References of "Misson, Jean-Paul"
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See detailEfficacy of Sublingual Lorazepam Versus Intrarectal Diazepam for Prolonged Convulsions in Sub-Saharan Africa.
Malu, Celestin Kaputu Kalala; Kahamba, Daniel Mukeba; Walker, Timothy David et al

in Journal of child neurology (2013)

In Sub-Saharan Africa, intrarectal diazepam is the first-line anticonvulsant mostly used in children. We aimed to assess this standard care against sublingual lorazepam, a medication potentially as ... [more ▼]

In Sub-Saharan Africa, intrarectal diazepam is the first-line anticonvulsant mostly used in children. We aimed to assess this standard care against sublingual lorazepam, a medication potentially as effective and safe, but easier to administer. A randomized controlled trial was conducted in the pediatric emergency departments of 9 hospitals. A total of 436 children aged 5 months to 10 years with convulsions persisting for more than 5 minutes were assigned to receive intrarectal diazepam (0.5 mg/kg, n = 202) or sublingual lorazepam (0.1 mg/kg, n = 234). Sublingual lorazepam stopped seizures within 10 minutes of administration in 56% of children compared with intrarectal diazepam in 79% (P < .001). The probability of treatment failure is higher in case of sublingual lorazepam use (OR = 2.95, 95% CI = 1.91-4.55). Sublingual lorazepam is less efficacious in stopping pediatric seizures than intrarectal diazepam, and intrarectal diazepam should thus be preferred as a first-line medication in this setting. [less ▲]

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See detailÉPIDÉMIOLOGIE ET CARACTÉRISTIQUES DES CONVULSIONS FEBRILES DE L'ENFANT
KAPUTU, Kalala Malu CELESTIN; MAFUTA, Musalu ERIC; DUBRU, Jean-Marie ULg et al

in Revue Médicale de Liège (2013), 68(4), 180-185

Summary : Febrile Seizures (FS), despite their usual benign clinical course, are still subject of controversies regarding the need for further investigation and treatment with anti-epileptic drugs (AEDs ... [more ▼]

Summary : Febrile Seizures (FS), despite their usual benign clinical course, are still subject of controversies regarding the need for further investigation and treatment with anti-epileptic drugs (AEDs). Our study aimed to inventory the clinical findings, laboratory and imaging data associated with FS and eventually influencing their management. 275 episodes admitted with FS at the emergency ward of the Liège CHR over a 5 year period were retrospectively analyzed regarding precipitating factors; clinical features; laboratory, electroencephalographic, and imaging studies; as well as treatment response. FS represented 1.4% of admissions to the pediatric service. 31.3% of patients had a family history of seizure disorder. 9% percent of seizures were focal, 11.7% recurrent, and 12.3% prolonged (greater than 10 minutes). Upper respiratory tract and otorhinolaryngologic viral infections were the most often implicated provoking factors, occurring in 69.5% of patients. Laboratory, electroencephalographic and radiographic studies were normal in more than 90% of cases. 73.8% of seizures resolved without intervention. An AED was required to manage the remaining 26.2%. This study confirms the favorable outcomes of FS as demonstrated in previous studies. This happens without requiring AEDs for resolution, and without recurrence. Laboratory, electroencephalographic and imaging studies, as well as initiation of AEDs should be based primarily on clinical severity. [less ▲]

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See detailConvulsions associées à le fièvre et développement psychomoteur en soins de santé primaires à Kinshasa
KAPUTU, Kalala Malu CELESTIN; Mafuta, EM; OKITUNDU, LE-A et al

in Annales Africaine de Médecine (2012), 5(3), 1106-1111

Summary A prospective and descriptive study including 148 children (age: 5-71 months) presenting with febrile seizures (FS) at two Primary Health Care centres in Kinshasa, was conducted over a period of 3 ... [more ▼]

Summary A prospective and descriptive study including 148 children (age: 5-71 months) presenting with febrile seizures (FS) at two Primary Health Care centres in Kinshasa, was conducted over a period of 3 months. Type of seizure (genaralized or focal), its duration, and its characteristic (recurrent or not), were documented, to assess the severity of the disorder. The Psychomotor Development (PMD) of each patient was evaluated, using the Gensini and Gavito scale and then the Psychomotor Development Quotient (PDQ) calculated, according to the motor, communication, and social domains. Main results were: a reduction in PDQ (6.7%), motor delay (5%), communication delay (3.4%), and social delay (2.7%), based on this scale. No significant link was found between global PDQ reduction and markers of FS severity. However, recurrent seizures seemed strongly associated to delayed motor development (p=0.02 [OR=1.096, CI: 1.060-1.128]). These findings suggest that the motor domain could be more affected in children presenting FS, especially those with recurrent seizures. This link needs to be clearly established through larger case-control studies. [less ▲]

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See detailProfils evolutifs à court terme des convulsions associées à la Fièvre chez le nourisson et le jeune enfant en milieu de soins de santé primaires à kinshasa
KAPUTU, Kalala Malu CELESTIN; Mafuta, Musalu Eric; okitundu, luwa E-Andjafono Daniel et al

in African journal of neurological sciences (2012), 31(1), 23-33

ABSTRACT Background The immediate prognosis of febrile convulsions is a subject of importance to both clinicians and families. Aim Our study aims to analyse the factors that establish the clinical course ... [more ▼]

ABSTRACT Background The immediate prognosis of febrile convulsions is a subject of importance to both clinicians and families. Aim Our study aims to analyse the factors that establish the clinical course in the first 24 hours in children admitted with febrile convulsion Methods 148 children, aged between 5 and 71 months, were prospectively enrolled at their admission for febrile convulsions in two paediatric reference centres in Kinshasa between 10th February and 10th May, 2008. The clinical course over 24 hours was documented and analysed with regard to the clinical features of the initial crisis. Results: 80% of children were less than 3 years old. Based on the clinical presentations, 8 subgroups were distinguished. The 2 groups characterized by the absence (Group 1) or presence (Group 8) of the three identified prognostic factors had significantly different clinical courses over 24 hours (p<0.05). Group 8 contained children with the worst clinical course, characterised by seizure recurrence, neurological deficits and death. Focal type seizures, prolonged seizures and recurrent seizures were all associated with a worse outcome on univariate analysis, but on multivariate analysis, only recurrent seizures predicted a significantly worse prognosis (OR 4.4, CI 2.0-9.6). Conclusion Febrile convulsions present with different clinical characteristics and these have short term prognostic value. Regardless of the underlying cause, recognition of these poor prognostic factors should allow the establishment of appropriate surveillance and preventative treatment measures. [less ▲]

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See detailAspects neurologiques associés au Syndrome de Down
Vaessen; Daron, aurore; DUBRU, Jean-Marie ULg et al

in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2012), 14(2), 40-43

Summary : Down syndrome is one of best caracterized genetic syndromes. Its phenotype includes specific morphological features, mental retardation and several organic impairments such as cardiac ... [more ▼]

Summary : Down syndrome is one of best caracterized genetic syndromes. Its phenotype includes specific morphological features, mental retardation and several organic impairments such as cardiac malformations, cutaneous disorders and immunologic abnormalities. Beside these disturbances neurological disorders have been less considered or thought to be the expression of the mental retardation. However it is important to pay attention to the high incidence of epilepsy such as West syndrome in infants and “Late-Onset of myoclonic epilepsy in Down Syndrome” in the adult. They might required specific treatment. ADHD as well as autistic behavior may be difficult to diagnose especially in children with severe mental retardation. They need precise attention and rigourous follow-up of their treatment. [less ▲]

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See detailDiastematomyelia: pre- and postnatal multimodal diagnostic approach.
Passoglou, V.; Tebache, M.; Collignon, L. et al

in Journal Belge de Radiologie (1924) (2011), 94(6), 333-5

Diastematomyelia is a relatively rare congenital abnormality presenting as a sagittal separation of the spinal cord. Although cases of diastematomyelia have been previously reported, fully documented ... [more ▼]

Diastematomyelia is a relatively rare congenital abnormality presenting as a sagittal separation of the spinal cord. Although cases of diastematomyelia have been previously reported, fully documented approaches by both prenatal and postnatal diagnostic workup are rare in the literature. We present a fully studied case of diastematomyelia type I investigated by prenatal US and MRI and postnatal US, MRI and radiography. [less ▲]

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See detailTemple-Baraitser syndrome: a rare and possibly unrecognized condition.
Jacquinet, Adeline ULg; Gerard, Marion; Gabbett, Michael T et al

in American Journal of Medical Genetics. Part A (2010), 152A(9), 2322-6

Temple-Baraitser syndrome, previously described in two unrelated patients, is the association of severe mental retardation and abnormal thumbs and great toes. We report two additional unrelated patients ... [more ▼]

Temple-Baraitser syndrome, previously described in two unrelated patients, is the association of severe mental retardation and abnormal thumbs and great toes. We report two additional unrelated patients with Temple-Baraitser syndrome, review clinical and radiological features of previously reported cases and discuss mode of inheritance. Patients share a consistent pattern of anomalies: hypo or aplasia of the thumb and great toe nails and broadening and/or elongation of the thumbs and halluces, which have a tubular aspect. All patients were born to unrelated parents and occurred as a single occurrence in multiple sibships, suggesting sporadic inheritance from a de novo mutation mechanism. Comparative genomic hybridization in Patients 1, 2 and 3 did not reveal any copy number variations. We confirm that Temple-Baraitser syndrome represents a distinct syndrome, probably unrecognized, possibly caused by a de novo mutation in a not yet identified gene. [less ▲]

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See detailGlucose-galactose transporter DEFICIENCY: a diagnosis based on clinical observations.
HARVENGT, Julie ULg; poskin, julie; etienne, isabelle et al

Poster (2009, March)

Dehydration and major diarrhea in young infants is mainly linked to infectious diseases. However in case leading to denutrition and growth retardation, metabolic causes or malabsorption should be evocated ... [more ▼]

Dehydration and major diarrhea in young infants is mainly linked to infectious diseases. However in case leading to denutrition and growth retardation, metabolic causes or malabsorption should be evocated. We report here the case of a few days old infant admitted for early recurrence of liquid stools and vomiting. XX is born at term (3450 grams, 51 cm) after an uneventful pregnancy. Consanguinity has been reported in the family. He was breastfed but presented rapidly liquid stools and vomiting. At 10 days old he was first admitted for dehydration, loss of weight below his birth weight (2900 grams) and severe hypernatremia. Semi elementary diet led to some improvement but he was readmitted at the age of one month for similar even worse symptoms including abdominal distension and explosive stools. Complementary investigations have excluded infection, parasitosis, malformation and immune deficits. Different diet formulas were tried with no significant benefit what led to the placement of parenteral nutrition thanks to which weight was gained. Hypothesis of peculiar carbohydrate malabsorption was made and the following tests have been carried out: -Clinitest: presence of reducing substances in the stools. -Lactose Breath test: between 15 and 90 ppm H2 with a peak value at 90 ppm H2 after 90 minutes. -Duodenal biopsy: normal histology; normal activity of lactase, maltase, saccharase-isomaltase. Considering the normality of these enzyme activities, hypothesis of “Na-dependant glucose-galactose transporter” deficit was put forward. This was confirmed according to the results of HGPO and glucose breath test. Search for SGTL1 gene mutation is still in progress. In conclusion despite of the huge progresses made at molecular biology level, clinical observation remain essential to the diagnosis of malabsorption. Precise reporting of the used milk formula and comparative analysis of their composition can orient the diagnosis and help to select the most accurate molecular test. Here, analyses exclude every enzyme activity deficiencies. Carbohydrate malabsorption from first days of live can be linked to a glucose-galactose transporter deficiency due to a SGLT1 mutation (chr 22). This autosomal recessive disorder has only been reported 200 times until now. [less ▲]

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See detailDéveloppement normal et pathologique du neocortex cérébral
Misson, Jean-Paul ULg; Evrard, Philippe

in Poncelet, Martine; Majerus, Steve; Van der Linden, Martial (Eds.) Traité de neuropsychologie de l'enfant (2009)

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See detailManagement of diffuse glioma in children: a retrospective study of 27 cases and review of literature.
Piette, Caroline ULg; Deprez, Manuel ULg; Born, Jacques et al

in Acta Neurologica Belgica (2008), 108(2), 35-43

Gliomas are the most common CNS tumours in children and present either as circumscribed tumours or diffusely infiltrative neoplasms. Diffuse gliomas develop both in the cerebral hemispheres and the ... [more ▼]

Gliomas are the most common CNS tumours in children and present either as circumscribed tumours or diffusely infiltrative neoplasms. Diffuse gliomas develop both in the cerebral hemispheres and the brainstem and have a poor prognosis. Guidelines for the therapy of these tumours are still debated. In this study, we reviewed the clinical features of 27 consecutive patients with diffuse gliomas admitted to the Department of Paediatrics of CHR Citadelle, University of Liege, between 1985 and 2005. We review their clinical presentation, diagnosis, treatment and outcome with reference to the published literature. [less ▲]

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See detailUrgences Pédiatriques
Carvelli, Thierry ULg; Viellevoye, Renaud ULg; Misson, Jean-Paul ULg

Book published by Université de Liège (2008)

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See detailPrise en charge du médulloblastome de l'enfant
Fransolet, A. C.; Born, J. D.; Misson, Jean-Paul ULg et al

in Revue Médicale de Liège (2007), 62(4), 200-4

We present the experience of the Citadelle Hospital (Liege, B) in the diagnosis, treatment and follow-up of medulloblastoma in children. A retrospective study of 10 cases of medulloblastoma was performed ... [more ▼]

We present the experience of the Citadelle Hospital (Liege, B) in the diagnosis, treatment and follow-up of medulloblastoma in children. A retrospective study of 10 cases of medulloblastoma was performed. Five years after diagnosis, the event-free survival was 77%. [less ▲]

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See detailActualites therapeutiques en neuropediatrie
Leroy, Patricia; Dubru, Jean-Marie ULg; Misson, Jean-Paul ULg

in Revue Médicale de Liège (2007), 62(5-6, May-Jun), 449-450

The most recent antiepileptic drugs used in children are lamotrigine, topiramate, oxcarbamaz6pine and levetiracetam. Their efficacy is proven, depending on the type of crisis, but in Belgium they are ... [more ▼]

The most recent antiepileptic drugs used in children are lamotrigine, topiramate, oxcarbamaz6pine and levetiracetam. Their efficacy is proven, depending on the type of crisis, but in Belgium they are reimbursed only in certain conditions. The treatment of children with attention deficit hyperactivity disorder (ADHD), which was only constituted of methylphenidate, can now benefit from atomoxetine whose mechanism of action is different. [less ▲]

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See detailIntoxication au CO: Mouvements athétosiques
Mohring, M.-P.; Dadoumont, Caroline ULg; Daron, A. et al

in Journal de Pédiatrie belge (2007)

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See detailEpilepsie chez des enfants infirmes moteurs-cérébraux
Peduzzi, M.; Defontaine, E.; Misson, Jean-Paul ULg

in Revue Médicale de Liège (2006), 61(4), 237-239

The incidence of epilepsy in 110 patients with cerebral palsy (the majority with spastic tetraplegia) was 46,4%. Almost half of the patients with spastic tetraplegia (45%) and hemiplegia (52%) had ... [more ▼]

The incidence of epilepsy in 110 patients with cerebral palsy (the majority with spastic tetraplegia) was 46,4%. Almost half of the patients with spastic tetraplegia (45%) and hemiplegia (52%) had epilepsy. The incidence was lower in patients with spastic diplegia (32%). Half of epilepsy in spastic hemiplegia were partial seizures and the other half consisted of generalized seizures, while generalized tonic-clonic episodes predominated in all other forms of C.P. A high incidence of West syndrome was observed in patients with spastic tetraplegia. Etiological factors of C.P. were perinatal in 75%. 16,65% had neonatal antecedents of convulsions; most of them had spastic tetraplegia (75%) and a significant mental retardation. A low intelligence quotient (I.Q.) was seen in most of the children with epilepsy, and patients with tetraplegia had significantly lower intelligence quotient than other groups. [less ▲]

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See detailLe syndrome de Prader Willi: intérêt d'une prise en charge pluridisciplinaire
Salmon, C.; Gaillez, Stephanie ULg; Pieltain, Catherine ULg et al

in Revue Médicale de Liège (2006), 61(7-8, Jul-Aug), 593-599

Prader Willi syndrome can be viewed as a physiopathological model of obesity. Such patients deserve specific management, preferably in a multidisciplinary setting. The paper reports on 6 patients followed ... [more ▼]

Prader Willi syndrome can be viewed as a physiopathological model of obesity. Such patients deserve specific management, preferably in a multidisciplinary setting. The paper reports on 6 patients followed in the paediatric endocrine service at the University of Liege. [less ▲]

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See detailMigraine specificities during childhood to adulthood: diagnosis and treatment
de Tourtchaninoff, M.; Misson, Jean-Paul ULg

in Acta Neurologica Belgica (2006)

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See detailEmpyème extradural et ostéite de la voûte crânienne associés à des infections ORL et un déficit immunitaire
Liegeois, S.; Lerusse, C.; Leroy, P. et al

in Revista de Neurologia (2006)

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See detailA propos d'un cas d'hémiparésie aigue chez l'enfant
Daron, Aurore; Leroy, Patricia; Misson, Jean-Paul ULg

in Percentile (2005), 10

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