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See detailEuropean consensus-based (S2k) Guideline on the Management of Herpes Zoster - guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV), Part 1: Diagnosis
WERNER R. N.; NIKKELS, Arjen ULg; MARINOVIC B. et al

in Journal of the European Academy of Dermatology & Venereology (2017), 31

Herpes zoster (HZ, shingles) is a frequent medical condition which may severely impact the quality of life of affected patients. Different therapeutic approaches to treat acute HZ are available. The aim ... [more ▼]

Herpes zoster (HZ, shingles) is a frequent medical condition which may severely impact the quality of life of affected patients. Different therapeutic approaches to treat acute HZ are available. The aim of this European project was the elaboration of a consensus-based guideline on the management of patients who present with HZ, considering different patient populations and different localizations. This interdisciplinary guideline aims at an improvement of the outcomes of the acute HZ management concerning disease duration, acute pain and quality of life of the affected patients and at a reduction of the incidence of postherpetic neuralgia and other complications. The guideline development followed a structured and predefined process, considering the quality criteria for guidelines development as suggested by the AGREE II instrument. The steering group was responsible for the planning and the organization of the guideline development process (Division of Evidence based Medicine, dEBM). The expert panel was nominated by virtue of clinical expertise and/or scientific experience and included experts from the fields of dermatology, virology/infectiology, ophthalmology, otolaryngology, neurology and anaesthesiology. Recommendations for clinical practice were formally consented during the consensus conference, explicitly considering different relevant aspects. The guideline was approved by the commissioning societies after an extensive internal and external review process. In this first part of the guideline, diagnostic means have been evaluated. The expert panel formally consented recommendations for the management of patients with (suspected) HZ, referring to the assessment of HZ patients, considering various specific clinical situations. Users of the guideline must carefully check whether the recommendations are appropriate for the context of intended application. In the setting of an international guideline, it is generally important to consider different national approaches and legal circumstances with regard to the regulatory approval, availability and reimbursement of diagnostic and therapeutic interventions. [less ▲]

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See detailEuropean consensus-based (S2k) Guideline on the Management of Herpes Zoster - guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV), Part 2: Treatment
WERNER R.N.; NIKKELS, Arjen ULg; MARINOVIC B. et al

in Journal of the European Academy of Dermatology & Venereology (2017)

Herpes zoster (HZ, shingles) is a frequent medical condition which may severely impact the quality of life of affected patients. Different therapeutic approaches to treat acute HZ are available. The aim ... [more ▼]

Herpes zoster (HZ, shingles) is a frequent medical condition which may severely impact the quality of life of affected patients. Different therapeutic approaches to treat acute HZ are available. The aim of this European project was the elaboration of a consensus-based guideline on the management of patients who present with HZ, considering different patient populations and different localizations. This interdisciplinary guideline aims at an improvement of the outcomes of the acute HZ management concerning disease duration, acute pain and quality of life of the affected patients and at a reduction in the incidence of postherpetic neuralgia (PHN) and other complications. The guideline development followed a structured and pre-defined process, considering the quality criteria for guidelines development as suggested by the AGREE II instrument. The steering group was responsible for the planning and the organization of the guideline development process (Division of Evidence-Based Medicine, dEBM). The expert panel was nominated by virtue of clinical expertise and/or scientific experience and included experts from the fields of dermatology, virology/infectiology, ophthalmology, otolaryngology, neurology and anaesthesiology. Recommendations for clinical practice were formally consented during the consensus conference, explicitly considering different relevant aspects. The guideline was approved by the commissioning societies after an extensive internal and external review process. In this second part of the guideline, therapeutic interventions have been evaluated. The expert panel formally consented recommendations for the treatment of patients with HZ (antiviral medication, pain management, local therapy), considering various clinical situations. Users of the guideline must carefully check whether the recommendations are appropriate for the context of intended application. In the setting of an international guideline, it is generally important to consider different national approaches and legal circumstances with regard to the regulatory approval, availability and reimbursement of diagnostic and therapeutic interventions. [less ▲]

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See detailNON-DERMATOPHYTE DERMATOSES MIMICKING DERMATOPHYTOSES IN HUMANS
Libon, Florence ULg; TASSOUDJI, Nazli ULg; DEZFOULIAN, Bita ULg et al

in Mycopathologia (2016)

Human dermatophytic cutaneous infections usually present as single or multiple slowly progressing annular erythemato-squamous lesions with a tendency to central healing on the hairless skin. In the ... [more ▼]

Human dermatophytic cutaneous infections usually present as single or multiple slowly progressing annular erythemato-squamous lesions with a tendency to central healing on the hairless skin. In the intertriginous regions (feet, inguinal, axillar, submammary), dermatophytic colonisations and infections manifest as whitish, slightly hyperkeratotic, pruritic and sometimes fissurated lesions. On the scalp, dermatophytic infections commonly lead to single or multiple more or less inflammatory and alopecic lesions. On the plantar and palmar aspects of the feet and hand, dermatophytosis presents as an eczema-like chronic dermatosis. Abscess-like lesions may occur due to zoophilic dermatomycosis. Dermatophytic infections of the nails reveal ill-defined whitish-yellowish colorations of the distal end or the lateral aspects of the nails, sometimes combined with partial nail embrittlement or even complete destruction. Despite the ubiquity of dermatophytic skin infections and their usually highly typical clinical features, a differential diagnosis has to be considered, in particular when treatment is not efficient or when treatment resistance occurs. This review presents the differential diagnosis in terms of frequency as well as the diagnostic methods permitting the distinction of annular, intertriginous, alopecic, palmoplantar, abscess-like and onychodystrophic lesions. [less ▲]

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See detailLocalized Eruptive Blue Nevi after Herpes Zoster
COLSON, Fany ULg; ARRESE ESTRADA, Jorge ULg; NIKKELS, Arjen ULg

in Case Reports in Dermatology (2016)

A 52-year-old White man presented with a dozen small, well-restricted, punctiform, asymptomatic, blue-gray macules on the left shoulder. A few months earlier, he had been treated with oral acyclovir for ... [more ▼]

A 52-year-old White man presented with a dozen small, well-restricted, punctiform, asymptomatic, blue-gray macules on the left shoulder. A few months earlier, he had been treated with oral acyclovir for herpes zoster (HZ) affecting the left C7–C8 dermatomes. All the blue macules appeared over a short period of time and then remained stable. The patient had not experienced any previous trauma or had tattooing in this anatomical region. The clinical diagnosis suggested blue nevi. Dermatoscopy revealed small, well-limited, dark-blue, compact, homogeneous areas evoking dermal blue nevi. An excisional biopsy was performed and the histological examination confirmed a blue nevus. As far as we are aware of, this is the first report of eruptive blue nevi following HZ, and it should be included in the differential diagnosis of zosteriform dermatoses responding to an isotopic pathway. In addition, a brief review concerning eruptive nevi is presented. [less ▲]

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See detailEffect of Apremilast and Etanercept on Pruritus and Health-Related Quality of Life in Patients With Moderate to Severe Plaque Psoriasis : Results From the LIBERATE Study
Green, Lawrence; Thaçi, Diamant; Zhang, Zuoshun et al

Poster (2016, May)

Psoriasis is a chronic, systemic inflammatory disease with skin maniifestations resulting from a dysregulated immune response. Itching is one of the most bothersome psoriasis symptoms for patients and ... [more ▼]

Psoriasis is a chronic, systemic inflammatory disease with skin maniifestations resulting from a dysregulated immune response. Itching is one of the most bothersome psoriasis symptoms for patients and important factor contributing to disease severity. Apremilast , is an oral small-molecule phosphodiesterase 4 (PDE4) inhibitor, works intracellularly within immune cells to regulate the production of inflammatory médiators associated with the pathogenesis of psoriasis by increasing cyclic adenosine monophophate (cAMP) levels. Apremilast was approved by the US Food and Drug Administration for the treatment of adult patients with patients with active psoriatic arthritis and for patients with moderate to severe plaque psoriasis. Apremilast has since been approved in multiple countries, including those in European Union,as well as Switzerland, Canada and Australia. LIBERATE (Evaluation in Placebo-Controlled Study of Oral Apremilast and Etanercept in Plaque Psoriasis; NCT01690299) is global phase 3b study evaluating the efficacity, safety, and tolerability of apremilast or etarnercept, compared with placebo, for the treatment of biologic-naive patients with moderate to severe plaque psoriasis. [less ▲]

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See detailHERPES ZOSTER IN PSORIASIS PATIENTS UNDERGOING TREATMENT WITH BIOLOGICAL AGENTS: PREVALENCE, IMPACT, AND MANAGEMENT CHALLENGES
EL HAYDERI, Lara ULg; COLSON, Fany ULg; DEZFOULIAN, Bita ULg et al

in PSORIASIS: TARGETS AND THERAPY (2016)

As TNF-α is a major factor in the immune defense against herpes zoster (HZ); an increased incidence and severity of HZ cases were suspected in patients undergoing treatment with TNF antagonists. Several ... [more ▼]

As TNF-α is a major factor in the immune defense against herpes zoster (HZ); an increased incidence and severity of HZ cases were suspected in patients undergoing treatment with TNF antagonists. Several studies and clinical experience provided evidence that the incidence of HZ increases by twofold to threefold in this patient category. The number of severe cases of HZ, with multisegmental, disseminated cutaneous, and/or systemic involvement, is also increased. Concerning psoriasis patients under biologicals, the clinician should be more alert for an eventual HZ event, in particular during the first year of biological treatment, and be aware of the possibility of more severe HZ cases. HZ may also undergo an age-shift toward younger patients. Rapid identification of risk factors for severe HZ, such as severe prodromal pains and/or the presence of satellite lesions, is recommended. The treatment recommendations of HZ in this patient group are identical to the recently published guidelines for the management of HZ. The live attenuated viral vaccine OKA/Merck strain anti-HZ vaccination is recommended before initiating biological treatment in psoriasis patients. The new adjuvanted anti-HZ vaccine will probably also benefit patients while on biological treatment. [less ▲]

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See detailMelanoma masquerading as nomelanocytic lesions
DETRIXHE, Audrey ULg; Libon, Florence ULg; MANSUY, Marion ULg et al

in Melanoma Research (2016)

Increased awareness among dermatologists as well as the development of dermoscopy and sequential dermoscopy have contributed significantly toward an increase in the diagnostic accuracy of pigmented ... [more ▼]

Increased awareness among dermatologists as well as the development of dermoscopy and sequential dermoscopy have contributed significantly toward an increase in the diagnostic accuracy of pigmented melanoma and even of amelanotic melanoma. However, the dermatologist's nightmare is the small group of melanomas that present as common skin diseases, often associated with a significant delay in diagnosis and hence a poor prognosis. The study was carried out to prospectively assess the number of melanomas lacking any clinical suspicion of melanoma and to describe their clinical and histological features over a 6-year observation period in an University Tertiary Skin Cancer Center. Out of 502 cases of newly diagnosed cases of melanoma, seven (1.4%) nonpigmented and nonamelanotic cases of melanoma were identified. The mean age of the patients was 69 years (two females/five males). All cases were discovered by chance on a punch biopsy. The clinical diagnostic suspicions were basal cell carcinoma, fungal intertrigo, keratoacanthoma, lichenoid keratoma, diabetic foot ulcer, eczema, and necrotic pressure ulcer. Dermoscopy, performed after the punch biopsies, was only partially contributive. The mean histological thickness was 2.7 mm, the mean number of mitoses was 7/mm, local micrometastases were present in 5/7 (71%), the mean Ki67 count was 18.9%, and a positive sentinel lymph node was observed in 4/6 (66%) cases. Nonpigmented and nonamelanotic melanomas are rare, are at high risk, and have a poor prognosis because of a delayed diagnosis. Dermoscopy is only of partial diagnostic aid. Treatment resistance or atypical behavior of the above-mentioned lesions should lead to biopsy. [less ▲]

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See detailPartie 1 : Les maladies bactériennes cutanées
Libon, Florence ULg; LEBAS, Eglantine ULg; ABDALLAH Rhim et al

in SKIN (2016), 19(6), 6-13

Les lignes de conduite thérapeutiques sont habituellement établies sur la base des données de la littérature internationale de la médecine basée sur des faits (evidence-based medecine, EBM) ainsi que sur ... [more ▼]

Les lignes de conduite thérapeutiques sont habituellement établies sur la base des données de la littérature internationale de la médecine basée sur des faits (evidence-based medecine, EBM) ainsi que sur les avis exprimés par des experts reconnus dans le domaine. Néanmoins, ces lignes de conduite sont souvent difficile à traduire vers la pratique quotidienne d'un pays donné vu les conditions de remboursement spécifiques et l'organisation des soins médicaux. En matière de maladies infectieuses de la peau, il n'y a que peu de littérature publiée de type EBM. Cette initiative, émanant des assistants en formation en dermatologie et vénérologie en Wallonie/Bruxelles et coordonnée par Florence Libon, Eglantine Lebas et Arjen Nikkels de l'ULg, vise à revoir les différentes recommandations nationales et internationales existantes afin de les adapter pour al situation actuellen en Wallonie/Bruxelles. Elle vise également à unifier les habitudes de prescription sur une base logique et sur les données de la littérature tout en créant des lignes de conduite pratiques. Comme toutes les recommandations diagnostiques et thérapeutiques, une adaptation individuelle devra être réalisée en fonction de chaque patient et le médecin reste in fine le seul décideur et responsable du plan thérapeutique. Ces recommandations n'ont pas pour prétention d'être exhaustives sur toutes les pathologies cutanées bactériennes mais concernent les situations cliniques les plus souvent rencontrées. Dans cette première partie, seront abordés les consensus thérapeutiques pour les maladies cutanées d'origine bactérienne, à partir des cas cliniques [less ▲]

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See detailLICHEN ET DERMATOSES LICHENOIDES - SPECTRE CLINIQUE ET BREF RAPPEL DE LA PRISE EN CHARGE
COLSON, Fany ULg; CAO, Sandrine ULg; MANSUY, Marion ULg et al

in SKIN (2016)

Bien connu dans sa forme typique, le lichen peut présenter des visages très variés dans ses formes atypiques (1-4). La reconnaissance de celles-ci est importante pour orienter le diagnostic et la prise en ... [more ▼]

Bien connu dans sa forme typique, le lichen peut présenter des visages très variés dans ses formes atypiques (1-4). La reconnaissance de celles-ci est importante pour orienter le diagnostic et la prise en charge. le mot lichen vient du Grec et signifie plante parasite. Le lichen a été décrit pour la première fois sous le nom de "lichen ruber" par Ferdinand Von Hebra en 1860. En effet, le réseau blanchâtre à la surface des lésions papuleuses ressemble au champignon lichen qui forme une symbiose avec un partenaire capable de photosynthèse (souvent une algue verte), généralement observée à la surface des rochers. L'appellation "lichen planus" a été proposée par Erasmus Wilson en 1866. Le lichen constitue le prototype de dermatoses lichénoïdes (Tableau 1). Ces maladies inflammatoires sont caractérisées, d'un point de vue clinique, par des lésions papuleuses et, d'un point de vue histologique, par un dense infiltrat lymphocytaire en bande dans le derme superficiel avec lésions des couches kératinocytaires inférieures de l'épiderme. [less ▲]

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See detailKoebner Phenomenon and Mycosis Fungoides
LEBAS, Eve ULg; Libon, Florence ULg; NIKKELS, Arjen ULg

in Case Reports in Dermatology (2015)

Mycosis fungoides (MF) is the most frequent type of primary cutaneous T-cell/NK-cell lymphoma. The Koebner phenomenon is defined as the appearance of cutaneous lesions on previously noninvolved skin ... [more ▼]

Mycosis fungoides (MF) is the most frequent type of primary cutaneous T-cell/NK-cell lymphoma. The Koebner phenomenon is defined as the appearance of cutaneous lesions on previously noninvolved skin following trauma and is observed in a series of cutaneous diseases including psoriasis, lichen planus, viral warts, molluscum contagiosum, etc. In this case report, 3 patients with longstanding MF are presented, the 1st with the appearance of a circumscribed early-stage type MF lesion rapidly following a surgical excision of an infundibular cyst, the 2nd with the appearance of a unique unilateral palmar tumoral MF lesion at the pressure site of a crutch, and the 3rd presented localized MF early stage lesions at the friction site of a belt. This report suggests that some MF patients may experience Koebner phenomenon-induced MF lesions and that MF should be added to the long list of skin diseases potentially exhibiting the Koebner phenomenon. [less ▲]

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See detailNouveau traitement contre le carcinome basocellulaire avancé
NIKKELS, Arjen ULg

in Mediaplanet (2015)

Chaque année, entre 17 000 et 18 000 nouveaux cas du carcinome basocellulaire sont diagnostiqués en Belgique

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See detailAbsence of Varicella Zoster Virus Reactivation after Infliximab Administration for Plaque Psoriasis
EL HAYDERI, Lara ULg; BONTEMS, Sébastien ULg; MEEX, Cécile ULg et al

in Dermatology (2015)

Background: Herpes zoster (HZ) in patients receiving tumor necrosis factor (TNF) antagonists may be more severe and the incidence seems increased. The influence of TNF antagonists on varicella zoster ... [more ▼]

Background: Herpes zoster (HZ) in patients receiving tumor necrosis factor (TNF) antagonists may be more severe and the incidence seems increased. The influence of TNF antagonists on varicella zoster virus (VZV) reactivation is unknown. Objective: To prospectively search in a pilot study for VZV DNA in sequential blood samples before and after infliximab administration. Setting: University medical center. Subjects and Methods: Blood samples of six patients with longstanding and severe plaque psoriasis were taken on day 1 (before infliximab administration) and on days 2, 7, 21 and 42 for the determination of VZV viremia by ORF21 real-time polymerase chain reaction. Patients with varicella, HZ and normal subjects were included as controls. Results: None of the six patients presented VZV viremia at any of the time points. Highload viremia was present during varicella, low-load viremia in some HZ patients and no viremia in the control patients. Limitations: Small number of patients. Conclusions: In this pilot study, infliximab did not reactivate VZV and did not induce subclinical VZV viremia. [less ▲]

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See detailOnychomycoses : de la clinique au traitement
DETROUX, Valentine ULg; PAQUET, Philippe ULg; ARRESE ESTRADA, Jorge ULg et al

Article for general public (2015)

L'onychomycose est une pathologie très fréquente dont le traitement est particulièrement long et contraignant. Les agents pathogènes sont principalement les dermatophytes et parfois les moisissures non ... [more ▼]

L'onychomycose est une pathologie très fréquente dont le traitement est particulièrement long et contraignant. Les agents pathogènes sont principalement les dermatophytes et parfois les moisissures non dermatophytiques ainsi que les levures. La présentation clinique classique comporte une modification blanc jaunâtre de l'ongle. Le diagnostic différentiel avec les onychodystrophies non mycotiques n'est pas toujours aisé. L'infection fongique peut être confirmée par un examen direct (test à la potasse caustique, KOH) ou histologique (coloration au PAS) d'un prélèvement unguéal. La mise en culture permet ensuite l'identification du pathogène responsable. Plusieurs options thérapeutiques sont possibles en fonction de l'importance et du type d'onychomycose : antimycosiques topiques et/ou systémiques couplés ou non à l'avulsion chimique ou chirurgicale. De nouveaux traitements par laser, thérapie photodynaique ou iontophorèse complèteront probablement l'arsenal thérapeutique dans le futur [less ▲]

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See detailZosteriform dermatoses-A review
EL HAYDERI, Lara ULg; LIBON, Florence ULg; TASSOUDJI, Nazli ULg et al

in Global Dermatology (2015), 2 (4)

The zosteriform distribution of cutaneous lesions is a common disease pattern in dermatology. It describes a unilateral girdle-like distribution restricted to the sensitive nerve territory of a dermatome ... [more ▼]

The zosteriform distribution of cutaneous lesions is a common disease pattern in dermatology. It describes a unilateral girdle-like distribution restricted to the sensitive nerve territory of a dermatome. Three different pathogenic pathways can lead to a zosteriform pattern. The neural pathway uses the axons of a nerve ganglion for viral transport to a specific dermatome. The arche type is Herpes Zoster (HZ) followed by Zosteriform Herpes Simplex Virus Type (HSV) I infection. The Blaschkoid pathway uses the Blaschko lines that represent embryonic migration patterns, often mimicking a dermatomal distribution, particularly on the trunk. The isotopic pathway defines a dermatosis that exclusively develops on the site of a previously healed HZ eruption. Before a zosteriform eruption, a history of prior HZ guides the diagnosis to the isotopic pathway, mainly represented by granulomatous reactions followed by, among others, lichen planus, vasculitis and basal cell carcinoma. With no prior history of HZ recent eruptions orientate towards HZ and zosteriform HSV, whereas chronic eruptions should primarily evoke cutaneous metastases, principally from breast, ovary and lung carcinoma. This review summarizes the relevant literature and presents a clinical algorithm for the differential diagnosis of zosteriform dermatoses. [less ▲]

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See detailVISMODEGIB ET CARCINOMES BASOCELLULAIRES LOCALEMENT AVANCES
LEBAS, Eglantine ULg; RORIVE, Andrée ULg; EL HAYDERI, Lara ULg et al

in Revue Médicale de Liège (2015)

Basal cell carcinoma is the most frequent skin cancer. Even though metastases are exceptional, these cancers may be locally highly aggressive. The Hedgehog signaling pathway plays a significant role in ... [more ▼]

Basal cell carcinoma is the most frequent skin cancer. Even though metastases are exceptional, these cancers may be locally highly aggressive. The Hedgehog signaling pathway plays a significant role in the pathogenesis of basal cell carcinoma. Vismodegib is a selective inhibitor of this pathway and may be administered orally. Its main indication is locally advanced basal cell carcinoma, when other therapeutic options have failed or are contra-indicated. Vismodegib can also be used as prophylactic therapy in the Gorlin syndrome or basal cell nevomatosis. Its principal adverse effects are muscle spasms, alopecia and altered taste. They are frequent, but often moderate in intensity; they sometimes restrict continuation of treatment. Two clinical cases are presented, relating the efficacity and tolerance of this new therapeutic option. [less ▲]

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See detailLa rosacée
LIBON, Florence ULg; EL HAYDERI, Lara ULg; TASSOUDJI, Nazli ULg et al

in Revue Médicale de Liège (2015)

Rosacea is a common centro-facial dermatosis with a high socio-esthétic impact. Ocular involvement is not uncommon. Different stypes are distinguished, classified into grades according to their severity ... [more ▼]

Rosacea is a common centro-facial dermatosis with a high socio-esthétic impact. Ocular involvement is not uncommon. Different stypes are distinguished, classified into grades according to their severity. This classification is essential for therapeutic management. In general, rosacea remains difficult to treat as its pathophysiology is still not entirely understood. Future research is needed for a better understanding of this disease and the development of targeted treatments. [less ▲]

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See detailInfections par les virus herpès simplex 1 et 2
EL HAYDERI, Lara ULg; NIKKELS, Arjen ULg

in Mokni, Mourad (Ed.) Dermatologie infectieuse (2014)

Les virus herpès simplex de type 1 (HSV-1) et de type 2 (HSV-2) font partie de la famille des alpha-herpesviridae, tout comme le virus de la varicelle et du zona (VZV). Ces virus partagent certaines ... [more ▼]

Les virus herpès simplex de type 1 (HSV-1) et de type 2 (HSV-2) font partie de la famille des alpha-herpesviridae, tout comme le virus de la varicelle et du zona (VZV). Ces virus partagent certaines caractéristiques biologiques, entre autres, l'épidermo-neurotropisme, les mécanismes de réplication, la latence ganglionnaire et un effet cytopatique. En revanche, les manifestations cliniques les distinguent clairement. L'HSV-1 et l'HSV-2 sont des virus icosaédriques à ADN linéaire et bicaténaire de 150 à 200 nm. Ils se différencient par certains critères structuraux et épidémiologiques. Ils partagent des antigènes communs et il existe un grand degré d'homologie génomique. Ils sont constitués d'une nucléocapside, renfermant l'ADN viral, et d'une enveloppe glycoprotéique. De manière générale, l'HSV-1 infecte plutôt la partie supérieure du corps, notamment la sphère otorhinolaryngologique (ORL) tandis que l'HSV-2 a un tropisme préférentiel anogénital. L'HSV est transmis par contact direct interhumain à partir des lésions herpétiques ou par des gouttelettes de salive. Il peut s'auto-inoculer et être transféré d'une lésion herpétique à un autre site anatomique chez le même individu. [less ▲]

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See detailInfection par le virus de la varicelle et du zona
EL HAYDERI, Lara ULg; NIKKELS, Arjen ULg

in EL HAYDERI, Lara; NIKKELS, Arjen (Eds.) Dermatologie infectieuse (2014)

Le virus de la varicelle et du zona (VZV) appartient à la famille des alpha-herpesviridae. Son cycle de réplication est similaire à celui des virus herpès simplex virus de type 1 et 2. Le VZV possède ... [more ▼]

Le virus de la varicelle et du zona (VZV) appartient à la famille des alpha-herpesviridae. Son cycle de réplication est similaire à celui des virus herpès simplex virus de type 1 et 2. Le VZV possède également un tropisme neuro-épidermique, une latence ganglionnaire et induit un effet cytopathique dans la cellule hôte. Le virus VZV se compose d'un ADN bicaténaire au sein de la capside virale. Le tout est enrobé d'une enveloppe contenant des glycoprotéines de sruface, qui ont un rôle important dans l'induction d'une réponse immunitaire de la part de l'hôte. L'ADN viral a été complètement séquencé. Il contient 124 884 paires de base, 71 ORF (Open Reading Frames) qui codent pour 67 protéines dont environ 33 ont été identifiées. Au stade latent, le VZV n'exprime que des protéines de latence, comme l'IE (protéine immédiate précoce) 4, 62 et 63. Lors de la réactivation virale, le VZV exprimera les gènes E et ensuite L, qui produiront respectivement des protéines E (protéines précoces), nécessaires à la synthèse de l'ADN viral et à la construction de la nucléocapside, et des protéines L (protéines tardives) consitutuant l'enveloppe virale. [less ▲]

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See detailRéaction immédiate à l'alcool
LIBON, Florence ULg; DEZFOULIAN, Bita ULg; NIKKELS, Arjen ULg

Poster (2014, April 17)

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