References of "Moonen, Martial"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailClinical and biological determinants of sclerostin plasma concentration in hemodialysis patients
DELANAYE, Pierre ULg; KRZESINSKI, Jean-Marie ULg; Warling, Xavier et al

in Nephron. Clinical Practice (in press)

Background: Sclerostin is a potent inhibitor of bone formation, but the meaning of its serum levels remains undetermined. We evaluated the association between sclerostin levels and clinical or biological ... [more ▼]

Background: Sclerostin is a potent inhibitor of bone formation, but the meaning of its serum levels remains undetermined. We evaluated the association between sclerostin levels and clinical or biological data in hemodialyzed patients (HD), notably parathormone (PTH), biomarkers of bone turnover, vascular calcifications and mortality after 2 years. Methods: 164 HD patients were included in this observational study. The calcification score was assessed with the Kauppila method. Patients were followed for 2 years. Results: Median sclerostin levels were significantly (p < 0.0001) higher in HD versus healthy subjects (n = 94) (1,375 vs. 565 pg/ml, respectively). In univariate analysis a significant association (p < 0.05) was found between sclerostin and age, height, dialysis vintage, albumin, troponin, homocysteine, PTH, C-terminal telopeptide of collagen type I, bone-specific alkaline phosphatase and osteoprotegerin, but not with the calcification score. In a multivariate model, the association remained with age, height, dialysis vintage, troponin, homocysteine, phosphate, PTH, but also with vascular calcifications. Association was positive for all variables, except PTH and vascular calcifications. The baseline sclerostin concentration was not different in survivors and non-survivors. Conclusions: We confirm a higher concentration of sclerostin in HD patients, a positive association with age and a negative association with PTH. A positive association with phosphate, homocysteine and troponin calls for additional research. The clinical interest of sclerostin to assess vascular calcifications in HD is limited and no association was found between sclerostin and mortality. [less ▲]

Detailed reference viewed: 22 (14 ULg)
Full Text
See detailLa maladie rénale chronique (MRC)
Krzesinski, Jean-Marie ULg; moonen, martial; WEEKERS, Laurent ULg

Scientific conference (2014, October 17)

Detailed reference viewed: 17 (1 ULg)
Full Text
Peer Reviewed
See detailDephosphorylated-uncarboxylated Matrix Gla protein concentration is predictive of vitamin K status and is correlated with vascular calcification in a cohort of hemodialysis patients.
DELANAYE, Pierre ULg; KRZESINSKI, Jean-Marie ULg; Warling, X et al

in BMC Nephrology (2014), 15

Background: Matrix Gla protein (MGP) is known to act as a potent local inhibitor of vascular calcifications. However, in order to be active, MGP must be phosphorylated and carboxylated, with this last ... [more ▼]

Background: Matrix Gla protein (MGP) is known to act as a potent local inhibitor of vascular calcifications. However, in order to be active, MGP must be phosphorylated and carboxylated, with this last process being dependent on vitamin K. The present study focused on the inactive form of MGP (dephosphorylated and uncarboxylated: dp-ucMGP) in a population of hemodialyzed (HD) patients. Results found in subjects being treated or not with vitamin K antagonist (VKA) were compared and the relationship between dp-ucMGP levels and the vascular calcification score were assessed. Methods: One hundred sixty prevalent HD patients were enrolled into this observational cohort study, including 23 who were receiving VKA treatment. The calcification score was determined (using the Kauppila method) and dp-ucMGP levels were measured using the automated iSYS method. Results: dp-ucMGP levels were much higher in patients being treated with VKA and little overlap was found with those not being treated (5604 [3758; 7836] vs. 1939 [1419; 2841] pmol/L, p <0.0001). In multivariate analysis, treatment with VKA was the most important variable explaining variation in dp-ucMGP levels even when adjusting for all other significant variables. In the 137 untreated patients, dp-ucMGP levels were significantly (p < 0.05) associated both in the uni- and multivariate analysis with age, body mass index, plasma levels of albumin, C-reactive protein, and FGF-23, and the vascular calcification score. Conclusion: We confirmed that the concentration of dp-ucMGP was higher in HD patients being treated with VKA. We observed a significant correlation between dp-ucMGP concentration and the calcification score. Our data support the theoretical role of MGP in the development of vascular calcifications. We confirmed the potential role of the inactive form of MGP in assessing the vitamin K status of the HD patients. [less ▲]

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailCholecaciferol in haemodialysis patients: a randomized, double-blind, proof-of-concept and safety study
DELANAYE, Pierre ULg; WEEKERS, Laurent ULg; WARLING, Xavier et al

in Nephrology Dialysis Transplantation (2013), 28(7), 1779-1786

Background. The role of cholecalciferol supplementation in end-stage renal disease (ESRD) patients has been questioned. The objective of this randomized double-blinded study is to assess whether ... [more ▼]

Background. The role of cholecalciferol supplementation in end-stage renal disease (ESRD) patients has been questioned. The objective of this randomized double-blinded study is to assess whether cholecalciferol therapy can increase serum 25-hydroxyvitamin D [25(OH)D] levels in haemodialysed patients and the safety implications of this therapy on certain biological parameters and vascular calcifications score. Methods. Forty-three haemodialysis patients were randomized to receive placebo or cholecalciferol (25 000 IU) therapy every 2 weeks. The biological parameters, serum calcium, phosphorus, 25(OH)D and parathormone (PTH) levels, were monitored monthly for 12 consecutive months. Vascular calcifications were assessed by lateral X-ray radiography. Results. At baseline, the mean serum 25(OH)D levels were low and similar in both groups. Thirty patients (16 treated and 14 placebo) completed the study: 11 patients died (5 placebo and 6 treated), 1 patient dropped out and 1 patient was transplanted (both from the placebo group). After 1 year, the percentage of 25(OH)D deficient patients was significantly lower in the treated group. None of the patients developed hypercalcaemia. The PTH levels tended to increase over the study period under placebo and to decrease in the cholecalciferol group. The median changes in PTH levels from baseline to 1 year were statistically different between the two groups [+80 (−58 to 153) and −115 (−192 to 81) under placebo and cholecalciferol treatment, respectively, P = 0.02].The calcification scores increased equivalently in both groups (+2.3 per year). Conclusions. Cholecalciferol is effective and safe, and does not negatively affect calcium, phosphorus, PTH levels and vascular calcifications. Additional studies are needed to compare the impacts of nutritional and active vitamin D agents on vascular calcification and mortality. [less ▲]

Detailed reference viewed: 33 (10 ULg)
Full Text
Peer Reviewed
See detailNative vitamin D in dialysis patients : safety and biological effects
WEEKERS, Laurent ULg; Warling, Xavier; Moonen, Martial et al

Conference (2011, June 25)

Native vitamine D (VTD) supplementation is recommended by the last KDIGO guidelines in CKD patients including dialysis patients. However, this recommendation is based on a low level of evidence. We ... [more ▼]

Native vitamine D (VTD) supplementation is recommended by the last KDIGO guidelines in CKD patients including dialysis patients. However, this recommendation is based on a low level of evidence. We designed a randomized double-blind prospective study comparing the effects of VTD and placebo in dialysis patients on mortality, vascular calcifications and different paremeters: 25-OH vitamine D- 25(OH)D -, parathormone (PTH), calcium and phosphorus. [less ▲]

Detailed reference viewed: 32 (0 ULg)
Full Text
Peer Reviewed
See detailL'insuffisance rénale et sa prise en charge
Krzesinski, Jean-Marie ULg; DELANAYE, Pierre ULg; Smelten, Nicole ULg et al

in Revue Médicale de Liège (2008, March 13)

Chronic kidney disease is a worldwide growing problem, especially nowadays due to 3 factors very often encountered together (old age, diabetes mellitus and arterial hypertension) A multidisciplinary ... [more ▼]

Chronic kidney disease is a worldwide growing problem, especially nowadays due to 3 factors very often encountered together (old age, diabetes mellitus and arterial hypertension) A multidisciplinary approach is needed to reduce this epidemic with important health implication. This needs of course well trained health partners. On the occasion of the world kidney day on March 2008, five lectures were given on the topic. The lecturers have insisted on the up to date management of chronic kidney insufficiency, a serious problem of public health. [less ▲]

Detailed reference viewed: 72 (5 ULg)
Full Text
Peer Reviewed
See detailReversal of oxalosis cardiomyopathy after combined liver and kidney transplantation
Detry, Olivier ULg; Honore, Pierre ULg; De Roover, Arnaud ULg et al

in Transplant International (2002), 15(1), 50-52

Few data have been published on the course of oxalosis cardiomyopathy after combined liver and kidney transplantation in hyperoxaluria patients with myocardial involvement. We report the case of a primary ... [more ▼]

Few data have been published on the course of oxalosis cardiomyopathy after combined liver and kidney transplantation in hyperoxaluria patients with myocardial involvement. We report the case of a primary hyperoxaluria type I patient with renal failure who developed end-stage cardiomyopathy. Left venticulography showed severe diffuse hypokinesia and left ventricular ejection fraction was calculated at 12%. Endomyocardial biopsy demonstrated platelike calcium oxalate crystals within the myocardium and the connective tissue, and mild perivascular fibrosis. The patient was first considered for combined liver-heart-kidney transplantation, but as his cardiac function improved slightly with an intensive dialysis program, combined liver and kidney transplantation was performed. Normal cardiac function was demonstrated at 1-year follow-up, and comparative endomyocardial biopsy showed regression of the myocardial oxalate deposits. This case adds stronger clinical, hemodynamic, and histopathological evidence that severe oxalosis cardiomyopathy may be reversed after combined liver and kidney transplantation. [less ▲]

Detailed reference viewed: 58 (8 ULg)
Peer Reviewed
See detailCommunication interventriculaire et infarctus récent du myocarde
Delanaye, Pierre ULg; Lancellotti, Patrizio ULg; Moonen, Martial et al

in Revue Médicale de Liège (2001), 56(12), 823-829

Rupture of the interventricular septum is a classical complication of acute myocardial infarction. The diagnosis should be evoked when the patient's hemodynamic condition deteriorates in the presence of a ... [more ▼]

Rupture of the interventricular septum is a classical complication of acute myocardial infarction. The diagnosis should be evoked when the patient's hemodynamic condition deteriorates in the presence of a new systolic murmur. A transthoracic or, preferably, transesophageal echocardiography confirms the diagnosis. Early surgical correction constitutes the best treatment. Despite recent progresses, mortality remains high but long term results are encouraging. The risk factors conditioning prognosis, the surgical options and the question of simultaneous coronary bypass will be discussed after a thorough review of the literature. [less ▲]

Detailed reference viewed: 57 (5 ULg)
Full Text
Peer Reviewed
See detailEvaluation of the wrist cuff oscillometric blood pressure measurement in clinical practice
Saint-Remy, Annie ULg; Moonen, Martial; Krzesinski, Jean-Marie ULg et al

in Journal of Hypertension (Supplement) (2000), 18(suppl 2), 55

Detailed reference viewed: 12 (1 ULg)
Peer Reviewed
See detailSignification et intérêt de la chute nocturne de la pression artérielle.
Moonen, Martial; Saint-Remy, Annie ULg; Rorive, Georges ULg

Conference (1998, February 14)

Detailed reference viewed: 29 (7 ULg)
Full Text
Peer Reviewed
See detailRelationships between left ventricular hypertrophy and the amplitude of the dipping
Saint-Remy, Annie ULg; moonen, martial; Krzesinski, Jean-Marie ULg et al

Conference (1997, October 04)

Detailed reference viewed: 14 (0 ULg)
Full Text
See detailIsolated systolic and diastolic dippers, an intermediate subgroup between dippers and non-dippers
Moonen, martial; Saint-Remy, Annie ULg; Krzesinski, Jean-Marie ULg et al

Conference (1997, October 04)

Detailed reference viewed: 14 (1 ULg)
Full Text
Peer Reviewed
See detailDoes nocturnal decrease of blood pressure predict left ventricular hypertrophy?
Saint-Remy, Annie ULg; moonen, martial; Rorive, Georges ULg

in Journal of Hypertension (Supplement) (1997, June), 15(4), 169

Detailed reference viewed: 15 (8 ULg)
Full Text
Peer Reviewed
See detailDoes isolated systolic or diastolic nocturnal fall of blood pressure have a signification?
Saint-Remy, Annie ULg; Moonen, Martial; Rorive, Georges ULg

in Journal of Hypertension (Supplement) (1997), 15(suppl 4), 190

Detailed reference viewed: 17 (4 ULg)
Full Text
Peer Reviewed
See detailAttempt of Definition on Dipping Phenomenon
Moonen, martial; Saint-Remy, Annie ULg; Rorive, Georges ULg

in Journal of Hypertension (Supplement) (1996), 14(1),

Detailed reference viewed: 17 (0 ULg)
Full Text
Peer Reviewed
See detailCharacteristics and determinants of the dipping phenomenon
Saint-Remy, Annie ULg; Moonen, martial; Rorive, Georges ULg

in Journal of Hypertension (Supplement) (1996), 14(1), 260

Detailed reference viewed: 16 (0 ULg)
Full Text
Peer Reviewed
See detailTentative definition of dipping phenomenom
moonen, martial; Saint-Remy, Annie ULg; Rorive, Georges ULg

Conference (1995, October 07)

Detailed reference viewed: 14 (0 ULg)