References of "PAQUET, Philippe"
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See detailCyanoacrylate skin surface strippings and the 3S-Bioket advent in tropical dermatology. A look from Liège.
PIERARD, Gérald ULg; Franchimont, Claudine ULg; PAQUET, Philippe ULg et al

in Scientific World Journal (The) (2014), 2014

In the dermatopathology field, some simple available laboratory tests require minimum equipment for establishing a diagnosis. Among them, the cyanoacrylate skin surface stripping (CSSS), formerly named ... [more ▼]

In the dermatopathology field, some simple available laboratory tests require minimum equipment for establishing a diagnosis. Among them, the cyanoacrylate skin surface stripping (CSSS), formerly named skin surface biopsy or follicular biopsy, represents a convenient low cost procedure. It is a minimally invasive method collecting a continuous sheet of stratum corneum and horny follicular casts. In the vast majority of cases, it is painless and is unassociated with adverse events. CSSS can be performed in subjects of any age. The method has a number of applications in diagnostic dermatopathology and cosmetology, as well as in experimental dermatology settings. A series of derived analytic procedures include xerosis grading, comedometry, corneofungimetry, corneodynamics of stratum corneum renewal, corneomelametry, corneosurfametry, and corneoxenometry. [less ▲]

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See detailEffect of N-acetylcysteine combined with infliximab on toxic epidermal necrolysis. A proof-of-concept study.
PAQUET, Philippe ULg; JENNES, Serge; ROUSSEAU, Anne-Françoise ULg et al

in Burns : Journal of the International Society for Burn Injuries (2014)

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See detailIntense pulsed light in infantile hemangiomas.
PAQUET, Philippe ULg; Caucanas, Marie; FRANCHIMONT, Claudine ULg et al

in Open Access Journal of Science and Technology (2014), 2

For more than 70 years, the watchful-waiting management of infantile strawberry hemangiomas still prevails in a number of clinical settings. This concept appears now outdated since the introduction of ... [more ▼]

For more than 70 years, the watchful-waiting management of infantile strawberry hemangiomas still prevails in a number of clinical settings. This concept appears now outdated since the introduction of well-suited beta-blockers, as well as noncoherent light and laser therapies. The aim of this work was to revisit the effect of intense pulsed light (IPL) therapy on infantile hemangioma. Information was collected from the peer-reviewed literature and illustrated by personal cases. When applied early in the evolution of infantile hemangiomas, IPL treatment stops the growth phase and induces regression with minimal cosmetic adverse effects and psychological damage. Initiating an adequate treatment is important because damage due to hemangiomas can be diminished by a timely and adequate approach. Beta-blockers have revolutionized the therapeutic strategy of infantile hemangiomas. The flash light therapy (IPL) represents an alternative therapy for some patients. [less ▲]

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See detailHedgehog- and mTOR-targeted therapies for advanced basal cell carcinomas.
FRANCHIMONT, Claudine ULg; Hermanns-Lê, Trinh ULg; PAQUET, Philippe ULg et al

in Current approaches to basal cell carcinoma (2014)

Basal cell carcinomas (BCCs) are the most frequent human cancer. Over 90% of all BCCs have a mutation in patched homologue 1 (PTCH 1) or smoothened (SMO), two conducting proteins of the Hedgehog (Hh ... [more ▼]

Basal cell carcinomas (BCCs) are the most frequent human cancer. Over 90% of all BCCs have a mutation in patched homologue 1 (PTCH 1) or smoothened (SMO), two conducting proteins of the Hedgehog (Hh) pathway. They rarely progress deeply and metastasize; however, if they do, these advanced BCC become amenable to treatment by inhibiting the Hedgehog and the P13K–mTOR pathways. Such innovative drugs include vismodegib, cyclopamine, itraconazole, everolimus and a few other agents that are in early clinical development. [less ▲]

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See detailSkin viscoelasticity during hormone replacement therapy for climacteric ageing.
Pierard, Gérald ULg; Hermanns-Le, T.; PAQUET, Philippe ULg et al

in International journal of cosmetic science (2013), 36

BACKGROUND: Climacteric ageing refers to the period of women's life centred by the perimenopause. This step of life is responsible for initiating skin atrophic withering and slackness responsible for ... [more ▼]

BACKGROUND: Climacteric ageing refers to the period of women's life centred by the perimenopause. This step of life is responsible for initiating skin atrophic withering and slackness responsible for changes in the viscoelasticity of the dermal connective tissue. Some women benefit from hormone replacement therapy (HRT) for controlling some unpleasant internal climacteric changes (osteoporosis, vasomotor instability, ...). OBJECTIVE: To investigate some corrective effects of HRT on the functional damages in the dermal tensile strength. PATIENTS AND METHODS: This study was performed on 200 healthy Caucasian women. In vivo skin viscoelasticity was assessed using the suction method. RESULTS: Skin distensibility and hysteresis appeared increased at menopause with or without HRT. By contrast, the biological elasticity significantly decreased out of HRT. CONCLUSION: Some drugs and cosmetics might attempt at improving such viscoelastic attributes of the skin at menopause. [less ▲]

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See detailSkin bioengineering
PIERARD, Gérald ULg; PAQUET, Philippe ULg; PREUDHOMME, Lorine et al

in Rustemeyer, T. (Ed.) Textbook of Kanerva’s occupational skin diseases. (2012)

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See detailIntense pulsed-light therapy for proliferative superficial strawberry haemangiomas of infancy.
CAUCANAS, Marie ULg; PAQUET, Philippe ULg; HENRY, Frédérique ULg et al

in Case Reports in Dermatological Medicine (2011), 2011(art.253607), 1-5

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See detailNew approaches in light/laser therapies and photodynamic treatment of acne.
Pierard-Franchimont, Claudine; PAQUET, Philippe ULg; PIERARD, Gérald ULg

in Expert Opinion on Pharmacotherapy (2011), 12(4), 493-501

Acne is a domain in which the technology and understanding of light/laser therapeutic procedures have advanced considerably. The aim of the paper was to revisit adjunctive physical treatments of acne ... [more ▼]

Acne is a domain in which the technology and understanding of light/laser therapeutic procedures have advanced considerably. The aim of the paper was to revisit adjunctive physical treatments of acne, including light/laser treatments and photodynamic therapy. This review summarizes findings about such treatment modalities with particular emphasis on efficacy and safety. A number of laser/light-based modalities have been developed to meet the increasing demand for new acne treatments. The current devices correspond, on the one hand, to light-emitting diode therapy and, on the other hand, to the 532-nm potassium titanyl phosphate laser, the 585- and 595-nm pulsed dye laser, the 1450-nm diode laser, the 1320-nm Nd:YAG laser and intense pulsed light. Photodynamic therapy is also available. It is claimed that light/laser treatments might induce a faster response compared with the 1-3 months needed for response to traditional oral and topical treatments. In conclusion, pulsed dye laser shows efficacy in some patients with mild to moderate acne. The relative effectiveness compared with other treatments is unconfirmed; from the published information, evidence-based efficacy assessment of light/laser therapies in acne remains almost impossible. [less ▲]

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See detailLa peau du patient sous chimiothérapie anticancéreuse.
PIERARD, Gérald ULg; PAQUET, Philippe ULg; FRANCHIMONT, Claudine ULg et al

in Dermatologie Actualité (2011), 124

Des effets cutanés indésirables peuvent survenir lors de chimiothérapies anticancéreuses. La morbidité peut être handicapante à des degrés divers. Certaines manifestations sont graves comme celles ... [more ▼]

Des effets cutanés indésirables peuvent survenir lors de chimiothérapies anticancéreuses. La morbidité peut être handicapante à des degrés divers. Certaines manifestations sont graves comme celles rencontrées lors de nécroses épithéliales et/ou vasculaires étendues. D’autres sont spécifiques à l’agent administré. Tel est le cas pour des éruptions acnéiformes induites par les antagonistes de l’EGFR. Dans la grande majorité des cas, les altérations de la structure de la couche cornée et de ses fonctions se résument seulement à un état de xérose. Parfois aussi, les altérations ne se décèlent qu’à l’examen histopathologique sans répercussion clinique manifeste. Pour chaque patient concerné, il convient d’identifier avec précision les effets indésirables de la chimiothérapie anticancéreuse afin de choisir les moyens les plus adéquats pour prévenir leur aggravation et les traiter au mieux. L’apport de l’examen dermatopathologique standard et fonctionnel est précieux au stade du diagnostic. [less ▲]

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See detailMechanobiology and cell tensegrity: the root of ethnic hair curling?
Pierard-Franchimont, Claudine; PAQUET, Philippe ULg; QUATRESOOZ, Pascale ULg et al

in Journal of Cosmetic Dermatology (2011), 10(2), 163-7

BACKGROUND: The hair shape, either straight, crimp, or curly, is basically under genetic influence. It is possibly altered by some drugs such as cytostatic agents. In addition, specific innate molecular ... [more ▼]

BACKGROUND: The hair shape, either straight, crimp, or curly, is basically under genetic influence. It is possibly altered by some drugs such as cytostatic agents. In addition, specific innate molecular characteristics are modulated by some cosmetic procedures to reshape the hair shafts. AIM: To revisit the possible implication of mechanobiology and cell tensegrity in shaping ethnic hair. MATERIALS AND METHODS: Optical and scanning electron microscopy of hairs. RESULTS: It is generally held that the cross-section shape of hair is related to differences in the global aspect of the hair shaft. A possible biologic link between these features may rely on shaping cell tensegrity at any portion of the hair shaft. Cell tensegrity encompasses all intrinsic and extrinsic forces responsible for the three-dimensional arrangement of intracellular macromolecules. CONCLUSION: We offer as a hypothesis that the hair shape in part depends on the organization of the cell proliferation in the hair matrix. This review gathers observations supporting the involvement of cell tensegrity in shaping the hair shaft. [less ▲]

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See detailPhotoaging under recreational sunbeds.
QUATRESOOZ, Pascale ULg; HENRY, Frédérique ULg; PAQUET, Philippe ULg et al

in Skin Research & Technology (2011)

Background: Artificial sources of restricted light wavelength, particularly tanning beds, are progressively gaining importance in photoaging. Objective: To assess the kinetics and the long-term evolution ... [more ▼]

Background: Artificial sources of restricted light wavelength, particularly tanning beds, are progressively gaining importance in photoaging. Objective: To assess the kinetics and the long-term evolution of skin pigmentation and tensile functions in sunbed worshippers over a period of 8 years. Methods: Photoaging was explored in women who were both sunshine and sunbed worshippers. A series of 65 phototype III women aged 31-46 years completed a 100-month survey. Quarterly assessments were performed on the forearms to measure (a) the skin color individual typology angle (ITA degrees ), (b) the extent in mottled subclinical melanoderma (MSM) using the ultraviolet light-enhanced visualization method and (c) the rheological properties of skin. Results: A progressive increase in both skin extensibility and hysteresis was observed, contrasting with a decrease in biologic elasticity. These rheological changes were correlated with the ITA degrees changes, but not with the MSM extent. The kinetics of evolution of each test variable were distinct over time. Discussion: This work is the first attempt at evaluating the kinetics of changes in physical parameters during a long period of frequent exposures to tanning sunbeds and sunshine for lifestyle purposes. The alterations were quite important in the color, MSM and rheological functions of the skin. [less ▲]

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See detailPre-study and in-study validation of a SPE-LC-MS-MS method for the determination of 5-S-cysteinyldopa, a melanoma biomarker, in human plasma.
Martin, Gaelle; Mansion, François ULg; Houbart, Virginie ULg et al

in Talanta (2011), 84(2), 280-6

The incidence of malignant melanoma has increased over the past decades, particularly in Caucasian population. This disease presents defavourable prognosis in terms of survey, especially when detection ... [more ▼]

The incidence of malignant melanoma has increased over the past decades, particularly in Caucasian population. This disease presents defavourable prognosis in terms of survey, especially when detection occurs at the metastatic phase. Reliable analytical methods for biomarker determination are thus an interesting tool in pathology detection and follow-up. In this context, a method using SPE-LC-ESI-MS-MS for the determination of 5-S-cysteinyldopa (5-SCD) in human plasma was optimized. The presence of matrix effect was investigated in details while 5-SCD stability was studied according to FDA requirements for the validation of bioanalytical methods. Pre-study and in-study validations of the entire method were then successfully performed by applying the approach based on total measurement error and accuracy profiles over a concentration ranges from 1.6 to 200 ng/ml. Good results with respect to accuracy, trueness and precision were obtained. The maximum risk of observing future measurements falling outside the acceptance limits during routine analysis was also estimated. [less ▲]

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See detailImmunohistochemical Aspects of the Fibrogenic Pathway in Nephrogenic Systemic Fibrosis.
Quatresooz, Pascale ULg; Paquet, Philippe ULg; Hermanns-Le, Trinh ULg et al

in Applied Immunohistochemistry & Molecular Morphology (2010)

Nephrogenic systemic fibrosis (NSF) is a rare gadolinium-dependent disorder of the skin and viscera. The aim of this study was to revisit some immunopathologic clues of NSF, including the characterization ... [more ▼]

Nephrogenic systemic fibrosis (NSF) is a rare gadolinium-dependent disorder of the skin and viscera. The aim of this study was to revisit some immunopathologic clues of NSF, including the characterization of glycosaminoglycans, cell tensegrity, and cell proliferation in the dermis. Immunohistochemistry was done using antibodies directed to vimentin, CD34, Factor XIIIa, calprotectin, alpha-smooth muscle actin, Ulex europaeus agglutinin-1 (UEA-1), and MIB1/Ki67 and to glycosaminoglycans, including CD44 var3, versican, and perlecan. The vimentin+ cell density was markedly increased. The vast majority of them corresponded to CD34+ or Factor XIIIa+ dermal dendrocytes (DD) showing distinct cell tensegrity. CD34+DD were slender, elongated, and usually scattered in the dermis but focally clustered in nodular collections. By contrast, Factor XIIIa+ was plump with squat dendrites showing no evidence for being under mechanical stress. Cells in the vicinity of the microvasculature were rounded and exhibited calprotectin immunoreactivity typical for monocyte/macrophages. The microvasculature highlighted by UEA-1 and alpha-smooth muscle actin looked unremarkable. The cell proliferation highlighted by the MIB/Ki67 immunoreactivity was unusually high (>20%) in the interstitial stromal cells. Stromal cells enriched in versican were plump, abundant, and seemed interconnected each other by a dense network of dendrites. By contrast, the immunolabeling for perlecan and CD44 var 3 was unremarkable. In conclusion, the cell population involved in NSF seemed phenotypically heterogeneous, and its growth fraction was clearly boosted in the skin. The intracellular load in versican was prominent. The aspect of cell tensegrity did not suggest the influence of mechanical stress putting stromal cells under tension in the dermis. [less ▲]

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See detailL'image du mois. Calcinose idiopathique du scrotum.
Paquet, Philippe ULg; Devillers, C.; Szepetiuk, Grégory ULg et al

in Revue Médicale de Liège (2010), 65(3), 113-4

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See detailCutaneous papules in a patient with AIDS.
Quatresooz, Pascale ULg; Franchimont, Claudine ULg; Paquet, Philippe ULg et al

in Dermatology Reports (2010), 2(e2), 4-5

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See detailPhysiopathological variations during aging
PIERARD, Gérald ULg; PAQUET, Philippe ULg; xhauflaire-uhoda, E. et al

in Textbook of aging skin (2010)

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See detailLa keratose actinique au diapason de la photocarcinogenese en champs. Un concept revisite.
QUATRESOOZ, Pascale ULg; PAQUET, Philippe ULg; PIERARD, Gérald ULg

in Revue Médicale de Liège (2010), 65(11), 619-22

Actinic keratosis should no more be considered as a single neoplasm calling for an individual treatment. The concept of actinic photocarcinogenesis presently turns upside down the perception of skin ... [more ▼]

Actinic keratosis should no more be considered as a single neoplasm calling for an individual treatment. The concept of actinic photocarcinogenesis presently turns upside down the perception of skin cancers induced by nonionizing electromagnetic radiations. Currently, the clinician should cope with the whole skin area that has been damaged by chronic exposures to the visible and the invisible spectrum of the light. The therapeutic archetypes are 5-fluorouracile 5% and imiquimod 5% carefully applied to the skin area. [less ▲]

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See detailCharacterization of the skin using capacitance imaging.
Xhauflaire, Emmanuelle ULg; Paquet, Philippe ULg; Quatresooz, Pascale ULg et al

in Expert Review of Dermatology (2010), 5

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See detailFacing towards epidermal stem cells (Review).
Schreder, Anelaure; Pierard, Gérald ULg; Paquet, Philippe ULg et al

in International Journal of Molecular Medicine (2010), 26(2), 171-4

Skin contains somatic stem cells that generate keratinocyte, melanocyte and mesenchymal cell lineages. These somatic stem cells have traditionally been thought to be restricted in their differentiation ... [more ▼]

Skin contains somatic stem cells that generate keratinocyte, melanocyte and mesenchymal cell lineages. These somatic stem cells have traditionally been thought to be restricted in their differentiation and regeneration potential to the tissues in which they reside. This review focused on epidermal stem cells (ESCs). These cells are distinguished from transitory amplifier cells and post-mitotic cells. ESC are found in the interadnexal epidermis and in the bulge region of hair follicles. A series of ESCs markers are available, but increased sensitivity and specificity require further development. [less ▲]

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