References of "Rajamäki, M.M"
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See detailCanine idopathic pulmonary fibrosis is not associated with herpes virus infection
Roels, Elodie ULg; Dourcy, Mickael ULg; Holopainen, S. et al

Poster (2015, October)

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See detailCHEMOKINE (CC-MOTIF) LIGAND 2 AS A PROGNOSTIC SERUM MARKER IN CANINE IDIOPATHIC PULMONARY FIBROSIS
Roels, Elodie ULg; Holopainen, S.; Teske, Erik ULg et al

Poster (2015, September 11)

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See detailVascular endothelial growth factor: a blood biomarker in canine idiopathic pulmonary fibrosis.
Roels, Elodie ULg; Krafft, Emilie ULg; Laurila, HP et al

Poster (2014, October 17)

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See detailVascular endothelial growth factor : a blood biomarker in canine pulmonary fibrosis.
Roels, Elodie ULg; Krafft, Emilie ULg; Heikkilä, H.P. et al

in Proceedings of the 24th Ecvim Meeting, Mainz, Germany - 4-6 September 2014 (2014, September)

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See detailLong-term outcome and use of 6-Minute Walk test in West Highland white Terriers with idiopathic pulmonary fibrosis
Lilja-Maula, LIO; Laurila, HP; Syrjä, P et al

in Journal of Veterinary Internal Medicine (2014), 28(2), 379-385

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See detailTransforming Growth Factor Beta 1 Activation, Storage, and Signaling Pathways in Idiopathic Pulmonary Fibrosis in Dogs.
Krafft, Emilie; Lybaert, P.; Roels, Elodie ULg et al

in Journal of Veterinary Internal Medicine (2014), 28

BACKGROUND: The pathogenesis of idiopathic pulmonary fibrosis (IPF) in dogs is poorly understood. In human, transforming growth factor beta1 (TGF-beta1) is considered central in the pathogenesis ... [more ▼]

BACKGROUND: The pathogenesis of idiopathic pulmonary fibrosis (IPF) in dogs is poorly understood. In human, transforming growth factor beta1 (TGF-beta1) is considered central in the pathogenesis. OBJECTIVES: To investigate TGF-beta1 pathway in IPF. ANIMALS: Lung tissues from 12 affected and 11 control dogs. Serum from 16 affected West Highland white Terriers (WHWTs) and healthy dogs from predisposed (13 WHWTs, 12 Scottish Terriers and 13 Bichons Frise) and nonpredisposed breeds (10 Whippets, 10 Belgian shepherds, 8 Labradors). METHODS: In this prospective study, immunohistochemistry was used to evaluate expression and localization of TGF-beta1 protein and proteins involved in TGF-beta1 signaling (TGF-beta receptor type I and phospho-Smad2/3). Pulmonary expression of TGF-beta1 and molecules involved in its storage (latent TGF-beta binding proteins [LTBP] 1, 2, and 4), activation (alphanubeta6 and alphanubeta8 integrins, thrombospondin-1) and signal inhibition (Smad 7) was analyzed by quantitative reverse transcriptase PCR. Circulating TGF-beta1 concentration was measured by ELISA. RESULTS: In IPF, high level of TGF-beta1 protein was found in areas of fibrosis, epithelial cells had strong expression of TGF-beta receptor type 1 and phospho-Smad2/3, gene expression was decreased for LTBP 4 (P = .009) and beta8 integrin (P < .001) and increased for thrombospondin-1 (P = .016); no difference was seen for Smad7, LTBP1 and 2. Serum TGF-beta1 concentration was higher in predisposed compared with nonpredisposed breeds (P < .0001). CONCLUSIONS AND CLINICAL IMPORTANCE: This study identified an enhanced TGF-beta1 signaling activity in IPF. TGF-beta1 storage and activation proteins with altered expression represent potential therapeutic targets. Higher circulating TGF-beta1 concentration in predisposed breeds might partly explain their susceptibility for IPF [less ▲]

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See detailThe histopathology of idiopathic pulmonary fibrosis in West Highland white terriers shares features of both non-specific interstitial pneumonia and usual interstitial pneumonia in man
Syrjä, P; Heikkilä, HP; Lilja-Maula, L et al

in Journal of Comparative Pathology (2013), 149(2-3), 303-313

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See detailIs the CXC-Chemokine CXCL8 involved in the breed predisposition of west highland white terrier to canine idiopathic pulmonary fibrosis ?
Roels, Elodie ULg; Krafft, Emilie ULg; Laurila, HP et al

in Proceedings of the 23th ECVIM Meeting (2013, September)

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See detailIMMUNOHISTOCHEMICAL ANALYSIS OF TRANSFORMING GROWTH FACTOR BETA 1 AND ITS SIGNALLING PATHWAYS IN CANINE IDIOPATHIC PULMONARY FIBROSIS
Krafft, Emilie ULg; Laurila, HP; Rajamäki, MM et al

in Proceedings of the 23th ECVIM Meeting (2013, September)

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See detailIs 5-Hydroxytryptamine (serotonin) involved in the pathogenesis of idiopathic pulmonary fibrosis in dogs ?
Krafft, Emilie ULg; Roels, Elodie ULg; Laurila et al

in Proceedings of the 23th ECVIM Meeting (2013, September)

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See detailImmunohistochemical transforming growth factor Beta1 and its activation, storage and signalling pathways in canine idiopathic pulmonary fibrosis
Krafft, Emilie ULg; Laurila, HP; Rajamäki, MM et al

in Proceedings of the 23th ECVIM Meeting (2013, September)

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See detailAnalysis of gene expression in canine idiopathic pulmonary fibrosis
Krafft, Emilie ULg; Laurila, HP; peters, IR et al

in Veterinary Journal (2013), 198(2), 479-486

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See detailTransforming growth factor beta 1 and its activation, storage and signalling pathways in canine idiopathic pulmonary fibrosis.
Krafft, Emilie ULg; Heikkilä, H.P.; Rajamäki, M.M. et al

Scientific conference (2013, July)

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See detailCCL2 as a serum biomarker of idiopathic pulmonary fibrosis in dogs
Krafft, Emilie ULg; Roels, Elodie ULg; Heikkilä, H.P. et al

Poster (2012, October 19)

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See detailGene expression profiles in canine idiopathic pulmonary fibrosis
Krafft, Emilie ULg; Heikkilä, H.P.; Peters, I. et al

in Proceedings of 17th International consortium on lung and airways fibrosis (2012, October 01)

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See detailCCL2 as a serum biomarker of idiopathic pulmonary fibrosis in dogs
Krafft, Emilie ULg; Roels, Elodie ULg; Heikkila, H.P. et al

in Proceedings of 22nd ECVIM Meeting - Masstricht, Netherlands (2012, September)

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