   5',6'-Dehydroguiachrysine and 5',6'-Dehydroguiaflavine, Two Curarizing Quaternary Indole Alkaloids from the Stem Bark of Strychnos Guianensis; ; et al in Phytochemistry (2001), 58(4), 619-26 Two new quaternary indole alkaloids 5',6'-dehydroguiachrysine (1) and 5',6'-dehydroguiaflavine (2) were isolated from Strychnos guianensis stem bark. Their structures were determined by analysis of ... [more ▼] Two new quaternary indole alkaloids 5',6'-dehydroguiachrysine (1) and 5',6'-dehydroguiaflavine (2) were isolated from Strychnos guianensis stem bark. Their structures were determined by analysis of spectral data. Their inhibitory effects on neuromuscular transmission are also reported and compared to that of other quaternary alkaloids. [less ▲] Detailed reference viewed: 8 (2 ULg)Main Glucosidase Conversion Products of the Gluco-Alkaloids Dolichantoside and Palicoside; Tits, Monique  ; et alin Phytochemistry (2001), 57(5), 653-9 The enzymatic glucose cleavage of palicoside revealed the biosynthetic pathway to akagerine, whereas the conversion of dolichantoside led to a new quaternary heteroyohimbine alkaloid named N(b)-methyl-21 ... [more ▼] The enzymatic glucose cleavage of palicoside revealed the biosynthetic pathway to akagerine, whereas the conversion of dolichantoside led to a new quaternary heteroyohimbine alkaloid named N(b)-methyl-21-beta-hydroxy-mayumbine. The hypothetical models of reactions occurring after the conversion of both substrates are proposed. Dolichantoside and palicoside, as well as Strychnos mellodora stem bark crude ethanol extract, exhibit significant antimycotic activity against human pathogens in presence of specific glucosidase. [less ▲] Detailed reference viewed: 18 (1 ULg)Strychnogucines a and B, Two New Antiplasmodial Bisindole Alkaloids from Strychnos IcajaFrederich, Michel ; Gillet, Marie-Claire ; Prosperi, Christelle et alin Journal of Natural Products (2001), 64(1), 12-16 A reinvestigation of Strychnos icaja roots has resulted in the isolation of two tertiary quasi-symmetric bisindole alkaloids named strychnogucines A (1) and B (2). Their structures were identified by ... [more ▼] A reinvestigation of Strychnos icaja roots has resulted in the isolation of two tertiary quasi-symmetric bisindole alkaloids named strychnogucines A (1) and B (2). Their structures were identified by means of spectroscopic data interpretation. Compound 2 was highly active in vitro and compound 1 moderately active against four strains of Plasmodium falciparum. Strychnogucine B (2) was more active against a chloroquine-resistant strain than against a chloroquine-sensitive one (best CI(50), 80 nM against the W2 strain). In addition, this compound showed a selective antiplasmodial activity with 25-180 times greater toxicity toward P. falciparum, relative to cultured human cancer cells (KB) or human fibroblasts (WI38). [less ▲] Detailed reference viewed: 45 (7 ULg)Guiaflavine, a New Bisindole Quaternary Alkaloid from the Stem Bark of Strychnos Guianensis; Tits, Monique ; et alin Journal of Natural Products (1999), 62(6), 898-900 A reinvestigation of Strychnos guianensis resulted in the isolation of a colored quaternary bisindole alkaloid from the stem bark. The structure of this new substance, guiaflavine (1), was defined by ... [more ▼] A reinvestigation of Strychnos guianensis resulted in the isolation of a colored quaternary bisindole alkaloid from the stem bark. The structure of this new substance, guiaflavine (1), was defined by detailed spectroscopic methods and comparison with model compounds. [less ▲] Detailed reference viewed: 16 (2 ULg)beta-carboline glucoalkaloids from Strychnos mellodora; Tits, Monique ; et alin Phytochemistry (1999), 51(8), 1171-1176 Detailed reference viewed: 9 (0 ULg)3 ',4 ',5 ',6 ' tetradehydrolongicaudatine Y, an anhydronium base from Strychnos usambarensisFrederich, Michel ; ; et alin Phytochemistry (1998), 48(7), 1263-1266 Detailed reference viewed: 13 (3 ULg) |
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