References of "Rigali, Sébastien"
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See detailRésistance aux antibiotiques : le retour à l’ère prébiotique ?
Galleni, Moreno ULg; Kerff, Frédéric ULg; Rigali, Sébastien ULg

Conference (2015, February 05)

Aujourd’hui, la résistance des bactéries aux antibiotiques relève d'une préoccupation croissante dans le domaine de la santé publique et s'impose plus que jamais comme une priorité. Ce problème a un coût ... [more ▼]

Aujourd’hui, la résistance des bactéries aux antibiotiques relève d'une préoccupation croissante dans le domaine de la santé publique et s'impose plus que jamais comme une priorité. Ce problème a un coût, sociétal et économique en Europe: 25.000 décès annuels par septicémie et 1,5 milliard d’euros d’augmentation du coût des traitements. Bien que le besoin de nouveaux agents antibactériens en milieu clinique est urgent, seules deux nouvelles classes d’antibiotiques ont pu être proposées durant ces 30 dernières années. En effet, la découverte et le développement de nouveaux antibiotiques posent des défis scientifiques, cliniques et financiers importants. [less ▲]

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See detailMultiple allosteric effectors control the affinity of DasR for its target sites
Tenconi, Elodie; Urem, Mia; Świątek-Połatyńska, Magdalena et al

in Biochemical and Biophysical Research Communications (2015)

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See detailGenome-Wide Analysis of In Vivo Binding of the Master Regulator DasR in Streptomyces coelicolor Identifies Novel Non-Canonical Targets
Świątek-Połatyńska, MA; Bucca, G; Laing, E et al

in PLoS ONE (2015)

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See detailThe Cellobiose Sensor CebR is the Gatekeeper of Streptomyces scabies Pathogenicity
Francis, Isolde; Jourdan, Samuel ULg; Fanara, Steven ULg et al

in MBio (2015)

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See detailOn the necessity and biological significance of threshold-free regulon prediction outputs
Rigali, Sébastien ULg; Nivelle, Renaud; Tocquin, Pierre ULg

in Molecular Biosystems (2015), 11

The in silico prediction of cis-acting elements in a genome is an efficient way to quickly obtain an overview of the biological processes controlled by a trans-acting factor, and connections between ... [more ▼]

The in silico prediction of cis-acting elements in a genome is an efficient way to quickly obtain an overview of the biological processes controlled by a trans-acting factor, and connections between regulatory networks. Several regulon prediction web tools are available, designed to identify DNA motifs predicted to be bound by transcription factors using position weight matrix-based algorithms. In this paper we expose and discuss the conflicting objectives of software creators (bioinformaticians) and software users (biologists), who aim for reliable and exhaustive prediction outputs, respectively. Software makers, concerned with providing tools that minimise the number of false positive hits, often impose a stringent threshold score for a sequence to be included in the list of the putative cis-acting sites. This rigidity eventually results in the identification of strongly reliable but largely straightforward sites, i.e. those associated with genes already anticipated to be targeted by the studied transcription factor. Importantly, this biased identification of strongly bound sequences contrasts with the biological reality where, in many circumstances, a weak DNA-protein interaction is required for the appropriate gene's expression. We show here a series of transcriptionally controlled systems involving weakly bound cis-acting elements that could never have been discovered because of the policy of preventing software users from modifying the screening parameters. Proposing only trustworthy prediction outputs thus prevents biologists from fully utilising their knowledge background and deciding to analyse statistically irrelevant hits that could nonetheless be potentially involved in subtle, unexpected, though essential cis-trans relationships. [less ▲]

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See detailDetonator and Bomb of Streptomyces coelicolor development
Rigali, Sébastien ULg

Scientific conference (2014, November 28)

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See detailPrediction of Regulatory Networks & Control of Secondary Metabolite Biosynthesis
Rigali, Sébastien ULg

Conference (2014, October 10)

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See detailThe cellobiose-sensor CebR is the gatekeeper of Streptomyces scabies pathogenicity
Jourdan, Samuel ULg; Francis, Isolde; Loria, Rosemary et al

Poster (2014, October)

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See detailOne click… and a novel Antibiotic !
Rigali, Sébastien ULg

Scientific conference (2014, September 26)

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See detailProdiginines: cell-death associated metabolites in Nature and Medicine
Rigali, Sébastien ULg

Conference (2014, September 09)

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See detailAltered Desferrioxamine-mediated Iron Utilization is a Common Trait of bald Mutants of Streptomyces coelicolor
Lambert, Stéphany ULg; Traxler, Matthew F; Craig, Matthias et al

in Metallomics (2014)

Detailed reference viewed: 52 (23 ULg)
See detailStreptomyces in nature and medicine
Rigali, Sébastien ULg

Scientific conference (2014, January 31)

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See detailGlnR-mediated regulation of nitrogen metabolism in the actinomycete Saccharopolyspora erythraea
Li-Li, Yao; Cheng-Heng, Liao; Gang, Huang et al

in Applied Microbiology and Biotechnology (2014)

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See detailControl of chitin and N-acetylglucosamine utilization in Saccharopolyspora erythraea.
Liao, Chengheng; Rigali, Sébastien ULg; Licona-Cassani, C et al

in Microbiology (2014)

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See detailStreptomyces in Nature and Medicine
Rigali, Sébastien ULg

Scientific conference (2013, November 22)

Detailed reference viewed: 17 (5 ULg)
See detailStory of a superman and a superbug
Rigali, Sébastien ULg

Scientific conference (2013, May)

Detailed reference viewed: 9 (2 ULg)
See detailStory of a superman and a superbug
Rigali, Sébastien ULg

Scientific conference (2013, April)

Detailed reference viewed: 6 (1 ULg)
See detailStreptomyces : a Superbug
Rigali, Sébastien ULg

Conference given outside the academic context (2013)

Detailed reference viewed: 25 (0 ULg)