References of "Penning, Sophie"
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See detailSurvey about diffusion and adoption of glycaemic controller in European intensive care units
Penning, Sophie ULg; Pironet, Antoine ULg; Chase, J. Geoffrey et al

Conference (2014, August)

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See detailSurvey about diffusion and adoption of glycaemic controller in European intensive care units
Penning, Sophie ULg; Pironet, Antoine ULg; Chase, J. Geoffrey et al

in Proceedings of the 19th IFAC Conference (2014, August)

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See detailInsulin Sensitivity Variability during Hypothermia
Sah Pri, Azurahisham; Chase, J. Geoffrey; Pretty, Christopher et al

in Proceedings of the 19th IFAC Conference (2014, August)

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See detailDoes the achievement of an intermediate glycemic target reduce organ failure and mortality? A post-hoc analysis of the Glucontrol Trial
Penning, Sophie ULg; Chase, J. Geoffrey; Preiser, Jean-Charles et al

in Journal of Critical Care (2014)

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See detailEvolution of insulin sensitivity and its variability in out of hospital cardiac arrest (OHCA) patients treated with hypothermia.
Sah Pri, Azurahisham; Chase, James G.; Pretty, Christopher G. et al

in Critical care (London, England) (2014), 18(5), 586

IntroductionTherapeutic hypothermia (TH) is often used to treat out of hospital cardiac arrest (OHCA) patients who also often simultaneously receive insulin for stress-induced hyperglycaemia. However, the ... [more ▼]

IntroductionTherapeutic hypothermia (TH) is often used to treat out of hospital cardiac arrest (OHCA) patients who also often simultaneously receive insulin for stress-induced hyperglycaemia. However, the impact of TH on systemic metabolism and insulin resistance in critical illness is unknown. This study analyses the impact of TH on metabolism, including the evolution of insulin sensitivity (SI) and its variability, in patients with coma after OHCA.MethodsThis study uses a clinically validated, model-based measure of SI. Insulin sensitivity was identified hourly using retrospective data from 200 post-cardiac arrest patients (8,522 hours) treated with TH, shortly after admission to the Intensive Care Unit (ICU). Blood glucose and body temperature readings were taken every one to two hours. Data were divided into three periods: 1) cool (T <35 degrees C); 2) an idle period of two hours as normothermia was re-established; and 3) warm (T >37 degrees C). A maximum of 24 hours each for the cool and warm periods were considered. The impact of each condition on SI is analysed per cohort and per patient for both level and hour-to-hour variability, between periods and in 6-hour blocks.ResultsCohort and per patient median SI levels increase consistently by 35% to 70% and 26% to 59% (P <0.001) respectively from cool to warm. Conversely, cohort and per patient SI variability decreased by 11.1% to 33.6% (P <0.001) for the first 12 hours of treatment. However, SI variability increases between the 18th and 30th hours over the cool-warm transition, before continuing to decrease afterward.ConclusionsOCHA patients treated with TH have significantly lower and more variable SI during the cool period, compared to the later warm period. As treatment continues, SI level rises, and variability decreases consistently except for a large, significant increase during the cool-warm transition. These results demonstrate increased resistance to insulin during mild induced hypothermia. Our study might have important implications for glycaemic control during targeted temperature management. [less ▲]

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See detailInterstitial insulin kinetic parameters for a 2-compartment insulin model with saturable clearance
Pretty, Christopher G.; Le Compte, Aaron; Penning, Sophie ULg et al

in Computer Methods & Programs in Biomedicine (2014)

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See detailCalculez l'âge de vos artères
Pironet, Antoine ULg; Penning, Sophie ULg

Learning material (2013)

Poster présenté lors de la Nuit des Chercheurs, édition 2013. L'activité consistait à calculer la résistance et la compliance (élasticité) des artères des visiteurs, sur base des mesures suivantes ... [more ▼]

Poster présenté lors de la Nuit des Chercheurs, édition 2013. L'activité consistait à calculer la résistance et la compliance (élasticité) des artères des visiteurs, sur base des mesures suivantes : taille, poids, pression artérielle et fréquence cardiaque. [less ▲]

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See detailImpact of sensor and measurement timing errors on model-based insulin sensitivity
Pretty, Christopher ULg; Signal, Matthew; Fisk, Liam et al

in Computer Methods & Programs in Biomedicine (2013)

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See detailInsulin Sensitivity during Hypothermia in Critically Ill Patients
Sah Pri, Azurahisham; Chase, J. Geoffrey; Le Compte, Aaron J. et al

Poster (2013, September)

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See detailModel-based glycemic control in critical care
Pretty, Christopher ULg; Penning, Sophie ULg; Le Compte, Aaron J. et al

Poster (2012, December)

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See detailModel-based glycemic control in critical care
Pretty, Christopher ULg; Penning, Sophie ULg; Le Compte, Aaron J. et al

in Proceedings of the 11th Belgian Day on Biomedical Engineering (2012, December)

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See detailInsulin clearance during hyper-insulinemia euglycemia therapy
Penning, Sophie ULg; MASSION, Paul ULg; Pretty, Christopher ULg et al

in Proceedings of the 11th Belgian Day on Biomedical Engineering (2012, December)

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See detailInsulin clearance during hyper-insulinemia euglycemia therapy
Penning, Sophie ULg; MASSION, Paul ULg; Pretty, Christopher ULg et al

Poster (2012, December)

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See detailCumulative time in band (cTIB): glycemic level, variability and patient outcome all in one
Penning, Sophie ULg; Signal, Matthew; Preiser, Jean-Charles et al

Conference (2012, October 15)

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See detailCumulative time in band: glycemic level, variability and patient outcome vs. mortality
Penning, Sophie ULg; Signal, Matthew; Preiser, Jean-Charles et al

Poster (2012, October)

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See detailCumulative Time in Band (cTIB): Glycemic Level, Variability and Patient Outcome All in 1
Penning, Sophie ULg; Signal, Matthew; Preiser, Jean-Charles et al

in Intensive Care Medicine (2012, October), 38 (Suppl 1)

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See detailSecond pilot trials of the STAR-Liege protocol for tight glycemic control in critically ill patients
Penning, Sophie ULg; Le Compte, Aaron J.; MASSION, Paul ULg et al

in BioMedical Engineering OnLine (2012)

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