Mechanical loading affects angiogenesis and osteogenesis in an in vivo bone chamber: a modeling study.

in Tissue Engineering. Part A (2010), 16(11), 3353-3361

Despite a myriad of studies confirming the interaction between biology and mechanics, the exact nature of the main mechanical stimuli and their influence on the bone regeneration processes are still ... [more ▼]

Despite a myriad of studies confirming the interaction between biology and mechanics, the exact nature of the main mechanical stimuli and their influence on the bone regeneration processes are still unclear. The hypothesis of this study was that the outcome of peri-implant healing under different implant loading regimens can be explained by the influence of fluid flow on the combination of angiogenesis and osteogenesis through its influence on cell proliferation and differentiation. To investigate this hypothesis a mathematical model of bone regeneration was applied to simulate the peri-implant healing in an in vivo repeated sampling bone chamber for different axial micromechanical implant loading regimes. When mechanical loading was modeled to influence both osteogenic and angiogenic processes, a good agreement was observed between simulations and experiments concerning the amount of bone in the bone chamber, its radial and longitudinal distribution, and the bone-implant contact for different implant displacement magnitudes. [less ▲]

Influence of immediate loading and implant design on bone formation

in Proceedings of the 85th General Session & Exhibition of the IADR (2007)

The effect of micro-motion on the tissue response around immediately loaded roughened titanium implants in the rabbit.

in European Journal of Oral Sciences (2007), 115(1), 21-9

Initial osteogenesis at the implant interface is, to a great extent, determined by the implant surface characteristics and the interfacial loading conditions. The present study investigated the effect of ... [more ▼]

Initial osteogenesis at the implant interface is, to a great extent, determined by the implant surface characteristics and the interfacial loading conditions. The present study investigated the effect of various degrees of relative movement on the tissue differentiation around a roughened screw-shaped immediately loaded implant. Repeated-sampling bone chambers were installed in the tibia of 10 rabbits. In each of the chambers, three experiments were performed by inducing 0 (control), 30, and 90 microm implant displacement for 9 wk. A linear mixed model and a logistic mixed model with alpha = 5% determined statistical significance. Tissue filling of the bone chamber was similar for the three test conditions. The bone area fraction was significantly higher for 90 microm implant displacement compared with no displacement. A significantly higher fraction of bone trabeculae was found for 30 and 90 microm implant displacement compared with the unloaded situation. The incidence of osteoid-to-implant and bone-to-implant contact was significantly higher for 90 microm implant displacement compared with 30 and 0 microm implant displacement. Significantly more osteoid in contact with the implant was found for the loaded conditions compared with no loading. Well-controlled micro-motion positively influenced bone formation at the interface of a roughened implant. An improved bone reaction was detected with increasing micro-motion. [less ▲]

Histodynamics of bone tissue formation around immediately loaded cylindrical implants in the rabbit.

in Clinical Oral Implants Research (2007), 18(4), 471-80

OBJECTIVES: The local mechanical environment influences early peri-implant tissue formation. It is still unclear whether immediate loading limits or promotes peri-implant osteogenesis and which mechanical ... [more ▼]

OBJECTIVES: The local mechanical environment influences early peri-implant tissue formation. It is still unclear whether immediate loading limits or promotes peri-implant osteogenesis and which mechanical parameters are important herein. The present study evaluated the influence of well-controlled mechanical stimuli on the tissue response around immediately loaded cylindrical turned titanium implants at two different observation periods. MATERIAL AND METHODS: A repeated sampling bone chamber, consisting of dual-structure perforated hollow cylinders with a cylindrical implant, was installed in the tibia of 14 rabbits and used to conduct three displacement-controlled immediate loading experiments: (i) 30 microm - 400 cycles/day - 1 Hz frequency - 2 x/week - 6 weeks; (ii) 30 microm - 400 cycles/day - 1 Hz - 2 x/week - 6 weeks, followed by another 6 weeks with a 50 microm - 800 cycles/day - 1 Hz - 2 x/week loading protocol; and (iii) 0 microm implant displacement for 12 weeks. A linear mixed model and logistic mixed model with alpha=5% were conducted on the data set. RESULTS: The tissue area fraction was significantly the highest after 12 weeks of loading. The bone area fraction was significantly different between all three loading conditions, with the highest values for the 12-week loading experiment. Twelve-week stimulation resulted in a significantly higher mineralized bone fraction than 6 weeks. Loading did have a significantly positive effect on the mineralized bone fraction. The incidence of osteoid-to-implant and bone-to-implant contact increased significantly when loading the implant for 12 weeks. CONCLUSION: Immediate loading had a positive effect on the tissue differentiation and bone formation around cylindrical turned titanium implants. Controlled implant micro-motion up to 50 microm had a positive effect on the bone formation at its interface. [less ▲]

Bone Formation around Immediately Loaded Implants: a Bone Chamber Model

in Proceedings of the 84th General Session & Exhibition of the IADR (2006)

De invloed van mechanische parameters op de weefselrespons bij immediaat belaste titanium implantaten

in Proceedings van het Congres Verbond der Vlaamse Tandartsen (2005)

Mechanobiology of bone regeneration and bone adaptation to achieve stable long-term fixation of endosseous implants

in Zeman, M. E.; Cerrolaza, M. (Eds.) Computational Modeling of Tissue Surgery (2005)

The effect of micromotion on tissues surrounding immediately loaded implants

in Computer Methods in Biomechanics & Biomedical Engineering (2005), 8(S1), 93-94

Prediction of bone regeneration in an in vivo bone chamber: application of different mathematical models

Poster (2004, June)

The mechanobiology of tissue differentiation around immediately loaded implants: a bone chamber experiment

in Proceedings of the 14th conference of the European Society of Biomechanics (2004)