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See detailThe Dual Role of Thymic Neurohypophysial-Related Self Peptides in T Cell Selection. Physiological and Pharmacological Implications
Geenen, Vincent ULg; Martens, Henri ULg; Robert, Françoise et al

in Annals of the New York Academy of Sciences (1993), 689

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See detailThymic neurohypophysial-related peptides and T cell selection
Geenen, Vincent ULg; Cormann-Goffin, Nadine; Martens, Henri ULg et al

in Regulatory Peptides (1993), 45(1-2), 273-278

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See detailEvidence that insulin-like growth factor 2 (IGF2) is the dominant thymic peptide of the insulin superfamily
Geenen, Vincent ULg; Achour, Imane; Robert, Françoise et al

in Thymus (1993), 21(2), 115-127

Central T-cell tolerance of neurondocrine functions has been proposed to be primarily induced by the thymic repertoire of neuroendocrine self antigens. The present study aimed at characterizing the human ... [more ▼]

Central T-cell tolerance of neurondocrine functions has been proposed to be primarily induced by the thymic repertoire of neuroendocrine self antigens. The present study aimed at characterizing the human thymic insulin-related self antigen able to represent the pancreatic islet ß cell function in face of the developing T cells. Immunofluorescence studies were performed on human and rat thymic sections, as wess as on the rat IT-45R1 thymic epithelial cell line using several antibodies to epitopes of the insulin peptide family. These studies identify beyond any doubt that IGF2 is the dominant thymic peptide of the insulin family. The sequence of an insulin-derived autoantigen is proposed. This autoantigen is a nonamer and has a hydrophobic residue leucine at position 9. In human species, this autoantigen would primarily be tolerogenic for the pancreatic ß-cell endocrine function during fetal development. [less ▲]

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See detailThymus Gland, Neuroendocrinology
Geenen, Vincent ULg; Robert, Françoise; Ericsson, Anders et al

in Smith, Barry; Adelman, George (Eds.) The Neuroscience Year, Supplement 2 to the Encyclopedia of Neuroscience (1992)

T-cell differentiation occurs primarily within the thymus and is regulated through intimate intercellular contacts, interactions between major histocompatibility proteins and the T-cell receptor complex ... [more ▼]

T-cell differentiation occurs primarily within the thymus and is regulated through intimate intercellular contacts, interactions between major histocompatibility proteins and the T-cell receptor complex, as well as exchanges of peptide signals between immature lymphocytes and thymic environmental cellular populations. There is now ample evidence that neuropeptide-lymphocyte interactions occur at multiple levels in the thymus, and that the sources of neuropeptides are encountered in different sites such as thymic innervating fibers, stromal cells, and developing thymocytes themselves. An important question to consider is the fact that neuropeptides are intrinsic components of the 'self' molecular structure, and therefore may contribuye to the induction of T-cell self tolerance. After immature thymocytes have escaped the deletion process of clones highly reactive for 'self' peptides, thymic neuropeptides could also represent accessory signals for activation (or inhibition) steps in the developmental programme of the T-cell system. [less ▲]

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See detailThe thymic repertoire of neuroendocrine self antigens and the central immune tolerance of neuroendocrine functions
Geenen, Vincent ULg; Cormann, Nadine; Robert, Françoise et al

in European Journal of Medicine (The) (1992), 1(3), 158-165

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See detailNouvelles approches pharmacologiques basées sur les interactions neuroendocrino-immunitaires
Geenen, Vincent ULg; Franchimont, Nathalie; Louis, Edouard ULg et al

in Médecine et Hygiène (1992), 50

La description des interactions neuroendocrino-immunitaires a été un domaine de recherche très fructueux au cours des dernières années. Si les circonstances physiopathologiques au cours desquelles ces ... [more ▼]

La description des interactions neuroendocrino-immunitaires a été un domaine de recherche très fructueux au cours des dernières années. Si les circonstances physiopathologiques au cours desquelles ces interactions interviennent restent encore à préciser, la caractérisation biochimique de signaux neuropeptidiques et de leurs récepteus exprimés par des cellules immunocompétentes permet d'entrevoir de nouvelles possibilités thérapeutiques. En particulier, l'action immunomodulatrice et antiinflammatoire potentielle d'antagonistes spécifiques de neuropeptides représente une voie intéressante pour la mise au point d'immunothérapies sélectives. [less ▲]

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See detailThymic neuropeptides and T-cell selection
Robert, Françoise; Geenen, Vincent ULg

in Annals of the New York Academy of Sciences (1992), 650

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See detailThe thymic education of developing T cells in self neuroendocrine principles
Geenen, Vincent ULg; Robert, Françoise; Martens, Henri ULg et al

in Journal of Endocrinological Investigation (1992), 15

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See detailLa communication cryptocrine et la reconnaissance des fonctions neuroendocrines par les cellules T au cours de leur différenciation
Geenen, Vincent ULg; Robert, Françoise; Martens, Henri ULg et al

in Revue Française d'Endocrinologie Clinique, Nutrition, et Métabolisme (La) (1992), 33

Le thymus, organe lymphoïde primaire responsable du développement des lymphocytes T, est le site d'expression de différents peptides appartenant à des familles hormonales distinctes. Le modèle classique ... [more ▼]

Le thymus, organe lymphoïde primaire responsable du développement des lymphocytes T, est le site d'expression de différents peptides appartenant à des familles hormonales distinctes. Le modèle classique de la neurosécrétion établi pour l'axe hypothalamo-neurohypophysaire ne peut cependant s'appliquer à la sécrétion de tels signaux par les cellules épithéliales thymiques. Un nouveau modèle de communication cellulaire, celui de la communication cryptocrine, a été proposé par John W. Funder pour décrire les échanges d'information entre une cellule épithéliale fixe et des cellules mobiles en différenciation à leur contact. Dans le thymus, la communication cryptocrine est étroitement associée à la présentation de la structure moléculaire du Soi par les molécules d'histocompatibilité (CMH) aux lymphocytes T au cours de leur différenciation. Sur la base de nos observations, le modèle du répertoire thymique des autoantigènes neuroendocrines permet de transposer au niveau moléculaire le double rôle physiologique du thymus dans les phénomènes de sélections négative et positive des cellules T, et d'apporter un éclairage nouveau sur les mécanismes responsables de la tolérance immunitaire centrale aux fonctions neuroendocrines. [less ▲]

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See detailImmunomodulatory properties of cyclic hexapeptide oxytocin antagonists
Geenen, Vincent ULg; Martens, Henri ULg; Robert, Françoise et al

in Thymus (1992), 20

A pharmacological manipulation of cryptocrine cell-to-cell signaling was tested by the investigation of the immunomodulatory properties of novel cyclic hexapeptide oxytocin (OT) antagonists (MSD Research ... [more ▼]

A pharmacological manipulation of cryptocrine cell-to-cell signaling was tested by the investigation of the immunomodulatory properties of novel cyclic hexapeptide oxytocin (OT) antagonists (MSD Research Laboratories). The compounds were found to significantly inhibit the productions of IL-1ß and IL-6 elicited by anti-CD3 treatment oh human whole blood cells cultures (WBC). Cytokine productions were more significantly reduced by OT antagonists in WBC derived from female volunteers than in those obtained from male donors, suggesting an influence of sex steroids on the expression of NHP receptors by immune cells. These observations support the concept of novel immunomodulating approaches through immune-specific neuropeptide antagonists, as well as the pharmacological value of such strategies in selective immunotherapy. [less ▲]

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See detailExpression of functional neurohypophysial peptide receptors by murine immature and cytotoxic T-cell lines
Martens, Henri ULg; Robert, Françoise; Geenen, Vincent ULg et al

in Progress in NeuroEndocrinImmunology (1992), 5

In order to demonstrate the cryptocrine model of neuroendocrine-immune interactions, specific neurohypophysial (NHP) receptors were detected on murine immature pre-T and cytotoxic T cell lines. A computer ... [more ▼]

In order to demonstrate the cryptocrine model of neuroendocrine-immune interactions, specific neurohypophysial (NHP) receptors were detected on murine immature pre-T and cytotoxic T cell lines. A computer analysis (LIGAND) revealed the heterogeneity of the binding sites. The Kd of Highest affinity were equivalent in both cell lines (0.15 nM), but the capacity (Bmax) of both low and high affinity sites was higher in the immature thymic lymphoma-derived pre-T-cell line. The functionality of these receptors was evidenced by their transduction of NHP-related ligands as an increase in intracellular inositol phosphates. These transductory properties were inhibited by a V1 receptor antagonist in pre-T cells, and by an oxytocin (OT) receptor antagonist in cytotoxic T cells. This work supports the involvement of NHP-related ligands and receptors in a process of cryptocrine signaling in the thymus, where the peptide concentration and the receptor affinity are in appropriate concordance. [less ▲]

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See detailNeuroendocrine-Immunology: from systemic interactions to the immune tolerance of self neuroendocrine functions
Geenen, Vincent ULg; Robert, Françoise; Legros, Jean-Jacques ULg et al

in Acta Clinica Belgica (1991), 46

In recent years, it appeared more and more that the three major integrating and adaptive systems of intercellular communication, nervous, endocrine, and immune systems, are closely interconnected. Through ... [more ▼]

In recent years, it appeared more and more that the three major integrating and adaptive systems of intercellular communication, nervous, endocrine, and immune systems, are closely interconnected. Through these interactions, psychological and neurological influences can modulate the immune response (neuroimmunomodulation), while immune cells may communicate to the neuroendocrine system by a regulatory feedback loop. On the basis of our own observations, it has been shown that the neuroendocrine-immune dialogue occurs in the thymus during the early steps of T-cell differentiation, and could be involved both in T-cell positive as well as negative selections. [less ▲]

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See detailColocalization of immunoreactive oxytocin, vasopressin and interleukin-1 in human thymic epithelial neuroendocrine cells
Robert, Françoise; Geenen, Vincent ULg; Schoenen, Jean ULg et al

in Brain, Behavior & Immunity (1991), 5

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See detailMonoclonal antibodies to oxytocin: production and characterization
Burgeon, Emmanuel; Chapleur, Michèle; Schoenen, Jean ULg et al

in Journal of Neuroimmunology (1991), 31

To induce a good immune response to oxytocin (OT) we developed a two-step technique to conjugate OT to thyroglobulin (TG) using glutaraldehyde. We obtained 30 hybridomas recognizing OT-ovalbumin ... [more ▼]

To induce a good immune response to oxytocin (OT) we developed a two-step technique to conjugate OT to thyroglobulin (TG) using glutaraldehyde. We obtained 30 hybridomas recognizing OT-ovalbumin conjugates and 16 stable lines. Three monoclonal antibodies were selected for further characterization. One of them (O13) was found to be very specific for OT using three different techniques (EIA, RIA and ICC); it si directed to the C-terminal tripeptide. The other two probably recongize tyrosine-containing epitope(s) also shared by vasopressin and other related nonapeptides. [less ▲]

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See detailThymic cryptocrine signaling and the immune recognition of self neuroendocrine functions
Geenen, Vincent ULg; Martens, Henri ULg; Robert, Françoise et al

in Progress in NeuroEndocrinImmunology (1991), 4

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See detailNeuroendocrinology of the thymus
Geenen, Vincent ULg; Robert, Françoise; Martens, Henri ULg et al

in Geenen, Vincent; Maggi, Mario (Eds.) Horizons in Endocrinology, Volume 2 (1991)

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See detailNeuropeptide signals and receptors in the thymus
Geenen, Vincent ULg; Robert, Françoise; Legros, Jean-Jacques ULg et al

in Plotnikoff, Nicholas; Murgo, Anthony; Faith, Robert (Eds.) et al Stress and Immunity (1991)

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See detailThymic cryptocrine signaling and the immune recognition of self neuroendocrine functions
Geenen, Vincent ULg; Martens, Henri ULg; Robert Françoise et al

in Progress in NeuroEndocrinImmunology (1991), 5

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See detailThymic cryptocrine signalling and the immune recognition of neuroendocrine functions
Geenen, Vincent ULg; Martens, Henri ULg; Benhida, Abdellah et al

in Proceedings of the Joint Meeting (1991)

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See detailCellular and molecular aspects of the neuroendocrine-immune dialogue in T-cell differentiation
Geenen, Vincent ULg; Robert, Françoise; Martens, Henri ULg et al

in Müller, Eugenio E.; MacLeod, Robert (Eds.) Neuroendocrine Perspectives, Volume 8 (1990)

Detailed reference viewed: 6 (0 ULg)