References of "Petrossians, Patrick"
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See detailMcCune-Albright Syndrome: A Detailed Pathological And Genetic Analysis of Disease Effects in an Adult Patient.
Vasilev, Vladimir; Daly, Adrian ULg; THIRY, Albert ULg et al

in The Journal of clinical endocrinology and metabolism (2014)

Context: McCune Albright syndrome (MAS) is a clinical association of endocrine and non-endocrine anomalies caused by post-zygotic mutation of the GNAS1 gene, leading to somatic activation of the ... [more ▼]

Context: McCune Albright syndrome (MAS) is a clinical association of endocrine and non-endocrine anomalies caused by post-zygotic mutation of the GNAS1 gene, leading to somatic activation of the stimulatory alpha subunit of G protein (Gsalpha). Important advances have been made recently in describing pathological characteristics of many MAS-affected tissues, particularly pituitary, testicular and adrenal disease. Other rarer disease related features are emerging. Objective: To study pathological and genetic findings of MAS on a tissue-by-tissue basis in classically and non classically affected tissues. Design: A comprehensive autopsy and genetic analysis Setting: Tertiary referral University Hospital Patients: Adult male patient with MAS and severe disease burden including gigantism Intervention(s): Clinical, hormonal and radiographic studies; gross and microscopic pathology analyses, conventional PCR and droplet digital PCR analyses of affected and non affected tissues Main Outcome Measure: Pathological findings, presence of GNAS1 mutations Results: The patient was diagnosed with MAS syndrome at six years of age based on the association of cafe-au-lait spots and radiological signs of polyostotic fibrous dysplasia. Gigantism developed and hyperprolactinemia, hypogonadotropic hypogonadism and hyperparathyroidism were diagnosed throughout adult period. The patient died at the age of 39 from pulmonary embolism. A detailed study revealed mosaiscism for the p.R201C GNAS mutation distributed across many endocrine and non-endocrine tissues. These genetically implicated tissues included rare or previously undescribed disease associations including primary hyperparathyroidism, and hyperplasia of the thymus and endocrine pancreas. Conclusions: This comprehensive pathological study of a single patient highlights the complex clinical profile of MAS and illustrates important advances in understanding the characteristics of somatic GNAS1 related pathology across a wide range of affected organs. [less ▲]

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See detailCorrelations of the High Resolution MRI aspect of GH-secreting pituitary adenomas prior to treatment
Potorac, Iulia ULg; PETROSSIANS, Patrick ULg; Schillo, F et al

in Abstract book - Symposium "Perspectives in Endocrinology" Congresses Highlights 2013:ECE Copenhagen, ENDO SF, SFE Paris (2014, February)

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See detailHypopituitarism in pituitary gigantism (results of an international study)
Rostomyan, L; Daly, Adrian ULg; Shah, N et al

in Abstract book - Symposium "Perspectives in Endocrinology" Congresses Highlights 2013:ECE Copenhagen, ENDO SF, SFE Paris (2014, February)

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See detailLiege acromegay Survey : An epidemiological study about the average age of death and the causes of mortality of acromegalic patients managed in liege
Petignot, S; PETROSSIANS, Patrick ULg; Daly, Adrian ULg et al

in Abstract book - Symposium "Perspectives in Endocrinology" Congresses Highlights 2013:ECE Copenhagen, ENDO SF, SFE Paris (2014, February)

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See detailHypopituitarism in pituitary gigantism (results of an international study)
Rostomyan, Liliya ULg; Daly, Adrian ULg; Shah, NS et al

in The 3rd ENEA Workshop : Hypopituitarism - Abstract book (2013, December)

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See detailCorrelations of the High Resolution MRI aspect of GH-secreting pituitary adenomas prior to treatment
Potorac, Iulia ULg; PETROSSIANS, Patrick ULg; Schillo, F et al

in 23rd meeting of the Belgian Endocrine Society - Abstract book (2013, October 19)

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See detailLe gigantisme : Les résultats d'une étude clinique et génétique internationale
Rostomyan, Liliya ULg; Daly, Adrian ULg; Lila, A et al

in Annales d'Endocrinologie (2013, October), 74

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See detailCorrélations significatives de l'aspect en IRM haute résolution des adénomes hypophysairesà GH avant traitement
Potorac, Iulia ULg; PETROSSIANS, Patrick ULg; Schillo, F et al

in Annales d'Endocrinologie (2013, October), 74

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See detailLessons from the Liege Acromegaly Survey (LAS)
PETROSSIANS, Patrick ULg; Zacharieva, Sabina; Chanson, Philippe et al

in Endocrine Abstracts - 15 the European Congress of Endocrinology (2013, May)

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See detailThe clinical and genetic characteristics of patients with gigantism
Rostomyan, Liliya ULg; Daly, Adrian ULg; Tichomirowa, M et al

in Symposium "Perspectives in Endocrinology" - Congresses Highlights 2012: ECE Firenze, ENDO Houston, ESPE Leipzig, SFE Toulouse, IWMEN Liège (2013)

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See detailMalabsorption des hormones thyroïdiennes... ou simple manque de compliance ?
Benoit, Arnaud ULg; BOUQUEGNEAU, Antoine ULg; PETROSSIANS, Patrick ULg et al

in Revue Médicale de Liège (2013), 68(3), 118-121

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See detailThe clinical and genetic characteristics of patients with gigantism
Rostomyan, Liliya ULg; Daly, Adrian ULg; Tichomirova, M et al

in Abstract Book - 13th International Workshop on Multiple Endocrine Neoplasia (2012, September)

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See detailErythropoiesis in acromegaly : effect of GH or IGF-1 ? Data from the LAS (Liege Acromegaly Survey)
PETROSSIANS, Patrick ULg; Zacharieva, S; Chanson, P et al

in Journal für Klinische Endokrinologie und Stoffwechsel (2012, September), 5(3), 45

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See detailGH or IGF-1 : which one is raising blood glucose ? Hints from the LAS (Liege Acromegaly Survey)
PETROSSIANS, Patrick ULg; Zacharieva, S; Chanson, P et al

in Journal of Klinische Endokrinologie und Stoffwechsel (2012, September), 5(3),

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See detailAge, GH and tumor size : the triangular relation in acromegaly. Data from the LAS (Liege Acromegaly Survey)
PETROSSIANS, Patrick ULg; Zacharieva, S; Chanson, P et al

in Journal für Klinische Endokrinologie und Stoffwechsel (2012, September), 5(3), 43

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See detailAging of the newly diagnosed acromegalic patients : data frome the LAS (Liege Acromegaly Survey)
PETROSSIANS, Patrick ULg; Zacharieva, S; Chanson, P et al

in Journal für Klinische Endokrinologie und Stoffwechsel (2012, September), 5(3), 33

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See detailCaracteristicas de prolactinomas resisitentes a dosis estandar de cabergolina : un estudio multicentrico en 92 pacientes
Beckers, Albert ULg; Jaffrain-Réa, ML; VROONEN, Laurent ULg et al

in Abstract book - 54 Congreso Sociedad Espanola de Endocrinologia y nutrition (2012, May 23)

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See detailEl sindrome tiro-gastrico : screening en 410 pacientes atendidos pro patologia tiroidea
Tome, M; VALDES SOCIN, Hernan Gonzalo ULg; Auriemma, R et al

in Abstract book - 54 Congreso Sociedad Espanola de Endocrinologia y nutrition (2012, May 23)

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