References of "ROMPEN, Eric"
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See detailLocalized Piezoelectric Alveolar Decortication for Orthodontic Treatment in Adults: A Randomized Controlled Trial
CHARAVET, Carole ULg; LECLOUX, Geoffrey ULg; BRUWIER, Annick ULg et al

in Journal of Dental Research (2016)

AIMS : This randomized controlled trial aimed to evaluate the benefits and clinical outcomes of piezocision, which is a minimally invasive approach to corticotomy that is used in orthodontic treatments ... [more ▼]

AIMS : This randomized controlled trial aimed to evaluate the benefits and clinical outcomes of piezocision, which is a minimally invasive approach to corticotomy that is used in orthodontic treatments. MATERIALS AND METHODS : Twenty-four adult patients presenting with mild overcrowdings were randomly allocated to either a control group that was treated with conventional orthodontics or a test group that received piezo-assisted orthodontics. The piezocisions were performed 1 wk week after the placement of the orthodontic appliances. Neither grafting material nor sutures were used. All patients were followed every 2 wk, and archwires were changed only when they were no longer active. The periods required for the completion of the overall orthodontic treatments were calculated, and the periodontal parameters were evaluated at baseline and at the end of the orthodontic treatment. Patient-centered outcomes were assessed with a visual analog scale; analgesic use following the procedures was also recorded. RESULTS : The patient characteristics were similar between the 2 groups. The overall treatment time was significantly reduced by 43% in the piezocision group as compared with the control group. In both groups, periodontal parameters (i.e., recession depth, pocket depth, plaque index, and papilla bleeding index) remained unchanged between the baseline and treatment completion time points. No increase in root resorption was observed in either group. Scars were observed in 50% of the patients in the piezocision group. Analgesic consumption was similar following orthodontic appliance placement and piezocision surgery. Patient satisfaction was significantly better in the piezocision group than in the control group. CONCLUSION : In these conditions, the piezocision technique seemed to be effective in accelerating orthodontic tooth movement. No gingival recessions were observed. The risk of residual scars might limit the indications for piezocision in patients with a high smile line (ClinicalTrials.gov NCT02590835) [less ▲]

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See detailA new method using insert-based systems (IBS) to improve cell behavior study on flexible and rigid biomaterials.
Grenade, Charlotte; Moniotte, Nicolas; Rompen, Eric ULg et al

in Cytotechnology (2016)

In vitro studies about biomaterials biological properties are essential screening tests. Yet cell cultures encounter difficulties related to cell retention on material surface or to the observation of ... [more ▼]

In vitro studies about biomaterials biological properties are essential screening tests. Yet cell cultures encounter difficulties related to cell retention on material surface or to the observation of both faces of permeable materials. The objective of the present study was to develop a reliable in vitro method to study cell behavior on rigid and flexible/permeable biomaterials elaborating two specific insert-based systems (IBS-R and IBS-F respectively). IBS-R was designed as a specific cylindrical polytetrafluoroethylene (PTFE) system to evaluate attachment, proliferation and morphology of human gingival fibroblasts (HGFs) on grade V titanium and lithium disilicate glass-ceramic discs characteristics of dental prostheses. The number of cells, their covering on discs and their morphology were determined from MTS assays and microscopic fluorescent images after 24, 48 and 72 h. IBS-F was developed as a two components system to study HGFs behavior on guided bone regeneration polyester membranes. The viability and the membrane barrier effect were evaluated by metabolic MTS assays and by scanning electron microscopy. IBS-R and IBS-F were shown to promote (1) easy and rapid handling; (2) cell retention on biomaterial surface; (3) accurate evaluation of the cellular proliferation, spreading and viability; (4) use of non-toxic material. Moreover IBS-F allowed the study of the cell migration through degradable membranes, with an access to both faces of the biomaterial and to the bottom of culture wells for medium changing. [less ▲]

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See detailOccurrence and risk indicators of medication-related osteonecrosis of the jaw after dental extraction: a systematic review and meta-analysis.
GAUDIN, Elise ULg; SEIDEL, Laurence ULg; Bacevic, Miljana ULg et al

in Journal of Clinical Periodontology (2015)

AIMS: The primary objective was to assess the occurrence rate of Medication-Related OsteoNecrosis of the Jaw (MRONJ) after dental extraction in patients treated with Anti-Resorptive Drugs (ARD) for ... [more ▼]

AIMS: The primary objective was to assess the occurrence rate of Medication-Related OsteoNecrosis of the Jaw (MRONJ) after dental extraction in patients treated with Anti-Resorptive Drugs (ARD) for OsteoPorosis (OP) or for oncological reasons. The secondary objective was to compare the extraction techniques regarding the occurrence of MRONJ. MATERIALS AND METHODS: A systematic search in PubMed/MEDLINE, EMBASE and LILACS databases was performed. Prospective studies considering human patients treated with ARD and providing information regarding the occurrence of MRONJ after dental extraction were selected. Meta-analysis for incidence of MRONJ at the patient level was performed. The effect of administration route and surgical technique on MRONJ was evaluated. RESULTS: The risk of MRONJ after dental extraction was significantly higher in patients treated with ARD for oncological reasons (3.2%) than in those treated with per os ARD for OP (0.15%) (p<0.0001). Dental extraction performed with adjusted extraction protocols decreased significantly MRONJ development. Potential risk indicators such as concomitant medications and pre-existing osteomyelitis were identified. CONCLUSION: The risk of MRONJ after dental extraction in patients treated with ARD exists, especially in patients treated for oncologic reasons. This risk tends to decrease with adjusted extraction protocols. This article is protected by copyright. All rights reserved. [less ▲]

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See detailRelation entre hygiène bucco-dentaire et tendinopathies chez les sportifs
Kipgen, Laurence; Kaux, Jean-François ULg; Rompen, Eric ULg et al

in 8ème Congrès Commun SFMES - SFTS (2015, September)

Intoduction : De nos jours, la majorité des patients consultent un dentiste pour des problèmes dentaires stricto senso et fort peu pour des pathologies liées au parodonte. Ce dernier est pourtant leur ... [more ▼]

Intoduction : De nos jours, la majorité des patients consultent un dentiste pour des problèmes dentaires stricto senso et fort peu pour des pathologies liées au parodonte. Ce dernier est pourtant leur structure d’ancrage permettant le maintien des dents et donc de l’appareil manducateur. La présence d’un saignement gingival au brossage quotidien, étant la plupart du temps non douloureux, ne déclenche souvent aucune inquiétude ni demande de consultation. Il s'agit pourtant d'un des signes cliniques les plus évidents des parodontopathies qui affectent, à des degrés divers, pratiquement 90% de la population en France dans toutes les tranches d'âge et cause la perte de 30 à 40% des dents. Objectif : Le parodonte représente un des points fragiles de notre corps permettant facilement l’entrée de bactéries dans la circulation sanguine et expliquant une relation entre la maladie parodontale et certaines maladies systémiques. Qu’en est-t-il des tendinopathies? Cette étude a pour objectif de mettre en évidence les relations entre l’hygiène bucco-dentaire et ses répercussions sur les tendinopathies. Matériel & méthode : Soixante-quatre sportifs réguliers ont participé à un examen parodontal complet au cours duquel les paramètres cliniques suivants ont été enregistrés: indices de plaque (PI), indice gingival (GI) et indice de saignement papillaire (PBI). Les athlètes ont été répartis en trois groupes en fonction de leur état de santé : « athlètes non blessés » (ANB), « athlètes blessés » (AB) et « athlètes régulièrement blessés » (ARB). Résultats : En comparant les groupes ANB et AB on remarque une différence significative entre les trois valeurs enregistrées (IP : p=0.023 ; IG : p<0.0001 ; PBI : p<0.0001). Le groupe ARB ne montre pas de différences significatives avec les deux autre groupes. Discussion et Conclusion : Notre étude montre une relation entre les parodontopathies et les tendinopathies mais le modèle ne permet pas à déterminer l’origine ni l’importance de cette relation. Il est recommandé aux athlètes de prêter suffisaient attention à leur hygiène de vie générale et de ne pas négliger leur hygiène dentaire. [less ▲]

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See detailImpact of biomaterial physical characteristics on bone regeneration: Comparison of three hydroxyapatites
LAMBERT, France ULg; Bacevic, Miljana ULg; Schupbach, P et al

Poster (2015, June 03)

Bone regeneration biomaterials with identical chemical compositions are frequently considered by clinicians as similar. However, the clinical performance of regenerative biomaterial may be influenced by ... [more ▼]

Bone regeneration biomaterials with identical chemical compositions are frequently considered by clinicians as similar. However, the clinical performance of regenerative biomaterial may be influenced by other parameters such as topographical properties. [less ▲]

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See detailImpact de l’hygiène bucco-dentaire sur le sport. Revue de la littérature
Kipgen, Laurence; Kaux, Jean-François ULg; Rompen, Eric ULg et al

in Journal de Traumatologie du Sport (2015), 32(1), 41-45

Teeth are the object of multiple attentions and care but unfortunately, it is not the same case of the periodonte, their point of anchoring and essential support. What could be more commonplace than a ... [more ▼]

Teeth are the object of multiple attentions and care but unfortunately, it is not the same case of the periodonte, their point of anchoring and essential support. What could be more commonplace than a bleeding arising during the daily brushing? Being not painful, it activates very often no concern and no request of consultation. It is nevertheless about one of the most obvious clinical signs of the periodontal diseases which affect, to varying degrees, practically 90 % of the population in France in all groups of ages and is responsible of the loss from 30 to 40 % of the teeth. For several decades, the scientific world admits a relation between the periodontal disease and certain systematic diseases, as the endocarditis, the atherosclerosis, the diabetes… And what about tendinopathies? Their appearance is often spontaneous without specific medical origin and their cure turns out long and painful. This review has for objective to highlight the relations between the oral hygiene and sportsmen. [less ▲]

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See detailDramatic osteonecrosis of the jaw associated with oral bisphosphonates, periodontitis and dental implant removal
Ayora, A F; HERION, Francine ULg; ROMPEN, Eric ULg et al

in Journal of Clinical Periodontology (2015), 42

Osteoporosis affects millions of elderly patients, and anti-resorptive drugs (ARD) such as bisphosphonates (BP) represent the first-line therapy. Despite the benefits related to the use of these ... [more ▼]

Osteoporosis affects millions of elderly patients, and anti-resorptive drugs (ARD) such as bisphosphonates (BP) represent the first-line therapy. Despite the benefits related to the use of these medications, osteonecrosis of the jaw is a significant complication in a subset of patients receiving these drugs. CASE PRESENTATION: This report documents a case of dramatic bisphosphonate-related osteonecrosis associated with periodontitis and dental implant removal in an osteoporotic patient treated with per os bisphosphonates for an uninterrupted period of 15 years. CONCLUSION: The aim of this report was to discuss the administration period of BP in the treatment of osteoporosis, the decision-making and clinical management of severe MRONJ and the indications for dental implant placement in these specific patients. [less ▲]

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See detailLess invasive surgical procedures using narrow diameter implants: a prospective study in 20 consecutive patients.
LAMBERT, France ULg; LECLOUX, Geoffrey ULg; GRENADE, Charlotte ULg et al

in Journal of Oral Implantology (The) (2015)

Narrow diameter implants (NDIs) are increasingly produced and used in implant dentistry especially since the introduction of new and more resistant materials. The objective of the present study was to ... [more ▼]

Narrow diameter implants (NDIs) are increasingly produced and used in implant dentistry especially since the introduction of new and more resistant materials. The objective of the present study was to evaluate the clinical performance of NDIs (3.3 mm) placed in thin alveolar crests. Methods: Twenty consecutive patients needing implant-supported fixed partial dentures and presenting an alveolar thickness ≤ 6 mm were treated with one or several NDIs. The surgical protocol was chosen according to the clinical situation: °1 flapless; °2 mini-cervical flap; 3° wide flap; 4° wide flap + guided bone regeneration (GBR). Implants were immediately loaded if the primary stability was higher than 20 Ncm. Implant survival and success, prosthodontic success rates and patient-centered outcomes were evaluated after a follow-up period of 1 year. Results: A total of 39 implants were placed in 20 patients, 12 and 27 implants in the anterior regions and in the posterior mandible, respectively. All implants but one reached an insertion torque higher than 20 Ncm and were loaded within 48 hours. The implant survival and success rates both reached 94.7 %. The need for GBR was avoided in 60 % of the implant sites. The mean peri-implant bone remodeling after a follow-up period of 1 year was -0.35 mm at the implant level. Peri-implant bone remodeling was higher in the posterior region, when the alveolar crest was thinner than 4 mm and GBR was required in addition.Conclusion: The use of NDIs to restore partial edentation in sites with limited horizontal bone thickness seems to be an effective treatment option that prevented GBR in the majority of the present cases. Immediate provisionalization of NDIs does not seem to impair the results. [less ▲]

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See detailTeriparatide Therapy for Denosumab-Induced Osteonecrosis of the Jaw in a Male Osteoporotic Patient.
Neuprez, Audrey; Rompen, Eric ULg; Crielaard, Jean-Michel ULg et al

in Calcified tissue international (2014), 95

We report the first case of teriparatide adjuvant role in the management of a denosumab-induced osteonecrosis of the jaw in a male subject with idiopathic osteoporosis. Clinical benefits and CT healing ... [more ▼]

We report the first case of teriparatide adjuvant role in the management of a denosumab-induced osteonecrosis of the jaw in a male subject with idiopathic osteoporosis. Clinical benefits and CT healing were obtained within 2 months of teriparatide initiation and denosumab withdrawal. Increase in bone turnover previously described, when denosumab treatment is removed, might have a synergistic effect to the stimulating effect of teriparatide on bone remodeling to promptly heal osteonecrosis of the jaw. [less ▲]

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See detailOsteonecrosis of the jaw in a male osteoporotic patient treated with denosumab
NEUPREZ, Audrey ULg; Coste, S; Rompen, Eric ULg et al

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2014), 25

Osteonecrosis of the jaw (ONJ) is a clinical condition associated with long-term exposure to inhibitors of bone resorption, mainly bisphosphonates. Denosumab (DMab) is a human monoclonal antibody of the ... [more ▼]

Osteonecrosis of the jaw (ONJ) is a clinical condition associated with long-term exposure to inhibitors of bone resorption, mainly bisphosphonates. Denosumab (DMab) is a human monoclonal antibody of the receptor activator of nuclear factor kappa-B ligand. It prevents osteoclast-mediated bone resorption and is widely prescribed for the management of postmenopausal osteoporosis. Whereas ONJ has already been reported in women treated with DMab, we report for the first time the development of ONJ, following tooth extraction, in a male patient treated for idiopathic osteoporosis with DMab. Due to the constant increase in DMab prescription, for the management of osteoporosis, in both genders, physicians should be made aware of this potential risk. [less ▲]

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See detailCoronally advanced flap versus the pouch technique combined with a connective tissuegraft to treat Miller's class I gingival recession: a randomized controlled trial
SALHI, Leila ULg; LECLOUX, Geoffrey ULg; Seidel, Laurence ULg et al

in Journal of Clinical Periodontology (2013)

AIM: The objective of this study was to compare two different periodontal plastic surgery procedures to treat Miller's class I recession: a coronally advanced flap (control group) versus the pouch ... [more ▼]

AIM: The objective of this study was to compare two different periodontal plastic surgery procedures to treat Miller's class I recession: a coronally advanced flap (control group) versus the pouch technique (test group), both of which were associated with connective tissue graft. METHODS: Forty consecutive patients were included, with 20 patients being allocated for each group. The level of recession coverage, the keratinized tissue (KT) quantity, gingival aesthetics (PES) and post-operative outcomes were assessed for a follow-up period of 6 months. RESULTS: After 6 months, both techniques allowed for the excellent mean root coverage of 96.3 ± 12.1% in the control group and of 91.3 ± 17.6% in the test group. Complete root coverage was achieved in 89.5% (17/19) and 79% (15/19) of the recession cases in the control and the test groups respectively. A significant increase in KT height (p = 0.0011) was observed in the test group. A significant improvement in the pink aesthetic score was found in the two groups, but gingival texture displayed significantly better results in the test group (p < 0.0001). No significant difference between the two groups was found in terms of the morbidity outcomes. Pain killer consumption was similar in the two groups and significantly decreased over time. CONCLUSIONS: Both surgical techniques are relevant in treating Miller's class I recession. The pouch technique seems to increase the height of KT better and provides good gingival-related aesthetic outcomes. [less ▲]

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See detailA new in vitro protocol to study HGF/HGK attachment and proliferation on prostheses materials
GRENADE, Charlotte ULg; MAINJOT, Amélie ULg; VAN HEUSDEN, Alain ULg et al

in Dental Materials (2013, December), 29(E15-E16),

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See detailDRAMATIC OSTEONECROSIS OF THE JAW ASSOCIATED WITH ORAL BIPHOSPHONATES TREATMENT AFTER IMPLANT REMOVAL: A CASE REPORT
FERNANDEZ AYORA, Alberto ULg; HERION, Francine ULg; LAMBERT, France ULg et al

Poster (2013, October)

BACKGROUND Osteoporosis affects millions of elderly patients. Bisphosphonates represent first-line therapy. Osteonecrosis of the jaws in patients treated with bisphosphonates is mostly associated with ... [more ▼]

BACKGROUND Osteoporosis affects millions of elderly patients. Bisphosphonates represent first-line therapy. Osteonecrosis of the jaws in patients treated with bisphosphonates is mostly associated with intravenous bisphosphonates while the incidence associated with oral bisphosphonates is not significant. AIM This report documents a case of bisphosphonate-related osteonecrosis of the jaw (BRONJ) after dental implant removal in an osteoporotic patient treated with alendronate and risedronate for 15 years. MATERIAL AND METHODS An 83-years-old patient with no significant systemic disease underwent implant removal in the first molar left hemimandible position in 2010 due to a peri-implantitis. The surgical procedure was uneventful thought preventive measures were no taken. In June 2011, the patient was referred to our department with a wide bone sequestration of the left mandibular body. A panoramic radiograph showed an increased bone marrow density with bone sequestration. Since then, the patient underwent several courses of antibiotics and conservative therapy, without relief of symptoms. RESULTS Since 2011, the patient has lost 13 teeth in the mandible and the osteonecrosis has disseminated to the entire jaw and the left mandible condyle. The patient has even lost the left hearing. Resective surgery under general anesthesia is not indicated due to the risk because of the age of the patient. CONCLUSION AND CLINICAL IMPLICATIONS Despite the low risk of BRONJ occurrence after implant surgery in oral N-BP users, the fate of dental implants in these patients remains uncertain. Therefore patients at risk must be given a full explanation of the potential risks of implant failure and BRONJ development. Osteonecrosis of the jaws in association with bisphosphonate therapy is a very serious condition with which all dentists should be familiar. Since the treatment of BRONJ is difficult, prevention is the main goal. When the osteonecrosis begins, it can be very painful to the patient, difficult to treat, and can lead to very deleterious sequelae. [less ▲]

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See detailEffect of Leukocyte- and Platelet-Rich Fibrin (L-PRF) on Bone Regeneration: A Study in Rabbits.
Knapen, Michel; Gheldof, Damien; Drion, Pierre ULg et al

in Clinical Implant Dentistry & Related Research (2013)

BACKGROUND: The positive effect of leukocyte- and platelet-rich fibrin (L-PRF) on osteogenesis has been widely described in vitro. However, clinical and preclinical studies are very little and ... [more ▼]

BACKGROUND: The positive effect of leukocyte- and platelet-rich fibrin (L-PRF) on osteogenesis has been widely described in vitro. However, clinical and preclinical studies are very little and controversial in demonstrating a significant beneficial effect of L-PRF in bone regeneration. PURPOSE: The goal of the present study was to compare the potential effect of L-PRF in a standardized model. MATERIALS AND METHODS: A total of 72 hemispheres were implanted on the calvaria of 18 rabbits and filled with three different space fillers: L-PRF, bovine hydroxyapatite (BHA), BHA + L-PRF, and an empty hemisphere was used as control. Six rabbits were sacrificed at three distinct time points: 1 week, 5 weeks, and 12 weeks. Histological and histomorphometrical analyses were carried out. RESULTS: At the early phase of bone regeneration (1 week), from a descriptive analysis, a higher proportion of connective tissue colonized the regeneration chamber in the two groups containing BHA particles. Nevertheless, no statistical differences were found within the four groups in terms of bone quantity and quality at each timepoint (p = .3623). CONCLUSIONS: According to the present study, L-PRF does not seem to provide any additional effect on the kinetics, quality, and quantity of bone in the present model of guided bone regeneration. [less ▲]

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See detailLe maxillaire édenté complet
ROMPEN, Eric ULg; LAMBERT, France ULg; LAMY, Marc ULg

in Missika, Patrick (Ed.) 25 cas d'école en implantologie (2013)

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