References of "Reboud-Ravaux, M"
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See detailCoumarinic derivatives show anti-inflamatory effects on alveolor macrophages, but their anti-elastase activity is essential to reduce lung inflammation in vivo
Bissonnette, E. Y.; Tremblay, G. M.; Turmel, V. et al

in International Immunopharmacology (2009), 9

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See detailTowards the control of intercellular protein turnover: Mitochondrial Lon protease inhibitors versus proteasome inhibitors
Bayot, A.; Basse, N.; Lee, I. et al

in Biochimie (2008), 90

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See detail3-Bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo
Kempen, I.; Papapostolou, D.; Thierry, N. et al

in British Journal of Cancer (2003), 88(7), 1111-1118

In search for new anticancer agents, we have evaluated the antiinvasive and antimigrative properties of recently developed synthetic coumarin derivatives among which two compounds revealed important ... [more ▼]

In search for new anticancer agents, we have evaluated the antiinvasive and antimigrative properties of recently developed synthetic coumarin derivatives among which two compounds revealed important activity: 3-chlorophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate and 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate, Both drugs were able to inhibit cell invasion markedly in a Boyden chamber assay, the bromo derivative being more potent than the reference matrix metalloprotease (MMP) inhibitor GI 129471. In vivo, tumour growth was reduced when nude mice grafted with HT 1080 or MDA-MB231 cells were treated i.p. 3 days week(-1) with the bromo coumarin derivative. These effects were not associated with the inhibition of urokinase, plasmin, MMP-2 or MMP-9. The mechanism of action of the drugs remains to be elucidated. However, these two coumarin derivatives may serve as new lead compounds of an original class of antitumour agents. [less ▲]

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See detailDesign et synthèse de nouveaux dérivés coumariniques inhibiteurs de thrombine
Frederick, R.; Pochet, L.; Pirotte, Bernard ULg et al

Poster (2002, May 31)

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See detailEffects on in vitro and in vivo cellular invasion of two 6-(acetoxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives
Kempen, I.; Pochet, L.; Papapostolou, D. et al

Poster (2001, October 16)

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See detailInhibition of thrombin by oxobenzopyran derivatives: structure-activity relationships
Kibirev, V. K.; Lacan, F.; Bourdel, F. et al

Poster (2001, July)

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See detailSynthèse et évaluation enzymatique de nouvelles coumarines en tant qu’inhibiteurs de thrombine
Pochet, L.; Doucet, C.; Pirotte, Bernard ULg et al

Poster (2001, June 01)

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See detailInhibition mechanism of serine protease by coumarin derivatives
Pochet; Doucet, C.; Dieu, M. et al

Conference (2001, May)

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See detailEffects on cellular invasion of two synthetic coumarins
Kempen, I.; Papapostolou, D.; Pochet, L. et al

Conference (2001, May)

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See detailEffects on cellular invasion of 6-(acetoxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives
Kempen, I.; Pochet, L.; Papapostolu, D. et al

Poster (2001, April 21)

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See detailComparaison de l’effet de deux coumarines sur l’inhibition de l’invasion cellulaire in vitro et in vivo
Kempen, I.; Pochet, L.; Papapostolu, D. et al

Poster (2001, January 26)

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See detailInhibition of cellular invasion by 3-chlorophenyl 6-(acetoxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylate
Kempen, I.; Pochet, L.; Papapostulu, D. et al

Poster (2000, September)

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See detailOxobenzopyran derivatives as thrombin inhibitors
Bourdel, F.; Lacan, F.; Doucet, C. et al

Poster (2000, September)

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See detailSpecific inhibitors of human leukocyte elastase
Reboud-Ravaux, M.; Pochet, L.; Doucet, C. et al

Poster (2000, August)

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See detailActivity and inhibition mechanism of coumarin-based derivatives as protease inhibitor
Pochet, L.; Doucet, C.; Dieu, M. et al

Poster (2000, June)

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See detailLe 6-(acetoxymethyl)-2-oxo-2H-1-benzopyrane-3-carboxylate de 3-chlorophényle agissant en tant qu’inhibiteur potentiel de l’invasion tumorale
Kempen, I.; Papapostolu, D.; Pochet, L. et al

Poster (2000, May)

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See detailInhibition of cancer cells invasion by coumarin derivatives
Kempen, I.; Pochet, L.; Doucet, C. et al

Poster (2000, January 29)

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See detailLes esters de l’acide 6-(acétoxyméthyl)-2-oxo-2H-1-benzopyrane-3-carboxylique en tant qu’agents antiinvasifs potentiels dans le traitement du cancer
Kempen, I.; Pochet, L.; Doucet, C. et al

Conference (2000, January 28)

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