References of "Paquay, Louis"
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See detailNeuropsychiatric Inventory data in a Belgian sample of elderly persons with and without dementia
Squelard, Gilles ULg; Missotten, Pierre ULg; Paquay, Louis et al

in Clinical Interventions in Aging (2012), 2(7), 423-430

Background/aims: This study assesses and compares prevalence of psychological and behavioral symptoms in a Belgian sample of people with and without dementia. Methods: A total of 228 persons older than 65 ... [more ▼]

Background/aims: This study assesses and compares prevalence of psychological and behavioral symptoms in a Belgian sample of people with and without dementia. Methods: A total of 228 persons older than 65 years with dementia and a group of 64 non- demented persons were assessed using the Neuropsychiatric Inventory (NPI) in 2004. Results: Within the group without dementia, the most frequent symptoms were depression, agitation, and irritability. Within the group with dementia, the most common symptoms were depression, irritability, apathy, and agitation. Prevalence of delusions (P [less ▲]

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See detailImpact of place of residence on relationship between quality of life and cognitive decline in dementia
Missotten, Pierre ULg; Thomas, Philippe; Squelard, Gilles ULg et al

in Alzheimer Disease and Associated Disorders (2009), 23(4), 395-400

The aim of this descriptive study was to estimate and compare the association between cognitive decline and quality of life (QOL) for 2 groups of dementia patients differing by place of residence: home or ... [more ▼]

The aim of this descriptive study was to estimate and compare the association between cognitive decline and quality of life (QOL) for 2 groups of dementia patients differing by place of residence: home or institution. Each subject was placed within a specific subgroup according to their Mini-Mental State Examination (MMSE) score and was evaluated by a QOL proxy-assessment [Alzheimer Disease Related Quality of Life (ADRQL)] and a dependency assessment (Katz Activities of Daily Living classification). For the ‘‘at home’’ and ‘‘institution’’ groups, global and subscale ADRQL scores showed significant differences between the 5 MMSE subgroups. Place of residence and MMSE subgroups significantly affected global and subscale ADRQL scores. The MMSE 4 to 8, 9 to 13, and 14 to 18 subgroups had ADRQL global scores significantly better in the institution group than the at home group. In contrast, the MMSE 19 to 23 and 0 to 3 subgroups had similar ADRQL global scores in both places of residence. In conclusion, there is no direct relationship between cognitive decline and QOL, and QOL does not seem to be better at home compared with the institution. [less ▲]

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See detailPrévalences des troubles psychologiques et comportementaux de la démence en fonction du stade évolutif
Squelard, Gilles ULg; Missotten, Pierre ULg; Ylieff, Michel ULg et al

in Revue Francophone de Clinique Comportementale et Cognitive (2009), 14(3), 22-31

Behavioural and psychological signs and symptoms - BPSD are clinical features of dementia. They have considerable impact on the daily life of patients and their caregivers. The aim of this study is to ... [more ▼]

Behavioural and psychological signs and symptoms - BPSD are clinical features of dementia. They have considerable impact on the daily life of patients and their caregivers. The aim of this study is to show the importance of these disorders in dementia semiology and to assess differences in their prevalence across levels of severity of dementia. The sample is made up of 160 subjects with dementia older than 65 years old. Diagnosis of dementia was based on DSM-IV criteria. BPSD were assessed with the NeuroPsychiatric Inventory-NPI and dementia staging was measured with Clinical Dementia Rating/Modified-CDR-M. Results show that prevalence of delusions is more important in severe dementia and that prevalence of agitation/ aggression is more important in profound dementia. These data may help to clarify objectives and treatment of BPSD. This study raises also some methodological problems with the NPI and underlines the importance to define the different disorders included in certain NPI domains accurately. [less ▲]

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See detailQuality of Life in Older Belgian People: Comparison between People with Dementia, Mild Cognitive Impairment, and Controls
Missotten, Pierre ULg; Squelard, Gilles ULg; Ylieff, Michel ULg et al

in International Journal of Geriatric Psychiatry (2008), 23(11), 1103-1109

OBJECTIVES: To assess the sensitivity of the 'Alzheimer's Disease Related Quality of Life' instrument (ADRQL) applied to Belgian people with dementia (n = 357), mild cognitive impairment (MCI) (n = 36 ... [more ▼]

OBJECTIVES: To assess the sensitivity of the 'Alzheimer's Disease Related Quality of Life' instrument (ADRQL) applied to Belgian people with dementia (n = 357), mild cognitive impairment (MCI) (n = 36), and controls (n = 72). We also determined the clinical parameters that influence the quality of life (QOL) of people with dementia. METHOD: Each subject was evaluated with the ADRQL, the Mini Mental State Examination (MMSE), the cognitive scale of the Cambridge Examination for Mental Disorders of the Elderly (CAMCOG), the Katz's ADL classification (ADL), the Instrumental Activities of Daily Living (IADL), the Behavior Rating Scale for Dementia (CERAD/BRSD), and the Clinical Dementia Rating/Modified (CDR-M). RESULTS: The ADRQL showed that QOL of the dementia group (65.77 +/- 17.04) was significantly inferior to that of the MCI (82.11 +/- 13.31) and control groups (79.75 +/- 15.82). There were no significant differences between the MCI and control groups. Within the dementia group, the five ADRQL subscale results were similar to those reported in other studies. Gender, age and place of residence had no significant influence on ADRQL scores. In contrast, ADRQL scores correlated significantly with MMSE, CAMCOG, IADL, ADL, CERAD/BRSD, and CDR-M. The MMSE and CERAD/BRSD were significant predictors of ADRQL variability. CONCLUSIONS: QOL of people with dementia is inferior to that of people with MCI and controls. This demonstrates the ADRQL instrument is sufficiently sensitive for evaluating the QOL of people with dementia. Longitudinal studies are needed to specifically examine the rate of QOL evolution throughout the entire dementia process. Copyright (c) 2008 John Wiley [less ▲]

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See detailRelationship between quality of life and cognitive decline in dementia
Missotten, Pierre ULg; Squelard, Gilles ULg; Ylieff, Michel ULg et al

in Dementia & Geriatric Cognitive Disorders (2008), 25(6), 564-572

Aims: We aimed to examine the association of cognitive decline with quality of life (QoL) in dementia compared to controls and to determine variables associated with QoL. Methods: Every subject was placed ... [more ▼]

Aims: We aimed to examine the association of cognitive decline with quality of life (QoL) in dementia compared to controls and to determine variables associated with QoL. Methods: Every subject was placed within a specific group depending on their designation by the Mini Mental State Examination and evaluated by the Alzheimer’s Disease Related Quality of Life (ADRQL) and clinical assessments. Results: QoL for the mild dementia group was lower (p = 0.08) than that of controls. The very severe dementia group had a significantly lower QoL than the other dementia groups, which all had similar ADRQL scores. The only predictor of ADRQL scores was found to be the behavioral and psychological symptoms of dementia. Conclusion: There is no direct relationship between cognitive decline and QoL. [less ▲]

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See detailQuality of life in dementia: a 2-year follow-up study
Missotten, Pierre ULg; Ylieff, Michel ULg; Di Notte, David et al

in International Journal of Geriatric Psychiatry (2007), 22(12), 1201-1207

Objectives To examine the evolution of quality of life (QOL) in demented subjects at base-line, one and 2 years later and to determine clinical variables associated with QOL. Method Longitudinal study of ... [more ▼]

Objectives To examine the evolution of quality of life (QOL) in demented subjects at base-line, one and 2 years later and to determine clinical variables associated with QOL. Method Longitudinal study of a cohort of 127 subjects living at home or in a long-term care institution. A QOL measure (Alzheimer Disease Related Quality of Life; ADRQL) was administered three times. In addition, several clinical instruments (MMSE, IADL, ADL and CDR/M) were also administered. Results ADRQL data analysis did not reveal significant modifications of QOL over the 2-year period, whereas results from clinical instruments showed a significant deterioration. On the group, the variations of ADRQL scores were limited, with some improvement after the first year followed by some deterioration after the second year. On the other hand, ADRQL scores fluctuated every year by at least 10 points for more than 50% of subjects. With dementia evolution, it was observed that the clinical variables were more strongly correlated with ADRQL scores and were more significant predictors. This varied from 5.9% (MMSE) in 2002 to 40.01 % in 2004 (MMSE and CDR/M). Conclusions QOL did not develop in a strictly linear manner following the deterioration of clinical state. This suggests that the evolution of QOL is also determined by other variables relating to the physical and social environment of the patients. Their role seems particularly important for the mild to moderate stages of dementia. Copyright (c) 2007 John Wiley [less ▲]

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See detailEvaluation du stade évolutif de la démence par la Clinical Dementia Rating-Modified (CDR-M)
Ylieff, Michel ULg; Di Notte, David; Missotten, Pierre ULg et al

Poster (2006, September)

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See detailLe NPI NH chez des sujets âgés déments et non déments
Ylieff, Michel ULg; Di Notte, David; Missotten, Pierre ULg et al

Poster (2006, September)

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See detailLa qualité de vie de sujets âgés déments, MCI et vulnérables : évaluations transversale et longitudinale
Missotten, Pierre ULg; Ylieff, Michel ULg; Schuerch, Michael et al

Conference (2006, September)

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