  Longitudinal study of magnetic resonance imaging and standard X-rays to assess disease progression in osteoarthritisBruyère, Olivier  ; ; et alin Osteoarthritis and Cartilage (2007), 15(1), 98-103 Objective: To investigate, over 1-year, the relationship between X-ray and magnetic resonance imaging (MRI) findings in patients with knee osteoarthritis (OA). Methods: Sixty-two osteoarthritic patients ... [more ▼] Objective: To investigate, over 1-year, the relationship between X-ray and magnetic resonance imaging (MRI) findings in patients with knee osteoarthritis (OA). Methods: Sixty-two osteoarthritic patients (46 women) were followed for 1 year. At baseline and after 1 year, volume and thickness of cartilage of the medial tibia, the lateral tibia and the femur were assessed by MRI. A global score from the multi-feature whole-organ MRI scoring system (WORMS) was calculated for each patient at baseline and after 1 year. This score combined individual scores for articular cartilage, osteophytes, bone marrow abnormality, subchondral cysts and bone attrition in 14 locations. It also incorporated scores for the medial and lateral menisci, anterior and posterior cruciate ligaments, medial and lateral collateral ligaments and synovial distension. Lateral and medial femorotibial joint space width (JSW) measurements, performed by digital image analysis, were assessed from fixed-flexion, postero-anterior knee radiographs. Results: One-year changes in medial femoro-tibial JSW reach 6.7 (20.5) % and changes in medial cartilage volume and thickness reach 0.4 (16.7) % and 2.1 (11.3) %, respectively. Medial femoro-tibial joint space narrowing (JSN) after 1 year, assessed by radiography, was significantly correlated with a loss of medial tibial cartilage volume (r = 0.25, P = 0.046) and medial tibial cartilage thickness (r = 0.28, P = 0.025), over the same period. We found also a significant correlation between the progression of the WORMS and radiographic medial JSN over 1 year (r = -0.35, P = 0.006). All these results remained statistically significant after adjusting for age, sex and body mass index. Conclusion: This study shows a moderate but significant association between changes in JSW and changes in cartilage volume or thickness in knee joint of osteoarthritic patients. (C) 2006 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. [less ▲] Detailed reference viewed: 12 (3 ULg) Osteoarthritis, magnetic resonance imaging, and biochemical markers: a one year prospective studyBruyère, Olivier ; Collette, Julien ; et alin Annals of the Rheumatic Diseases (2006), 65(8), 1050-1054 Objective: To investigate the relation between biochemical markers of bone, cartilage, and synovial remodelling and the structural progression of knee osteoarthritis. Methods: 62 patients of both sexes ... [more ▼] Objective: To investigate the relation between biochemical markers of bone, cartilage, and synovial remodelling and the structural progression of knee osteoarthritis. Methods: 62 patients of both sexes with knee osteoarthritis were followed prospectively for one year. From magnetic resonance imaging ( MRI), done at baseline and after one year, the volume and thickness of cartilage of the femur, the medial tibia, and the lateral tibia were assessed. A whole organ magnetic resonance imaging score ( WORMS) of the knee was calculated for each patient at baseline and at the one year visits. This score consists in a validated, semiquantitative scoring system for whole organ assessment of the knee in osteoarthritis using MRI. Biochemical markers ( serum hyaluronic acid, osteocalcin, cartilage glycoprotein 39 ( YKL-40), cartilage oligomeric matrix protein ( COMP), and C-telopeptide of type I collagen ( CTX-I), and urine C-telopeptide of type II collagen ( CTX-II)) were measured at baseline and after three months. Results: Baseline markers were not correlated with one year changes observed in cartilage volume and thickness. However, an increase in CTX-II after three months was significantly correlated with a one year decrease in mean thickness of medial tibial and lateral tibial cartilage. Patients in the highest quartile of three month changes in CTX-II experienced a mean loss of 0.07 ( 0.08) mm of their medial thickness, compared with a mean increase of 0.05 ( 0.19) mm for patients in the lowest quartile ( p = 0.04) Multiple regression analysis showed that high baseline levels of hyaluronic acid are predictive of a worsening in WORMS ( p = 0.004). Conclusions: These results suggest that a single measurement of serum hyaluronic acid or short term changes in urine CTX-II could identify patients at greatest risk of progression of osteoarthritis. [less ▲] Detailed reference viewed: 26 (6 ULg)Longitudinal study of magnetic resonance imaging and fixed-flexion radiography to assess progression of osteoarthritis of the kneeBruyère, Olivier ; ; et alin Osteoporosis International (2006, March), 17(Suppl.1), 85 Detailed reference viewed: 3 (1 ULg)Baseline hyaluronic acid measurement predicts one-year changes in knee magnetic resonance imaging global score (WORMS) in patients with knee osteoarthritisBruyère, Olivier ; COLLETTE, Julien ; et alin Osteoporosis International (2005, March), 16(Suppl.3), 47 Detailed reference viewed: 10 (2 ULg)One-year progression of knee osteoarthritis: correlations between X-Rays and magnetic resonance imaging changesBruyère, Olivier ; ; et alin Osteoporosis International (2005, March), 16(Suppl.3), 46-47 Detailed reference viewed: 11 (6 ULg)Femoro-tibial joint space width, assessed by standard X-Ray, is associated with tibial cartilage volume and thickness, assessed by magnetic resonance imagingBruyère, Olivier ; ; et alin Osteoporosis International (2005, March), 16(Suppl.3), 46 Detailed reference viewed: 11 (1 ULg)Knee whole-organ MRI score (WORMS) as a surrogate marker for X-ray joint space narrowingBruyère, Olivier ; ; et alin Osteoporosis International (2005, March), 16(Suppl.3), 6 Detailed reference viewed: 38 (2 ULg) |
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