References of "Pinto, Emmanuel"
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See detailOcytocine plamsatique et dimensions de personnalité dans la dépression unipolaire
Scantamburlo, Gabrielle ULg; Reggers, Jean; Hansenne, Michel ULg et al

in Encéphale (L') (2010), 36

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See detailGuérir la dépression : une question d'objectif et de détermination.
PITCHOT, William ULg; Scantamburlo, Gabrielle ULg; Pinto, Emmanuel ULg et al

in Revue Médicale de Liège (2010), 65(5-6), 370-380

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See detailDelirium et anorexie
FARCY, Laurent; PIETTE, Catherine ULg; MAVROPOULOS, Gloria ULg et al

in Acta Psychiatrica Belgica (2010), 110

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See detailFacteurs genetiques de l'alcoolo-dependance Revue des principales donnees de la litterature.
Pinto, Emmanuel ULg; Ansseau, Marc ULg

in Encéphale (L') (2009), 35(5), 461-9

INTRODUCTION: Alcohol dependence is a complex and multifactorial disease resulting both from neurobiological mechanisms and environmental factors. It is frequently associated with comorbid psychiatric ... [more ▼]

INTRODUCTION: Alcohol dependence is a complex and multifactorial disease resulting both from neurobiological mechanisms and environmental factors. It is frequently associated with comorbid psychiatric disorders or with specific personality or behavioral features. Although action can be taken on the environment in order to decrease the risk of the illness, current methods used to prevent or to treat this pathology show moderate efficacy: problematic consumption of ethanol in the general population as well as relapse rates under treatment in dependent patients remain indeed very high. LITERATURE FINDINGS: It is therefore of major importance to broaden our knowledge of alcohol dependence and its comorbidities so as to improve both their prevention and treatment. In this perspective, recent progress in the field of neurosciences may contribute to achieve this goal. Precisely, genetics is a promising way benefiting from many advances in genetic epidemiology, cellular and molecular biology, neuroimaging and pharmacology. In parallel with a better understanding of the neurobiology of addictions and associated behaviors, these techniques led to the identification of brain mechanisms in which a genetic variation may influence the individual vulnerability towards alcohol dependence. Moreover, there is growing evidence that alcoholism results from the interaction of genetic and environmental factors influencing both its expression and its course. Given the fact that alcohol-dependence seems highly heritable (50 to 60% of the variance in both men and women), this review assesses the role of some of the genomic regions linked with the disease, as well as the principal variants of candidate genes identified as specifically involved in the predisposition. Polymorphisms of genes influencing alcohol metabolism, GABAergic, dopaminergic and serotonergic neurotransmission seem, indeed, at stake in the development of alcohol-dependence and its related features such as personality, behavior, impulse control or craving. In the future, a better characterization of the links between genotypes and phenotypes will probably increase our ability to treat alcoholic patients. [less ▲]

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See detailThe TaqI A DRD2 polymorphism in type II alcohol dependence: a marker of age at onset or of a familial disease?
Pinto, Emmanuel ULg; Reggers, Jean ULg; Gorwood, Philip et al

in Alcohol (2009), 43(4), 271-5

Cloninger's type II is a severe, early-onset, male-limited, and genetically influenced, impulsive form of alcoholism. Significant association has been reported between the A1 allele of the D2 dopamine ... [more ▼]

Cloninger's type II is a severe, early-onset, male-limited, and genetically influenced, impulsive form of alcoholism. Significant association has been reported between the A1 allele of the D2 dopamine receptor (DRD2) gene, substance misuse and personality traits of impulsivity and novelty seeking. We assessed the association between the TaqI A DRD2 gene polymorphism with Cloninger's typology and family history of alcohol abuse, which is thought to be more frequent in type II alcoholics. Fifty-one male alcohol-dependent patients were discriminated between type I and type II according to age at onset of alcohol-related problems and interviewed about family history of alcoholism. The associations between DRD2 (A1 or A2 alleles), family history, and typology were assessed by Pearson's chi-square test. Although typology was not associated with the studied polymorphism, a higher rate of general family history of alcohol abuse was still observed in type II patients (chi(2)(1)=4.53; P=.033). Furthermore, the A1 allele of the DRD2 was significantly associated with paternal history of alcoholism (chi(2)(1)=4.66; P=.031) and male, first-degree, collateral history of alcoholism (chi(2)(1)=4.40; P=.036). Age at onset of alcohol-related problems as main discriminator between type I and type II alcohol dependence does not seem to be associated by the TaqI A DRD2 polymorphism. However, the A1 allele of the DRD2 may be a marker of male familial alcoholism, which has been associated with type II alcohol dependence. [less ▲]

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See detailThe short allele of the serotonin transporter promoter polymorphism influences relapse in alcohol dependence.
Pinto, Emmanuel ULg; Reggers, Jean ULg; Gorwood, Philip et al

in Alcohol & Alcoholism (2008), 43

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See detailVasopressin-neurophysin and DST in major depression : Relationship with suicidal behavior.
Pitchot, William ULg; Scantamburlo, Gabrielle ULg; Pinto, Emmanuel ULg et al

in Journal of Psychiatric Research (2008), 42

The purpose of the present study was to assess if AVP-neurophysin is associated with hypercortisolemia and suicidal behaviour in depressed patients. The study included 28 patients subgrouped into suicide ... [more ▼]

The purpose of the present study was to assess if AVP-neurophysin is associated with hypercortisolemia and suicidal behaviour in depressed patients. The study included 28 patients subgrouped into suicide attempters (n=13) and nonattempters (n=15). We assessed basal AVP-neurophysins concentrations and post-dexamethasone (DST) cortisol levels. Concentrations of AVP-neurophysins did not differ between DST suppressors and nonsuppressors: 0.29+/-0.13ng/ml vs 0.36+/-0.21ng/ml, (F=1.1, df=1, 27, p=0.30). Suicide attempters did not differ from nonattempters for AVP-neurophysins levels. Our results fail to support a role of AVP in the early cortisol escape. [less ▲]

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See detailLa marche du sujet fibromyalgique et d’un sujet dépressif est-elle différenciable ? Exploration de deux affections « voisines » à partir d’un accéléromètre tri-axial.
Maquet, Didier ULg; Jaspar, J.; Lecart, Marie-Paule ULg et al

in Revue du Rhumatisme (2008), 75

Objectif : Analyser la marche de populations souffrant d’affections présentant certaines similitudes en termes de symptomatologie (fatigue, stress, anxiété, ralentissement psychomoteur, …) et pour ... [more ▼]

Objectif : Analyser la marche de populations souffrant d’affections présentant certaines similitudes en termes de symptomatologie (fatigue, stress, anxiété, ralentissement psychomoteur, …) et pour lesquelles le diagnostic différentiel apparaît parfois malaisé. Patients et méthodes : Cette étude inclut 32 sujets fibromyalgiques (46  10 ans), 20 sujets hospitalisés pour un état dépressif (49  14 ans) et 20 sujets volontaires contrôles (49  16 ans). L’analyse tri-dimensionnelle de la marche est réalisée à partir d'un système ambulatoire d'accélérométrie triaxial (Locometrix® Centaure Metrix, France) et d'une ligne de chronométrage. Le sujet marche à sa vitesse de confort, équipé de l'accéléromètre fixé à l'aide d'une ceinture élastique. L'épreuve, composée de 6 trajets rectilignes de 40 mètres, permet de suivre le profil des paramètres analysés tout au long de la distance totale parcourue (240 mètres). Les paramètres analysés sont : la vitesse de marche, la fréquence de pas, la longueur de pas, la symétrie et la régularité des pas, la puissance mécanique suivant les axes antéro-postérieur, crânio-caudal et médio-latéral, le coût énergétique. Résultats : La marche de la population fibromyalgique présente diverses altérations significatives non seulement en comparaison de la population contrôle mais aussi de la population dépressive. Nous observons chez le fibromyalgique une réduction significative (p < 0,05) de la vitesse de marche, de la longueur de pas, des activités suivant les axes antéro-postérieur et crânio-caudal. En outre, cette population présente une marche moins régulière (p < 0,05) alors que le coût énergétique de la marche est diminué (p < 0,05). Les paramètres de marche enregistrés au sein de la population dépressive apparaissent intermédiaires entre sujets contrôles et fibromyalgiques. Cependant, aucune modification significative ne s’observe entre populations contrôle et dépressive. Des travaux ultérieurs tenteront en outre de mettre en relation l’altération des paramètres de marche avec le degré d’anxiété et de dépression objectivé. Discussion : Bien que l’on évoque régulièrement un ralentissement fonctionnel chez les sujets souffrant de ces 2 affections « voisines », ce travail démontre que la marche d’un sujet dépressif et d’un sujet fibromyalgique semble différenciable. Ce dernier adopte une marche plus lente, moins régulière et visant à une « économie » d’énergie comme l’atteste le coût énergétique et les activités suivant les 3 axes. Conclusion : Cette épreuve pourrait constituer un outil original dans la caractérisation d’une population pathologique et le suivi longitudinal d’un patient. [less ▲]

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See detailLes psychostimulants.
Pinto, Emmanuel ULg; Pitchot, William ULg; Ansseau, Marc ULg

in Revue Médicale de Liège (2008), 63

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See detailNeurobiologie et pharmacothérapie du trouble obsessionnel-compulsif.
Ansseau, Marc ULg; Scantamburlo, Gabrielle ULg; Pinto, Emmanuel ULg et al

in Revue Médicale de Liège (2008), 63

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See detailSyndrome de discontinuation associé aux antidépresseurs.
Pitchot, William ULg; Scantamburlo, Gabrielle ULg; Pinto, Emmanuel ULg et al

in Revue Médicale de Liège (2007), 62

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See detailTherapeutic utilisations of vasopressin and oxytocin in mood disorders.
Scantamburlo, Gabrielle ULg; Pitchot, William ULg; Pinto, Emmanuel ULg et al

in Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (2007), 1

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See detailAVP- and OT-neurophysins response to apomorphine and clonidine in major depression
Scantamburlo, Gabrielle ULg; Fuchs, Sonia; Pitchot, William ULg et al

in Psychoneuroendocrinology (2005), 30(9), 839-845

A number of studies have reported abnormalities of neurohypophyseal secretions in major depressive disorder. The purpose of the present study was to test the influence of apomorphine and clonidine ... [more ▼]

A number of studies have reported abnormalities of neurohypophyseal secretions in major depressive disorder. The purpose of the present study was to test the influence of apomorphine and clonidine injections on plasma vasopressin (AVP)-neurophysins and oxytocin(OT)-neurophysins levels, as direct index of posterior pituitary activation in major depression. Apomorphine and clonidine tests were carried out in 25 medication-free depressive patients and 25 age and gender-matched healthy controls. Blood for neurophysins analysis was drawn by venipuncture at t0, t+20, t+40, t+60 and t+120. Baseline AVP-neurophysins concentrations were significantly tower in depressives (0.12 +/- 0.14 ng/ml) than in healthy subjects (0.24 +/- 2.15 ng/ml) (p < 0.04). The response to apomorphine test revealed a significant reduced response at 20 (p=0.01), 40 (p=0.007) and 60 (p=0.02) and 120 (p=0.02) min. Following clonidine test, post hoc tests also revealed a significant decrease at 0 (p=0.04), 20 (p=0.01), 40 (p=0.007) and 60 (p=0.02) and 120 (p=0.006) min. Concerning OT-neurophysins, no significant differences were found between depressed and controls in response to clonidine or apomorphine injections. Following clonidine and apomorphine, major depressives exhibited a significantly lower peak GH response than controls. The study supports partially the hypothesis of a reduced vasopressinergic activity in depression. Moreover, we did not find any influence of acute apomorphine or clonidine injections on vasopressin-neurophysin or oxytocin-neurophysin in depressive patients. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

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See detailAlcohol craving and the A1 allele of the D2 dopamine receptor gene
Pinto, Emmanuel ULg; Gorwood, P.; Reggers, Jean ULg et al

in European Psychiatry (2005, March), 20(Suppl. 1), 25

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See detailTherapeutic application of right prefrontal low repetitive transcranial magnetic stimulation on depressed patients
Fuchs, S.; Reggers, Jean ULg; Pinto, Emmanuel ULg et al

in European Neuropsychopharmacology (2004, October), 14(Suppl. 3), 226

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See detailNeurohypophyseal response to apomorphine and clonidine stimulation in major depression
Scantamburlo, Gabrielle ULg; Fuchs, Sonia; Pitchot, William ULg et al

in European Neuropsychopharmacology (2004, October), 14(Suppl. 3), 291-292

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See detailPolymorphisms in the CYP 2D6 gene: Association with plasma concentrations of fluoxetine and paroxetine
Charlier, Corinne ULg; Broly, Franck; Pinto, Emmanuel ULg et al

in Therapeutic Drug Monitoring (2003), 25(6), 738-742

Most antidepressants are metabolized by cytochrome P450 (CYP) 2D6, and it is well known that there may be significant interindividual variation in the capacity to metabolize xenobiotics. About 7 to 10% of ... [more ▼]

Most antidepressants are metabolized by cytochrome P450 (CYP) 2D6, and it is well known that there may be significant interindividual variation in the capacity to metabolize xenobiotics. About 7 to 10% of whites are poor metabolisers (PM), and, on the contrary, about 5% are ultrarapid metabolizers (UM), inducing very different rates in the transformation of antidepressants extensively metabolized by CYP 2D6. CYP 2D6 polymorphism can be a potential risk factor for the development of side effects or a reason for the poor efficacy of the treatment. Various probe drugs may be used for phenotyping CYP 2D6, but genotyping is now available using leukocyte DNA and is independent of concomitant drug use. in this study, we used PCR-based methods for the identification of CYP 2D6 genotypes in 49 patients receiving standard doses of fluoxetine or paroxetine and found that plasma concentration of the antidepressant drugs was significantly correlated with genetic status. In one patient who displayed CYP 2D6 gene duplication (UM), paroxetine plasma concentration was extremely low. in PM fluoxetine-treated patients, drug plasma concentration was significantly higher than that seen in extensive metabolizers. [less ▲]

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See detailRelationships between DRD2 and DAT polymorphisms and personality traits in healthy subjects
Pinto, Emmanuel ULg; Reggers, Jean ULg; Adam, Martine ULg et al

in European Neuropsychopharmacology (2003, September), 13(Suppl. 4), 427-428

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