of the ophtalmic nerve with the Cefaly® device is effective as a preventive therapy for ... [more ▼]

Background: A recent multicentre RCT has shown that supraorbital transcutaneous stimulation (STS) targeting branches of the ophtalmic nerve with the Cefaly® device is effective as a preventive therapy for migraine (Schoenen et al., Neurology 2013). However, the mechanisms of action in the central nervous system remain unknown. Here, we conducted voxel-based analyses of [18]FDG-PET to evaluate metabolic changes immediately after the first STS session and after 3 months of treatment in patients with migraine. Methods: Twenty-eight subjects participated in the experiment: 14 patients with episodic migraine (ICHD3 beta criteria) and 14 age-matched controls. Healthy volunteers underwent only one [18]FDG-PET scan whereas patients were scanned at baseline, directly after a first session of STS and after 3 months of daily treatment. Results: Compliant patients showed a significant decrease in the number of attacks (p = 0.03). When compared to controls, patients (n = 14) at baseline were hypometabolic in the fronto-temporal regions (p < 0.001), especially in the orbitofrontal (OFC) and perigenual anterior cingulate cortex. OFC hypometabolism was not correlated with medication intake. In compliant patients, daily STS for 3 months was followed by a normalization of the fronto-temporal hypometabolism (p< 0.001; OFC: pFWE<0.01). Conclusion: Our study suggests that the OFC is hypoactive in episodic migraine. STS with the Cefaly° device is able to normalize this hypoactivity. This indicates that STS exerts its beneficial effect via slow neuromodulatory mechanisms, as also previously shown for percutaneous occipital nerve stimulation in refractory cluster headache (Magis et al., BMC Neurology 2011). [less ▲]

Detailed reference viewed: 85 (1 ULg)
Full Text
Peer Reviewed
See detailOne-year Prevalence of Migraine Using a Validated Extended French Version of the ID MigraineTM: a Belgian Population-Based Study
Schoenen, Jean ULg; Streel, Sylvie ULg; Donneau, Anne-Françoise ULg et al

in Cephalalgia : An International Journal of Headache (2015, May), 35(6), 155-156

Detailed reference viewed: 21 (4 ULg)
Full Text
Peer Reviewed
See detailTargeting pericranial nerve branches to treat migraine: Current approaches and perspectives.
Ambrosini, Armin; D'Alessio, Costantino; MAGIS, Delphine ULg et al

in Cephalalgia : An International Journal of Headache (2015)

Detailed reference viewed: 23 (5 ULg)
Full Text
Peer Reviewed
See detailDiagnosis, pathophysiology and management of chronic migraine: a proposal of the Belgian Headache Society.
Paemeleire, K; Louis, P; MAGIS, Delphine ULg et al

in Acta Neurologica Belgica (2015), 35(5), 437-442

This is a review of the pathophysiology of chronic migraine and of available therapies with a proposal for an algorithm of management.

Detailed reference viewed: 30 (0 ULg)
Full Text
Peer Reviewed
See detailHeadache during cryoballoon ablation for atrial Fibrillation
Pison, L; Peeters, P; Blaauw, Y et al

in Europace (2015), 17(6), 898-901

Objective Headache has been reported to occur during cryoballoon ablation for atrial fibrillation (AF). No study has systematically analyzed this phenomenon. Methods Twenty consecutive patients with ... [more ▼]

Objective Headache has been reported to occur during cryoballoon ablation for atrial fibrillation (AF). No study has systematically analyzed this phenomenon. Methods Twenty consecutive patients with symptomatic AF, underwent cryoballoon ablation without sedation. Headache was evaluated before, during and after the first cryoapplication in every pulmonary vein (PV) using a visual representation of a head for location of the headache, a numerical rating scale (NRS) for measuring pain intensity and the short-form McGill pain questionnaire (MPQ) for qualitative analysis of pain. The order in which the PVs were ablated, was randomized. Results Sixteen (80%) patients perceived mainly frontal headache during cryoablation. The overall NRS scores were significantly higher during (5.1±1.7), compared to before (2.7±1.4), and after (3.5±2.2) a cryoapplication (p<0.05). The NRS score was significantly higher during ablation of the first PV. The intensity of the perceived headache was not related to the temperature reached 150 s after initiation of a cryoapplication (p = 0,81). Of the MPQ, 3 sensory adjectives and 1 affective adjective averaged between score 1 and 2, representing mild to moderate severity of pain. Conclusions The majority of patients treated by balloon cryoablation, experienced headache during a cryoapplication. There was no correlation between the temperature reached during a cryoballoon freeze and the intensity of the headache. Cryoballoon ablation of the first PV, was significantly more painfull than the remaining PV [less ▲]

Detailed reference viewed: 15 (3 ULg)
Full Text
Peer Reviewed
See detailValidation of an extended French version of ID MigraineTM as a migraine-screening tool
Streel, Sylvie ULg; Donneau, Anne-Françoise ULg; Dardenne, Nadia ULg et al

in Cephalalgia : An International Journal of Headache (2015), 35(5), 437-442

Introduction: Migraine has a considerable social, economic, physical and emotional burden but remains underdiagnosed and undertreated. A specific migraine screening tool could help remove barriers to ... [more ▼]

Introduction: Migraine has a considerable social, economic, physical and emotional burden but remains underdiagnosed and undertreated. A specific migraine screening tool could help remove barriers to health care and be an attractive instrument for epidemiological studies. The objective of this work was to assess the validity of an extended French version of ID MigraineTM as a migraine-screening tool. Methods: Sixty-seven subjects from the NESCaV study (2010–2012) completed the migraine screen and were diagnosed by a neurologist specializing in headache medicine using the International Classification of Headache Disorders, 2nd edition criteria (gold standard). Agreement between the two diagnoses was evaluated by Cohen kappa coefficient (k). Sensitivity, specificity and predictive values of the migraine screen were calculated. Results: Migraine was diagnosed in 21 (31.3%) of the 67 subjects according to the screening tool and in 24 (35.8%) by the neurologist (k¼0.90). The prevalence of migraine was unrelated to age, gender, education and perception of financial resources. Sensitivity and specificity of the screen were 87.5% and 100%, respectively. The screen prevalence of migraine with aura was 10.4% (sensitivity and specificity: 83.3% and 96.7%, respectively). Conclusion: The extended French version of ID MigraineTM (ef-ID Migraine) is a validated tool to screen migraine in French-speaking countries. [less ▲]

Detailed reference viewed: 53 (26 ULg)
Full Text
Peer Reviewed
See detailCortical spreading depression decreases Fos expression in rat periaqueductal gray matter.
Borysovich Bogdanov, Volodymir; LOMBARD, Arnaud ULg; Multon, Sylvie ULg et al

in Neuroscience Letters (2015)

Detailed reference viewed: 28 (14 ULg)
Full Text
Peer Reviewed
See detailAnalysis and clinical correlates of 20 Hz photic driving on routine EEG in migraine.
Fogang, Y; Gérard, P; De Pasqua, V et al

in Acta Neurologica Belgica (2015), 115(1), 1-17

Detailed reference viewed: 24 (2 ULg)
Full Text
Peer Reviewed
See detailPrevalence of right-to-left shunts on transcranial Doppler in chronic migraine and medication-overuse headache.
Guo, Song; SCHOENEN, Jean ULg

in Cephalalgia : An International Journal of Headache (2014), 34(1), 37-41

The prevalence of right-to-left shunts on transcranial Doppler is not increased in chronic migraine.

Detailed reference viewed: 32 (6 ULg)
Full Text
Peer Reviewed
See detailAltered processing of sensory stimuli in patients with migraine.
de Tommaso, Maxime; Ambrosini, A; Brighina, F et al

in Nature Reviews. Neurology (2014), 10(3), 144-155

This a review of neurophysiological studies in migraine showing that the disorder is characterized by a cycling change in cortical responsivity and thalamocortical dysrhythlmia.

Detailed reference viewed: 22 (4 ULg)
Full Text
Peer Reviewed
See detailMigraine and serotonin: The quest for the Holy Grail goes on.
SCHOENEN, Jean ULg

in Cephalalgia : An International Journal of Headache (2014), 34(3), 163-164

Detailed reference viewed: 14 (1 ULg)
Full Text
Peer Reviewed
See detailSphenopalatine ganglion neuromodulation in migraine: What is the rationale?
SCHOENEN, Jean ULg; Khan, S; Ashina, M

in Cephalalgia : An International Journal of Headache (2014), 34(5), 382-391

This article examines the pathophysiological facets of migraine that would made the disorder amenable by sphenopalatine ganglion neurostimulation.

Detailed reference viewed: 58 (2 ULg)
Full Text
Peer Reviewed
See detailDiagnosis, pathophysiology and management of chronic migraine: a proposal of the Belgian Headache Society.
Paemeleire, Koen; Louis, Paul; MAGIS, Delphine ULg et al

in Acta neurologica Belgica (2014)

Chronic migraine (CM) is a disabling neurological condition affecting 0.5-2 % of the population. In the current third edition of the International Classification of Headache Disorders, medication overuse ... [more ▼]

Chronic migraine (CM) is a disabling neurological condition affecting 0.5-2 % of the population. In the current third edition of the International Classification of Headache Disorders, medication overuse is no longer an exclusion criterion and CM is diagnosed in patients suffering from at least 15 headache days per month of which at least eight are related to migraine. CM is difficult to treat, and preventive treatment options are limited. We provide a pathogenetic model for CM, integrating the latest findings from neurophysiological and neuroimaging studies. On behalf of the Belgian Headache Society, we present a management algorithm for CM based on the international literature and adapted to the Belgian situation. Pharmacological treatment options are discussed, and recent data on transcranial and invasive neuromodulation studies in CM are reviewed. An integrated multimodal treatment programme may be beneficial to refractory patients, but at present, this approach is only supported by a limited number of observational studies and quite variable between centres. [less ▲]

Detailed reference viewed: 32 (1 ULg)
Full Text
Peer Reviewed
See detailEffects of visual cortex activation on the nociceptive blink reflex in healthy subjects.
Sava, Simona L.; de Pasqua, Victor; MAGIS, Delphine ULg et al

in PloS one (2014), 9(6), 100198

Bright light can cause excessive visual discomfort, referred to as photophobia. The precise mechanisms linking luminance to the trigeminal nociceptive system supposed to mediate this discomfort are not ... [more ▼]

Bright light can cause excessive visual discomfort, referred to as photophobia. The precise mechanisms linking luminance to the trigeminal nociceptive system supposed to mediate this discomfort are not known. To address this issue in healthy human subjects we modulated differentially visual cortex activity by repetitive transcranial magnetic stimulation (rTMS) or flash light stimulation, and studied the effect on supraorbital pain thresholds and the nociceptive-specific blink reflex (nBR). Low frequency rTMS that inhibits the underlying cortex, significantly decreased pain thresholds, increased the 1st nBR block ipsi- and contralaterally and potentiated habituation contralaterally. After high frequency or sham rTMS over the visual cortex, and rMS over the right greater occipital nerve we found no significant change. By contrast, excitatory flash light stimulation increased pain thresholds, decreased the 1st nBR block of ipsi- and contralaterally and increased habituation contralaterally. Our data demonstrate in healthy subjects a functional relation between the visual cortex and the trigeminal nociceptive system, as assessed by the nociceptive blink reflex. The results argue in favour of a top-down inhibitory pathway from the visual areas to trigemino-cervical nociceptors. We postulate that in normal conditions this visuo-trigeminal inhibitory pathway may avoid disturbance of vision by too frequent blinking and that hypoactivity of the visual cortex for pathological reasons may promote headache and photophobia. [less ▲]

Detailed reference viewed: 31 (1 ULg)
Full Text
Peer Reviewed
See detailAnalysis and clinical correlates of 20 Hz photic driving on routine EEG in migraine.
Fogang, Y.; Gérard, Paul ULg; De Pasqua, V. et al

in Acta neurologica Belgica (2014)

Enhanced photic driving (PD) during high-frequency flicker stimulation, the so-called H response, is a classical feature of migraine patients between attacks, but is thought to be of poor clinical utility ... [more ▼]

Enhanced photic driving (PD) during high-frequency flicker stimulation, the so-called H response, is a classical feature of migraine patients between attacks, but is thought to be of poor clinical utility. Visual inspection of the EEG for its detection may not be reliable, however, data on its possible correlations with clinical features and migraine pathophysiology are scarce. We have compared visual inspection and EEG spectral analysis to detect abnormal PD in 280 consecutive migraine patients of our headache clinic (episodic migraine without aura, n = 171; chronic migraine, n = 48; migraine with aura, n = 61) and in a group of 24 non-migrainous neurological controls. Spectral frequency analyses were performed blindly by one of us (YF). On visual inspection, 50.4 % of migraineurs were thought to have increased 20 Hz PD. After spectral analysis, only 62.4 % of them had PD power superior to the mean + 95 % CI of the control group. Sensitivity of visually identified PD was 82.24 %, specificity 69.36 %. Increased PD on spectral analysis was more prevalent in episodic migraine than in chronic migraine, in patients with low attack frequency, in those with ictal autonomic symptoms in addition to nausea and in those with a strong family history of migraine. We confirm therefore that 20 Hz photic driving is of little diagnostic utility and its prevalence in migraine overestimated on visual inspection. Its presence on spectral analysis of the EEG, however, might be of pathophysiological interest, as it identifies subgroups of migraineurs of whom the common denominator could be lack of habituation of cortical responses during repetitive stimulation. [less ▲]

Detailed reference viewed: 13 (0 ULg)
Full Text
Peer Reviewed
See detailInfluence of ovarian hormones on cortical spreading depression and its suppression by L-kynurenine in rat.
Chauvel, Virginie ULg; Schoenen, Jean ULg; Multon, Sylvie ULg

in PLoS ONE (2013), 8(12), 82279

Migraine is sexually dimorphic and associated in 20-30% of patients with an aura most likely caused by cortical spreading depression (CSD). We have previously shown that systemic L-kynurenine (L-KYN), the ... [more ▼]

Migraine is sexually dimorphic and associated in 20-30% of patients with an aura most likely caused by cortical spreading depression (CSD). We have previously shown that systemic L-kynurenine (L-KYN), the precursor of kynurenic acid, suppresses CSD and that this effect depends on the stage of the estrous cycle in female rats. The objectives here are to determine the influence of ovarian hormones on KCl-induced CSD and its suppression after L-KYN by directly modulating estradiol or progesterone levels in ovariectomized rats. Adult female rats were ovariectomized and subcutaneously implanted with silastic capsules filled with progesterone or 17β-estradiol mixed with cholesterol, with cholesterol only or left empty. Two weeks after the ovariectomy/capsule implantation, the animals received an i.p. injection of L-KYN (300 mg/kg) or NaCl as control. Thirty minutes later CSDs were elicited by applying KCl over the occipital cortex and recorded by DC electrocorticogram for 1 hour. The results show that both estradiol and progesterone increase CSD frequency after ovariectomy. The suppressive effect of L-KYN on CSD frequency, previously reported in normal cycling females, is not found anymore after ovariectomy, but reappears after progesterone replacement therapy. Taken together, these results emphasize the complex role of sex hormones on cortical excitability. The CSD increase by estradiol and, more surprisingly, progesterone may explain why clinically migraine with aura appears or worsens during pregnancy or with combined hormonal treatments. [less ▲]

Detailed reference viewed: 47 (20 ULg)