Prophylactic CNS Therapy (with or without Radiation Therapy) in Medium-High Risk Acute Lymphoblastic Leukemia (ALL) Children: Long-Term Outcome Evaluation of the Randomized BFM-oriented Trial 58832 (period 1983-1989) of the EORTC Children Leukemia Group
in Blood (2016, December 04)Detailed reference viewed: 13 (0 ULg)
Validation of the French version of a quality of life instrument designed for teenagers with cancer
Geurten, Claire ; Hoyoux, Claire ; Piette, Caroline et al
Poster (2016, March)Detailed reference viewed: 18 (4 ULg)
Prolapsus rectal revelant une tumeur : interet de l'echographie abdominale, a propos de 3 cas.
; ; et al
in Archives de pediatrie : organe officiel de la Societe francaise de pediatrie (2016), 23(7), 723-6
Rectal prolapse is rare in children and usually benign. However, there are various diseases that can be associated with it, such as cystic fibrosis or other causes of increased abdominal pressure. Here ... [more ▼]
Rectal prolapse is rare in children and usually benign. However, there are various diseases that can be associated with it, such as cystic fibrosis or other causes of increased abdominal pressure. Here, we review the various underlying conditions that pediatricians or pediatric gastroenterologists should consider in the case of rectal prolapse. We report on three cases of children with a rectal prolapse and intra-abdominal tumors. Current recommendations and practice do not include a systematic check via abdominal imaging in cases of rectal prolapse. However, in some situations, imaging is indicated to detect a possible expansive process. Thus, in the presence of recurrent prolapse or of associated urinary or neurological signs, imaging is justified so as to allow for an early diagnosis and treatment of these neoplasms. Given its lack of radiation exposure and good sensitivity in children, ultrasound imaging is the first choice. [less ▲]Detailed reference viewed: 12 (1 ULg)
Impact of Age and Treatment Group in Childhood High Hyperdiploid Low Risk B-Cell Acute Lymphoblastic Leukemia (ALL): Results of the CLG-EORTC 58951 Study
; ; et al
in Blood (2016)Detailed reference viewed: 19 (1 ULg)
Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus.
; ; et al
in Lancet Oncology (2016), 17(6), 231-9
Although there are high survival rates for children with acute lymphoblastic leukaemia, their outcome is often counterbalanced by the burden of toxic effects. This is because reported frequencies vary ... [more ▼]
Although there are high survival rates for children with acute lymphoblastic leukaemia, their outcome is often counterbalanced by the burden of toxic effects. This is because reported frequencies vary widely across studies, partly because of diverse definitions of toxic effects. Using the Delphi method, 15 international childhood acute lymphoblastic leukaemia study groups assessed acute lymphoblastic leukaemia protocols to address toxic effects that were to be considered by the Ponte di Legno working group. 14 acute toxic effects (hypersensitivity to asparaginase, hyperlipidaemia, osteonecrosis, asparaginase-associated pancreatitis, arterial hypertension, posterior reversible encephalopathy syndrome, seizures, depressed level of consciousness, methotrexate-related stroke-like syndrome, peripheral neuropathy, high-dose methotrexate-related nephrotoxicity, sinusoidal obstructive syndrome, thromboembolism, and Pneumocystis jirovecii pneumonia) that are serious but too rare to be addressed comprehensively within any single group, or are deemed to need consensus definitions for reliable incidence comparisons, were selected for assessment. Our results showed that none of the protocols addressed all 14 toxic effects, that no two protocols shared identical definitions of all toxic effects, and that no toxic effect definition was shared by all protocols. Using the Delphi method over three face-to-face plenary meetings, consensus definitions were obtained for all 14 toxic effects. In the overall assessment of outcome of acute lymphoblastic leukaemia treatment, these expert opinion-based definitions will allow reliable comparisons of frequencies and severities of acute toxic effects across treatment protocols, and facilitate international research on cause, guidelines for treatment adaptation, preventive strategies, and development of consensus algorithms for reporting on acute lymphoblastic leukaemia treatment. [less ▲]Detailed reference viewed: 20 (0 ULg)
Purpura thrombocytopénique idiopathique...idiopathique, vraiment?
LONGTON, Julie ; DRESSE, Marie-Françoise ; et al
in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2016), 18(1), 112Detailed reference viewed: 20 (2 ULg)
t(12;21)/TEL-AML1 confers a specific pattern of in vivo sensitivity to treatments in childhood B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL)
Piette, Caroline ; ; et al
in Blood (2015, December 07)Detailed reference viewed: 12 (1 ULg)
Dexamethasone in childhood ALL : split versus continuous - What's best for bones. A review.
Geurten, Claire ; Piette, Caroline ; Hoyoux, Claire
Conference (2015, October 22)Detailed reference viewed: 18 (1 ULg)
Atypical location of intracranial germinoma: a case report.
Piette, Caroline ; ; et al
in Clinical Neuroradiology (2015), 25(1), 79-82Detailed reference viewed: 10 (1 ULg)
Nasal heterotopia versus pilocytic astrocytoma: A narrow border.
; ; et al
in Neuro-Chirurgie (2015), 61(4), 279-82
Failure of the anterior neuropore can lead to three main types of anomalies: nasal dermal sinus, encephalocele and nasal glioma or heterotopia. In this report, we describe a case of intracranial and ... [more ▼]
Failure of the anterior neuropore can lead to three main types of anomalies: nasal dermal sinus, encephalocele and nasal glioma or heterotopia. In this report, we describe a case of intracranial and extracranial glial heterotopia that probably resulted from a common failure of anterior neuropore development. We describe the prenatal radiological assessment based on ultrasound and MRI results, and consider their limitation for early fetal diagnosis. We also discuss the embryogenesis and the possible pathogenic mechanisms involved. [less ▲]Detailed reference viewed: 15 (0 ULg)
Tumeurs rhabdoïdes néonatales : à propos de deux cas.
; FORGET, Patricia ; Piette, Caroline et al
in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2015), 17(1),Detailed reference viewed: 20 (2 ULg)
Posterior Reversible Encephalopathy Syndrome in Pediatric Leukemia
Carichon, Tifenn ; Piette, Caroline ; et al
in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2015), 17(1), 48Detailed reference viewed: 20 (2 ULg)
UNE TUMEUR RARE DE LA FACE CHEZ UN NOURRISSON DE 6 MOIS
; DEMEZ, Pierre ; FORGET, Patricia et al
in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2015), 17(1), 46Detailed reference viewed: 24 (5 ULg)
LE CANCER DU TRES JEUNE ENFANT : EPIDEMIOLOGIE LIEGEOISE
; RIGO, Vincent ; FORGET, Patricia et al
in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2015), 17(1), 47Detailed reference viewed: 17 (2 ULg)
Osteopetrosis mimicking juvenile myelomonocytic leukemia.
Hoyoux, Claire ; DRESSE, Marie-Françoise ; FORGET, Patricia et al
in Pediatrics International : Official Journal of the Japan Pediatric Society (2014)Detailed reference viewed: 17 (2 ULg)
Long-term follow-up studies: the Children's Leukemia Group experience
Conference (2013)Detailed reference viewed: 14 (1 ULg)
Pilot project in CHR Citadelle - Liège : inviting siblings of children with cancer to a creative and expressive week end with psychologists and oncologist.
FORGET, Patricia ; BADOT, Isabelle ; Missotten, Pierre et al
in Pediatric Blood & Cancer (2013)Detailed reference viewed: 23 (2 ULg)
Primary spinal cord ependymoma WHO grade II - a multi-institutional European series of 29 patients
; ; et al
in Pediatric Blood & Cancer (2013)Detailed reference viewed: 16 (1 ULg)
Second malignant neoplasms after treatment of childhood acute lymphoblastic leukemia.
; ; et al
in Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2013), 31(19), 2469-76
PURPOSE: Second malignant neoplasms (SMNs) after diagnosis of childhood acute lymphoblastic leukemia (ALL) are rare events. PATIENTS AND METHODS: We analyzed data on risk factors and outcomes of 642 ... [more ▼]
PURPOSE: Second malignant neoplasms (SMNs) after diagnosis of childhood acute lymphoblastic leukemia (ALL) are rare events. PATIENTS AND METHODS: We analyzed data on risk factors and outcomes of 642 children with SMNs occurring after treatment for ALL from 18 collaborative study groups between 1980 and 2007. RESULTS: Acute myeloid leukemia (AML; n = 186), myelodysplastic syndrome (MDS; n = 69), and nonmeningioma brain tumor (n = 116) were the most common types of SMNs and had the poorest outcome (5-year survival rate, 18.1% +/- 2.9%, 31.1% +/- 6.2%, and 18.3% +/- 3.8%, respectively). Five-year survival estimates for AML were 11.2% +/- 2.9% for 125 patients diagnosed before 2000 and 34.1% +/- 6.3% for 61 patients diagnosed after 2000 (P < .001); 5-year survival estimates for MDS were 17.1% +/- 6.4% (n = 36) and 48.2% +/- 10.6% (n = 33; P = .005). Allogeneic stem-cell transplantation failed to improve outcome of secondary myeloid malignancies after adjusting for waiting time to transplantation. Five-year survival rates were above 90% for patients with meningioma, Hodgkin lymphoma, thyroid carcinoma, basal cell carcinoma, and parotid gland tumor, and 68.5% +/- 6.4% for those with non-Hodgkin lymphoma. Eighty-nine percent of patients with brain tumors had received cranial irradiation. Solid tumors were associated with cyclophosphamide exposure, and myeloid malignancy was associated with topoisomerase II inhibitors and starting doses of methotrexate of at least 25 mg/m(2) per week and mercaptopurine of at least 75 mg/m(2) per day. Myeloid malignancies with monosomy 7/5q- were associated with high hyperdiploid ALL karyotypes, whereas 11q23/MLL-rearranged AML or MDS was associated with ALL harboring translocations of t(9;22), t(4;11), t(1;19), and t(12;21) (P = .03). CONCLUSION: SMNs, except for brain tumors, AML, and MDS, have outcomes similar to their primary counterparts. [less ▲]Detailed reference viewed: 21 (0 ULg)