References of "Moonen, Marie"
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See detailRepeatability, variability and reference values of pulsed wave Doppler echocardiographic measurements in healthy Saanen goats.
Leroux, Aurélia ULg; Farnir, Frédéric ULg; Moonen, Marie ULg et al

in BMC Veterinary Research (2012), 8

Background Pulsed wave (PW) Doppler echocardiography has become a routine non invasive cardiac diagnostic tool in most species. However, evaluation of intracardiac blood flow requires reference values ... [more ▼]

Background Pulsed wave (PW) Doppler echocardiography has become a routine non invasive cardiac diagnostic tool in most species. However, evaluation of intracardiac blood flow requires reference values, which are poorly documented in goats. The aim of this study was to test the repeatability, the variability, and to establish the reference values of PW measurements in healthy adult Saanen goats. Using a standardised PW Doppler echocardiographic protocol, 10 healthy adult unsedated female Saanen goats were investigated three times at one day intervals by the same observer. Mitral, tricuspid, aortic and pulmonary flows were measured from a right parasternal view, and mitral and aortic flows were also measured from a left parasternal view. The difference between left and right side measurements and the intra-observer inter-day repeatability were tested and then the reference values of PW Doppler echocardiographic parameters in healthy adult female Saanen goats were established. Results As documented in other species, all caprine PW Doppler parameters demonstrated a poor inter-day repeatability and a moderate variability. Tricuspid and pulmonary flows were best evaluated on the right side whereas mitral and aortic flows were best obtained on the left side, and reference values are reported for healthy adult Saanen goats. Conclusions PW Doppler echocardiography allows the measurement of intracardiac blood flow indices in goats. The reference values establishment will help interpreting these indices of cardiac function in clinical cardiac cases and developing animal models for human cardiology research. [less ▲]

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See detailAnimal Models of Mitral Regurgitation Induced by Mitral Valve Chordae Tendineae Rupture.
Leroux, Aurélia ULg; Moonen, Marie ULg; Pierard, Luc ULg et al

in Journal of Heart Valve Disease (The) (2012), 21

Background – Mitral regurgitation (MR) is a common valvular disease throughout the world. Various diagnostic techniques have been developed to assess the causes and severity of MR, and the therapeutic ... [more ▼]

Background – Mitral regurgitation (MR) is a common valvular disease throughout the world. Various diagnostic techniques have been developed to assess the causes and severity of MR, and the therapeutic approaches to this disease have been widely documented. However, treatments for chronic MR remain controversial, and various animal models of chronic MR (including chordae tendineae rupture, rapid pacing and ischemia) have been developed to study the pathophysiology and therapeutic approaches to this disease. The objective of this paper is to review the animal MR models that have been developed using a mitral valve chordae tendineae rupture technique. Animal models – Dogs and sheep have been the animals most commonly used in MR models induced by mitral valve chordae tendineae rupture, mainly due to considerations of cardiac size. Chordae tendineae cutting is performed using closed or open chest techniques. In the closed chest model, long flexible grasping forceps are positioned percutaneously in order to tear the mitral valve chordae. In the open chest model, cardiopulmonary bypass is performed and either selected chordae are cut under direct visualization, or a non specified number of chordae are cut using a metal device inserted through the left ventricular apex. Whatever the model used, MR has been found to become chronic 3 to 6 months after the induction of MR by chordae rupture. The reported mortality and complication rates of these models are high. Conclusion – In the long term, experimental evolution of chronic MR is similar to the evolution occurring naturally in patients suffering from chronic MR. These models could thus be useful in understanding the disease better and in testing new therapeutic modalities. This review summarizes the physiological effects of each of these techniques and compares the advantages and disadvantages of each procedure. [less ▲]

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See detailTwo-dimensional and M-mode echocardiographic reference values in healthy adult Saanen goats
Leroux, Aurélia ULg; Moonen, Marie ULg; Farnir, Frédéric ULg et al

in Veterinary Record : Journal of the British Veterinary Association (2012), 170(6), 154

Echocardiography has become a routine non invasive cardiac diagnostic tool in most species. Accurate measurement of cardiac dimensions requires reference values, which are poorly documented in goats. The ... [more ▼]

Echocardiography has become a routine non invasive cardiac diagnostic tool in most species. Accurate measurement of cardiac dimensions requires reference values, which are poorly documented in goats. The aim of this study was to test the inter-day repeatability and to establish the reference values of two-dimensional (2D-) and time-motion (M-) mode echocardiographic variables in healthy adult Saanen goats. Six goats were investigated three times by the same observer at one day interval using a standardized 2D- and M-mode echocardiographic protocol. The intra-observer inter-day repeatability was tested using analysis of variance, calculation of the coefficient of variation and confidence intervals. A single echocardiographic examination was performed in 6 other goats, and values obtained in the 12 goats were used to establish the 2D- and M-mode echocardiographic reference values in healthy adult female Saanen goats. Statistical analysis revealed a good inter-day repeatability of the echocardiographic cardiac measurements. Echocardiographic reference values obtained in healthy adult Saanen goats seemed slightly higher than those reported in healthy Swedish domestic goats and were similar to those reported in healthy adult sheep. [less ▲]

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See detailRecommandations Europeennes 2011 pour la prise en charge des maladies cardiovasculaires pendant la grossesse. Partie 1: valvulopathies et anticoagulation.
Legrand, D.; Moonen, Marie ULg; LANCELLOTTI, Patrizio ULg

in Revue Médicale de Liège (2012), 67(9), 452-7

In this article, we describe the 2011 European guidelines on the management of cardiovascular diseases during pregnancy, with particular attention to the management of valvular heart disease and ... [more ▼]

In this article, we describe the 2011 European guidelines on the management of cardiovascular diseases during pregnancy, with particular attention to the management of valvular heart disease and anticoagulation.We will also describe cardiologic conditions in which pregnancy is contraindicated and the preferred way of delivery. [less ▲]

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See detailRecommandations Europeennes 2011 pour la prise en charge des maladies cardiovasculaires pendant la grossesse. Partie 2: Prise en charge de l'hypertension arterielle.
Moonen, Marie ULg; Legrand, D.; LANCELLOTTI, Patrizio ULg

in Revue Médicale de Liège (2012), 67(10), 509-12

In this article, we report the 2011 European guidelines on the management of cardiovascular diseases during pregnancy, with particular attention to the management of hypertension as hypertensive disorders ... [more ▼]

In this article, we report the 2011 European guidelines on the management of cardiovascular diseases during pregnancy, with particular attention to the management of hypertension as hypertensive disorders are the most frequent cardiovascular complications in pregnancy. [less ▲]

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See detailRecommandations Europeennes 2011 pour la prise en charge du syndrome coronarien aigu sans elevation du segment ST (Partie 2). Revascularisation coronaire: indications.
Lempereur, M.; Moonen, Marie ULg; Gach, O. et al

in Revue Médicale de Liège (2012), 67(1), 8-10

New European guidelines about the management of non-ST elevated acute coronary syndromes emphasize the importance of early risk stratification. This article summarizes the modifications in the guidelines ... [more ▼]

New European guidelines about the management of non-ST elevated acute coronary syndromes emphasize the importance of early risk stratification. This article summarizes the modifications in the guidelines about risk stratification and invasive management of these syndromes. [less ▲]

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See detailStructural model of the mitral valve included in a cardiovascular closed loop model
Paeme, Sabine ULg; Moorhead, Kate; Chase, J. Geoffrey et al

Poster (2011, December)

A minimal cardiovascular system (CVS) model including mitral valve dynamics has been previously validated in silico. However parameters of this model are difficult to link with structural and anatomical ... [more ▼]

A minimal cardiovascular system (CVS) model including mitral valve dynamics has been previously validated in silico. However parameters of this model are difficult to link with structural and anatomical components of the valve. This research describes the integration of a structural model of the mitral valve in an existing closed-loop cardiovascular system (CVS) model [less ▲]

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See detailMathematical multi-scale model of the cardiovascular system including mitral valve dynamics. Application to ischemic mitral insufficiency
Paeme, Sabine ULg; Moorhead, Katherine; Chase, J. Geoffrey et al

in BioMedical Engineering OnLine (2011), 10(1), 86

Valve dysfunction is a common cardiovascular pathology. Despite significant clinical research, there is little formal study of how valve dysfunction affects overall circulatory dynamics. Validated models ... [more ▼]

Valve dysfunction is a common cardiovascular pathology. Despite significant clinical research, there is little formal study of how valve dysfunction affects overall circulatory dynamics. Validated models would offer the ability to better understand these dynamics and thus optimize diagnosis, as well as surgical and other interventions. A cardiovascular and circulatory system (CVS) model has already been validated in silico, and in several animal model studies. It accounts for valve dynamics using Heaviside functions to simulate a physiologically accurate “open on pressure, close on flow” law. However, it does not consider real-time valve opening dynamics and therefore does not fully capture valve dysfunction, particularly where the dysfunction involves partial closure. This research describes an updated version of this previous closed-loop CVS model that includes the progressive opening of the mitral valve, and is defined over the full cardiac cycle. Simulations of the cardiovascular system with healthy mitral valve are performed, and, the global hemodynamic behaviour is studied compared with previously validated results. The error between resulting pressure-volume (PV) loops of already validated CVS model and the new CVS model that includes the progressive opening of the mitral valve is assessed and remains within typical measurement error and variability. Simulations of ischemic mitral insufficiency are also performed. Pressure-Volume loops, transmitral flow evolution and mitral valve aperture area evolution follow reported measurements in shape, amplitude and trends. The resulting cardiovascular system model including mitral valve dynamics provides a foundation for clinical validation and the study of valvular dysfunction in vivo. The overall models and results could readily be generalised to other cardiac valves. [less ▲]

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See detailLeft ventricular dyssynchrony: a dynamic condition.
Lancellotti, Patrizio ULg; Moonen, Marie ULg

in Heart Failure Reviews (2011)

Left ventricular dyssynchrony (LVD) is common in heart failure patients with LV systolic dysfunction. Contrary to what it could be expected, LVD is not a stable phenomenon. Various conditions (inducible ... [more ▼]

Left ventricular dyssynchrony (LVD) is common in heart failure patients with LV systolic dysfunction. Contrary to what it could be expected, LVD is not a stable phenomenon. Various conditions (inducible ischemia, exercise, drug administration) may significantly alter the presence and the magnitude of LVD, which could per se modulate response to treatment for heart failure. LVD can be evaluated using validated Doppler-echocardiographic techniques as tissue Doppler imaging. Exercise and dobutamine stress echocardiography can be used tests to unmask LVD. Changes in LV synchronicity during stress test occur independently of inducible ischemia and irrespective of QRS width. The degree of LVD varies substantially from patient to patient. The dynamic increase in LVD represents a strong contributor: (1) to exercise-induced changes in mitral regurgitation, (2) to limitation of stroke volume adaptation during exercise, and (3) to exertional dyspnea. Whether dynamic LVD might independently affect the outcome has not yet been demonstrated. In the setting of CRT, the assessment of dynamic LVD might help patient selection, predict the magnitude of response, and optimize pacing delivery during exercise. Further longitudinal studies are required to confirm the value of assessing dynamic LVD. [less ▲]

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See detailMinimal cardiovascular system model including a physiological description of progressive mitral valve orifice dynamics for studying valve dysfunction
Paeme, Sabine ULg; Moorhead, Katerine; Chase, J. Geoffrey et al

in XXIIIrd congress of the International Society of Biomechanics, July 3-7, 2011 (2011, July)

This research presents a new closed-loop cardiovascular system model including a description of the progressive opening and closing dynamic of the mitral valve. Furthermore, this model includes a ... [more ▼]

This research presents a new closed-loop cardiovascular system model including a description of the progressive opening and closing dynamic of the mitral valve. Furthermore, this model includes a mathematical description of the left atrium. This new CVS model enables the study of valve dysfunction in the appropriate clinical context of the overall cardiac and circulatory hemodynamics. [less ▲]

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See detailTwo-Dimensional, M-Mode and Pulsed Wave Doppler Echocardiographic Reference Values in Healthy Adult Saanen Goats
Leroux, Aurélia ULg; Moonen, Marie ULg; Farnir, Frédéric ULg et al

Poster (2011, March 18)

Echocardiography has become a routine non invasive cardiac diagnostic tool in most species. Accurate measurement of cardiac dimensions requires reference values, which are poorly documented in goats ... [more ▼]

Echocardiography has become a routine non invasive cardiac diagnostic tool in most species. Accurate measurement of cardiac dimensions requires reference values, which are poorly documented in goats. Goats are animals easy to handle with a body and heart size comparable to humans’. This makes goats an attractive candidate for the development of animal models for human cardiology research. The aim of this study was to test the repeatability and to establish the reference values of bi-dimensional (2D-), time-motion (M-) mode and pulsed wave (PW) Doppler echocardiographic variables in adult goats. Six healthy female adult Saanen goats were investigated three times by the same observer at one day interval using a standardized 2D-, M-mode and PW Doppler echocardiographic protocol. Calculation of the coefficient of variation for each variable measured within day and depending on the day allowed to evaluate their degree of variability. A single echocardiographic examination was performed in 6 other goats by the same observer, and the obtained values were added to these obtained on the third day of the 6 first goats. Then the observed mean, the standard deviation and the range of these measurements were calculated to establish the reference values of echocardiographic parameters in unsedated adult healthy female Saanen goats. Statistical analysis revealed a good inter-day repeatability of the 2D- and M-mode echocardiographic cardiac measurements, but PW Doppler parameters presented moderate to high variability, as documented in other species. Echocardiographic reference values obtained in healthy adult Saanen goats were similar to those reported in healthy adult sheep and in healthy adult humans. [less ▲]

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See detailChanges in mitral regurgitation and left ventricular geometry during exercise affect exercise capacity in patients with systolic heart failure.
Izumo, Masaki; Suzuki, Kengo; Moonen, Marie ULg et al

in European Journal of Echocardiography (2011), 12(1), 54-60

AIMS: exercise may dramatically change the extent of functional mitral regurgitation (MR) and left ventricular (LV) geometry in patients with chronic heart failure (CHF). We hypothesized that dynamic ... [more ▼]

AIMS: exercise may dramatically change the extent of functional mitral regurgitation (MR) and left ventricular (LV) geometry in patients with chronic heart failure (CHF). We hypothesized that dynamic changes in MR and LV geometry would affect exercise capacity. METHODS AND RESULTS: this study included 30 CHF patients with functional MR who underwent symptom-limited bicycle exercise stress echocardiography and cardiopulmonary exercise testing for quantitative assessment of MR (effective regurgitant orifice; ERO), and pulmonary artery systolic pressure (PASP). LV sphericity index was obtained from real-time three-dimensional echocardiograms. The patients were stratified into exercised-induced MR (EMR; n = 10, an increase in ERO by >/=13 mm(2)) or non-EMR (NEMR; n = 20, an increase in ERO by <13 mm(2)) group. At rest, no differences in LV volume and function, ERO, and PASP were found between the two groups. At peak exercise, PASP and sphericity index were significantly greater (all P < 0.01) in the EMR group. The EMR group revealed lower peak oxygen uptake (peak VO(2); P = 0.018) and greater minute ventilation/carbon dioxide production slope (VE/VCO(2) slope; P = 0.042) than the NEMR group. Peak VO(2) negatively correlated with changes in ERO (r = -0.628) and LV sphericity index (r = -0.437); meanwhile, VE/VCO(2) slope was well correlated with these changes (r = 0.414 and 0.364, respectively). A multivariate analysis identified that the change in ERO was the strongest predictor of peak VO(2) (P = 0.001). CONCLUSION: dynamic changes in MR and LV geometry contributed to the limitation of exercise capacity in patients with CHF. [less ▲]

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See detailRecommandations européennes 2011 pour la prise en charge du syndrome coronarien aigu sans élévation du segment ST (partie 1)
Moonen, Marie ULg; Lempereur, Mathieu; GACH, Olivier ULg et al

in Revue Médicale de Liège (2011), 66(12), 624-630

Dans cet article, nous présentons les recommandations 2011 pour la prise en charge du syndrome coronarien aigu sans élévation du segment ST, «non-ST-elevation myocardial infarction» (NSTEMI). Les ... [more ▼]

Dans cet article, nous présentons les recommandations 2011 pour la prise en charge du syndrome coronarien aigu sans élévation du segment ST, «non-ST-elevation myocardial infarction» (NSTEMI). Les modifications concernant l’approche pharmacologique, et plus particulièrement l’antiagrégation plaquettaire et l’anticoagulation, y sont détaillées. [less ▲]

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See detailminimal cardiovascular system model including physiological mitral valve opening
Paeme, Sabine ULg; Moorhead, Katherine ULg; chase, J. Geoffrey et al

in 9th Belgian National Day on Biomedical Engineering, Bruxelles, 26th november (2010, November 26)

A minimal cardiovascular system (CVS) model has been previously validated in silico, and in several animal model studies. It accounts for valve dynamics by means of a Heaviside function to simulate the ... [more ▼]

A minimal cardiovascular system (CVS) model has been previously validated in silico, and in several animal model studies. It accounts for valve dynamics by means of a Heaviside function to simulate the “open on pressure, close on flow” law. However, this model does not describe the progressive valve opening and therefore, it is not suitable for studying valve dysfunctions. [less ▲]

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See detailMinimal cardiovascular system model including physiological mitral valve opening
Paeme, Sabine ULg; Moorhead, Katherine ULg; Chase, J. Geoffrey et al

Poster (2010, November 26)

This research describes a new closed-loop cardiovascular system (CVS) model including a model of the left atrium and a model describing the progressive aperture of the mitral valve

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See detailMathematical model of the mitral valve and the cardiovascular system, application for studying, monitoring and in the diagnosis of valvular pathologies
Paeme, Sabine ULg; Moorhead, Katherine ULg; Chase, J. Geoffrey et al

in UKACC international Conference on Control 2010 : Coventry, 7-10 september 2010 (2010, September 07)

A cardiovascular and circulatory system (CVS) model has been validated in silico, and in several animal model studies. It accounts for valve dynamics using Heaviside functions to simulate a physiological ... [more ▼]

A cardiovascular and circulatory system (CVS) model has been validated in silico, and in several animal model studies. It accounts for valve dynamics using Heaviside functions to simulate a physiological accurate “open on pressure, close on flow” law. Thus, it does not consider the real time scale of the valve aperture dynamics and thus doesn’t fully capture valve dysfunction particularly where the dysfunction involves partial closure. This research describes a new closed-loop CVS model including a model describing the progressive aperture of the mitral valve and valid over the full cardiac cycle. This new model is solved for a healthy and diseased mitral valve. [less ▲]

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See detailActualités thérapeutiques dans la cardiomyopathie hypertrophique.
Moonen, Marie ULg; Pierard, Luc ULg

in Revue Médicale Suisse (2010), 6(260), 1591-4

The management of patients with hypertrophic cardiomyopathy has largely evolved over the past two decades. One important finding is that medical treatment appears under used. Invasive procedure are ... [more ▼]

The management of patients with hypertrophic cardiomyopathy has largely evolved over the past two decades. One important finding is that medical treatment appears under used. Invasive procedure are reserved to patients with obstructive hypertrophic cardiomyopathy who remain symptomatic despite optimal medical treatment. Indications for implantable cardiac defibrillator are still debated. A global and multidisciplinary approach of the patient and of his family is mandatory. [less ▲]

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See detailRisk stratification in asymptomatic moderate to severe aortic stenosis: the importance of the valvular, arterial and ventricular interplay.
Lancellotti, Patrizio ULg; Donal, Erwan; Magne, Julien ULg et al

in Heart (2010), 96(17), 1364-71

OBJECTIVE: We sought to evaluate prognostic markers of clinical outcome in asymptomatic patients with moderate to severe aortic stenosis (AS). DESIGN: Prospective follow-up of asymptomatic patients with ... [more ▼]

OBJECTIVE: We sought to evaluate prognostic markers of clinical outcome in asymptomatic patients with moderate to severe aortic stenosis (AS). DESIGN: Prospective follow-up of asymptomatic patients with moderate to severe AS. The patients underwent clinical and Doppler echocardiographic evaluation. SETTING: Department of Cardiology. PATIENTS: 163 patients with moderate to severe AS (aortic valve area < or =0.6 cm(2)/m(2)). MAIN OUTCOME MEASURES: Risk stratification. Predefined endpoints for assessing the outcome were the occurrence during follow-up of symptoms, aortic valve replacement or death. RESULTS: During follow-up (mean, 20 (19) months), 11 patients developed symptoms but were not operated on, 57 required aortic valve replacement and six patients died. In multivariable Cox regression analysis, four parameters that were associated with the outcome were identified: peak aortic jet velocity, left ventricular systolic (LV) longitudinal deformation, valvulo-arterial impedance and indexed left atrial area. Using receiver-operator characteristic curve analysis, a peak aortic jet velocity > or =4.4 m/s, a LV longitudinal myocardial deformation < or =15.9%, a valvular-arterial impedance > or =4.9 mm Hg/ml per m(2) and an indexed left atrial area > or =12.2 cm(2)/m(2) were identified as the best cut-off values to be associated with events. CONCLUSIONS: In asymptomatic patients with moderate to severe AS, measurements that integrate the ventricular, vascular and valvular components of the disease improve risk stratification. [less ▲]

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See detailImpact of mitral regurgitation and myocardial viability on left ventricular reverse remodeling after cardiac resynchronization therapy in patients with ischemic cardiomyopathy.
Senechal, Mario; Lancellotti, Patrizio ULg; Magne, Julien ULg et al

in American Journal of Cardiology (2010), 106(1), 31-7

This study investigated the impact of ischemic mitral regurgitation (MR) severity and viability on left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT) in patients with ... [more ▼]

This study investigated the impact of ischemic mitral regurgitation (MR) severity and viability on left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT) in patients with ischemic cardiomyopathy. Severe MR and ischemic cardiomyopathy have been associated with lack of LV reverse remodeling after CRT. Fifty-seven consecutive patients with ischemic MR, LV ejection fraction < or =35%, QRS duration > or =120 ms, and intraventricular dyssynchrony > or =50 ms were prospectively included. Stress echocardiography was performed before CRT implantation. Viability in the region of the LV pacing lead was defined as the presence of viability in 2 contiguous segments. Response to CRT at 6 months was defined by evidence of > or =15% LV decrease in end-systolic volume. Severe MR was defined by an effective regurgitant orifice (ERO) area > or =20 mm(2). Thirty-three patients (58%) were responders at follow-up. Baseline ERO area and prevalence of severe MR were not different between responders and nonresponders (19 +/- 11 vs 21 +/- 13 mm(2), p = 0.67; 52% vs 53%, p = 0.84). In responders, MR was decreased by 58% (ERO 19 +/- 12 to 8 +/- 6 mm(2)). In the presence of viability in the region of the pacing lead, 74% (n = 29 patients) were responders (sensitivity 88%, specificity 58%); in the subgroup of patients with viability in the region of the pacing lead and severe MR, 83% (n = 17 patients) were responders. In conclusion, LV remodeling is frequent and ischemic MR decrease important in patients with viability in the region of the pacing lead without regard to MR severity. [less ▲]

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See detailStress echocardiography for selecting potential responders to cardiac resynchronisation therapy.
Moonen, Marie ULg; O'Connor, Kim; Magne, Julien ULg et al

in Heart (2010), 96(14), 1142-6

In the current ESC/ACC/AHA guidelines, the selection of patients for cardiac resynchronisation therapy (CRT) is based upon the QRS duration, which reflects interventricular dyssynchrony. However, about 30 ... [more ▼]

In the current ESC/ACC/AHA guidelines, the selection of patients for cardiac resynchronisation therapy (CRT) is based upon the QRS duration, which reflects interventricular dyssynchrony. However, about 30% of patients do not respond to CRT. It has previously been demonstrated that the presence of left ventricular mechanical dyssynchrony is predictive of response to CRT after implantation. Most criteria assessing such dyssynchrony were derived from data obtained with resting Doppler echocardiography. The recently published PROSPECT (Predictors of Response to CRT) trial failed to identify echocardiographic measures of dyssynchrony that could routinely be recommended for patient selection before CRT implantation. Therefore, solutions may come from other echocardiographic modalities, such as dobutamine stress echocardiography and exercise echocardiography. The purpose of this review is to evaluate the usefulness of stress echocardiography to predict response to CRT. This review will show how exercise-induced changes in dyssynchrony and severity of mitral regurgitation and the role of preserved contractile reserve may help to better identify potential responders. [less ▲]

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