References of "Rigo, Jean-Marie"
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See detailUtilisation des géosynthétiques en génie civil
Courard, Luc ULg; Rigo, Jean-Marie ULg

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See detailA Cell Type-Specific and Gap Junction-Independent Mechanism for the Herpes Simplex Virus-1 Thymidine Kinase Gene/Ganciclovir-Mediated Bystander Effect
Princen, Frederic; Robe, Pierre ULg; Lechanteur, Chantal ULg et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (1999), 5(11), 3639-44

Tumor cells expressing the herpes simplex virus type 1 thymidine kinase (HSV-tk) gene are killed by nucleoside analogues such as ganciclovir (GCV). GCV affects not only the cells expressing HSV-tk but ... [more ▼]

Tumor cells expressing the herpes simplex virus type 1 thymidine kinase (HSV-tk) gene are killed by nucleoside analogues such as ganciclovir (GCV). GCV affects not only the cells expressing HSV-tk but also neighboring cells that do not express the gene; this phenomenon commonly is called "bystander effect." GCV metabolites transfer via gap junctional intercellular communication (GJIC) accounts for the bystander effect in different cell lines, but other mechanisms have also been described. In this study, we analyzed the mechanisms of the bystander effect in two cell lines exhibiting different capacities of communication (DHD/K12 and 9L). The 9L cells exhibited a very good bystander effect, which was completely blocked by a long-term inhibitor of GJIC, 18 alpha-glycyrrhetinic acid. DHD/K12 cells exhibited a moderate bystander effect that was not abolished by 18 alpha-glycyrrhetinic acid or 1-octanol, another strong inhibitor of GJIC. Interestingly, we also observed a bystander effect in cultures where HSV-tk-expressing DHD/K12 cells were physically separated from their untransfected counterparts but grown in the same medium. Moreover, the transfer of filtered conditioned medium from GCV-treated HSV-tk-expressing DHD/K12 cells to DHD/K12 parental cells induced a decrease of survival in a concentration-dependent manner, suggesting that the bystander effect in this cell line was mediated by a soluble factor. [less ▲]

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See detailExpression of Growth Factors and Their Receptors in the Postnatal Rat Cochlea
Malgrange, Brigitte ULg; Rogister, Bernard ULg; Lefebvre, P. P. et al

in Neurochemical Research (1998), 23(8), 1133-8

RT-PCR was used to assay for growth factors and receptors from seven different protein families in cochlea tissues of the juvenile rat. There was a broad representation of the growth factor families in ... [more ▼]

RT-PCR was used to assay for growth factors and receptors from seven different protein families in cochlea tissues of the juvenile rat. There was a broad representation of the growth factor families in all the cochlea tissues examined, though the organ of Corti and stria vascularis expressed a greater variety than the spiral ganglion. This broad expression suggests that a variety of known growth factors play significant roles in the development, maintenance, and repair of the inner ear. The results of this survey serve as a basis for the design of future in vitro experiments that will address the ability of growth factors to protect hair cells from damage and to evoke a repair-regeneration response by injured hair cells. [less ▲]

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See detailBeta-Carbolines Induce Apoptotic Death of Cerebellar Granule Neurones in Culture
Malgrange, Brigitte ULg; Rigo, Jean-Marie ULg; Coucke, Paul et al

in Neuroreport (1996), 7(18), 3041-5

Apart from its role in fast inhibitory transmission, only neurotrophic effects have been reported following activation of the GABAA receptor. Here, we show that n-butyl-beta-carboline-3-carboxylate and n ... [more ▼]

Apart from its role in fast inhibitory transmission, only neurotrophic effects have been reported following activation of the GABAA receptor. Here, we show that n-butyl-beta-carboline-3-carboxylate and n-methyl-beta-carboline-3-carboxamide, which are negative allosteric modulators of the GABAA receptor acting at the benzodiazepine site, are neurotoxic for cerebellar granule neurones in culture. The beta-carboline-induced neuronal death is apoptotic since DNA internucleosomal fragmentation was induced and the neurotoxicity could be prevented by inhibitors of mRNA or protein synthesis. As GABA and benzodiazepine ligands (diazepam and Ro 15-1788) protect cerebellar granule cells against beta-carboline-induced toxicity, these data raise the possibility that the interaction between the beta-carbolines and the GABAA receptor is the triggering event leading to neuronal apoptosis. [less ▲]

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See detailOxidative induction time: a quality assurance measurement to predict environmental stress-cracking
Courard, Luc ULg; Rigo, Jean-Marie ULg

in De Groot, M.B.; Den Hoedt, G.; Termaat, R.J. (Eds.) Proceedings of the 1st European Geosynthetics Conference EUROGEO 1 (1996)

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See detailLining systems stability in landfill slopes : parametric study
Frédéric, Bernard; Rigo, Jean-Marie ULg; Bolle, Albert ULg et al

in Proceedings of the Fifth International Landfill Symposium (1995)

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See detailContribution to the study of stress cracking phenomenon by oxidative induction time measurements
Rigo, Jean-Marie ULg; Courard, Luc ULg; Detaille, Laurence et al

in Delmas, Philippe; Gourc, Jean-Pierre (Eds.) Proceedings of the Rencontres 95 (1995)

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See detailEffect of geotextiles on crack propagation in the pavement overlays
Courard, Luc ULg; Rigo, Jean-Marie ULg

in Karunaratne, G.P.; Wong, C. (Eds.) Proceedings of the 5th International Conference on Geotextiles, Geomembranes and Related Products (1994)

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See detailCreation of a new storage cell in the Wauthier-Braine Waste disposal
Courard, Luc ULg; Rigo, Jean-Marie ULg; Canivet, Philippe et al

in Karunaratne, S.H.; Wong, C. (Eds.) Proceedings of the 5th International Conference on Geotextiles, Geomembranes and Related Products (1994)

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See detailThe durability and development of optimum seaming parameters for a FCEA geomembrane
Rigo, Jean-Marie ULg; Courard, Luc ULg; Peggs, I.D. et al

in Geosynthetics 93 Conference (1993)

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See detailEvaluation of the Crack Propagation in an overlay subjected to both traffic and thermal effects
Rigo, Jean-Marie ULg; Courard, Luc ULg; Cescotto, Serge ULg et al

in Rigo, Jean-Marie; Degeimbre, Robert; Franken, Louis (Eds.) Reflective cracking in Pavements - State of ARt and Design Recommendations (1993)

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See detailThe use of fibers in bituminous concrete as a solution to decrease rutting
Courard, Luc ULg; Rigo, Jean-Marie ULg

in Proceedings of the 5th Eurobitume Volume 1 Session 3 (1993)

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See detailConditions de pose et succès de l'utilisation de géosynthétiques dans la lutte contre la remontée des fissures
Rigo, Jean-Marie ULg; Courard, Luc ULg

in Delmas, Philippe; Gourc, Jean-Pierre (Eds.) Compte-rendu des rencontres 93 (1993)

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See detailThe problem of rutting in asphalt pavement in Belgium: how to resolve this problem with steel and synthetic fibers ?
Courard, Luc ULg; Rigo, Jean-Marie ULg

in Iliescu, M. (Ed.) Proceedings of Constructions 2000 (1993)

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See detailThe use of geosynthetics for waste storage containment: technical aspects and recommendations
Rigo, Jean-Marie ULg; Courard, Luc ULg

in Iliescu, M. (Ed.) Proceedings of Constructions 2000 (1993)

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See detailIn Vitro and in Vivo Modulation of 5-Hydroxytryptamine-, Thyrotropin-Releasing Hormone- and Calcitonin-Gene Related Peptide-Like Immunoreactivities in Adult Rat Sensory Neurons
Delree, P.; Martin, Didier ULg; Sadzot-Delvaux, Catherine ULg et al

in Neuroscience (1992), 51(2), 401-10

In a previous work we have shown that culturing adult rat dorsal root ganglia neurons modifies their neurotransmitter phenotype in such a way that cultured neurons synthesize transmitters that are not ... [more ▼]

In a previous work we have shown that culturing adult rat dorsal root ganglia neurons modifies their neurotransmitter phenotype in such a way that cultured neurons synthesize transmitters that are not found in situ, while several other transmitters are expressed in a much higher percentage of neurons in culture than in situ [Schoenen J. et al. (1989) J. Neurosci. Res. 22, 473-487]. The aim of the present study was to investigate the origin and the nature of the relevant environmental signals that allow this plasticity to be expressed, focusing on three neurotransmitters: 5-hydroxytryptamine, thyrotropin-releasing hormone and calcitonin-gene related peptide. The main results can be summarized as follows: (1) culturing cells in fetal calf serum or on feeder layers of astrocytes, Schwann cells or fibroblasts partially inhibits the serotoninergic phenotype of dorsal root ganglia neurons; (2) in vivo disconnection of dorsal root ganglia from their spinal targets but not from their peripheral or supraspinal targets induces a significant increase of the percentage of 5-hydroxytryptamine- and thyrotropin-releasing hormone-positive neurons in disconnected ganglia; (3) growth factors such as ciliary neuronotrophic factor or basic fibroblast growth factor but not nerve growth factor repress 5-hydroxytryptamine and calcitonin gene-related peptide immunoreactivity in cultured sensory neurons. In conclusion, neurotransmitter gene expression of adult dorsal root ganglia neurons is controlled by complex influences. Our data suggest that thyrotropin-releasing hormone and 5-hydroxytryptamine gene expression are tonically repressed in vivo by factors originating from the spinal segmental level and that growth factors such as ciliary neurotrophic factor or basic fibroblast growth factor could be potential vectors of this repressing effect. [less ▲]

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See detailThe use of bituminous concrete reinforced by fibres for road surfaces
Courard, Luc ULg; Rigo, Jean-Marie ULg

in Studia Geotechnica et Mechanica (1992), XV(3-4), 31-48

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See detailGeosynthetics : geotextiles, geotextiles related-products and geomembranes
Rigo, Jean-Marie ULg; Courard, Luc ULg

in Machajski, J.; Winter, J. (Eds.) Proceedings of the IV International Conference on Slope Stability and Protection (1991)

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See detailNeurono-Glial Interactions and Neural Plasticity
Moonen, Gustave ULg; Rogister, Bernard ULg; Leprince, Pierre ULg et al

in Coleman, Paul; Higgins, G.; Phelps, C. (Eds.) Progress In Brain research: Neuronal Plasticity in aging and dementia (1990)

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