References of "Renard, Cécile"
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See detailTreating verbal short-term memory deficits by increasing the duration of temporary phonological representations : a case study
Majerus, Steve ULg; Van Der Kaa, M. A.; Renard, Cécile ULg et al

in Brain & Language (2005), 95(1), 174-175

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See detailOntogenesis and functional aspects of oxytocin and vasopressin gene expression in the thymus network
Hansenne, Isabelle ULg; Rasier, G.; Pequeux, Christel ULg et al

in Journal of Neuroimmunology (2005), 158(1-2), 67-75

Ontogenesis of oxytocin (OT) and vasopressin (VP) gene expression and function were investigated in murine thymus. OT and VP transcripts were detected in the thymus on embryonic days 13 and 15 ... [more ▼]

Ontogenesis of oxytocin (OT) and vasopressin (VP) gene expression and function were investigated in murine thymus. OT and VP transcripts were detected in the thymus on embryonic days 13 and 15, respectively. Corresponding messenger RNAs were evidenced in thymic epithelial cells by in situ hybridization with a neurophysin probe. From all OT and VP receptors, only OTR was expressed by all T-cell subsets, while V1bR was found in double positive and single positive CD8 cells. In fetal thymic organ cultures, OTR antagonist d[DTyr(Et)(2), Thr(4)]OVT increased early apoptosis of CD8 cells, while V1bR antagonist (Sanofi SSR 149415) inhibited T-cell differentiation, and favored CD8 T-cell commitment. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailNouvelles donnees sur la pathogenie du diabete de type 1
Geenen, Vincent ULg; Brilot, F.; Louis, Céline ULg et al

in Revue Médicale de Liège (2005), 60(5-6, May-Jun), 291-6

The autoimmune nature of the diabetogenic process and the major contribution of T lymphocytes stand now beyond any doubt. However, despite the identification of the three major type 1-diabetes-related ... [more ▼]

The autoimmune nature of the diabetogenic process and the major contribution of T lymphocytes stand now beyond any doubt. However, despite the identification of the three major type 1-diabetes-related autoantigens (insulin, GAD65 and phosphatase IA-2), the origin of this immune dysregulation still remains unknown. More and more evidence supports a thymic dysfunction in the establishment of central self-tolerance to the insulin family as a crucial factor in the development of the autoimmune response selective of pancreatic insulin-secreting islet beta cells. All the genes of the insulin family (INS, IGF1 and IGF2) are expressed in the thymus network. However, IGF-2 is the dominant member of this family first encountered by T cells in the thymus, and only IGFs control early T-cell differentiation. IGF2 transcription is defective in the thymus in one animal model of type 1 diabetes, the Bio-Breeding (BB) rat. The sequence B9-23, one dominant autoantigen of insulin, and the homologous sequence B11-25 derived from IGF-2 exibit the same affinity and fully compete for binding to DQ8, one class-II major histocompatibility complex (MHC-II) conferring major genetic susceptibility to type 1 diabetes. Compared to insulin B9-23, the presentation of IGF-2 B11-25 to peripheral mononuclear cells (PBMCs) isolated from type 1 diabetic DQ8+ adolescents elicits a regulatory/tolerogenic cytokine profile (*IL-10, *IL-10/IFN-g, *IL-4). Thus, administration of IGF-2 derived self-antigen(s) might constitute a novel form of vaccine/immunotherapy combining both an antagonism for the site of presentation of a susceptible MHC allele, as well as a downstream tolerogenic/regulatory immune response. [less ▲]

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See detailFibromyalgie et performances musculaires
Maquet, Didier ULg; Croisier, Jean-Louis ULg; Renard, Cécile ULg et al

in Revue du Rhumatisme [Ed Fr] (2002), 69(3), 518-525

Objectifs. Évaluer la fonction musculaire d’un groupe de patientes fibromyalgiques et la comparer à celle d’une population féminine de référence. Méthodes. Seize patientes fibromyalgiques et 87 sujets ... [more ▼]

Objectifs. Évaluer la fonction musculaire d’un groupe de patientes fibromyalgiques et la comparer à celle d’une population féminine de référence. Méthodes. Seize patientes fibromyalgiques et 87 sujets sains féminins sédentaires ou sportifs de loisir ont exécuté un protocole expérimental composé de quatre épreuves. La première évaluait le moment de force isocinétique concentrique maximum des muscles extenseurs et fléchisseurs du genou dominant. Un dynamomètre de Colin autorisait une mesure de la force manuelle isométrique. La résistance musculaire à la fatigue s’appréciait lors d’une épreuve isocinétique de flexion–extension des genoux : le sujet enchaînait 30 contractions concentriques d’intensité maximale à la vitesse angulaire de 180 °/s. La dernière épreuve évaluait l’endurance musculaire statique à l’aide de tests exigeant le maintien d’une position donnée. Résultats. Toutes les variables musculaires apparaissaient réduites chez les sujets fibromyalgiques. Ce déficit, déjà manifeste pour les efforts anaérobiques, s’accentuait lors des efforts en aérobie. Le déficit moyen correspondait à 39 % (p < 0,001) pour la force musculaire, 40 % (p < 0,0001) pour la résistance musculaire à la fatigue et 81 % (p < 0,0001) pour l’endurance musculaire statique. Les perceptions nociceptives au cours de l’effort, évaluées à l’aide d’une échelle visuelle analogique, étaient supérieures chez les patientes fibromyalgiques. Conclusion. L’exploration combinée des trois filières énergétiques confirme l’altération générale de la fonction musculaire du sujet fibromyalgique. Cette étude suggère cependant une perturbation préférentielle des composantes oxydatives. [less ▲]

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See detailInvolvement of Insulin-Like Growth Factors in Early T Cell Development: A Study Using Fetal Thymic Organ Cultures
Kecha, O.; Brilot, F.; Martens, Henri ULg et al

in Endocrinology (2000), 141(3), 1209-17

The expression of insulin-like growth factor (IGF) and IGF receptor genes was investigated by RT-PCR during ontogeny of the murine thymus. IGF-1, IGF-1R, M6P/IGF-2R genes are expressed in the thymus both ... [more ▼]

The expression of insulin-like growth factor (IGF) and IGF receptor genes was investigated by RT-PCR during ontogeny of the murine thymus. IGF-1, IGF-1R, M6P/IGF-2R genes are expressed in the thymus both in fetal and postnatal life, whereas IGF-2 messenger RNAs (mRNAs) decline after birth but are still detectable on the seventh week. By in situ hybridization, IGF-2 transcripts were located in the outer cortex and medulla of the postnatal thymus, and on the whole surface ofthe epithelial-like network in the fetal thymus. The effects of anti-IGFs and IGF-receptors neutralizing Abs on the generation of pre-T cell subpopulations were then investigated using fetal thymic organ cultures (FTOC). FTOC treatment with an anti-IGF-2 mAb, an anti-IGF-1R mAb, or an anti-M6P/IGF-2R polyclonal Ab induced a blockade of T cell differentiation at the CD4-CD8- stage, as shown by a significant increase in the percentage of CD4-CD8- cells and a decrease in the percentage of CD4+CD8+ cells. Moreover, anti-IGF-2 Ab treatment induced an increase in CD8+ cells suggesting that thymic IGF-2 might have a role in determining differentiation into the CD4 or CD8 lineage. Anti-IGF-1 Ab treatment decreased the proportion in CD4-CD8- cells and increased the frequency in CD4+CD8+. FTOC treatment with anti-(pro)insulin did not exert any significant effect on T cell development. These data indicate that the intrathymic IGF-mediated signaling plays an active role in the early steps of T cell differentiation during fetal development. [less ▲]

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See detailIn-vivo studies on Haemaccel-fibronectin interaction in man.
Damas, Pierre ULg; Adam, Aurore ULg; Buret, J. et al

in European Journal of Clinical Investigation (1987), 17(2), 166-73

An enzyme-linked immunoassay has been recently set up for direct measurement of the binding capacity of plasma fibronectin to gelatin. This binding capacity could be completely inhibited in vitro by an ... [more ▼]

An enzyme-linked immunoassay has been recently set up for direct measurement of the binding capacity of plasma fibronectin to gelatin. This binding capacity could be completely inhibited in vitro by an eight-fold excess of gelatin, of Haemaccel, but not of Geloplasma. On the contrary, the levels of immunoreactive fibronectin measured by laser nephelometry did not change, in presence of 10 to 1000 micrograms ml-1 of gelatin, of Haemaccel or of Geloplasma. When infused into normal volunteers, Haemaccel provoked a strong and immediate inhibition of the plasma fibronectin binding capacity to gelatin. This inhibition was dose-dependent and maximal after infusion of 500 ml of Haemaccel. Twenty-four hours after this infusion, there was a progressive recovery of the gelatin-binding capacity, which was almost completely achieved 96 h later. The formation of complexes between Haemaccel and fibronectin was demonstrated by gel filtration chromatography and by affinity chromatography. Immunoreactive plasma fibronectin levels remained unchanged up to 24 h after infusion of 500 ml of Haemaccel. A transient decline to 50% of its initial value then occurred the second day after the infusion. Therefore, a delay existed between the formation of fibronectin-Haemaccel complexes and their elimination from the bloodstream. This delay decreased when smaller volumes of Haemaccel were infused, which strongly suggests that plasma fibronectin is cleared by means of Haemaccel and does not seem to play a role of opsonin in these conditions.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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