Coumarinic derivatives show anti-inflamatory effects on alveolor macrophages, but their anti-elastase activity is essential to reduce lung inflammation in vivo

in International Immunopharmacology (2009), 9

3-Bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo

in British Journal of Cancer (2003), 88(7), 1111-1118

In search for new anticancer agents, we have evaluated the antiinvasive and antimigrative properties of recently developed synthetic coumarin derivatives among which two compounds revealed important ... [more ▼]

In search for new anticancer agents, we have evaluated the antiinvasive and antimigrative properties of recently developed synthetic coumarin derivatives among which two compounds revealed important activity: 3-chlorophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate and 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate, Both drugs were able to inhibit cell invasion markedly in a Boyden chamber assay, the bromo derivative being more potent than the reference matrix metalloprotease (MMP) inhibitor GI 129471. In vivo, tumour growth was reduced when nude mice grafted with HT 1080 or MDA-MB231 cells were treated i.p. 3 days week(-1) with the bromo coumarin derivative. These effects were not associated with the inhibition of urokinase, plasmin, MMP-2 or MMP-9. The mechanism of action of the drugs remains to be elucidated. However, these two coumarin derivatives may serve as new lead compounds of an original class of antitumour agents. [less ▲]

Effects on in vitro and in vivo cellular invasion of two 6-(acetoxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives

Poster (2001, October 16)

Comparaison de l’effet de deux dérivés de l’acide 6-(acetoxymethyl)-2-oxo-2H-1-benzopyrane-3-carboxylique sur l’inhibition de l’invasion cellulaire in vitro et in vivo

Poster (2001, June 01)

Inhibition mechanism of serine protease by coumarin derivatives

Conference (2001, May)

Effects on cellular invasion of 6-(acetoxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives

Poster (2001, April 21)

Inhibition of cellular invasion by 3-chlorophenyl 6-(acetoxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylate

Poster (2000, September)

Specific inhibitors of human leukocyte elastase

Poster (2000, August)

Le 6-(acetoxymethyl)-2-oxo-2H-1-benzopyrane-3-carboxylate de 3-chlorophényle agissant en tant qu’inhibiteur potentiel de l’invasion tumorale

Poster (2000, May)

Les esters de l’acide 6-(acétoxyméthyl)-2-oxo-2H-1-benzopyrane-3-carboxylique en tant qu’agents antiinvasifs potentiels dans le traitement du cancer

Conference (2000, January 28)