Modulating skeletal muscle mass by postnatal, muscle-specific inactivation of the myostatin gene

in Genesis (2003), 35(4), 227-238

By using a conditional gene targeting approach exploiting the cre-lox system, we show that postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a generalized muscular ... [more ▼]

By using a conditional gene targeting approach exploiting the cre-lox system, we show that postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a generalized muscular hypertrophy of the same magnitude as that observed for constitutive myostatin knockout mice. This formally demonstrates that striated muscle is the production site of functional myostatin and that this member of the TGFbeta family of growth and differentiation factors regulates muscle mass not only during early embryogenesis but throughout development. It indicates that myostatin antagonist could be used to treat muscle wasting and to promote muscle growth in man and animals. (C) 2003 Wiley-Liss, Inc. [less ▲]

Grandir en l'an 2000 : étude longitudinale d'un échantillon d'enfants de la région wallonne, de la naissance à l'état adulte : mise en relation du niveau de maîtrise en lecture en 2e primaire avec des éléments des contextes familial et scolaire

in Le point sur la recherche en éducation en Communauté française : actes du 1er congrès des chercheurs en éducation, Bruxelles, 24-25 mai 2000 (2001)