References of "Rikir, Estelle"
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See detailApproche électro-physiologique non invasive des malformations du développement cortical: EEG
RIKIR, Estelle ULg

Conference (2014, November 13)

L’électro-encéphalogramme (EEG) de surface, technique non invasive et peu couteuse, demeure la pierre angulaire de la mise au point des épilepsies. Le développement de dispositifs d’enregistrement au ... [more ▼]

L’électro-encéphalogramme (EEG) de surface, technique non invasive et peu couteuse, demeure la pierre angulaire de la mise au point des épilepsies. Le développement de dispositifs d’enregistrement au moyen de 64 à 256 électrodes a permis d’augmenter considérablement la résolution spatiale de l’EEG de surface (Lantz et al., Clin Neurophysiol 2003). D’autre part, le développement de l’imagerie de source électrique (ISE) a permis au moyen de modèles mathématiques de localiser le générateur cortical responsable du signal EEG enregistré en surface (Scherg et al., 1990; Pascual-Marqui, 2002). Les malformations corticales (MCs) représentent un large spectre d’anomalies structurelles congénitales (Barkovich et al., Brain 2012) et constituent une des principales causes d’épilepsie de l’adulte (Spencer & Huh, Lancet Neurol 2008). Cette épilepsie s’avère malheureusement pharmaco-résistante dans la plupart des cas (85%) (Papayannis et al., Seizure 2012). Si les MCs sont hétérogènes d’un point de vue structurel (radiologique et anatomopathologique), les études électro-physiologiques (EEG) ont démontré que cette hétérogénéité existait également au niveau fonctionnel, non seulement entre les différents types de MCs mais aussi parfois au sein d’une même malformation. Les dysplasies corticales focales (DCF), hautement épileptogènes (Chassoux et al., Brain 2000; Aubert et al., Brain 2009), restent « invisibles » à l’IRM dans 30 à 50 % des cas (Hauptman et al., Epilepsia 2012). Dans ce cas, l’EEG de surface et l’ISE aident à la localisation du foyer épileptique (Brodbeck et al., Epilepsia 2010; Rikir et al.,Epilepsia 2014). Morphologiquement, aucune anomalie en EEG de surface n’est spécifique d’une DCF (Sisodiya et al., Lancet Neurol 2009). Les MCs, notamment les schizencéphalies et polymicrogyries, sont parfois très vastes et impliquent structurellement plusieurs régions lobaires et sous-lobaires, compliquant l’approche chirurgicale. L’EEG haute résolution couplé à l’ISE peut montrer le caractère hétérogène de la malformation en terme d’épilpetogénicité et désigner ainsi la partie impliquée dans les crises d’épilepsie (Rikir et al., 2014 ; Maillard et al., 2009). En cas de malformation multifocale (sclérose tubéreuse de Bourneville, hétérotopies nodulaires), les anomalies EEG critiques et inter-critiques désignent parfois une origine unifocale des crises épileptiques rendant éventuellement possible un traitement chirurgical. Enfin, il a été montré prospectivement que l’EEG haute densité couplé à l’ISE contribuait à localiser la zone épileptogène dans les épilepsies en rapport les MCs , qu’il présentait une valeur ajoutée par rapport à une mise au point classique basée sur l’enregistrement VIDEOEEG et l’IRM cérébrale, et qu’il était particulièrement indiqué en cas d’IRM négative ainsi qu’en cas de discordance entre hypothèses électro-cliniques (VIDEOEEG) et données structurelles (IRM) (Rikir et al., Epilepisa 2014). [less ▲]

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See detailElectrical Source Imaging in cortical malformation-related epilepsy : a prospective EEG-SEEG concordance study
RIKIR, Estelle ULg; KOESSLER, Laurent; GAVARET, Martine et al

in Epilepsia (2014), 55(6), 918-932

OBJECTIVE: Delineating the epileptogenic zone (EZ) in refractory epilepsy related to malformations of cortical development (MCD) often requires intracranial EEG recordings, especially in cases of negative ... [more ▼]

OBJECTIVE: Delineating the epileptogenic zone (EZ) in refractory epilepsy related to malformations of cortical development (MCD) often requires intracranial EEG recordings, especially in cases of negative MRI or discordant MRI and video-EEG findings. It is therefore crucial to promote the development of non-invasive methods such as electrical source imaging (ESI). We aimed to (i) analyze the localization concordance of ESI derived from interictal discharges and EZ estimated by stereo-electroencephalography (SEEG), (ii) compare the concordance of ESI, MRI and electro-clinical correlations (ECC) with SEEG-EZ, and (iii) assess ESI added value in the EZ localization. METHODS: We prospectively analyzed 28 consecutive patients undergoing presurgical investigation for MCD-related refractory epilepsy in 2009-2012. ESI derived from 64-channel scalp EEG was interpreted blinded to- and subsequently compared with SEEG estimated ΕZ. Anatomical concordance of ESI with SEEG-ΕZ was compared to that of video-EEG and MRI. We further assessed ESI added value to ECC and MRI. RESULTS: Twelve (43%) patients had temporal and 16 (57%) extratemporal epilepsy. MRI was negative in 11 (39%) and revealed a cortical malformation in 17 (61%). ESI was fully concordant with the EZ in ten (36%) and partly concordant in 15 (53%). ECC presented a full and partial concordance with EZ in 11% and 82% of cases respectively and MRI in 11% and 46% respectively. Of 11 patients with negative MRI, ESI was fully concordant with the EZ in seven (64%), partly concordant in four (36%). ESI correctly confirmed, restricted or added localizations to ECC and MRI in 12 of 28 patients (43%) and in eight of 11 patients (73%) with negative MRI. SIGNIFICANCE: ESI contributes to estimate the EZ in MCD-related epilepsy. The added value of ESI to ECC is particularly high in patients with MCD and negative MRI, who represent the most challenging cases for epilepsy surgery. [less ▲]

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See detailExpression pattern of synaptic vesicle protein 2 (SV2) isoforms in patients with temporal lobe epilepsy and hippocampal sclerosis
CREVECOEUR, Julie ULg; Kaminski, RM; Rogister, Bernard ULg et al

in Neuropathology & Applied Neurobiology (2014), 40(2), 191-204

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See detailDirect evidence of nonadherence to antiepileptic medication in refractory focal epilepsy
CARPENTIER, Nicolas; Jonas, Jacques; Frismand, Solène et al

in Epilepsia (2013), 54(1), 20-23

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See detailFunctional neuroimaging of the reciprocal influences between sleep and wakefulness.
Jedidi, Zayd ULg; Rikir, Estelle ULg; Muto, Vincenzo ULg et al

in Pflugers Archiv : European journal of physiology (2011), 463(1), 103-9

The activity patterns adopted by brain neuronal populations differ dramatically between wakefulness and sleep. However, these vigilance states are not independent and they reciprocally interact. Here, we ... [more ▼]

The activity patterns adopted by brain neuronal populations differ dramatically between wakefulness and sleep. However, these vigilance states are not independent and they reciprocally interact. Here, we provide evidence that in humans, regional brain activity during wakefulness is influenced by sleep regulation, namely by the interaction between sleep homeostasis and circadian signals. We also show that, by contrast, regional brain activity during sleep is influenced by the experience acquired during the preceding waking period. These data reveal the dynamic interactions by which the succession of vigilance states support normal brain function and human cognition. [less ▲]

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See detailL’OBSERVANCE THERAPEUTIQUE DU PATIENT SOUFFRANT D’EPILEPSIE. Un problème fréquent et complexe.
RIKIR, Estelle ULg; Grisar, Thierry ULg; SADZOT, Bernard ULg

in Revue Médicale de Liège (2010), 65(5-6), 370-380

Epilepsy is a chronic disease, requiring a medical treatment which is essentially preventive (avoiding further seizure). Because of these characteristics, one third to one half of the epileptic patients ... [more ▼]

Epilepsy is a chronic disease, requiring a medical treatment which is essentially preventive (avoiding further seizure). Because of these characteristics, one third to one half of the epileptic patients does not always comply with their treatment. In this article, we review the different factors of poor compliance. Some are specific to this medical condition while others are more general, like treatment complexity. We list here some suggestions to improve the compliance of the epileptic patient in routine medical practice. [less ▲]

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See detailGuillain-Barré syndrome following hepatitis E
Loly, Jean-Philippe ULg; Rikir, Estelle ULg; Seivert, Maxime ULg et al

in World Journal of Gastroenterology (2009), 15(13), 1645-1647

Guillain-Barré syndrome (GBS) is often triggered by a preceding bacterial or viral infection. Occasionally, it has been observed in association with acute hepatitis A, B and C, and three cases have been ... [more ▼]

Guillain-Barré syndrome (GBS) is often triggered by a preceding bacterial or viral infection. Occasionally, it has been observed in association with acute hepatitis A, B and C, and three cases have been previously described in India in which GBS was associated with acute hepatitis E. A molecular mimicry mechanism is supposed to be involved in the pathogenesis of GBS triggered by infectious agents, although the nature of the shared epitopes has not been characterized in most instances, including that in the case of hepatotropic viruses. We report a case of GBS following acute hepatitis E in a European individual. The presence of antiganglioside GM2 antibodies in this patient suggested molecular mimicry involving ganglioside GM2 in the pathogenesis of GBS associated with hepatitis E. [less ▲]

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See detailTime is brain: prise en charge de l'accident vasculaire cérébral ischémique à la phase aigue.
SADZOT, Bernard ULg; RIKIR, Estelle ULg; Moonen, Gustave ULg

in Revue Médicale de Liège (2008), 63(5-6), 257-262

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See detailLa neuroborréliose: quand la tique a piqué
Cuvelier, M.L.; LEONARD, Philippe ULg; RIKIR, Estelle ULg et al

in Revue Médicale de Liège (2008), 63(5-6), 349-353

L’infection à Borrelia burgdorferi est fréquente dans nos régions. Les complications neurologiques de cette infection se rencontrent essentiellement lors de la phase de dissémination précoce et à la phase ... [more ▼]

L’infection à Borrelia burgdorferi est fréquente dans nos régions. Les complications neurologiques de cette infection se rencontrent essentiellement lors de la phase de dissémination précoce et à la phase tardive de l’infection. La neuroborréliose se manifeste surtout par des radiculalgies rebelles au traitement, parfois associées à une neuropathie crânienne, en grande majorité faciale. L’évolution est satisfaisante sous antibiothérapie adaptée. Celle-ci reste nécessaire en dépit du fait que la plupart des complications de la neuroborréliose disparaissent spontanément. Le traitement permet d’éviter la survenue de complications tardives ou de voir apparaître des atteintes extraneurologiques éventuelles. [less ▲]

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See detailWhen HIV gets into the brain
Cuvelier, Marie-Laure ULg; Leonard, Philippe ULg; Rikir, Estelle ULg et al

in Revue Médicale de Liège (2008), 63(5-6), 338-341

Besides opportunistic infections, direct or indirect HIV-mediated lesions of cerebral vascular or neural cells can also occur during the natural course of HIV infection. The main non-infectious ... [more ▼]

Besides opportunistic infections, direct or indirect HIV-mediated lesions of cerebral vascular or neural cells can also occur during the natural course of HIV infection. The main non-infectious complications of HIV are cerebral lymphomas, cerebrovascular disorders, HIV dementia and myelitis. [less ▲]

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See detailHIV-related infections of the brain
Cuvelier, Marie-Laure ULg; Leonard, Philippe ULg; Rikir, Estelle ULg et al

in Revue Médicale de Liège (2008), 63(5-6), 342-348

During the natural course of human immunodeficiency virus infection, central nervous system insults are very common. They can consist of infectious complications, consequently to the collapse of the ... [more ▼]

During the natural course of human immunodeficiency virus infection, central nervous system insults are very common. They can consist of infectious complications, consequently to the collapse of the patient's immune system. Alternatively, direct or indirect HIV-mediated lesions of cerebral vascular or neural cells can also occur. It is crucial to detect HIV-related infectious complications since their prognosis will depend on early and accurate treatments. The diagnosis is generally made by means of magnetic resonance imaging and lumbar puncture. [less ▲]

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See detailTherapeutic armamentarium in neurology: the birth of a new era
Belachew, Shibeshih ULg; Magis, Delphine ULg; Lievens, Isabelle ULg et al

in Revue Médicale de Liège (2007), 62(5-6), 432-448

The field of neurology was long infamous for a lack of therapeutic options. How many of you have once thought: "Neurologists don't cure the disease, they admire it". But those days have passed into ... [more ▼]

The field of neurology was long infamous for a lack of therapeutic options. How many of you have once thought: "Neurologists don't cure the disease, they admire it". But those days have passed into history, and the field is now vibrant with new treatments and hope even for patients with the worst neurodegenerative diseases. We summarized in the present review the latest major advances in therapeutic principles and practice for some of the most frequent chronic neurological disorders such as headaches, epilepsy, multiple sclerosis, dementias, Parkinson's disease, sleep/wake disturbances and peripheral neuropathies. We cannot cure or prevent, but we can now halt or control symptoms and disease progression to provide physical and psychological relief, and a better quality of life for patients who suffer from these otherwise devastating neurological conditions. [less ▲]

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See detailComment j'explore... Une valeur élevée de calcitonine?
Rikir, Estelle ULg; Valdes Socin, Hernan Gonzalo ULg; Vroonen, Laurent ULg et al

in Revue Médicale de Liège (2006), 61(3), 195-200

This article describes a case of lung cancer with associated hypercalcitoninemia in a man with a goitre. The case raises the problem of the differential diagnosis between medullary thyroid carcinoma and a ... [more ▼]

This article describes a case of lung cancer with associated hypercalcitoninemia in a man with a goitre. The case raises the problem of the differential diagnosis between medullary thyroid carcinoma and a neuroendocrine neoplasm with ectopic calcitonin secretion. The article first reviews the physiology of calcitonin, then outlines the diagnostic tests that are required to investigate hypercalcitoninemia and finally discusses the interpretation of test results. [less ▲]

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See detailRole of estrogens in the modulation of inflammatory pain : a study in aromatase knock-out mice using the trigeminal formalin model
Multon, Sylvie ULg; RIKIR, Estelle ULg; HALLEUX, Sandrine ULg et al

in Book of Abstracts of the 33th Annual Meeting Society for Neuroscience (Nov 2003) (2003, November)

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