References of "Penning, Sophie"
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See detailSurvey about diffusion and adoption of glycaemic controller in European intensive care units
Penning, Sophie ULg; Pironet, Antoine ULg; Chase, J. Geoffrey et al

Conference (2014, August)

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See detailSurvey about diffusion and adoption of glycaemic controller in European intensive care units
Penning, Sophie ULg; Pironet, Antoine ULg; Chase, J. Geoffrey et al

in Proceedings of the 19th IFAC Conference (2014, August)

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See detailInsulin Sensitivity Variability during Hypothermia
Sah Pri, Azurahisham; Chase, J. Geoffrey; Pretty, Christopher et al

in Proceedings of the 19th IFAC Conference (2014, August)

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See detailDoes the achievement of an intermediate glycemic target reduce organ failure and mortality? A post-hoc analysis of the Glucontrol Trial
Penning, Sophie ULg; Chase, J. Geoffrey; Preiser, Jean-Charles et al

in Journal of Critical Care (2014)

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See detailInterstitial insulin kinetic parameters for a 2-compartment insulin model with saturable clearance
Pretty, Christopher G.; Le Compte, Aaron; Penning, Sophie ULg et al

in Computer Methods & Programs in Biomedicine (2014)

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See detailCalculez l'âge de vos artères
Pironet, Antoine ULg; Penning, Sophie ULg

Learning material (2013)

Poster présenté lors de la Nuit des Chercheurs, édition 2013. L'activité consistait à calculer la résistance et la compliance (élasticité) des artères des visiteurs, sur base des mesures suivantes ... [more ▼]

Poster présenté lors de la Nuit des Chercheurs, édition 2013. L'activité consistait à calculer la résistance et la compliance (élasticité) des artères des visiteurs, sur base des mesures suivantes : taille, poids, pression artérielle et fréquence cardiaque. [less ▲]

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See detailImpact of sensor and measurement timing errors on model-based insulin sensitivity
Pretty, Christopher ULg; Signal, Matthew; Fisk, Liam et al

in Computer Methods & Programs in Biomedicine (2013)

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See detailInsulin Sensitivity during Hypothermia in Critically Ill Patients
Sah Pri, Azurahisham; Chase, J. Geoffrey; Le Compte, Aaron J. et al

Poster (2013, September)

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See detailModel-based glycemic control in critical care
Pretty, Christopher ULg; Penning, Sophie ULg; Le Compte, Aaron J. et al

Poster (2012, December)

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See detailModel-based glycemic control in critical care
Pretty, Christopher ULg; Penning, Sophie ULg; Le Compte, Aaron J. et al

in Proceedings of the 11th Belgian Day on Biomedical Engineering (2012, December)

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See detailInsulin clearance during hyper-insulinemia euglycemia therapy
Penning, Sophie ULg; MASSION, Paul ULg; Pretty, Christopher ULg et al

in Proceedings of the 11th Belgian Day on Biomedical Engineering (2012, December)

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See detailInsulin clearance during hyper-insulinemia euglycemia therapy
Penning, Sophie ULg; MASSION, Paul ULg; Pretty, Christopher ULg et al

Poster (2012, December)

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See detailCumulative time in band (cTIB): glycemic level, variability and patient outcome all in one
Penning, Sophie ULg; Signal, Matthew; Preiser, Jean-Charles et al

Conference (2012, October 15)

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See detailCumulative time in band: glycemic level, variability and patient outcome vs. mortality
Penning, Sophie ULg; Signal, Matthew; Preiser, Jean-Charles et al

Poster (2012, October)

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See detailCumulative Time in Band (cTIB): Glycemic Level, Variability and Patient Outcome All in 1
Penning, Sophie ULg; Signal, Matthew; Preiser, Jean-Charles et al

in Intensive Care Medicine (2012, October), 38 (Suppl 1)

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See detailSecond pilot trials of the STAR-Liege protocol for tight glycemic control in critically ill patients
Penning, Sophie ULg; Le Compte, Aaron J.; MASSION, Paul ULg et al

in BioMedical Engineering OnLine (2012)

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See detailInsulin Kinetics during Hyper-Insulinemia Euglycemia Therapy (HIET)
Penning, Sophie ULg; MASSION, Paul ULg; Le Compte, Aaron J. et al

in Proceedings of the 8th IFAC Symposium on Biological and Medical Systems (2012, August)

Hyper-insulinemia euglycemia therapy (HIET) is a supra-physiological insulin dosing protocol used in acute cardiac failure to reduce dependency on inotropes to augment or generate cardiac output, and is ... [more ▼]

Hyper-insulinemia euglycemia therapy (HIET) is a supra-physiological insulin dosing protocol used in acute cardiac failure to reduce dependency on inotropes to augment or generate cardiac output, and is based on the inotropic effects of insulin at high doses up to 45-250x normal daily dose. Such high insulin doses are managed using intravenous glucose infusion to control glycemia and prevent hypoglycemia. However, both insulin dosing and glycemic control in these patients is managed ad-hoc. This research examines a selection of clinical data to determine the effect of high insulin dosing on renal clearance and insulin sensitivity, to assess the feasibility of using model-based methods to control and guide these protocols. The results show that the model and, in particular, the modeled renal clearance constant are adequate and capture measured data well, although not perfectly. Equally, insulin sensitivity over time is similar to broader critical care cohorts in level and variability, and these results are the first time they have been presented for this cohort. While more data is needed to confirm and further specify these results, it is clear that the model used is adequate for controlling HIET in a model-based framework. [less ▲]

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