References of "Plomteux, Guy"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailEnvironmental hazards and the skin.
Pierard, Claudine ULg; Quatresooz, Pascale ULg; Berardesca, E. et al

in European Journal of Dermatology (2006), 16(3), 322-4

Detailed reference viewed: 9 (1 ULg)
Full Text
Peer Reviewed
See detailLa dioxine, info ou intox? A propos de l'acné de Seveso et de Yushchenko.
Pierard, Gérald ULg; Plomteux, Guy ULg; Denooz, Raphael ULg et al

in Revue Médicale de Liège (2005), 60(1), 18-22

The generic term "dioxin" covers more than 400 chemicals of which less than 30 prove to be toxic. Such compounds are involved in environmental pollutions and in food contaminations. Some selected dioxins ... [more ▼]

The generic term "dioxin" covers more than 400 chemicals of which less than 30 prove to be toxic. Such compounds are involved in environmental pollutions and in food contaminations. Some selected dioxins have also been used as a non-lethal chemical weapon. The assessment of the impact on health needs a precise toxicological identification. Without that basic assessment, a discrepancy may appear between the real risk linked to the exposure and the concerns and fear generated in the population, particularly because in animals the toxic concentrations of dioxins can interfere with some hormonal systems, alter immunity, induce chloracne, and participate in the development of sarcomas, lymphomas and some carcinomas. They may be responsible for some birth defects. [less ▲]

Detailed reference viewed: 78 (18 ULg)
See detailEnvironmental hazards and the skin
PIERARD-FRANCHIMONT, Claudine ULg; QUATRESOOZ, Pascale ULg; Berardesca, E. et al

in European Dermatology Forum White Book (2005)

Detailed reference viewed: 5 (1 ULg)
Full Text
Peer Reviewed
See detailFatal overdosage with cisplatin
Charlier, Corinne ULg; Kintz, Pascal; Dubois, Nathalie ULg et al

in Journal of Analytical Toxicology (2004), 28(2), 138-140

This paper presents a case of fatal overdosage due to an accidental massive administration (750 mg instead of 170 mg) of cisplatin, an anticancer agent, to a 63-year-old patient suffering from lymphoma ... [more ▼]

This paper presents a case of fatal overdosage due to an accidental massive administration (750 mg instead of 170 mg) of cisplatin, an anticancer agent, to a 63-year-old patient suffering from lymphoma. Platinum was measured in various postmortem samples by means of inductively coupled plasma mass spectrometry. Heart and peripheral blood concentrations of platinum were 1515 and 1253 micro g/L, respectively. Concentrations in urine and bile were 1038 and 501 micro g/L, respectively. Renal dialysis was started immediately after the end of cisplatin perfusion, when the mistake was noticed, but the patient deceased at day 16, presenting renal and hepatic insufficiency, ototoxicity, and pancytopenia. [less ▲]

Detailed reference viewed: 26 (1 ULg)
Full Text
Peer Reviewed
See detailEnvironmental dichlorodiphenyltrichlorethane or hexachlorobenzene exposure and breast cancer: is there a risk?
Charlier, Corinne ULg; Foidart, Jean-Michel ULg; Pitance, François ULg et al

in Clinical Chemistry & Laboratory Medicine (2004), 42(2), 222-227

The carcinogenic potential of environmental xenoestrogens (i.e., organochlorines) is a matter of controversy. Their pathogenic role as promoters in breast cancer has been previously suggested. In Europe ... [more ▼]

The carcinogenic potential of environmental xenoestrogens (i.e., organochlorines) is a matter of controversy. Their pathogenic role as promoters in breast cancer has been previously suggested. In Europe, despite their prohibition since the '70s, residues persist in soil and rivers resulting in a widespread contamination of the general population. In this study, we have compared the serum levels of p,p'-1,1-dichloro-2, 2-bis (4-chlorophenyl) ethylene (DDE) and hexachlorobenzene (HCB) in 231 women at the time of breast cancer discovery and in 290 agematched healthy controls. p,p'-DDE was found in 76.2% of cases and in 71.1% of controls but HCB was present only in 12.6% of cases (29 from 231) and in 8.9% of controls (26 from 290). Even if taking all undetectable results (recorded as "0") into consideration, mean values were significantly different in cases when compared to controls. The serum level of p,p'-DDE was 3.46+/-3.48 ppb (0.58+/-0.58 mug/g lipid) in patients and 1.85+/-2.09 ppb (0.31+/-0.35 mug/g lipid) in controls (p<0.0001). The HCB serum level was 0.66+/-1.25 ppb (0.11+/-0.21 mug/g lipid) in patients and 0.20+/-1.02 ppb (0.03+/-0.17 mug/g lipid) in controls (p<0.0001). When considering p,p'-DDE and HCB as binary variables (1 if higher than the limit of quantification, 0 if lower), the presence of both residues was significantly associated with an increased risk of breast cancer development (OR 2.21, 95% CI 1.41-3.48 for p,p'-DDE and OR 4.99, 95% CI 2.95-8.43 for HCB). No excess was observed among parous women or when familial history of breast cancer was considered. In the cancer group, no differences in serum levels of p,p'-DDE or HCB were found in relation with estrogenreceptor (ER) status, Bloom stage or lymph node metastasis, but the HCB level was moderately correlated with tumor size (p=0.026). [less ▲]

Detailed reference viewed: 43 (11 ULg)
Full Text
Peer Reviewed
See detailpolychlorinated biphenyls contamination in women with breast cancer
Charlier, Corinne ULg; Albert, Adelin ULg; Zhang, Lixin ULg et al

in Clinica Chimica Acta (2004), 347

Detailed reference viewed: 41 (14 ULg)
Full Text
Peer Reviewed
See detailPolymorphisms in the CYP 2D6 gene: Association with plasma concentrations of fluoxetine and paroxetine
Charlier, Corinne ULg; Broly, Franck; Pinto, Emmanuel ULg et al

in Therapeutic Drug Monitoring (2003), 25(6), 738-742

Most antidepressants are metabolized by cytochrome P450 (CYP) 2D6, and it is well known that there may be significant interindividual variation in the capacity to metabolize xenobiotics. About 7 to 10% of ... [more ▼]

Most antidepressants are metabolized by cytochrome P450 (CYP) 2D6, and it is well known that there may be significant interindividual variation in the capacity to metabolize xenobiotics. About 7 to 10% of whites are poor metabolisers (PM), and, on the contrary, about 5% are ultrarapid metabolizers (UM), inducing very different rates in the transformation of antidepressants extensively metabolized by CYP 2D6. CYP 2D6 polymorphism can be a potential risk factor for the development of side effects or a reason for the poor efficacy of the treatment. Various probe drugs may be used for phenotyping CYP 2D6, but genotyping is now available using leukocyte DNA and is independent of concomitant drug use. in this study, we used PCR-based methods for the identification of CYP 2D6 genotypes in 49 patients receiving standard doses of fluoxetine or paroxetine and found that plasma concentration of the antidepressant drugs was significantly correlated with genetic status. In one patient who displayed CYP 2D6 gene duplication (UM), paroxetine plasma concentration was extremely low. in PM fluoxetine-treated patients, drug plasma concentration was significantly higher than that seen in extensive metabolizers. [less ▲]

Detailed reference viewed: 61 (3 ULg)
Full Text
Peer Reviewed
See detailPCB residues in a breast cancer patient population
Charlier, Corinne ULg; Pitance, François ULg; Plomteux, Guy ULg

in Bulletin of Environmental Contamination & Toxicology (2003), 71(5), 887-891

Detailed reference viewed: 5 (1 ULg)
Full Text
Peer Reviewed
See detailBreast cancer and serum organochlorine residues
Charlier, Corinne ULg; Albert, Adelin ULg; Herman, Philippe ULg et al

in Occupational and Environmental Medicine (2003), 60(5), 348-351

Background: Controversy still exists about the breast carcinogenic properties in humans of environmental xenoestrogens (organochlorines), justifying new investigations. Aims: To compare the blood levels ... [more ▼]

Background: Controversy still exists about the breast carcinogenic properties in humans of environmental xenoestrogens (organochlorines), justifying new investigations. Aims: To compare the blood levels of total dichlorodiphenyltrichloroethane (DDT) and hexachlorobenzene (HCB) in samples collected at the time of breast cancer discovery, in order to avoid the potential consequences of body weight change ( after chemotherapy or radiotherapy) on the pesticide residue levels. Methods: Blood levels of HCB and total DDT (we calculated total DDT concentrations by adding all DDT and DDE isomers) were compared in 159 women with breast cancer and 250 presumably healthy controls. Risk of breast cancer associated with organochlorine concentration was evaluated. Results: Mean levels of total DDT and HCB were significantly higher for breast cancer patients than for controls. No differences in serum levels of total DDT or HCB were found between oestrogen receptor positive and oestrogen receptor negative patients with breast cancer. Conclusions: These results add to the growing evidence that certain persistent pollutants may occur in higher concentrations in blood samples from breast cancer patients than controls. [less ▲]

Detailed reference viewed: 32 (7 ULg)
See detailPartial Androgen Deficiency of Aging Male (PADAM) might in part be due to excessive organochlonide pesticide (OC) impregnation
Legros, Jean-Jacques ULg; Charlier, Corinne ULg; Bouillon, G. et al

in Annales d'Endocrinologie (2003), 64(2), 136-136

Detailed reference viewed: 21 (0 ULg)
Full Text
Peer Reviewed
See detailAnalysis of polychlorinated biphenyl residues in human plasma by gas chromatography-mass spectrometry
Charlier, Corinne ULg; Dubois, Nathalie ULg; Cucchiaro, Sabine ULg et al

in Journal of Analytical Toxicology (2003), 27(2), 74-77

A method for the determination of seven polychlorinated biphenyl residues in plasma by gas chromatography-mass spectrometry was developed. The analytes were isolated from human plasma by liquid-liquid ... [more ▼]

A method for the determination of seven polychlorinated biphenyl residues in plasma by gas chromatography-mass spectrometry was developed. The analytes were isolated from human plasma by liquid-liquid extraction, followed by solid-phase extraction, and separation on an HP5 Trace column. Ionization mode was electronic impact, and selected ion storage was used for isolation and quantitation of the compounds. The method was evaluated for its analytical performances and therefore applied to monitor the prevalence of these seven polychlorinated biphenyl residues in a female population. Eighty samples were analyzed, and 82.5% presented detectable amounts of at least one residue. For the population study, results were reported on a lipid-adjusted basis. Because the proposed method is satisfying and seems to be suitable for the quantitation of PCB congeners in a general population, epidemiological studies to evaluate the widespread contamination with these environmental compounds can be proposed. [less ▲]

Detailed reference viewed: 20 (4 ULg)
Full Text
Peer Reviewed
See detailDoes radiotherapy have consequences on plasma concentration of toxic pollutants?
Charlier, Corinne ULg; Closon, Marie-Thérèse ULg; Plomteux, Guy ULg

in Bulletin of Environmental Contamination & Toxicology (2003), 70(1), 17-21

Detailed reference viewed: 14 (0 ULg)
Full Text
Peer Reviewed
See detailVenlafaxine: the relationship between dose, plasma concentration and clinical response in depressive patients
Charlier, Corinne ULg; Pinto, Emmanuel ULg; Ansseau, Marc ULg et al

in Journal of Psychopharmacology (2002), 16(4), 369-372

The relationship between plasma drug level of venlafaxine and daily intake was studied in 89 major depressive inpatients. In addition, changes over time in severity were assessed weekly in a subgroup of ... [more ▼]

The relationship between plasma drug level of venlafaxine and daily intake was studied in 89 major depressive inpatients. In addition, changes over time in severity were assessed weekly in a subgroup of 22 depressed patients using the Montgomery and Asberg Depression Rating Scale (MADRS) and the Clinical Global Impression improvement scale. The results indicate a moderate correlation between daily doses and plasma concentrations, together with a higher relationship between improvement on the MADRS scale and concentration. Moreover, plasma concentrations (for venlafaxine and its predominant metabolite, O-desmethylvenlafaxine) up to 400 microg/l can be considered as effective, as already suggested in a previous study. No case of venlafaxine discontinuation occurred during the longitudinal study, and the incidence of adverse event, as estimated by the Target Emergent Symptoms and Side-effects scale, was low, suggesting that the drug is well tolerated for such plasma concentrations. [less ▲]

Detailed reference viewed: 55 (2 ULg)
Full Text
Peer Reviewed
See detailHuman exposure to endocrine disrupters: consequences of gastroplasty on plasma concentration of toxic pollutants
Charlier, Corinne ULg; Desaive, Claude ULg; Plomteux, Guy ULg

in International Journal of Obesity (2002), 26(11), 1465-1468

BACKGROUND: Body weight loss occurring after a hypoenergetic diet or a gastroplasty could be followed by an increase in blood concentration of potentially toxic pollutants that can interfere with the ... [more ▼]

BACKGROUND: Body weight loss occurring after a hypoenergetic diet or a gastroplasty could be followed by an increase in blood concentration of potentially toxic pollutants that can interfere with the hormonal system (endocrine disrupters). DESIGN: Thirty obese individuals recruited for gastroplasty were compared before and after treatment with 45 normal-weight people. MEASUREMENTS: Blood samples were analyzed for DDT, DDE, HCB and PCBs no. 28, 52, 101, 118, 138, 153 and 180, by gas chromatography-mass spectrometry. RESULTS: The results indicate clearly that body weight loss occurring after gastroplasty increases plasma concentration of lipophilic pollutants. CONCLUSION: Gastroplasty increases plasma concentration of organochlorine pesticides and PCBs, which could be a risk factor of endocrine disruption. Future longitudinal research will have to determine if the advantages of body weight loss are reduced by this potentially harmful effect. [less ▲]

Detailed reference viewed: 28 (5 ULg)
Full Text
Peer Reviewed
See detailEffets perturbateurs endocriniens des pesticides organochlorés
Charlier, Corinne ULg; Plomteux, Guy ULg

in Acta Clinica Belgica. Supplementum (2002), (1), 2-7

Xenoestrogens such organochlorine pesticides are known to induce changes in reproductive development, function or behaviour in wildlife. Because these compounds are able to modify the estrogens metabolism ... [more ▼]

Xenoestrogens such organochlorine pesticides are known to induce changes in reproductive development, function or behaviour in wildlife. Because these compounds are able to modify the estrogens metabolism, or to compete with estradiol for binding to the estrogen receptor, it may be possible that these products affect the risk of developing impaired fertility, precocious puberty or some kinds of cancer in man. [less ▲]

Detailed reference viewed: 154 (13 ULg)
Full Text
Peer Reviewed
See detailPollution chimique de l'environnement et risque toxique pour l'homme. Le rôle particulier des dérivés pesticides organochlorés
Charlier, Corinne ULg; Plomteux, Guy ULg

in Annales de Biologie Clinique (2002), 60(1, Jan-Feb), 37-46

There is an increasing concern about environmental exposure to multiple chemicals and adverse changes in reproductive development, function, or behaviour in wildlife. The major group of environmental ... [more ▼]

There is an increasing concern about environmental exposure to multiple chemicals and adverse changes in reproductive development, function, or behaviour in wildlife. The major group of environmental chemicals, such as organochlorine pesticides, polychlorinated biphenyls (PCBs) and other xenoestrogens are currently known to have estrogenic effects in vertebrates or fishes. Recent studies suggest that past exposure to such estrogenic compounds may affects the risk of developing breast cancer, precocious puberty, or impaired fertility in man. [less ▲]

Detailed reference viewed: 208 (26 ULg)
Full Text
Peer Reviewed
See detailDetermination of organochlorine pesticide residues in the blood of healthy individuals
Charlier, Corinne ULg; Plomteux, Guy ULg

in Clinical Chemistry & Laboratory Medicine (2002), 40(4), 361-364

Detailed reference viewed: 11 (4 ULg)
Full Text
Peer Reviewed
See detailSexual Precocity after Immigration from Developing Countries to Belgium: Evidence of Previous Exposure to Organochlorine Pesticides
Krstevska-Konstantinova, M.; Charlier, Corinne ULg; Craen, M. et al

in Human Reproduction (2001), 16(5), 1020-6

In a retrospective auxological study of 145 patients seen in Belgium during a 9-year period for treatment of precocious puberty, 28% appeared to be foreign children (39 girls, one boy) who immigrated 4 to ... [more ▼]

In a retrospective auxological study of 145 patients seen in Belgium during a 9-year period for treatment of precocious puberty, 28% appeared to be foreign children (39 girls, one boy) who immigrated 4 to 5 years earlier from 22 developing countries, without any link to a particular ethnic or country background. The patients were either adopted (n = 28) or non-adopted (n = 12), the latter having normal weight and height at immigration and starting early puberty without evidence of earlier deprivation. This led to the hypothesis that the mechanism of precocious puberty might involve previous exposure to oestrogenic endocrine disrupters. A toxicological plasma screening for eight pesticides detected p,p'-DDE, which is derived from the organochlorine pesticide DDT. Median p,p'-DDE concentrations were respectively 1.20 and 1.04 ng/ml in foreign adopted (n = 15) and non-adopted (n = 11) girls with precocious puberty, while 13 out of 15 Belgian native girls with idiopathic or organic precocious puberty showed undetectable concentrations (<0.1 ng/ml). A possible relationship between transient exposure to endocrine disrupters and sexual precocity is suggested, and deserves further studies in immigrant children with non-advanced puberty. [less ▲]

Detailed reference viewed: 32 (5 ULg)
Full Text
Peer Reviewed
See detailMethadone Maintenance Treatment: Is It Possible to Adapt the Daily Doses to the Metabolic Activity of the Patient?
Charlier, Corinne ULg; Dessalles, M. C.; Plomteux, Guy ULg

in Therapeutic Drug Monitoring (2001), 23(1), 1-3

Controversy still exists concerning the proper daily dose of methadone to be used in opiate dependency treatment. Because it is admitted that serum methadone concentration may be significantly correlated ... [more ▼]

Controversy still exists concerning the proper daily dose of methadone to be used in opiate dependency treatment. Because it is admitted that serum methadone concentration may be significantly correlated with the amount of drug available at the receptor level, it could be interesting to predict the methadone daily doses necessary to reach such a serum concentration. The authors have attempted to correlate the serum methadone level with the daily intake, considering the metabolic activity of the patients. A poor correlation was found between methadone doses and methadone serum concentrations (r2 = 0.0409, p = 0.048). The test used to determine the metabolic activity of patients is the 6-OH cortisol/17-OH corticosteroids ratio in urine. This urinary 6-OH cortisol/17-OH corticosteroids ratio was tested because cortisol is metabolized through the same P450 cytochromes as methadone, namely cytochrome P450 3A4. This determination could be of interest because it could be tested before methadone administration to predict optimal doses. But when the authors tried to correlate the methadone serum concentration with the steroid ratio, they failed to find a significant correlation (r2 = 0.0046, N.S.), even when they took into account the daily doses (r2 = 0.0015, N.S.), most probably because of some limitations of the cortisol ratio. [less ▲]

Detailed reference viewed: 14 (5 ULg)
Full Text
Peer Reviewed
See detailRelationship between Clinical Effects, Serum Drug Concentration, and Concurrent Drug Interactions in Depressed Patients Treated with Citalopram, Fluoxetine, Clomipramine, Paroxetine or Venlafaxine
Charlier, Corinne ULg; Pinto, Emmanuel ULg; Ansseau, Marc ULg et al

in Human Psychopharmacology (2000), 15(6), 453-459

The relationship between clinical effects and plasma concentrations of citalopram, fluoxetine, clomipramine, paroxetine and venlafaxine was studied in 119 cases of major depression. Clinical effects were ... [more ▼]

The relationship between clinical effects and plasma concentrations of citalopram, fluoxetine, clomipramine, paroxetine and venlafaxine was studied in 119 cases of major depression. Clinical effects were evaluated using the Clinical Global Impression (CGI) improvement scale. Antidepressants were quantified by a separative chromatographic methodology. Plasma concentrations in responder patients were compared with the plasma concentrations proposed in literature as effective values. We found that the usual therapeutic window is convenient for citalopram and clomipramine, but could be reduced for fluoxetine and increased for venlafaxine and paroxetine. Concurrent drug interactions were also evaluated and clomipramine or citalopram plasma levels were found to be influenced by the presence of associated drugs. A larger study is needed, taking into account not only plasma concentrations and clinical effects, but also some pharmacokinetic data, especially the metabolic activity characterising the patient, and the presence or not of associated drugs. Copyright 2000 John Wiley [less ▲]

Detailed reference viewed: 43 (8 ULg)