References of "Pujol, JP"
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See detailThe role of reactive oxygen species in homeostasis and degradation of cartilage.
Henrotin, Yves ULg; Bruckner, P.; Pujol, J. P.

in Osteoarthritis and Cartilage (2003), 11(10), 747-55

OBJECTIVES: The metabolism of cells in articular joint tissues in normal and pathological conditions is subject to a complex environmental control. In addition to soluble mediators such as cytokines and ... [more ▼]

OBJECTIVES: The metabolism of cells in articular joint tissues in normal and pathological conditions is subject to a complex environmental control. In addition to soluble mediators such as cytokines and growth factors, as well as mechanical stimuli, reactive oxygen species (ROS) emerge as major factors in this regulation. ROS production has been found to increase in joint diseases, such as osteoarthritis and rheumatoid arthritis, but their role in joint diseases initiation and progression remains questionable. METHOD: This review is focused on the role of ROS, mainly nitric oxide, peroxynitrite and superoxide anion radicals, in the signaling mechanisms implied in the main cellular functions, including synthesis and degradation of matrix components. The direct effects of ROS on cartilage matrix components as well as their inflammatory and immunomodulatory effects are also considered. RESULTS: Some intracellular signaling pathways are redox sensitive and ROS are involved in the regulation of the production of some biochemical factors involved in cartilage degradation and joint inflammation. Further, ROS may cause damage to all matrix components, either by a direct attack or indirectly by reducing matrix components synthesis, by inducing apoptosis or by activating latent metalloproteinases. Finally, we have highlighted the uncoupling effect of ROS on tissue remodeling and synovium inflammation, suggesting that antioxidant therapy could be helpful to treat structural changes but not to relieve symptoms. CONCLUSIONS: This review of the literature supports the concept that ROS are not only deleterious agents involved in cartilage degradation, but that they also act as integral factors of intracellular signaling mechanisms. Further investigation is required to support the concept of antioxidant therapy in the management of joint diseases. [less ▲]

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See detailReactive oxygen species downregulate the expression of pro-inflammatry genes by humachondrocytes
Henrotin, Yves ULg; Mathy-Hartert, Marianne ULg; Martin, G. et al

in Osteoporosis International (2002, November), 13(Suppl. 3), 53

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See detailThe expression of IL-1β, iNOS and COX-2 genes by human chondrocytes is differentially regulated by reactive oxygen species
Henrotin, Yves ULg; Mathy, M; Deby, G et al

in Tissue Engineering (2001), 7

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See detailThe expression of IL-1 β, iNOS and COX-2 genes by human chondrocytes is differentially regulated by reactive oxygen species
Mathy-Hartert, M; Deby, GP; Ayache, N et al

in Osteoarthritis and Cartilage (2001), 9SB

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See detailInterleukine-1 β regulation of transforming growth factor-β1 expression in articular chondrocytes : influence of aceclofenac
Andriamanalijaona, R; Ayache, N; Mathy-Hartert, M et al

in Osteoarthritis and Cartilage (2001), 9SB

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See detailExpression of transforming growth factors and their receptors is differentially modulated by reactive oxygen species and nitric oxide in human articular chondocytes
Ayache, N; Boumediene, K; Mathy-Hartert, M et al

in Osteoarthritis and Cartilage (2001), 9SB

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See detailThe expression of IL-1bêta, iNOS and COX-2 genes by human chondrocytes in differentially regulated by reactive oxygen species
Henrotin, Yves ULg; Mathy-Hartert, M; Deby, GP et al

in Clinical Rheumatology (2001), 20

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See detailRegulation by reactive oxygen species (ROS) of interleukin-1 bêta, nitric oxide and prostaglandin E2 production by human chondrocytes
Henrotin, Yves ULg; Mathy-Hartert, M; Ayache, N et al

in Clinical Rheumatology (2001), 20

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See detailEffects of antioxidants on interleukin-1β, nitric oxide and prostaglandin E2 production by human chondrocytes
Mathy-Hartert, M; Ayache, N; Boumediene, K et al

in Osteoarthritis and Cartilage (2000), 8

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See detailRecommendations for registration of drugs used in the treatment of osteoarthritis
Dougados, M; Devogelaer, JP; Annefeldt, M et al

in Annals of the Rheumatic Diseases (1996), 55

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