References of "Mokni, Moncef"
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See detailIn-utero coxsackievirus B4 infection of the mouse thymus
Jaïdane, Hela; Halouani, Aymen; Jmii, H. et al

in Clinical & Experimental Immunology (2016), Sous presse

Type B coxsackievirus (CV-B) infections are involved frequently in the triggering of several autoimmune diseases such as myocarditis, dilated cardiomyopathy, pericarditis, pancreatitis, type 1 diabetes ... [more ▼]

Type B coxsackievirus (CV-B) infections are involved frequently in the triggering of several autoimmune diseases such as myocarditis, dilated cardiomyopathy, pericarditis, pancreatitis, type 1 diabetes, encephalitis, thyroiditis or Sjo€gren’s syndrome. Serological and virological evidence suggests that maternal infections during pregnancy can play a role in the appearance of these diseases in offspring. The current study aims to explore the effect of an in-utero CV-B infection on the fetal thymus, the central site for programming immunological self-tolerance. In this perspective, female Swiss albino mice were inoculated intraperitoneally or orally with the diabetogenic CV-B4 E2 strain at gestational days 10 or 17. Offspring were killed at different post-inoculation times, and their thymuses were analysed for evidence of infection and alterations in thymic T cell subsets. In-utero CV-B infection of the thymus was demonstrated during the course of vertical transmission, as attested by viral RNA and infectious virus detection in most analysed samples. No histopathological changes were evident. Thymic T cells were not depleted, despite being positive for viral RNA. As evidenced by flow cytometry analysis, CV-B infection of the fetal thymus induced significant changes of thymic T cell populations, particularly with maternal inoculation at gestational day 10. Altogether, these findings suggest that CV-B infection of the fetal thymus may play an important role in the genesis of autoimmune diseases. [less ▲]

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See detailUtilité de l'immuno-histochimie dans la détection des altérations des gènes réparateurs des mésappariements de l'ADN À propos d'une série de 48 cas de cancers colorectaux
Ziadi, Sonia; Ben Gacen, Riadh; Haoues, Imen et al

in Annales de Biologie Clinique (2011), 69(2), 167-173

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See detailPrevalence and characteristics of the MMTV-like associated breast carcinomas in Tunisia
Hachana, Mohamed Ridha ULg; Trimeche, Mounir; Ziadi, Sonia et al

in Cancer Letters (2008), 271(2), 222-230

The involvement of a retrovirus homologous to the mouse mammary tumor virus (MMTV) in the pathogenesis of human breast cancer (BC) has long been assumed, but has never been proven. Previous studies have ... [more ▼]

The involvement of a retrovirus homologous to the mouse mammary tumor virus (MMTV) in the pathogenesis of human breast cancer (BC) has long been assumed, but has never been proven. Previous studies have reported the detection of MMTV-like env sequences in variable proportions that did not exceed 40% of BC cases in several countries. However, these viral sequences have been found in higher proportion (74%) in Tunisian diagnosed with BC during the seventies. This study is an attempt to evaluate the current prevalence of MMTV-like env gene in BC in Tunisian women. We used semi-nested PCR that amplify a 190-bp MMTV-like env sequence, followed by direct sequencing to screen a series of 122 cases of BC randomly selected. The findings were correlated to clinicopathological data and immunohistochemical expression status of progesterone and oestrogen receptors, HER2, and P53. Specific MMTV-like env sequences were found in 17 (13.9%) cases of breast carcinomas, whereas the same sequences were not detected in matched normal breast tissues. The presence of the viral sequences correlates inversely with progesterone receptor expression (6.8% versus 20.3%; P = 0.03) and HER2 overexpression (3.1% versus 17.7%; P = 0.04). This present study confirms the presence of MMTV-like env sequences in BC in Tunisian women but describes an important decrease in the prevalence of the viral sequences compared with pervious studies. This reduction may be due to some changes in the virological characteristics or exposure to the virus. [less ▲]

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See detailProfile of methylaion of tumour related genes in breast cancer in Tunisian women
Hachana, Mohamed Ridha ULg; Trimeche, Mounir; Ziadi, Sonia et al

in European Journal of Cancer (2008), 6(9), 195

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See detailContribution de l’inactivation épigénétique des gènes BRCA1 et BRCA2 dans les cancers du sein sporadiques en Tunisie
Trimeche, Mounir; Ziadi, Sonia; Hachana, Mohamed Ridha ULg et al

in Bulletin du Cancer (2008)

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See detailPresence of simian virus 40 DNA sequences in diffuse large B-cell lymphomas in Tunisia correlates with aberrant promoter hypermethylation of multiple tumor suppressor genes
Amara, Khaled; Trimeche, Mounir; Ziadi, Sonia et al

in International Journal of Cancer = Journal International du Cancer (2007), 121(12), 2693-2702

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See detailFréquence de l’hyperméthylation du promoteur du gène BLU dans le cancer du sein en Tunisie
Trimeche, Mounir; Ziadi, Sonia; Hachana, Mohamed Ridha ULg et al

in Bulletin du Cancer (2007)

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See detailInvestigation of Epstein-Barr virus (EBV) prevalence in thyroid carcinomas in Tunisia
Trimeche, Mounir; Ziadi, Sonia; Hachana, Mohamed Ridha ULg et al

in Virchows Archiv : An International Journal of Pathology (2007)

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See detailInvestigation of human papillomavirus (HPV) in breast cancer among women from Tunisia
Trimeche, Mounir; Hachana, Mohamed Ridha ULg; Ziadi, Sonia et al

in Virchows Archiv : An International Journal of Pathology (2007)

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See detailDNA promoter hypermethylation of BLU gene in invasive breast ductal carcinoma in Tunisia
Hachana, Mohamed Ridha ULg; Trimeche, Mounir; Amara, Khaled et al

in Virchows Archiv : An International Journal of Pathology (2007)

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See detailCD10 expression by fusiform stromal cells in nasopharyngeal carcinoma correlates with tumor progression
Braham, Hend; Trimeche, Mounir; Ziadi, Sonia et al

in Virchows Archiv : An International Journal of Pathology (2006), 449(2), 220-224

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See detailPrevalence of Epstein-Barr virus in Sjögren's syndrome in Tunisia
Trimeche, Mounir; Ziadi, Sonia; Amara, Khaled et al

in Revue de Médecine Interne (2006), 27(7), 519-523

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