References of "Ouedraogo, M"
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See detailLe Projet Léopard du Parc W : un Echange de Savoir Intra-Africain au Service de la Conservation de la Nature
Marchal, A.; Marchal, J.; Ouedraogo, M. et al

in Parcs & Réserves (2013), 67(4), 18-25

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See detailPreliminary Clinical Assessment of a Gentamicin-Loaded Monoolein Gel Intended to Treat Chronic Osteomyelitis
Ouédraogo, M; Da, C.S; Nacoulma, I.S et al

in Trends in Medical Research (2008), 3(2), 82-89

The aim of this current study was to perform a preliminary clinical assessment of efficacy and safety of a biodegradable gentamicin-loaded monoolein gel. An open single dose, one treatment study including ... [more ▼]

The aim of this current study was to perform a preliminary clinical assessment of efficacy and safety of a biodegradable gentamicin-loaded monoolein gel. An open single dose, one treatment study including 19 patients with chronic osteomyelitis caused by a microorganism sensitive to gentamicin was conducted. After surgical curettage of the infected bone, the dead space was filled in with the gentamicin-loaded monoolein gel. To prevent post-operative septicaemia, a systemic antibiotherapy was prescribed for 3 days following the operation. Clinical, biological and radiological follow-up was performed to assess the efficacy and the safety of the treatment. After a follow-up period ranging from 2 to 12 months, all 19 patients included in the study felt well. Eighteen patients recovered from chronic osteomyelitis without adverse events. The wound of one patient whose bone was exposed did not scar over after 10 months. However, it was no longer infected. In conclusion, gentamicin-loaded monoolein gel was efficacious in treating chronic osteomyelitis without side-effects. [less ▲]

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See detailIn vitro Biocompatibility and Genotoxicity Assessment of a Gentamicin-Loaded Monoolein Gel Intended to Treat of Chronic Osteomyelitis
Ouédraogo, M; Nacoulma, E.C; Semdé, R et al

in Journal of Pharmacology & Toxicology (2008), 3(5),

The aim of the study was to assess in vitro the biocompatibility and the genotoxicity of a gentamicin-loaded monoolein gel intended to treat of chronic osteomyelitis. Indeed, we are developing ... [more ▼]

The aim of the study was to assess in vitro the biocompatibility and the genotoxicity of a gentamicin-loaded monoolein gel intended to treat of chronic osteomyelitis. Indeed, we are developing biodegradable implants based on monoolein and gentamicin. The results of formulations, physico-chemical characterization of the formulated implants and in vitro release kinetic of gentamicin from implants were encouraging. As biocompatibility and absence of genotoxicity are the prerequisites for safe use of implants, we performed in vitro hemolysis, cytotoxicity and, genotoxicity tests. Hemolysis was evaluated by incubating human erythrocytes in direct contact with the implant whereas cytotoxicity was evaluated by 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) assay using fibroblasts and macrophages. Alkaline comet Assay was used to evaluate genotoxic potential of the implants. From these in vitro assays, the implant based on monoolein and gentamicin showed no genotoxic potential and has satisfactory biocompatibility. [less ▲]

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See detailIn vivo Biocompatibility and Toxicity Assessment of a Gentamicin-Loaded Monoolein Gel Intended to Treat Chronic Osteomyelitis
Ouédraogo, M; Sanou, M; Ramdé, N et al

in Journal of Pharmacology & Toxicology (2008), 3(5), 386-393

Biocompatibility and preliminary toxicity of a novel gentamicin-loaded monoolein gel (implant) intended for the local treatment of chronic osteomyelitis were investigated in mice. The mice, randomly ... [more ▼]

Biocompatibility and preliminary toxicity of a novel gentamicin-loaded monoolein gel (implant) intended for the local treatment of chronic osteomyelitis were investigated in mice. The mice, randomly allotted in 3 groups of 10, received respectively a single dose (0.05 mL) of normal saline, monoolein and the gel by subplantar injection. Clinical monitoring and assessment of induced oedema were carried out during 52 days after implantation. A histologic examination of the implantation site was performed at the end of the experiment. Renal and hepatic functions of the implant were also assessed on 52 days post-implantation by using biochemical and histological methods. In mice, no adverse reaction occurred after implantation. Only, a transitional foreign body reaction was observed in mice implanted by the monoolein and the implant. The paw volume of the mice increased within 3 h post-implantation and returned to baseline by 52 days. The liver and kidneys histology at light microscopy and biochemical parameters were similar for all mice. Further investigation is undertaken to detect eventual early damages which could have been resolved with time. Nevertheless, the novel gel is biocompatible and doesn`t show sub-chronic toxicity. [less ▲]

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See detailMonoolein-water liquid crystalline gels of gentamicin as bioresorbable implants for the local treatment of chronic osteomyelitis: in vitro characterization
Ouédraogo, M; Semdé, R; Somé, I.T et al

in Drug Development & Industrial Pharmacy (2008), 34

To maximize the efficacy of chronic osteomyelitis antibiotherapy while reducing antibiotic systemic toxicity, as well as time and costs of hospitalizations, it has been thought that monoolein-water gels ... [more ▼]

To maximize the efficacy of chronic osteomyelitis antibiotherapy while reducing antibiotic systemic toxicity, as well as time and costs of hospitalizations, it has been thought that monoolein-water gels incorporating gentamicin sulfate could be used as local, bioresorbable,and sustained-release implants. For this purpose, four formulations were examined with regard to their physicochemical and in vitro drug release characteristics. Hot stage microscopy, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA),and X-ray diffraction showed cubic liquid crystalline and eutectic structures. The more suitable formulation consisting of 80-15-5%wt/wt monoolein-water-gentamicin sulfate progressively released the antibiotic for a period of 3 weeks without burst effect. Moreover, the content and the release profile of gentamicin sulfate were not significantly changed after storage at 2-6 degrees C for a period of 10 months. [less ▲]

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See detailLes principales formations végétales
Ouédraogo, M.; Vermeulen, Cédric ULg; Cornélis, D.

in Delvingt, W.; Vermeulen, Cédric (Eds.) Nazinga (2007)

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See detailEtude comparative de la diversité et de la structure génétique de populations sauvages de Phaseolus lunatus L. à l'aide des marqueurs enzymatiques et microsatellites
Ouedraogo, M.; Maquet, A.; Baudoin, Jean-Pierre ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2005), 9(3), 195-205

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See detailGene flow among wild Phaseolus lunatus L. populations in the Central Valley of Costa Rica
Ouedraogo, M.; Maquet, A.; Baudoin, Jean-Pierre ULg

in Annual Report Bean Improvement Cooperative (2003), 46

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See detailLa Zone Villageoise de Chasse de Sia (Ranch de Gibier de Nazinga, Burkina Faso)
Vermeulen, Cédric ULg; Ouédraogo, M.

in Parcs & Réserves (2003), 58(2), 32-44

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See detailL'élevage du "mouton de case" : aspects techniques, socio-économiques et perspectives d'amélioration au Yatenga (Burkina Faso)
Hamidou, B.; Ilboudo, J.-B.; Ouedraogo, M. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2001), 5(4), 201-208

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