Management of vaginal stenosis by balloning dilation after vaginourethrography in a dog

Poster (2012)

Clinical evaluation of a single daily dose of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch

in Canadian Veterinary Journal = Revue Vétérinaire Canadienne (2011), 52

Abstract The objective of this retrospective study was to report the efficacy of a single daily oral dose of phenylpropanolamine (PPA) in the treatment of urethral sphincter mechanism incompetence (USMI ... [more ▼]

Abstract The objective of this retrospective study was to report the efficacy of a single daily oral dose of phenylpropanolamine (PPA) in the treatment of urethral sphincter mechanism incompetence (USMI) in bitches. Nine bitches diagnosed with USMI were treated with a single daily dose (1.5 mg/kg) of PPA for at least 1 month. Urethral pressure profiles (UPP) were performed in 7 dogs before treatment and repeated in 4 of them after treatment. Treatment with PPA resulted in long-term continence in 8/9 bitches. One dog did not respond to PPA and was treated surgically later. Recheck UPPs showed a significant increase in maximal urethral closure pressure in the 4 bitches after treatment with PPA compared to before treatment. In conclusion, long-term continence can be achieved in bitches affected with USMI after administration of a single daily dose of PPA (1.5 mg/kg). [less ▲]

Urodynamic findings secondary to compressive spinal cord lesions and surgical decompression in dogs

in Proceedings of the 19th Annual Scientific Meeting of the ECVS (2010, July)

Acquired urinary incontinence in the bitch: Update and perspectives from human medicine. Part 3: The urethral component and surgical treatment.

in Veterinary Journal (2010), 186

Urethral sphincter mechanism incompetence (USMI) is the most common cause of urinary inence in dogs. Surgery may be recommended if the animal does not respond to medical treatment or becomes refractory ... [more ▼]

Urethral sphincter mechanism incompetence (USMI) is the most common cause of urinary inence in dogs. Surgery may be recommended if the animal does not respond to medical treatment or becomes refractory. In this third part of a three-part review, surgical options for the treatment of USMI are described. Colposuspension is the most frequently described procedure and offers a fair prognosis, with about 50% of the dogs being continent after surgery and most of the reminder being improved or more responsive to medical treatment. Urethropexy offers a similar success rate, but with a higher rate of complications. Endoscopic injection of collagen is an attractive technique due to its minimally invasive nature and low risk of adverse effects. Initial results may however deteriorate with time. Other procedures have been reported, but involve a low number of cases and have resulted in variable success rates. In women, stress urinary incontinence is mainly treated by minimally invasive procedures involving vaginal placement of sub-urethral slings. [less ▲]

Etude couplée pharmacocinétique et urodynamique de l'administration orale de différents dosages de phenylpropanolamine chez la chienne continente.

Master of advanced studies dissertation (2007)

The goal of this study is to establish the pharmacokinetic characteristics of oral administration of phenylpropanolamine at different dosages (1.5 mg/Kg once a day and three times a day), in continent ... [more ▼]

The goal of this study is to establish the pharmacokinetic characteristics of oral administration of phenylpropanolamine at different dosages (1.5 mg/Kg once a day and three times a day), in continent bitches, and to assess the associated urodynamic effects. The influence of phenylpropanolamine on systemic arterial pressure and heart rate is also studied. Maximal concentration appears two hours after the administration of phenylpropanolamine. Since the half-life lasts four hours and due to a mechanism of accumulation, a repeated daily administration induces an increase of the maximal concentration after each administration. After one week of a single administration of phenylpropanolamine per day, an increased urethral resistance and functional profile length are observed at the time of maximal concentration. This increase could explain the successful treatment of incontinent bitches with a single daily administration of phenylpropanolamine. However, a repeated administration of phenylpropanolamine three times a day does not increase the urethral resistance, probably after desensitization of the adrenergic receptors. The increase in arterial pressure after the administration of phenylpropanolamine is compensated by a decreased heart rate occurring at the time of maximal concentration. [less ▲]