Analyse des facteurs pronostiques des gliomes cérébraux
Kaschten, Bruno ; Dubuisson, Annie ; Lenelle, Jacques et al
Conference (1998, March 14)Detailed reference viewed: 26 (2 ULg)
Gliomatosis Cerebri: Clinical, Radiological and Pathological Report of a Case with a Stroke-Like Onset
Schoenen, Jean ; ;
in Acta Neurologica Belgica (1996), 96(4), 294-300
A 62 year-old man was admitted with a right hemiparesis, sensory aphasia and right hemianopia which appeared on awakening. He was initially thought to have a stroke, but EEG showed diffuse slowing and ... [more ▼]
A 62 year-old man was admitted with a right hemiparesis, sensory aphasia and right hemianopia which appeared on awakening. He was initially thought to have a stroke, but EEG showed diffuse slowing and both CT scan and MRI irregular white matter lesion suggesting a leucoencephalopathy. His neurological deficit regressed, and he was discharged after 2 weeks. He was readmitted 6 months later because of mental confusion. MRI revealed diffuse white matter lesions extending up to the frontal lobes, these were hyperintense on T2 weighted images and suggested the diagnosis of gliomatosis cerebri (GC). The patient became progressively comatose and died 6 weeks later. At autopsy the brain looked diffusely swollen with irregular greyish areas of the white matter of both centrum ovale and brain stem. On microscopic examination the cerebrum and brain stem were diffusely and asymmetrically infiltrated by numerous neoplastic glial cells without angiogenesis or disruption of architectonic boundaries. There were no mitoses nor necrosis. Many tumour cells were GFAP- and S100-positive. A high proportion of cells contained the leucocyte antigen Leu-7. This case of gliomatosis cerebri is compared to the 9 published cases of GC with an initial focal neurological deficit and to the 19 publications reporting MRI results. The controversial nosological boundaries and etiopathogenetic hypotheses of this peculiar neoplastic disease are discussed. [less ▲]Detailed reference viewed: 29 (2 ULg)
Type II to type I transformation of chronically stimulated goat latissimus dorsi muscle: a histoenzymological, biochemical, bioenergetic, and functional study.
; ; et al
in European Surgical Research = Europäische Chirurgische Forschung = Recherches Chirurgicales Européennes (1996), 28
Five goat latissimus dorsi muscles (LDM) were submitted to a progressive chronic electrostimulation program to reach an integrated understanding of the fast-to-slow transformation process in large mammals ... [more ▼]
Five goat latissimus dorsi muscles (LDM) were submitted to a progressive chronic electrostimulation program to reach an integrated understanding of the fast-to-slow transformation process in large mammals. LDM were regularly sampled and followed during a period of 8 months. Each sample was simultaneously assessed for histoenzymological study, myosin and LDH isoforms and bioenergetic capacities [NADH dehydrogenase cytochrome c oxidoreductase (NADH Cyt c OR), succinate dehydrogenase cytochrome c oxidoreductase (Succ Cyt c OR), cytochrome c oxidase (Cyt c Ox) and LDH]. Such muscles were also tested with and without completion of II to I transformation for their mechanical properties in isometric and isotonic strain gauge testing. The conversion of fast-to-slow myosin monitored by heavy chain (HC I) and light chain slow component (LC2s) began a few days after stimulation and was almost 100% after 100 days. The H-LDH isoforms evolved similarly but did not reach 100% conversion after 200 days. The activity of respiratory chain oxidases increased within 36 h but to a variable extent and peaked after 32 days, corresponding to a 75% transformation of myosin compared to initial levels. NADH Cyt c OR, Succ Cyt c OR, and Cyt c Ox, respectively increased 10-, 5- and 5-fold. These activities then significantly decreased before the completion of the myofibrillar transformation and reached a plateau with stable activities that remained 2- to 3-fold higher than the unstimulated LDM. LDH activity sharply decreased until day 62 (5-fold) and then plateaued. Functionally, muscle showed a reduced speed of contraction and moderate reduction in power output but had become fatigue-resistant. This study documents the transformation process in large mammals and suggests the dynamic relation between workload, aerobic-anaerobic metabolism and the contractile myofibrillar system. [less ▲]Detailed reference viewed: 18 (7 ULg)
Fundamentals of transformed skeletal muscle used for cardiac assistance. An overview
; ; Sluse, Francis et al
in Research in Surgery (1995), 7Detailed reference viewed: 14 (6 ULg)
Fate of unstimulated Latissimus Dorsi transposed into the chest and applied to cardiomyoplasty
; ; et al
in Research in Surgery (1994), 6(1), 35-39Detailed reference viewed: 11 (7 ULg)
Aldosterone-secreting adrenal adenoma as part of multiple endocrine neoplasia type 1 (MEN1) : loss of heterozygosity for polymorphic chromosome 11 DNA markers, including the MEN1 locus.
Beckers, Albert ; ; et al
Conference (1992)Detailed reference viewed: 5 (3 ULg)
Quantification and distribution pattern of corticotropin-releasing hormone receptors at the cellular level in normal and adenomatous human pituitary.
; ; Beckers, Albert et al
Conference (1992)Detailed reference viewed: 12 (0 ULg)
Influence of tension reduction and peripheral dissection on histologic, biochemical and bioenergetic profiles, and kinetics of skeletal muscle fast-to-slow transformation.
; Sluse, Francis ; et al
in Journal of Cardiac Surgery (1991), 6(1), 195-206Detailed reference viewed: 6 (3 ULg)
Localization of gonadotropins in pituitaries of various animals especies and in humans
; Beckers, Albert ; et al
in de la Cruz, L. F.; Garcia Luna, M. T. (Eds.) Recent advances in growth and reproduction (1990)Detailed reference viewed: 4 (0 ULg)
Immunocytochemical evidence that LH and FSH are produced by distinct cells in bovine pituitary.
; Beckers, Albert ; et al
in Theriogenology January (1990)Detailed reference viewed: 1 (1 ULg)
Gonadotropin secretion in the bovine : localization of LH and FSH in pituitaries by electron microscopy.
; Beckers, Albert ; et al
in Journal of Endocrinological Investigation (1990)Detailed reference viewed: 4 (0 ULg)
Myositis During Borrelia Burgdorferi Infection (Lyme Disease)
Schoenen, Jean ; ; et al
in Journal of Neurology, Neurosurgery & Psychiatry (1989), 52(8), 1002-5
During the second stage of an illness caused by Borrelia burgdorferi, a young woman developed a myopathic syndrome characterised by severe muscular pains, incapacitating weakness of the proximal limb and ... [more ▼]
During the second stage of an illness caused by Borrelia burgdorferi, a young woman developed a myopathic syndrome characterised by severe muscular pains, incapacitating weakness of the proximal limb and the neck, as well as the bulbar muscles and elevated serum CK levels. Muscle biopsy revealed a non-inflammatory necrotising myopathy. B. burgdorferi infection was confirmed by a considerable rise of specific IgG antibodies. A course of high dose steroids alleviated the myalgias, but paresis began to improve only after treatment with antibiotics. Our observations confirm that B burgdorferi can cause, through an undertermined mechanism, a necrotising myopathy, in addition to the wide spectrum of already known neurological complications. [less ▲]Detailed reference viewed: 31 (1 ULg)
Substance P, enkephalins, somatostatin, cholecystokinin, oxytocin, and vasopressin in human spinal cord.
Schoenen, Jean ; ; et al
in Neurology (1985), 35(6), 881-90
Several neuropeptides were immunohistologically studied in normal human spinal cords. Substance P, methionine-enkephalin, leucine-enkephalin, and cholecystokinin positive fibers were found in all ... [more ▼]
Several neuropeptides were immunohistologically studied in normal human spinal cords. Substance P, methionine-enkephalin, leucine-enkephalin, and cholecystokinin positive fibers were found in all cytoarchitectonic layers, with a specific distribution pattern for each peptide. Somatostatin, oxytocin, and vasopressin immunoreactivities were restricted to particular spinal layers. Perikarya and proximal dendrites were visualized and classified by comparison with previous Golgi analyses. Substance P was contained in "radiate cells" of layer III, methionine-enkephalin in marginal neurons as well as in layer II "stellate cells," and somatostatin in layer II "islet cells." Several results differed from those reported in other species. Chemical neuroanatomy may provide new insights into the neuronal organization of the human spinal cord. [less ▲]Detailed reference viewed: 18 (0 ULg)
; Schoenen, Jean
in Acta Neuropathologica (1983), 59(2), 88-94
A new case of Lhermitte-Duclos disease (dysplastic gangliocytoma of the cerebellum) was recognized in an adult man after neurosurgery. Conventional, Golgi, and electron-microscopic investigations support ... [more ▼]
A new case of Lhermitte-Duclos disease (dysplastic gangliocytoma of the cerebellum) was recognized in an adult man after neurosurgery. Conventional, Golgi, and electron-microscopic investigations support the view that this rare lesion results from a progressive hypertrophy of granular cell neurons with excess of myelination of their axons in the molecular layer while inducing the local disappearance of Purkinje cells and the central core of the cerebellar folia. After a follow-up of 4 years, the patient now leads a normal life; no recurrence has occurred and no other neuropathologic alteration have been detected. [less ▲]Detailed reference viewed: 20 (0 ULg)