References of "Pretty, Chris"
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See detailEvaluation of a plasma insulin model for glycaemic control in intensive care.
Dickson, Jennifer; Thomas, Felicity Louise ULg; Pretty, Chris et al

in Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference (2015), 2015

Hyperglycaemia is a common complication in the intensive care unit (ICU), and is associated with worsened outcomes. Model-based insulin therapy protocols have been shown to be safe and effective in ... [more ▼]

Hyperglycaemia is a common complication in the intensive care unit (ICU), and is associated with worsened outcomes. Model-based insulin therapy protocols have been shown to be safe and effective in intensive care. Such protocols rely on correct modeling of glucose-insulin dynamics. In particular, model-based control typically relies on insulin sensitivity (SI) metrics, which are heavily influenced by plasma insulin kinetics. Plasma insulin samples were taken as part of a sepsis study and compared to modeled plasma insulin. Samples were taken in septic patients at the onset of glycaemic control, and once the patient consistently met less than two of the SIRs criteria that help define sepsis. It was found that inter-patient insulin dynamics were more variable at the onset of insulin therapy, than in the later samples after sepsis abated. Overall, the model adequately captured crucial steady state dynamics. Transient dynamics in plasma insulin following a bolus were faster than modeled, indicating greater clearance of insulin than currently modeled. [less ▲]

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See detailAccuracy and optimization of a subcutaneous insulin model for less acute critical care patients.
Thomas, Felicity Louise ULg; Dickson, Jennifer; Pretty, Chris et al

in Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference (2015), 2015

Extending safe, effective glycemic control to the general wards requires a simple approach using subcutaneous (SC) insulin. However, this approach can increase relative risk compared to intravenous ... [more ▼]

Extending safe, effective glycemic control to the general wards requires a simple approach using subcutaneous (SC) insulin. However, this approach can increase relative risk compared to intravenous insulin due to the increased variability of SC insulin appearance. This paper evaluates the accuracy of a SC plasma insulin model and optimizes its parameters using measured plasma insulin data from 6 less acute critical care patients treated with SC insulin. The SC plasma insulin model used captures the dynamics of regular SC insulin well. However, there appears to be a positive bias leading to an overall median [IQR] residual error of -28.3 [-37 - 19] mU/L. The optimized model reduced the RMS residual error by 20-70% for each patient. The distinct inter- and intra-patient, and cohort variation seen in this data highlights the importance to of understanding how SC insulin appearance dynamics may be affected by the subject condition. [less ▲]

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See detailValidation of a Virtual Patient and Virtual Trials Method for Accurate Prediction of TGC Protocol Performance
Suhaimi, Fatanah; Le Compte, Aaron; Penning, Sophie ULg et al

Poster (2011, March)

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See detailEnhanced insulin sensitivity variability in the first 3 days of ICU stay: Implications for TGC
Chase, Geoffrey; Le Compte, Aaron; Penning, Sophie ULg et al

Poster (2011, March)

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