References of "Pirson, Laurence"
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See detailDosage de l'alcool dans le cadre de la sécurité routière : approche statistique
Pirson, Laurence ULg

Conference (2009, October 09)

Detailed reference viewed: 17 (3 ULg)
See detailGestion du contrôle de qualité interne
Denooz, Raphael ULg; Pirson, Laurence ULg

Conference (2009, February)

Detailed reference viewed: 24 (4 ULg)
See detailBiomarqueurs en toxicologie: ADN oxydé et adduits à l'ADN
Pirson, Laurence ULg

Conference (2008, September 05)

Detailed reference viewed: 27 (1 ULg)
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See detailDespite inhibition of hematopoietic progenitor cell growth in vitro, the tyrosine kinase inhibitor imatinib does not impair engraftment of human CD133+ cells into NOD/SCIDbeta2mNull mice.
Pirson, Laurence ULg; Baron, Frédéric ULg; Meuris, Nathalie ULg et al

in Stem Cells (2006), 24(7), 1814-21

There is potential interest for combining allogeneic hematopoietic cell transplantation (HCT), and particularly allogeneic HCT with a nonmyeloablative regimen, to the tyrosine kinase inhibitor imatinib ... [more ▼]

There is potential interest for combining allogeneic hematopoietic cell transplantation (HCT), and particularly allogeneic HCT with a nonmyeloablative regimen, to the tyrosine kinase inhibitor imatinib (Glivec; Novartis, Basel, Switzerland, http://www.novartis.com) in order to maximize anti-leukemic activity against Philadelphia chromosome-positive leukemias. However, because imatinib inhibits c-kit, the stem cell factor receptor, it could interfere with bone marrow engraftment. In this study, we examined the impact of imatinib on normal progenitor cell function. Imatinib decreased the colony-forming capacity of mobilized peripheral blood human CD133(+) cells but not that of long-term culture-initiating cells. Imatinib also decreased the proliferation of cytokine-stimulated CD133(+) cells but did not induce apoptosis of these cells. Expression of very late antigen (VLA)-4, VLA-5, and CXCR4 of CD133(+) cells was not modified by imatinib, but imatinib decreased the ability of CD133(+) cells to migrate. Finally, imatinib did not decrease engraftment of CD133(+) cells into irradiated nonobese diabetic/severe combined immunodeficient/beta2m(null) mice conditioned with 3 or 1 Gy total body irradiation. In summary, our results suggest that, despite inhibition of hematopoietic progenitor cell growth in vitro, imatinib does not interfere with hematopoietic stem cell engraftment. [less ▲]

Detailed reference viewed: 68 (33 ULg)
See detailImpact of Imatinib on immune function in vitro
Pirson, Laurence ULg; Baron, Frédéric ULg; Gothot, André ULg et al

Poster (2006)

Detailed reference viewed: 23 (2 ULg)
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See detailTraitement moléculaire du cancer: le STI571, un inhibiteur des tyrosines kinases
Humblet-Baron, Stéphanie ULg; Baron, Frédéric ULg; Pirson, Laurence ULg et al

in Revue Médicale Suisse (2002), 60(598), 1504-1508

Detailed reference viewed: 114 (20 ULg)