References of "RADERMECKER, Marc"
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See detailHeart Team Liege - Session Video Link
PIERARD, Luc ULg; vahanian, Alec; LANCELLOTTI, Patrizio ULg et al

Conference (2016, September)

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See detailHeart Team Session
PIERARD, Luc ULg; LANCELLOTTI, Patrizio ULg; PETERMANS, Jean ULg et al

Conference (2016, August)

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See detailMANAGEMENT OF NON-SMALL CELL LUNG CANCER
Sibille A; Paulus A; Martin M et al

in Revue Médicale de Liège (2015), 70(9), 432-441

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See detailNew biomarkers for primary mitral regurgitation.
Deroyer, Céline ULg; Magne, Julien; Moonen, Marie ULg et al

in Clinical proteomics (2015), 12

BACKGROUND: Mitral regurgitation is a frequent valvular heart disease affecting around 2.5 % of the population with prevalence directly related to aging. Degeneration of mitral valve is broadly considered ... [more ▼]

BACKGROUND: Mitral regurgitation is a frequent valvular heart disease affecting around 2.5 % of the population with prevalence directly related to aging. Degeneration of mitral valve is broadly considered as a passive ongoing pathophysiological process and little is known about its physiological deregulation. The purpose of this study was to highlight new biomarkers of mitral regurgitation in order to decipher the underlying pathological mechanism as well as to allow the diagnosis and the monitoring of the disease. RESULTS: Modulation of various blood proteins expression was examined in patients suffering from different grades of mitral regurgitation (mild, moderate and severe) compared to healthy controls. To this end, several routine clinical assays and the multi analyte profile technology targeting 184 proteins were used. High-density lipoprotein, apolipoprotein-A1, haptoglobin and haptoglobin-alpha2 chain levels significantly decreased proportionally to the degree of mitral regurgitation when compared to controls. High-density lipoprotein and apolipoprotein-A1 levels were associated with effective regurgitant orifice area and regurgitant volume. Apolipoprotein-A1 was an independent predictor of severe mitral regurgitation. Moreover, with ordinal logistic regression, apolipoprotein-A1 remained the only independent factor associated with mitral regurgitation. In addition, myxomatous mitral valves were studied by immunocytochemistry. We observed an increase of LC3, the marker of autophagy, in myxomatous mitral valves compared with healthy mitral valves. CONCLUSION: These potential biomarkers of mitral regurgitation highlighted different cellular processes that could be modified in myxomatous degenerescence: reverse cholesterol transport, antioxidant properties and autophagy. [less ▲]

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See detailLa prothèse valvulaire idéale n’existe toujours pas. Quels facteurs entrent en compte pour orienter les choix d’une valve mécanique ou biologique ?
GREGOIRE, Céline ULg; Nellessen, Eric; Defraigne, Jean-Olivier ULg et al

in Revue Médicale de Liège (2014), 69(11), 600-604

The prevalence of valvular heart diseases reaches 2.5% in the overall population. Aortic valve replacement is one of the most common surgical procedures. We report the story of a female patient whose ... [more ▼]

The prevalence of valvular heart diseases reaches 2.5% in the overall population. Aortic valve replacement is one of the most common surgical procedures. We report the story of a female patient whose aortic mechanical valve, implanted at the age of 54 years at the time of a mitral valve repair surgery, had to be replaced 14 years later, due to the development of a subvalvular pannus narrowing the valvular orifice. We use this clinical story to compare the advantages and disadvantages of repair surgery and valve replacement with a biological or mechanical prosthesis, and summarize the latest evidence for the choice of the most adequate prosthesis for a particular patient’s profile. [less ▲]

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See detailNew Insights Into Aortic Diseases A Report From the Third International Meeting on Aortic Diseases (IMAD3)
KUIVANIEMI, Helena; SakalihasanN, Natzi ULg; LEDERLE, Franck et al

in AORTA (2013), 1

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See detailEmerging pathogenic mechanisms in human myxomatous mitral valve: lessons from past and novel data.
Hulin, Alexia; Deroanne, Christophe ULg; Lambert, Charles ULg et al

in Cardiovascular Pathology (2013), 22

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See detailSubacute Transcatheter CoreValve Thrombotic Obstruction.
LANCELLOTTI, Patrizio ULg; Radermecker, Marc ULg; Weisz, Sara H et al

in Circulation: Cardiovascular Interventions (2013), 6(3), 32-3

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See detailLe cas clinique du mois. Pericardite constrictive.
Johnen, J.; RADERMECKER, Marc ULg; Defraigne, Jean-Olivier ULg

in Revue Médicale de Liège (2012), 67(3), 107-12

Constrictive pericarditis (CP) is a common disease with difficult diagnosis. We report a well-documented case of CP with extended pericardial calcification treated by total pericardiectomy. A brief review ... [more ▼]

Constrictive pericarditis (CP) is a common disease with difficult diagnosis. We report a well-documented case of CP with extended pericardial calcification treated by total pericardiectomy. A brief review of symptoms and signs of CP is presented, as well as additional examination allowing the diagnosis to be confirmed. The differential diagnosis with restictive cardiomyopathy is also discussed. [less ▲]

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See detailSurgical treatment of cardiovascular complications in patients with Marfan syndrome: a report of two cases and literature review.
BRULS, Samuel ULg; Radermecker, Marc ULg; Creemers, E. et al

in Acta Chirurgica Belgica (2012), 112(3), 213-8

Cardiovascular disease is the main cause of morbidity and mortality in patients with Marfan syndrome. The most life threatening complication is aortic root aneurysms leading to aortic dissection or ... [more ▼]

Cardiovascular disease is the main cause of morbidity and mortality in patients with Marfan syndrome. The most life threatening complication is aortic root aneurysms leading to aortic dissection or rupture. It can be prevented by regular aortic follow-up and prophylactic aortic surgery. Modern aortic surgery has led to a substantial increase in the life expectancy of these patients. We report two cases of Marfan syndrome with cardiovascular complications. Their management is discussed according to the most recent literature. [less ▲]

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See detailCardiac paraganglioma : diagnostic work up and review of the literature.
Sooknunden, Marvyn ULg; HAMOIR, Etienne ULg; de Leval, Laurence ULg et al

in Acta Chirurgica Belgica (2012), 112

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See detailNursing care after Transcatheter Aortic Valve Implantation with the Medtronic CoreValve Revalving® system
ERPICUM, Marie ULg; RADERMECKER, Marc ULg; DEFRAIGNE, Jean ULg et al

Poster (2011, April 02)

The risks, complications and results of the transcatheter aortic valve implantation (TAVI) are widely described. But to our knowledge, no one has yet defined the nursing cares required after this ... [more ▼]

The risks, complications and results of the transcatheter aortic valve implantation (TAVI) are widely described. But to our knowledge, no one has yet defined the nursing cares required after this procedure and their effects on the TAVI results. The aims of this review are to describe the nursing cares required after TAVI and to determine which aspects of the management could be optimized to improve the results of the procedure. [less ▲]

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See detailMasse supra-diaphragmatique droite fluctuant pendant 6 ans
LAURENT, A ULg; MILICEVIC, Mladen ULg; RADERMECKER, Marc ULg et al

in Revue Médicale de Liège (2011), 66(11), 564-567

Le kyste pleuro-péricardique est une entité rare d'origine embryologique. Nous rapportons le cas d'une patiente présentant une importante masse médiastinale au départ asymptomatique. La découverte ... [more ▼]

Le kyste pleuro-péricardique est une entité rare d'origine embryologique. Nous rapportons le cas d'une patiente présentant une importante masse médiastinale au départ asymptomatique. La découverte fortuite d'une masse médiastinale doit amener à évoquer, entre autres, le diagnostic de kyste pleuro-péricarique. [less ▲]

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See detailOptions interventionnelles en matière de traitement moderne de la cardiomyopathie hypertrophique obstructive
DULGUEROV, Filip ULg; RADERMECKER, Marc ULg; LEGRAND, Victor ULg

in Revue Médicale de Liège (2011), 66(1), 13-7

Obstructive hypertrophic cardiomyopathy is a complex pathology. The understanding of its physiopathology and, notably, of the SAM phenomenon (Systolic Anterior Motion), is crucial for all available ... [more ▼]

Obstructive hypertrophic cardiomyopathy is a complex pathology. The understanding of its physiopathology and, notably, of the SAM phenomenon (Systolic Anterior Motion), is crucial for all available treatments. Amongst the most efficient therapies, one can cite the septal myectomy and its most recent technical updates, as well as the alcohol septal ablation. The choice between these two methods depends on the general state of the patient, the thickness of the interventricular septum and the coronary anatomy of the patients. [less ▲]

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See detailLe cas clinique du mois. A propos d'un cas de sequestration pulmonaire intralobaire diagnostique a l'age adulte.
Somja, Joan ULg; de Leval, Laurence ULg; Boniver, Jacques ULg et al

in Revue Médicale de Liège (2011), 66(1), 7-12

Pulmonary sequestration is a rare congenital lung malformation characterized by an abnormal segment of bronchopulmonary tissue supplied by aberrant systemic arteries. Due to the non-specific ... [more ▼]

Pulmonary sequestration is a rare congenital lung malformation characterized by an abnormal segment of bronchopulmonary tissue supplied by aberrant systemic arteries. Due to the non-specific symptomatology, the diagnosis can be missed. Imaging is the cornerstone of the diagnosis. Complete surgical resection provides the definitive treatment. We report a case of pulmonary sequestration associated with an asymptomatic aspergillosis presenting during adulthood and describe briefly the epidemiology, embryology, histology, imaging and surgical treatment of this congenital abnormality. [less ▲]

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See detailLe laboratoire d’Anatomie : un banc d’essai des nouvelles technologies
Bonnet, Pierre ULg; Carlier, Alain ULg; Radermecker, Marc ULg et al

in Revue Médicale de Liège (2010), 65(Synthèse 2010), 35-40

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See detailThiamine Status in Humans and Content of Phosphorylated Thiamine Derivatives in Biopsies and Cultured Cells
Gangolf, Marjorie ULg; Czerniecki, Jan; Radermecker, Marc ULg et al

in PLoS ONE (2010), 5(10), 13616

Background Thiamine (vitamin B1) is an essential molecule for all life forms because thiamine diphosphate (ThDP) is an indispensable cofactor for oxidative energy metabolism. The less abundant thiamine ... [more ▼]

Background Thiamine (vitamin B1) is an essential molecule for all life forms because thiamine diphosphate (ThDP) is an indispensable cofactor for oxidative energy metabolism. The less abundant thiamine monophosphate (ThMP), thiamine triphosphate (ThTP) and adenosine thiamine triphosphate (AThTP), present in many organisms, may have still unidentified physiological functions. Diseases linked to thiamine deficiency (polyneuritis, Wernicke-Korsakoff syndrome) remain frequent among alcohol abusers and other risk populations. This is the first comprehensive study on the distribution of thiamine derivatives in human biopsies, body fluids and cell lines. Methodology and Principal Findings Thiamine derivatives were determined by HPLC. In human tissues, the total thiamine content is lower than in other animal species. ThDP is the major thiamine compound and tissue levels decrease at high age. In semen, ThDP content correlates with the concentration of spermatozoa but not with their motility. The proportion of ThTP is higher in humans than in rodents, probably because of a lower 25-kDa ThTPase activity. The expression and activity of this enzyme seems to correlate with the degree of cell differentiation. ThTP was present in nearly all brain and muscle samples and in ~60% of other tissue samples, in particular fetal tissue and cultured cells. A low ([ThTP]+[ThMP])/([Thiamine]+[ThMP]) ratio was found in cardiovascular tissues of patients with cardiac insufficiency. AThTP was detected only sporadically in adult tissues but was found more consistently in fetal tissues and cell lines. Conclusions and Significance The high sensitivity of humans to thiamine deficiency is probably linked to low circulating thiamine concentrations and low ThDP tissue contents. ThTP levels are relatively high in many human tissues, as a result of low expression of the 25-kDa ThTPase. Another novel finding is the presence of ThTP and AThTP in poorly differentiated fast-growing cells, suggesting a hitherto unsuspected link between these compounds and cell division or differentiation. [less ▲]

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