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See detailCanine idiopathic pulmonary fibrosis : improvement of the phenotype characterization and search for biomarkers and for etiologic agents
Roels, Elodie ULg

Doctoral thesis (2016)

Canine idiopathic pulmonary fibrosis (CIPF) is a progressive parenchymal lung disease of unknown origin, mainly described in old-aged West Highland white terriers (WHWTs). It is characterized by exercise ... [more ▼]

Canine idiopathic pulmonary fibrosis (CIPF) is a progressive parenchymal lung disease of unknown origin, mainly described in old-aged West Highland white terriers (WHWTs). It is characterized by exercise intolerance, cough and dyspnoea/tachypnea with a progressive deterioration until death from respiratory insufficiency. CIPF shares clinical features with human idiopathic pulmonary fibrosis (IPF), while tomodensitometric and histopathological findings do not appear to be exactly the same. Over the past 10 years, several studies have been performed to improve our knowledge about CIPF. However, this disease is still misunderstood and clinicians are dealing with several challenges including the absence of clinical or biological markers for estimating the presence, severity or progression of the disease and related comorbidities such as pulmonary hypertension, the absence of etiologic agent, and the absence of targeted therapy. Consequently, the aims of the present project were (1) to investigate whether high-resolution computed tomography (HRCT) of the lungs obtained under sedation can be used for the diagnosis and for the follow-up of the disease, (2) to study a new echocardiographic parameter for the diagnosis of precapillary pulmonary hypertension induced by CIPF, (3) to study the potential roles of 2 chemokines of interest, CCL2 and CXCL8, as biomarkers of fibrosis and as actors in the pathogenesis of the disease, (4) to determine breed variation of basal blood concentrations of the same chemokines, vascular endothelial growth factor (VEGF), and serotonin, and (5) to search for the presence of herpesvirus as a possible etiologic agent. [less ▲]

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See detailNo Evidence of Herpesvirus Infection in West Highland Terriers with Canine Idiopathic Pulmonary Fibrosis
Roels, Elodie ULg; Dourcy, Mickael ULg; Holopainen, S. et al

in Veterinary Pathology (2016)

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See detailComparison of 4 point-of-care blood gas analyzers for arterial blood gas analysis in healthy dogs and dogs with cardiopulmonary disease
Roels, Elodie ULg; Gommeren, Kris ULg; Farnir, Frédéric ULg et al

in Journal of Veterinary Emergency and Critical Care (2016), 00(0), 1-8

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See detailCanine idopathic pulmonary fibrosis is not associated with herpes virus infection
Roels, Elodie ULg; Dourcy, Mickael ULg; Holopainen, S. et al

Poster (2015, October)

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See detailCHEMOKINE (CC-MOTIF) LIGAND 2 AS A PROGNOSTIC SERUM MARKER IN CANINE IDIOPATHIC PULMONARY FIBROSIS
Roels, Elodie ULg; Holopainen, S.; Teske, Erik ULg et al

Poster (2015, September 11)

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See detailPulmonary Vein-to-Pulmonary Artery Ratio is an Echocardiographic Index of Congestive Heart Failure in Dogs with Degenerative Mitral Valve Disease
Merveille, Anne-Christine ULg; Bolen, Géraldine ULg; Krafft, Emilie et al

in Journal of Veterinary Internal Medicine (2015), 29

Background Early recognition of left-sided congestive heart failure (CHF) in dogs with degenerative mitral valve disease (DMVD) is important because it influences medical therapy, timing of follow-up, and ... [more ▼]

Background Early recognition of left-sided congestive heart failure (CHF) in dogs with degenerative mitral valve disease (DMVD) is important because it influences medical therapy, timing of follow-up, and outcome.HypothesisPulmonary vein diameter-to-pulmonary artery diameter ratio (PV/PA) measured by echocardiography can predict CHF.AnimalsNinety-eight client-owned dogs, 37 controls, and 61 dogs with DMVD.Methods Prospective clinical cohort study. History, physical examination and Doppler-echocardiography were performed. Dogs were classified as International Small Animal Cardiac Health Council class I, II or III. Congestive heart failure was identified in a subset of 56 dogs based on radiographic findings. The PV/PA was measured in bidimensional (2D) and M-mode by 2 investigators blinded to the radiologists’ conclusions.ResultsInterobserver coefficients of variation for PV/PA acquisition and measurement were <10%. The PV/PA in control dogs was approximately 1 and increased with class of heart failure. The presence of CHF could be best predicted by measuring PV/PA in 2D echocardiography (cut-off, 1.7; area under the curve, 0.98; CI, 0.97–0.98; P < .001) with a sensitivity of 96% and a specificity of 91%.Conclusion and clinical importanceThe PV/PA is a simple and reproducible echocardiographic variable that increases with class of heart failure and may help discriminate dogs in CHF from asymptomatic dogs with DMVD. Additional studies are required to determine whether PV/PA might provide additional information in the integrated interpretation of Doppler-echocardiographic indices of left ventricular filling pressures and could be used for rapid assessment of CHF in dogs in a critical care setting. [less ▲]

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See detailCanine idiopathic pulmonary fibrosis is not associated with herpes virus infection
Roels, Elodie ULg; Dourcy, Mickael ULg; Holopainen, S. et al

Poster (2015)

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See detailVascular endothelial growth factor: a blood biomarker in canine idiopathic pulmonary fibrosis.
Roels, Elodie ULg; Krafft, Emilie ULg; Laurila, HP et al

Poster (2014, October 17)

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See detailCorrelation between thoracic ct-scan angiography findings and echocardiographic right pulmonary vein to pulmonary artery ratio in west highland white terriers with idiopathic pulmonary fibrosis.
Roels, Elodie ULg; Merveille, Anne-Christine ULg; Couvreur, T. et al

in Proceedings of the 24th Ecvim Meeting, Mainz, Germany - 4-6 September 2014 (2014, September)

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See detailDetection of Angiostrongylus vasorum in the bronchoalveolar lavage fluid or faeces of coughing and healthy dogs in Belgium.
Canonne-Guibert, Morgane ULg; Roels, Elodie ULg; Caron, Yannick ULg et al

in Proceedings of the 24th Ecvim Meeting, Mainz, Germany - 4-6 September 2014 (2014, September)

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