References of "Peeters, Dominique"
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See detailAspergillosis - Canine
Billen, Frédéric ULiege; Peeters, Dominique ULiege

in Ettinger, Stephen; Feldman, Edward; Côté, Etienne (Eds.) Textbook of Veterinary Internal Medicine, 8 th Edition (2017)

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See detailCytology of reactional spleen may be misleading
Ramery, Eve ULiege; Vangrinsven, Emilie ULiege; Gommeren, Kris ULiege et al

Poster (2016, October)

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See detailComputed tomography-guided injection of muscle-derived mesenchimal stem cells in the intervertebral disc of dogs affected by natural disc degeneration: clinical safety and intervertebral disc imaging assessment
Liotta, Annalisa Pia ULiege; Sandersen, Charlotte ULiege; Ceusters, Justine ULiege et al

Poster (2016, September 01)

Introduction/Purpose: Pre-clinical randomized controlled animal trials have been conducted to evaluate the effects of mesenchymal stem cell (MSCs) transplantation on intervertebral disc (IVD) degeneration ... [more ▼]

Introduction/Purpose: Pre-clinical randomized controlled animal trials have been conducted to evaluate the effects of mesenchymal stem cell (MSCs) transplantation on intervertebral disc (IVD) degeneration. According to their histological results and to imaging assessment of the IVD, intradiscal injection of MSCs is effective, arresting or slowing IVDD process, and is associated with a low complication rate. Few of these studies have been conducted on canine artificially degenerated IVD, using bone marrow or adipose-derived MSCs. Therefore a systematic study on naturally degenerated IVD using MSCs obtained from autologous muscular tissue in dogs is still lacking. The aims of this study were to evaluate the clinical effects of intradiscal injection of muscle-derived MSCs and its effects on imaging features of the intervertebral disc. Methods: Eight experimental dogs were randomly included with the approval of the University’s Animal Care and Use Committee. The final inclusion criteria were the presence of naturally degenerated lumbosacral IVD detected on low-field magnetic resonance (MRI) images and the obtaining of 3 x 106 autologous muscle-derived MSCs. A computed tomography (CT) and MRI examination was performed before and 2 months after the procedure and 13 imaging parameters were assessed. Mesenchymal stem cells diluted in 0,2 ml of FRS Hypothermosol were injected in the lumbosacral IVD under CT-guidance. Clinical examinations were performed regularly during 1 month after the procedure. Results: Six dogs met the inclusion criteria. The remaining 2 dogs did not undergo intradiscal injections, but were used as control group. No major or minor complications were reported during the procedure. No abnormalities were noticed during the clinical examinations. No statistically significant variations of IVD imaging features were noticed before and after the injections. Discussion/Conclusions: Intradiscal injection of muscle-derived MSCs is clinically safe and it is not associated with any progression of the IVD degeneration, detected by CT or low-field MRI imaging. Further studies are needed to assess its efficacy as treatment for the canine natural IVD degeneration. [less ▲]

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See detailQuantitative PCR and Cytology of Bronchoalveolar Lavage Fluid in Dogs with Bordetella bronchiseptica Infection
Canonne-Guibert, Morgane ULiege; Billen, Frédéric ULiege; Tual, Charlotte ULiege et al

in Journal of Veterinary Internal Medicine (2016), 30(4), 1204-1209

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See detailEvaluation of the effect of oral omeprazole on canine cerebrospinal fluid production: A pilot study.
Girod, Maud ULiege; Allerton, F.; Gommeren, Kris ULiege et al

in Veterinary journal (London, England : 1997) (2016), 209

Administration of omeprazole by ventriculo-cisternal perfusion or intravenously has been shown to decrease cerebrospinal fluid (CSF) production in dogs and rabbits. Oral omeprazole has consequently been ... [more ▼]

Administration of omeprazole by ventriculo-cisternal perfusion or intravenously has been shown to decrease cerebrospinal fluid (CSF) production in dogs and rabbits. Oral omeprazole has consequently been recommended to reduce CSF production in dogs with conditions in which clinical signs may be attributable to an accumulation of CSF in the central nervous system (e.g. hydrocephalus, syringomyelia). The albumin quotient (QAlb), the ratio between CSF and serum albumin concentration, has been proposed as a reliable means to evaluate CSF production; decreasing CSF production should cause an increase in QAlb. The aims of this study were to assess the effect of oral administration of omeprazole on QAlb in dogs and to compare two methods to assess CSF albumin concentration. Fifteen healthy Beagle dogs received omeprazole (1.2 mg/kg/day) orally for 14 days; CSF and blood were obtained before and after treatment. CSF albumin concentrations were evaluated by nephelometry and high-resolution protein electrophoresis. Regardless of the method used for measuring albumin, QAlb did not change significantly following oral omeprazole administration, suggesting that CSF production in healthy dogs may not be affected by chronic oral therapy with omeprazole. [less ▲]

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See detailClinical effects of computed tomography-guided lumbosacral facet joint, transforaminal epidural, and translaminar epidural injections of methylprednisolone acetate in healthy dogs.
Liotta, Annalisa Pia ULiege; Girod, Maud ULiege; Peeters, Dominique ULiege et al

in American Journal of Veterinary Research (2016), 77(10), 1132-9

OBJECTIVE To determine clinical effects of CT-guided lumbosacral facet joint, transforaminal epidural, and translaminar epidural injections of methylprednisolone acetate in healthy dogs. ANIMALS 15 ... [more ▼]

OBJECTIVE To determine clinical effects of CT-guided lumbosacral facet joint, transforaminal epidural, and translaminar epidural injections of methylprednisolone acetate in healthy dogs. ANIMALS 15 healthy Beagles. PROCEDURES Dogs were randomly assigned to 3 groups (5 dogs/group) and received a single CT-guided lumbosacral facet joint, transforaminal epidural, or translaminar epidural injection of methylprednisolone acetate (0.1 mg/kg). Contrast medium was injected prior to injection of methylprednisolone to verify needle placement. Neurologic examinations were performed 1, 3, 7, and 10 days after the injection. In dogs with neurologic abnormalities, a final neurologic examination was performed 24 days after the procedure. RESULTS Methylprednisolone injections were successfully performed in 14 of the 15 dogs. In 1 dog, vascular puncture occurred, and the methylprednisolone injection was not performed. No major or minor complications were identified during or immediately after the procedure, other than mild transient hyperthermia. During follow-up neurologic examinations, no motor, sensory, or postural deficits were identified, other than mild alterations in the patellar, withdrawal, cranial tibial, and perineal reflexes in some dogs. Overall, altered reflexes were observed in 11 of the 14 dogs, during 27 of 65 neurologic examinations. CONCLUSIONS AND CLINICAL RELEVANCE Results suggested that CT-guided lumbosacral facet joint, transforaminal epidural, and translaminar epidural injections of methylprednisolone acetate were associated with few complications in healthy dogs. However, the number of dogs evaluated was small, and additional studies are needed to assess clinical efficacy and safety of these procedures. [less ▲]

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See detailFeline panleukopenia virus in cerebral neurons of young and adult cats.
Garigliany, Mutien-Marie ULiege; Gilliaux, Gautier ULiege; Jolly, Sandra et al

in BMC veterinary research (2016), 12(1), 28

BACKGROUND: Perinatal infections with feline panleukopenia virus (FPV) have long been known to be associated with cerebellar hypoplasia in kittens due to productive infection of dividing neuroblasts. FPV ... [more ▼]

BACKGROUND: Perinatal infections with feline panleukopenia virus (FPV) have long been known to be associated with cerebellar hypoplasia in kittens due to productive infection of dividing neuroblasts. FPV, like other parvoviruses, requires dividing cells to replicate which explains the usual tropism of the virus for the digestive tract, lymphoid tissues and bone marrow in older animals. RESULTS: In this study, the necropsy and histopathological analyses of a series of 28 cats which died from parvovirus infection in 2013 were performed. Infections were confirmed by real time PCR and immunohistochemistry in several organs. Strikingly, while none of these cats showed cerebellar atrophy or cerebellar positive immunostaining, some of them, including one adult, showed a bright positive immunostaining for viral antigens in cerebral neurons (diencephalon). Furthermore, infected neurons were negative by immunostaining for p27(Kip1), a cell cycle regulatory protein, while neighboring, uninfected, neurons were positive, suggesting a possible re-entry of infected neurons into the mitotic cycle. Next-Generation Sequencing and PCR analyses showed that the virus infecting cat brains was FPV and presented a unique substitution in NS1 protein sequence. Given the role played by this protein in the control of cell cycle and apoptosis in other parvoviral species, it is tempting to hypothesize that a cause-to-effect between this NS1 mutation and the capacity of this FPV strain to infect neurons in adult cats might exist. CONCLUSIONS: This study provides the first evidence of infection of cerebral neurons by feline panleukopenia virus in cats, including an adult. A possible re-entry into the cell cycle by infected neurons has been observed. A mutation in the NS1 protein sequence of the FPV strain involved could be related to its unusual cellular tropism. Further research is needed to clarify this point. [less ▲]

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See detailComparaison de l’effet du guidage échographique sur les ponctions de liquide céphalo-rachidien entre les localisations cisternales et lombaires chez le chien : une étude ex vivo
Etienne, Anne-Laure ULiege; Peeters, Dominique ULiege; Busoni, Valeria ULiege

in Annales de Médecine Vétérinaire (2015), 158

RÉSUMÉ : Le placement échoguidé de l’aiguille spinale pour les ponctions cisternale et lombaire chez le chien a été décrit. L’objectif de ce travail était de comparer l’effet du guidage échographique pour ... [more ▼]

RÉSUMÉ : Le placement échoguidé de l’aiguille spinale pour les ponctions cisternale et lombaire chez le chien a été décrit. L’objectif de ce travail était de comparer l’effet du guidage échographique pour la ponction de liquide céphalo-rachidien entre les ponctions cisternale et lombaire. Quatre-vingt-trois opérateurs ont participé à l’étude. Ils étaient divisés en quatre groupes selon leur expérience. Après une formation théorique courte, chaque opérateur a réalisé une ponction cisternale et lombaire en aveugle et sous contrôle échographique sur des cadavres tirés au sort. L’échoguidage lombaire était direct alors que celui cisternal était indirect. Après chaque procédure, les opérateurs ont rempli un questionnaire sur leur expérience, leur performance et leur confiance en soi. L’échoguidage augmentait significativement le taux de réussite global de la ponction (comparée à la méthode en aveugle) mais plus clairement avec la localisation lombaire. Le guidage échographique cisternal améliorait significativement le nombre de tentatives, le temps et la confiance en soi chez les opérateurs inexpérimentés et expérimentés. La première cause d’échec citée était différente selon la localisation de la ponction et était liée à la nature de l’échoguidage. Cette étude démontre que les opérateurs inexpérimentés sont capables de réaliser des ponctions échoguidées après une formation théorique courte, justifiant l’utilité du guidage échographique à des fins pédagogiques. [less ▲]

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See detailCharacterization of Proteinuria in Dogue de Bordeaux Dogs, a Breed Predisposed to a Familial Glomerulonephropathy: A Retrospective Study.
Lavoue, Rachel; Trumel, Catherine; Smets, Pascale M. Y. et al

in PLoS ONE (2015), 10(7), 0133311

Dogue de Bordeaux dog has been reported to be predisposed to a familial glomerulonephropathy that displays some morphological modifications reported in focal and segmental glomerulosclerosis. Prevalence ... [more ▼]

Dogue de Bordeaux dog has been reported to be predisposed to a familial glomerulonephropathy that displays some morphological modifications reported in focal and segmental glomerulosclerosis. Prevalence of quantitatively abnormal renal proteinuria was recently reported to be 33% in this breed. The nature of the proteinuria was assessed by sodium dodecyl sulfate-agarose gel electrophoresis and determinations of urinary markers (urinary retinol-binding protein, urinary N-acetyl-beta-glucosaminidase, urinary albumin and urinary immunoglobulin G) on stored specimens. Diagnostic performances of sodium dodecyl sulfate-agarose gel electrophoresis to identify dogs with elevated urinary biomarkers were assessed. Samples from 102 adult Dogue de Bordeaux dogs (47 non-proteinuric [urine protein-to-creatinine ratio </= 0.2], 20 borderline-proteinuric [0.2< urine protein-to-creatinine ratio </= 0.5] and 35 proteinuric dogs [urine protein-to-creatinine ratio >0.5]) were used, of which 2 were suffering from familial glomerulonephropathy. The electrophoretic protein patterns, for all but one proteinuric dog, were indicative of a glomerular origin and, in all dogs, the urinary albumin concentration related to creatinine concentration and the urinary immunoglobulin G concentration related to creatinine concentration were above the upper limit of the reference interval established for the breed. Sensitivity and specificity of sodium dodecyl sulfate-agarose gel electrophoresis identifying dogs with elevated urinary albumin concentration were 94% and 92%, respectively, while diagnostic performance of sodium dodecyl sulfate-agarose gel electrophoresis in detecting dogs with elevated urinary immunoglobulin G concentration yielded sensitivity and specificity of 90% and 74%, respectively. These results suggest that all proteinuric and some borderline-proteinuric Dogue de Bordeaux dogs likely have underlying glomerular lesions and that sodium dodecyl sulfate-agarose gel electrophoresis and urinary markers might be useful to screen dogs with borderline-proteinuria. Additional investigations are warranted to assess if these findings are related to the familial glomerulonephropathy. [less ▲]

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See detailDetection of Angiostrongylus vasorum in the bronchoalveolar lavage fluid or faeces of coughing and healthy dogs in Belgium.
Canonne-Guibert, Morgane ULiege; Roels, Elodie ULiege; Caron, Yannick ULiege et al

in Proceedings of the 24th Ecvim Meeting, Mainz, Germany - 4-6 September 2014 (2014, September)

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See detailAssessment of Toll-like receptor 2, 4 and 9 SNP genotypes in canine sino-nasal aspergillosis
Mercier; Peters, Iain; Farnir, Frédéric ULiege et al

in BMC Veterinary Research (2014)

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See detailCHARACTERIZATION OF PROTEINURIA IN DOGUE DE BORDEAUX DOGS USING ELECTROPHORESIS AND URINARY BIOMARKERS
Lavoué, Rachel; Smets, P.; Trumel, Cathy et al

in Proceedings of the 2014 ACVIM Forum (2014, June)

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See detailCT SCAN FEATURES OF PRESUMPTIVE HAEMORRHAGIC STROKE IN A DOG WITH CUSHING’S DISEASE
Liotta, Annalisa Pia ULiege; Cavrenne, Romain; Peeters, Dominique ULiege et al

in Case reports in Veterinary Medicine (2014)

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See detailEVALUATION OF A RAPID BEDSIDE SCORING SYSTEM FOR MICROCIRCULATION VIDEOS ACQUIRED FROM DOGS
Gommeren, Kris ULiege; Allerton, Fergus; Morin, Elise et al

in Journal of Veterinary Emergency and Critical Care (2014), 24(5)

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See detailBreed-specific hematologic reference intervals in healthy adult Dogue de Bordeaux dogs
Lavoué, Rachel; Geffré, A; Braun, JP et al

in Veterinary Clinical Pathology (2014), 43

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See detailEosinophilic pulmonary diseases
Clercx, Cécile ULiege; Peeters, Dominique ULiege

in Bonagura, John; Twedt, David (Eds.) Kirk's Current Veterinary Therapy (2014)

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See detailNo serologic evidence for emerging Schmallenberg virus infection in dogs (Canis domesticus)
Garigliany, Mutien-Marie ULiege; Desmecht, Daniel ULiege; Bayrou, Calixte ULiege et al

in Vector Borne & Zoonotic Diseases (2013), 13(11), 1-4

Schmallenberg virus, a novel orthobunyavirus, is spreading among ruminants, especially sheep and cattle throughout Europe. To determine the risk for domestic dog infection, we conducted a survey among ... [more ▼]

Schmallenberg virus, a novel orthobunyavirus, is spreading among ruminants, especially sheep and cattle throughout Europe. To determine the risk for domestic dog infection, we conducted a survey among cases referred to the university Companion Animal Clinic to assess possible seroconversion. No evidence of transmission to dogs was detected. [less ▲]

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