References of "Michaux, C"
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See detailEffect of heart failure on dipeptidyl peptidase IV activity in plasma of dogs.
Gomez, N.; Matheeussen, V.; Damoiseaux, Cécile ULg et al

in Journal of Veterinary Internal Medicine (2012)

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See detailStructure-based pharmacophore of COX-2 selective inhibitors and identification of original lead compounds from 3D database searching method
Michaux, C.; De Leval, X.; Julémont, F. et al

in European Journal of Medicinal Chemistry (2006), 41

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See detailA new potential cyclooxygenase-2 inhibitor, pyridinic analogue of nimesulide
Michaux, C.; Charlier, C.; Julémont, F. et al

in European Journal of Medicinal Chemistry (2005), 40

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See detailPharmacophore generation to design new leads for selective cyclooxygenase-2 inhibition
Michaux, C.; Julemont, F.; De Leval, X. et al

Poster (2004, October 07)

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See detailIdentification d’inhibiteurs sélectifs de la cyclooxygénase-2 (COX-2)
Michaux, C.; Julemont, F.; De Leval, X. et al

Conference (2004, June)

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See detailIdentification d’un inhibiteur COX-2 sélectif », 18èmes Journées Franco-belges de Pharmacochimie
Michaux, C.; Julemont, F.; De Leval, X. et al

Poster (2004, June)

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See detailDesign, synthesis and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors
Julémont, F.; de Leval, X.; Michaux, C. et al

in Journal of Medicinal Chemistry (2004), 47

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See detailIdentification of COX-2 selective inhibitor
Michaux, C.; Julémont, F.; de Leval, X. et al

in Fundamental & Clinical Pharmacology (2004)

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See detailSynthèse et évaluation pharmacologique de N-pyridinyl-alkanesulfonamides apparentés au nimésulide
Julemont, F.; De Leval, X.; Michaux, C. et al

Poster (2003, May)

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See detailPyridinic sulfonamides as potential COX-2 inhibitors
Julemont, F.; De Leval, X.; Damas, J. et al

Poster (2003, May)

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See detailPharmacophore generation to design new leads for selective cyclooxygenase-2 (COX-2) inhibition
Michaux, C.; De Leval, X.; Julemont, F. et al

Poster (2003, May)

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See detailPharmacological evaluation of the novel thromboxane modulator BM-567 (I/II). Effects of BM-567 on platelet function
Dogne, J. M.; de Leval, X.; Kolh, Philippe ULg et al

in Prostaglandins, Leukotrienes, and Essential Fatty Acids (2003), 68(1), 49-54

The aim of this work was to evaluate the effects of BM-567 ( N-pentyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea), a torasemide derivative. on both thromboxane A(2) (TXA(2)) receptors (TP) and ... [more ▼]

The aim of this work was to evaluate the effects of BM-567 ( N-pentyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea), a torasemide derivative. on both thromboxane A(2) (TXA(2)) receptors (TP) and thromboxane synthase of human platelets. The drug affinity for TP receptors of human washed platelets has been determined. In this test BM-567 showed a high affinity (IC50: 1.1+/-0.1 nM) for the TP receptors in comparison with BM-531 (IC50: 7.8+/-0.7 nM) and sulotroban (IC50: 931+/-85 nM), two TXA(2) antagonists. We also demonstrated that BM-567 prevented platelet aggregation induced by arachidonic acid (AA) (600 muM) (ED100: 0.20+/-0.10muM), U-46619, a stable TXA(2) agonist (1 muM) (ED50: 0.30+/-0.04 muM) and collagen (1 mug ml(-1)) (% of inhibition: 44.3+/-4.3% at 10 muM) and inhibited the second wave of ADP (2 muM). Moreover, when BM-567 was incubated in whole blood from healthy donors, the closure time measured by the Platelet Function analyzer (PFA-100) was significantly prolonged (closure time: 215+/-21 s) by using collagen/epinephrine cartridges. Finally, at the concentration of 1 muM, BM-567 completely reduced the TXB2 production from human platelets stimulated with AA (600 muM). These results indicate that BM-567 is a novel combined TXA(2) receptor antagonist and thromboxane synthase inhibitor characterized by a powerful antiplatelet potency. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailPharmacological evaluation of the novel thromboxane modulator BM-567 (I/II). Effects of BM-567 on platelet function
Dogné, Jean-Michel ULg; De Leval, X.; Kolh, Philippe ULg et al

in Prostaglandins, Leukotrienes, and Essential Fatty Acids (2003)

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See detailRationalization of the binding mode of pyridinic compounds derived from nimesulide, a preferential cyclooxygenase-2 inhibitor
Michaux, C.; Charlier, C.; Julemont, F. et al

Poster (2002, November 15)

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See detailEffects of thromboxane A2 receptor antagonists and thromboxane synthase inhibitors on osteogenic sarcoma cell induced platelet aggregation
De Leval, X.; Benoît, V.; Neven, P. et al

Poster (2002, October)

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See detailRationalization of the binding mode of pyridinic compounds derived from nimesulide, a preferential cyclooxygenase-2 inhibitor
Michaux, C.; Charlier, C.; Julemont, F. et al

Poster (2002, September 26)

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See detailEffects of thromboxane A2 receptor antagonists and thromboxane synthase inhibitors on osteogenic sarcoma cell induced platelet aggregation
De Leval, X.; Benoît, V.; Neven, P. et al

Poster (2002, May)

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See detailEffects of thromboxane A2 receptor antagonists and thromboxane synthase inhibitors on osteogenic sarcoma cell-induced platelet aggregation
De Leval, X.; Benoit, V.; Neven, P. et al

Poster (2002, March 02)

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See detailEvaluation of pyridinic sulfonamides related to nimesulide as COX-2 selective inhibitors
Julemont, F.; De Leval, X.; Neven, P. et al

Poster (2002, March 02)

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