References of "Muylkens, Benoît"
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See detailPrevalence of naturally occuring cartilage defects in the ovine stifle
Pierson, Audrey ULg; Muylkens, Benoît ULg; Hontoir, Fanny et al

Poster (2012)

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See detailIn vitro-generated interspecific recombinants between bovine herpesviruses 1 and 5 show attenuated replication characteristics and establish latency in the natural host
Del Medico Zajac, M. P.; Romera, S. A.; Ladelfa, M. F. et al

in BMC Veterinary Research (2011), 7

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See detailCharacterization of BoHV-5 field strains circulation and report of transient specific subtype of bovine herpesvirus 5 in Argentina
Maidana, S. S.; Ladelfa, M. F.; Perez, S. et al

in BMC Veterinary Research (2011), 7

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See detailComparative study of the in vitro and in vivo properties of two bovine herpesvirus-5 reference strains
Ladelfa, M. F.; De Medico Zajac, M. P.; Kotsias, F. et al

in Acta Veterinaria Scandinavica (2011), 53

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See detailExperimental evidence of recombination in murine noroviruses
Mathijs, Elisabeth ULg; Muylkens, Benoît ULg; Mauroy, Axel ULg et al

in Journal of General Virology (The) (2010)

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See detailRuminant herpesviruses
Muylkens, Benoît ULg; Thiry, Julien ULg; Thiry, Etienne ULg

in Lefèvre, P. C.; Blancou, J.; Chermette, R. (Eds.) et al Infectious and Parasitic Diseases of Livestock (2010)

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See detailInfectious bovine rhinotracheitis
Muylkens, Benoît ULg; Thiry, Julien ULg; Thiry, Etienne ULg

in Lefèvre, P. C.; Blancou, J.; Chermette, R. (Eds.) et al Infectious and Parasitic Diseases of Livestock (2010)

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See detailCharacterization of interspecific recombinants generated from closely related bovine herpesviruses 1 and 5 through multiple PCR sequencing assays
Del Médico Zajac, M. P.; Romera, S. A.; Ladelfa, M. F. et al

in Journal of Virological Methods (2009)

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See detailBiology of bovine herpesvirus 5
Del Medico Zajac, M. P.; Ladelfa, M. F.; Kotsias, F. et al

in Veterinary Journal (2009)

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See detailCo-infection with two closely related alphaherpesviruses results in a highly diversified recombination mosaic displaying negative genetic interference
Muylkens, Benoît ULg; Farnir, Frédéric ULg; Meurens, François et al

in Journal of Virology (2009), 83(7), 3127-3137

Phylogenetic studies of the emergence and spread of natural recombinants in herpesviruses infecting humans and animals have been reported recently. However, despite an ever-increasing amount of evidence ... [more ▼]

Phylogenetic studies of the emergence and spread of natural recombinants in herpesviruses infecting humans and animals have been reported recently. However, despite an ever-increasing amount of evidence of recombination in herpesvirus history, the recombination process and the consequences on the genetic diversity of the progeny remain poorly characterized. We addressed this issue by using multiple single-nucleotide polymorphisms (SNPs) differentiating the two subtypes of an alphaherpesvirus, bovine herpesvirus 1 (BoHV-1). Analysis of a large sample of progeny virions obtained in a single growth cycle of coinfected BoHV-1 strains provided a prospective investigation of the recombination dynamics by using SNPs as recombination markers. We found that the simultaneous infection with two closely related herpesviruses results in a highly diversified recombination mosaic. From the analysis of multiple recombinants arising in the progeny, we provide the first evidence of genetic interference influencing the recombination process in herpesviruses. In addition, we report striking differences in the levels of recombination frequency observed along the BoHV-1 genome. With particular emphasis on the genetic structure of a progeny virus population rising in vitro, our data show to which extent recombination participates to the genetic diversification of herpesviruses [less ▲]

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See detailLes mécanismes et les conséquences sur l'organisme des infections virales chez les équidés
Thiry, Etienne ULg; Dal Pozzo, Fabiana ULg; Mathijs, Elisabeth ULg et al

in Nouveau Praticien Vétérinaire Equine (2008), 5

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See detailInfectious bovine rhinotracheitis
Muylkens, Benoît ULg; Thiry, Julien ULg; Thiry, Etienne ULg

in Lefèvre, P. C.; Blancou, J.; Chermette, R. (Eds.) Infectious and parasitic diseases of Livestock (2008)

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See detailRuminant herpesviruses
Muylkens, Benoît ULg; Thiry, Julien ULg; Thiry, Etienne ULg

in Lefèvre, P. C.; Blancou, Jean; Chermette, R. (Eds.) Infectious and parasitic diseases of Livestock (2008)

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See detailInfectious bovine rhinotracheitis and the epidemiological role of the other ruminant species
Thiry, Julien ULg; Muylkens, Benoît ULg; Thiry, Etienne ULg

in Magyar Allatorvosok Lapja = Hungarian Veterinary Journal (2008), 130(1), 116-123

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See detailMarker vaccines and the impact of their use on diagnosis and prophylactic measures
Vannier, P.; Capua, I.; Le Potier, M. F. et al

in Revue Scientifique et Technique-Office International des Epizooties (2007), 26(2), 351-372

Molecular biology and technical advances in DNA recombination have ushered in a new era in vaccinology. This article examines the recent development of specific marker vaccines and examines the impact of ... [more ▼]

Molecular biology and technical advances in DNA recombination have ushered in a new era in vaccinology. This article examines the recent development of specific marker vaccines and examines the impact of their use on the diagnosis and prevention of major infectious diseases. Gene-deleted vaccines, DIVA strategies (differentiating infected from vaccinated animals) and similar methods have been successfully applied in the control and eradication of Aujeszky's disease, infectious bovine rhinotracheitis, classical swine fever, foot and mouth disease and, recently, avian influenza. The efficacy and performance of existing marker vaccines and their companion diagnostic tools (which should be assesed by an independent body) are discussed, as are the ways in which these tools are deployed by competent authorities. The limits and the advantages of the use of marker vaccines are carefully analysed in the light of practical experiences. Although these vaccines can limit the speed and the extent of virus dissemination and thus reduce the number of animals slaughtered, marker vaccines are no substitute for sanitary measures. Early detection and warning systems and the quick implementation of sanitary measures, including stamping out, remain key issues in the control of highly contagious diseases. [less ▲]

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See detailLa recombinaison, moteur de diversité chez les alphaherpèsvirus, a de profondes implications médicales
Thiry, Etienne ULg; Meurens, François; Schynts, Frédéric et al

in Bulletin de l'Académie Royale de Médecine de Belgique (2007), 168

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See detailMalattia di Aujeszky. Il virus, patogenesi ed epidemiologia
Thiry, Etienne ULg; Muylkens, Benoît ULg

in Suinicoltura (2007), 9

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See detailClinical Protection against Caprine Herpesvirus 1 Genital Infection by Intranasal Administration of a Live Attenuated Glycoprotein E Negative Bovine Herpesvirus 1 Vaccine
Thiry, Julien ULg; Tempesta, M.; Camero, M. et al

in BMC Veterinary Research (2007), 3

BACKGROUND: Caprine herpesvirus 1 (CpHV-1) is responsible of systemic diseases in kids and genital diseases leading to abortions in goats. CpHV-1 is widespread and especially in Mediterranean countries as ... [more ▼]

BACKGROUND: Caprine herpesvirus 1 (CpHV-1) is responsible of systemic diseases in kids and genital diseases leading to abortions in goats. CpHV-1 is widespread and especially in Mediterranean countries as Greece, Italy and Spain. CpHV-1 is antigenically and genetically closely related to bovine herpesvirus 1 (BoHV-1). Taking into account the biological properties shared by these two viruses, we decided in the current study to assess the protection of a live attenuated glycoprotein E (gE) negative BoHV-1 vaccine against a genital CpHV-1 infection in goats. RESULTS: The vaccine was inoculated intranasally twice three weeks apart followed by a subsequent CpHV-1 intravaginal challenge which is the natural route of infection in three goats. To analyse the safety and the efficacy of this marker vaccine, two groups of three goats served as controls: one immunised with a virulent CpHV-1 and one uninoculated until the challenge. Goats were clinically monitored and all sampling procedures were carried out in a blind manner. The vaccine did not induce any undesirable local or systemic reaction and goats did not excrete gE-negative BoHV-1. After challenge, a significant reduction in disease severity was observed in immunised goats. Moreover, goats immunised with either gE-negative BoHV-1 or CpHV-1 exhibited a significant reduction in the length and the peak of viral excretion. Antibodies neutralising both BoHV-1 and CpHV-1 were raised in immunised goats. CONCLUSION: Intranasal application of a live attenuated gE-negative BoHV-1 vaccine is able to afford a clinical protection and a reduction of virus excretion in goats challenged by a CpHV-1 genital infection. [less ▲]

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