Severity of incident vertebral fracture and future fracture risk: a 3-year prospective study

in Annals of the Rheumatic Diseases (2012, June), 71(Suppl.3), 716

Severe prevalent vertebral fractures predict subsequent vertebral and nonvertebral fractures: a 3-year prospective study

in Osteoporosis International (2012, March), 23(Suppl. 2), 361-362

Weekly alendronate plus vitamin D3 5,600 IU vs. standard care: effect on serum 25(OH) vitamin D, bone turnover markers, and BMD in osteoporotic postmenopausal women with vitamin D inadequacy - 1 year results of a randomized trial

in Osteoporosis International (2011, March), 22(Suppl.1), 291-292

Randomized trial of alendronate plus vitamin D3 versus standard care in osteoporotic postmenopausal women with vitamin D insufficiency.

in Calcified Tissue International (2011), 88(6), 485-94

Vitamin D insufficiency is common in patients with osteoporosis. We conducted a randomized trial comparing alendronate 70 mg combined with vitamin D(3) 5,600 IU in a single tablet (ALN/D5600, n = 257 ... [more ▼]

Vitamin D insufficiency is common in patients with osteoporosis. We conducted a randomized trial comparing alendronate 70 mg combined with vitamin D(3) 5,600 IU in a single tablet (ALN/D5600, n = 257) with standard care chosen by the patients' personal physicians (n = 258) in patients with postmenopausal osteoporosis (BMD T score </=2.5 or </=1.5 and a prior fragility fracture) who had vitamin D insufficiency (serum 25[OH]D values 8-20 ng/ml) and who were at risk of falls. Virtually all patients randomized to standard care received bisphosphonate therapy, and in approximately 70% of cases this was combined with vitamin D supplements. However, only 24% took >/=800 IU/day of supplemental vitamin D. At 6 months the proportion of patients with vitamin D insufficiency was 8.6% in the ALN/D5600 group compared with 31.0% in the standard care group (P < 0.001). Those in the ALN/D5600 group also had a greater reduction in urinary NTX/creatinine ratio (-57% vs. -46%, P < 0.001) and bone-specific alkaline phosphatase (-47% vs. -40%, P < 0.001). In the ALN/5600 group, by 12 months the increase in BMD was greater at the lumbar spine (4.9% vs. 3.9%, P = 0.047) and the total hip (2.2% vs. 1.4%, P = 0.035), significantly fewer patients were vitamin D-insufficient (11.3% vs. 36.9%, P < 0.001), and bone turnover marker (BTM) results were similar to those at 6 months. There was no difference between groups in those who experienced falls or fractures, and adverse events were similar. Based on the finding that ALN/D5600 was more effective than standard care at correcting vitamin D insufficiency, increasing BMD, and reducing BTMs in this patient group, greater attention needs to be directed toward optimizing the treatment of osteoporosis and correcting vitamin D deficiency in postmenopausal women. [less ▲]

Building and tracking root shapes.

in IEEE Transactions on Biomedical Engineering (2010), 57(3), 696-707

An algorithm aiming at robust and simultaneous registrations of a sequence of 3-D shapes was recently presented by Jacq et al. [IEEE Trans. Biomed. Eng., vol. 55, no. 5, 2008]. This algorithm has to carry ... [more ▼]

An algorithm aiming at robust and simultaneous registrations of a sequence of 3-D shapes was recently presented by Jacq et al. [IEEE Trans. Biomed. Eng., vol. 55, no. 5, 2008]. This algorithm has to carry out an implicit representation of their common root shape (RS). A particular emphasis was put on the median consensus shape, which is a specific type of RS. Unlike this previous study, mainly focusing on the algorithm foundations while dealing with very specific applications examples, this paper attempts to show the versatility of the RS concept through a set of three problems involving a wider scope of application. The first problem copes with the design of prosthetic cortical plates for the hip joint. It shows how an explicit reconstruction of the RS, coming with its consensus map, could bring out an intermediary anatomical support from which pragmatic choices could be made, thereby performing a tradeoff between morphological, surgical, and production considerations. The second problem addresses in vivo real-time shoulder biomechanics through a miniature 3-D video camera. This new protocol implicitly operates through RS tracking of the content of virtual spotlights. It is shown that the current medical-oriented protocol, while operating within expert offices through low-cost equipments, could challenge high-end professional equipments despite some limitations of the 3-D video cameras currently available. The last problem deals with respiratory motions. This is an auxiliary measurement required by some medical imaging systems that can be handled as a basic application case of the former new protocol. [less ▲]

Effect on single annual infusion of zoledronic acid (5mg) on lumbar spine bone mineral density versus daily oral risedronate (5mg) in subgroups of patients receiving glucocorticoid therapy.

in Osteoporosis International (2009, March), 20(Suppl.1), 7-8

A single infusion of zoledronic acid 5 mg is significantly more effective than daily oral risedronate 5 mg in increasing bone mineral density of the lumbar spine, hip, femoral neck and trochanter in patients with glucocorticoid-induced osteoporosis

in Annals of the Rheumatic Diseases (2008, June), 67(Suppl.II), 56

Relationship between Change in Femoral Neck Bone Mineral Density and Hip Fracture Incidence During Treatment with Strontium Ranelate

in Current Medical Research & Opinion (2007), 23(12), 3041-5

OBJECTIVE: Strontium ranelate (SR) increases bone mineral density (BMD) in postmenopausal osteoporotic women and reduces vertebral and non-vertebral fracture incidence. Hip fracture reduction has also ... [more ▼]

OBJECTIVE: Strontium ranelate (SR) increases bone mineral density (BMD) in postmenopausal osteoporotic women and reduces vertebral and non-vertebral fracture incidence. Hip fracture reduction has also been observed during 3-year treatment with SR in osteoporotic women at high risk of hip fracture. The objective of this study is to analyse the association between BMD changes and hip fracture incidence during treatment with SR. MATERIAL AND METHODS: In this post-hoc analysis, 465 women aged over 74 years with low BMD at the femoral neck (T-score < or = -2.4 according to NHANES normative values) were selected from the population of a recently published study (the Treatment of Peripheral Osteoporosis Study - TROPOS). BMD was assessed at the femoral neck at baseline and after a follow-up of 3 years. Hip fractures were reported by study investigators. RESULTS: After adjusting for age, body mass index, femoral neck BMD at baseline and number of prevalent vertebral fractures, we found that for each 1% increase in femoral neck BMD observed after 3 years, the risk to experience a hip fracture after 3 years decreased by 7% (95% CI: 1-14%) (p = 0.04). In patients experiencing a hip fracture over 3 years of treatment with SR, femoral neck BMD increased by (mean [SE]) 3.41 (1.02)% compared to 7.23 (0.81)% in patients without hip fracture (p = 0.02). CONCLUSION: In this post-hoc analysis of women undergoing 3 years of SR treatment, an increase in femoral neck BMD is associated with a decrease in hip fracture incidence. [less ▲]

Increase in femoral neck bone mineral density is associated with decrease in vertebral and hip fracture incidence during a 3-year treatment with strontium ranelate

in Annals of the Rheumatic Diseases (2007, June), 66(Suppl.II), 521

Effect of age on a fractal bone texture parameter assessed by high resolution digital X Ray: a multicenter pilot study

in Osteoporosis International (2007, March), 18(Suppl.1), 102