  CCL2 as a serum biomarker of idiopathic pulmonary fibrosis in dogsKrafft, Emilie  ; Roels, Elodie ; et alPoster (2012, October 19) Detailed reference viewed: 16 (4 ULg)Gene expression profiles in canine idiopathic pulmonary fibrosisKrafft, Emilie ; ; et alin Proceedings of 17th International consortium on lung and airways fibrosis (2012, October 01) Detailed reference viewed: 6 (1 ULg)CCL2 as a serum biomarker of idiopathic pulmonary fibrosis in dogsKrafft, Emilie ; Roels, Elodie ; et alin Proceedings of 22nd ECVIM Meeting - Masstricht, Netherlands (2012, September) Detailed reference viewed: 8 (1 ULg)Transforming growth factor-beta 1 and its activating pathways in canine idiopathic pulmonary fibrosisKrafft, Emilie ; ; et alin Proceedings of the 22nd ECVIM-CA Congress (2012, September) Detailed reference viewed: 9 (4 ULg)Investigation of cytokine expression in canine idiopathic pulmonary fibrosisKrafft, Emilie ; ; Vanherberghen, Morgane et alin Proceeding of 29th VCRS Symposium (2011, November 02) Detailed reference viewed: 7 (3 ULg)High serum transforming growth factor-beta 1 concentration in West Highland white terriers : a key to the breed predisposition in canine idiopathic pulmonary fibrosisKrafft, Emilie ; ; et alin Proceedings of the 21st ECVIM-CA Congress (2011, September) Detailed reference viewed: 9 (1 ULg)Use of expression microarray to identify potential biomarkers of idiopathic pulmonary fibrosis in dogsKrafft, Emilie ; ; Vanherberghen, Morgane et alin Proceedings of 29th ACVIM Forum (2011, June) Detailed reference viewed: 8 (0 ULg)Gene expression profiles in canine idiopathic pulmonary fibrosisKrafft, Emilie ; ; Vanherberghen, Morgane et alin Proceedings of the 29th ACVIM Forum (2011, June) Detailed reference viewed: 9 (1 ULg) Serum and bronchoalveolar lavage fluid endothelin-1 concentrations as diagnostic biomarkers of canine idiopathic pulmonary fibrosisKrafft, Emilie ; ; et alin Journal of Veterinary Internal Medicine (2011) Background: Diagnosis of canine idiopathic pulmonary fibrosis (IPF) is challenging. Endothelin-1 (ET1) is a biomarker of IPF in humans, but whether ET1 can detect and differentiate IPF from other canine ... [more ▼] Background: Diagnosis of canine idiopathic pulmonary fibrosis (IPF) is challenging. Endothelin-1 (ET1) is a biomarker of IPF in humans, but whether ET1 can detect and differentiate IPF from other canine respiratory diseases is unknown. Objective: To evaluate whether measurement of the concentration of ET1 in serum and bronchoalveolar lavage fluid (BALF) can be used to distinguish canine IPF from chronic bronchitis (CB) and eosinophilic bronchopneumopathy (EBP). Animals: Twelve dogs with IPF, 10 dogs with CB, 6 dogs with EBP, 13 privately owned healthy West Highland White Terriers (WHWT), and 9 healthy Beagle dogs. Methods: Prospective, case control study. ET1 concentration was determined by ELISA in serum and in BALF. Results: No significant difference in serum ET1 concentration was detected between healthy Beagle dogs and WHWT. Serum ET1 concentration was higher in dogs with IPF (median interquartile range; 2.32 pg/mL, 2.05-3.38) than healthy Beagle dogs (1.28, 1.07-1.53; P < .001), healthy WHWT (1.56, 1.25-1.85; P < .001), dogs with EBP (0.94 0.68-1.01; P = .001), and dogs with CB (1.54 0.74-1.82; P = .005). BALF ET1 concentration was below the detection limit in healthy WHWT and in dogs with CB, whereas it was measurable in all dogs with IPF. A cut-off serum concentration of 1.8 pg/mL had a sensitivity of 100% and a specificity of 81.2% for detection of IPF, with an area under the receiver operating characteristic curve of 0.818. Conclusions and Clinical Importance: Serum ET1 can differentiate dogs with IPF from dogs with EBP or CB. ET1 can be detected in BALF of dogs with IPF. [less ▲] Detailed reference viewed: 11 (2 ULg)Clinical, bronchoscopic, histopathologic, diagnostic imaging, and arterial oxygenation findings in West Highland White Terriers with idiopathic pulmonary fibrosis.; ; et al in Journal of Veterinary Internal Medicine (2011) BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic, interstitial lung disease primarily affecting West Highland White Terriers (WHWTs). OBJECTIVE: To describe the clinicopathological and ... [more ▼] BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic, interstitial lung disease primarily affecting West Highland White Terriers (WHWTs). OBJECTIVE: To describe the clinicopathological and diagnostic imaging features in WHWTs with IPF. ANIMALS: Twelve WHWTs with IPF and 14 healthy control WHWTs. METHOD: Prospective study. Clinical signs and findings of physical examination, blood and arterial blood gas analyses, radiography, high-resolution computed tomography (HRCT), bronchoscopy and bronchoalveolar lavage (BAL) of IPF dogs were obtained and compared with controls. Histopathologic changes in IPF dogs were evaluated. RESULTS: Mean partial pressure of oxygen was significantly lower in IPF (mean ± SD, 65.5 ± 15.4 mmHg) than in controls (99.1 ± 7.8 mmHg, P<.001). The alveolar-arterial oxygen gradient was significantly higher in IPF (50.1 ± 17.3 mmHg) than in controls (17.5 ± 4.9 mmHg, P<.001). In HRCT, ground glass opacity (GGO) was detected in all IPF dogs, traction bronchiectasis in 4, and honeycombing in 1. Bronchoscopic airway changes were noted in all IPF dogs. On BAL fluid (BALF) cytology, the total cell count (TCC) was higher in IPF dogs, and the numbers but not the percentages of macrophages, neutrophils, and mast cells were increased. On histopathology, multifocal or diffuse interstitial fibrosis, type II pneumocyte hyperplasia, prominent intraalveolar macrophages, distortion of alveolar architecture, and emphysematous change were detected. CONCLUSION AND CLINICAL IMPORTANCE: IPF causes substantial hypoxemia. In HRCT, GGO is a consistent finding. IPF dogs have concurrent airway changes and an increase in BALF TCC. [less ▲] Detailed reference viewed: 10 (4 ULg)Procollagen type III amino terminal propeptide concentration in dogs with iodiopathic pulmonary fibrosis, chronic bronchitis and eosinophilic bronchopneumopathy; Krafft, Emilie ; et alin 20th ECVIM Meeting - Toulouse - France - 9-12 septembre 2010 (2010, September 09) Detailed reference viewed: 9 (0 ULg)Elevation of procollagen type III amino terminal propeptide concentration in bronchoalveolar lavage fluid of dogs with idiopathic pulmonary fibrosis; Krafft, Emilie ; et alPoster (2010, June 09) Detailed reference viewed: 7 (2 ULg)Serum endothelin-1 concentration in terrier dogs with idiopathic pulmonary fibrosis.Krafft, Emilie ; ; et alin Proceedings of the 28th ACVIM Forum (2010, June) Detailed reference viewed: 17 (7 ULg)Endothelin-1 as a serum biomarker in idiopathic pulmonary fibrosis in dogsKrafft, Emilie ; ; et alin Proceedings of the 20th ECVIM-CA Congress (2010) Detailed reference viewed: 10 (1 ULg) |
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